Thierry Hennet

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. pmc Milk sialyllactose influences colitis in mice through selective intestinal bacterial colonization
    Andrea Fuhrer
    Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland
    J Exp Med 207:2843-54. 2010
  2. pmc Identification of domains and amino acids essential to the collagen galactosyltransferase activity of GLT25D1
    Claire Perrin-Tricaud
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    PLoS ONE 6:e29390. 2011
  3. doi request reprint Decoding breast milk oligosaccharides
    Thierry Hennet
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland
    Swiss Med Wkly 144:w13927. 2014
  4. doi request reprint Diseases of glycosylation beyond classical congenital disorders of glycosylation
    Thierry Hennet
    Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057, Switzerland
    Biochim Biophys Acta 1820:1306-17. 2012
  5. doi request reprint From glycosylation disorders back to glycosylation: what have we learned?
    Thierry Hennet
    Institute of Physiology, University of Zurich, Switzerland
    Biochim Biophys Acta 1792:921-4. 2009
  6. pmc Milk oligosaccharide sialyl(α2,3)lactose activates intestinal CD11c+ cells through TLR4
    Ekaterina Kurakevich
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:17444-9. 2013
  7. pmc Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases
    Belinda Schegg
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Mol Cell Biol 29:943-52. 2009
  8. pmc Identification and functional analysis of a defect in the human ALG9 gene: definition of congenital disorder of glycosylation type IL
    Christian G Frank
    Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Hum Genet 75:146-50. 2004
  9. doi request reprint Fibrotic response in fibroblasts from congenital disorders of glycosylation
    M Rita Lecca
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Cell Mol Med 15:1788-96. 2011
  10. pmc Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid
    Micha A Haeuptle
    Institute of Physiology, University of Zurich, CH 8057 Zurich, Switzerland
    J Biol Chem 286:6085-91. 2011

Collaborators

Detail Information

Publications27

  1. pmc Milk sialyllactose influences colitis in mice through selective intestinal bacterial colonization
    Andrea Fuhrer
    Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland
    J Exp Med 207:2843-54. 2010
    ..Thus, exposure to sialyllactose during infancy affects bacterial colonization of the intestine, which influences the susceptibility to DSS-induced colitis in adult mice...
  2. pmc Identification of domains and amino acids essential to the collagen galactosyltransferase activity of GLT25D1
    Claire Perrin-Tricaud
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    PLoS ONE 6:e29390. 2011
    ..Because multiple mutations in different regions of CEECAM1 contribute to the lack of galactosyltransferase activity, we deduced that CEECAM1 is functionally different from the related GLT25D1 protein...
  3. doi request reprint Decoding breast milk oligosaccharides
    Thierry Hennet
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland
    Swiss Med Wkly 144:w13927. 2014
    ..The availability of pure oligosaccharides in large amounts will soon enable the study of these compounds in humans in the context of intestinal and metabolic disorders associated to various forms of dysbiosis. ..
  4. doi request reprint Diseases of glycosylation beyond classical congenital disorders of glycosylation
    Thierry Hennet
    Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057, Switzerland
    Biochim Biophys Acta 1820:1306-17. 2012
    ..CDG are mainly caused by defects of N-glycosylation, owing to the simple detection of under-glycosylated serum transferrin by isoelectric focusing...
  5. doi request reprint From glycosylation disorders back to glycosylation: what have we learned?
    Thierry Hennet
    Institute of Physiology, University of Zurich, Switzerland
    Biochim Biophys Acta 1792:921-4. 2009
    ..However, beyond establishing the developmental and physiological roles of glycosylation how did glycosylation disorders provided new insights to the field of glycobiology?..
  6. pmc Milk oligosaccharide sialyl(α2,3)lactose activates intestinal CD11c+ cells through TLR4
    Ekaterina Kurakevich
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:17444-9. 2013
    ..Thus, 3SL directly modulates mucosal immunity, which increases susceptibility to colitis. ..
  7. pmc Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases
    Belinda Schegg
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Mol Cell Biol 29:943-52. 2009
    ..The GLT25D1 and GLT25D2 genes now allow addressing of the biological significance of collagen glycosylation and the importance of this posttranslational modification in the etiology of connective tissue disorders...
  8. pmc Identification and functional analysis of a defect in the human ALG9 gene: definition of congenital disorder of glycosylation type IL
    Christian G Frank
    Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Hum Genet 75:146-50. 2004
    ..The ALG9 defect presented here defines a novel form of CDG named "CDG-IL."..
  9. doi request reprint Fibrotic response in fibroblasts from congenital disorders of glycosylation
    M Rita Lecca
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Cell Mol Med 15:1788-96. 2011
    ..The fibrotic response identified in CDG fibroblasts may account for the elevated tissue fibrosis, which is often encountered in CDG patients...
  10. pmc Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid
    Micha A Haeuptle
    Institute of Physiology, University of Zurich, CH 8057 Zurich, Switzerland
    J Biol Chem 286:6085-91. 2011
    ..This study shows that manipulation of the cellular Dol pool, as achieved by zaragozic acid A addition, may represent a valuable approach to improve N-linked glycosylation in CDG cells...
  11. doi request reprint Glycoprotein maturation and the UPR
    Andreas J Hülsmeier
    Institute of Physiology, University of Zurich, Winterthurerstrasse, Zurich, Switzerland
    Methods Enzymol 491:163-82. 2011
    ..We also provide detailed methods for the analysis of O-glycosylation, whose role in intracellular protein maturation is often overlooked...
  12. ncbi request reprint Selective proliferation of intestinal Barnesiella under fucosyllactose supplementation in mice
    Gisela A Weiss
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Br J Nutr 111:1602-10. 2014
    ..The present study underlines the ability of specific milk oligosaccharides to change the composition of intestinal microbiota and thereby to shape an intestinal milieu resilient to inflammatory diseases. ..
  13. pmc Human RFT1 deficiency leads to a disorder of N-linked glycosylation
    Micha A Haeuptle
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Am J Hum Genet 82:600-6. 2008
    ..RFT1 deficiency in both yeast and human cells leads to the accumulation of incomplete DolPP-GlcNAc(2)Man(5) and to a profound glycosylation disorder in humans...
  14. pmc The role of milk sialyllactose in intestinal bacterial colonization
    G Adrienne Weiss
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland
    Adv Nutr 3:483S-8S. 2012
    ..By contrast, the exposure to milk containing or deficient in 3SL had no impact on the development of mucosal leukocyte populations. Milk 3SL mainly affected the colonization of the intestine by clostridial cluster IV bacteria...
  15. doi request reprint An Echinococcus multilocularis coproantigen is a surface glycoprotein with unique O-gycosylation
    Andreas J Hülsmeier
    Institute of Parasitology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Glycobiology 20:127-35. 2010
    ..multilocularis. The observation that the EmA9 antigen expression is developmentally regulated suggests an involvement of this glycoprotein in the establishment of the parasite in its canine host...
  16. ncbi request reprint Deficiency of the first mannosylation step in the N-glycosylation pathway causes congenital disorder of glycosylation type Ik
    Claudia E Grubenmann
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    Hum Mol Genet 13:535-42. 2004
    ..The ALG1 mannosyltransferase defect described here represents a novel type of CDG, which should be referred to as CDG-Ik...
  17. ncbi request reprint Characterization of mucin-type core-1 beta1-3 galactosyltransferase homologous enzymes in Drosophila melanogaster
    Reto Müller
    Institute of Physiology, University of Zurich, Switzerland
    FEBS J 272:4295-305. 2005
    ..melanogaster suggests an increased complexity of core-1 O-glycan expression, which is possibly related to multiple developmental and physiological functions attributable to this class of glycans...
  18. doi request reprint Deficiency in COG5 causes a moderate form of congenital disorders of glycosylation
    Patricie Paesold-Burda
    University Children s Hospital Zurich, Division of Metabolism, Zurich, Switzerland
    Hum Mol Genet 18:4350-6. 2009
    ..This case demonstrates that COG deficiency and thereby CDG must be taken into consideration even in children presenting mild neurological impairments...
  19. pmc Mimivirus collagen is modified by bifunctional lysyl hydroxylase and glycosyltransferase enzyme
    Kelvin B Luther
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Biol Chem 286:43701-9. 2011
    ..These results suggest that giant viruses may have contributed to the evolution of collagen biology...
  20. pmc The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo
    Franziska Biellmann
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland
    BMC Dev Biol 8:109. 2008
    ..The beta1,3 N-acetylglucosaminyltransferase-V (B3gnt5) enzyme catalyzes the formation of the Lc3 structure, which is the core of lactoseries derived GSL...
  21. doi request reprint HPLC and mass spectrometry analysis of dolichol-phosphates at the cell culture scale
    Micha A Haeuptle
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Anal Biochem 396:133-8. 2010
    ..The effect of pravastatin, a 3-hydroxy-3-methyl-glutaryl coenzyme-A reductase inhibitor, on the formation of Dol-P in HeLa cells was investigated. As expected, this treatment led to a decrease of Dol-P down to 35% of normal levels...
  22. doi request reprint Congenital disorders of glycosylation: an update on defects affecting the biosynthesis of dolichol-linked oligosaccharides
    Micha A Haeuptle
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    Hum Mutat 30:1628-41. 2009
    ....
  23. pmc Exposure to mimivirus collagen promotes arthritis
    Nikunj Shah
    Institute of Physiology and Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Virol 88:838-45. 2014
    ..Accordingly, our study shows that environmental exposure to mimivirus represents a risk factor in triggering autoimmunity to collagens. ..
  24. ncbi request reprint Recombinant expression of hydroxylated human collagen in Escherichia coli
    Christoph Rutschmann
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Appl Microbiol Biotechnol 98:4445-55. 2014
    ....
  25. ncbi request reprint Genome-wide analysis of the unfolded protein response in fibroblasts from congenital disorders of glycosylation type-I patients
    M Rita Lecca
    Institute of Physiology, University of Zurich, Switzerland
    FASEB J 19:240-2. 2005
    ..This was paralleled by elevated expression of genes involved in amino acid biosynthesis and transport, which defined a new component of the cellular response to glycosylation stress...
  26. ncbi request reprint N-glycosylation site occupancy in serum glycoproteins using multiple reaction monitoring liquid chromatography-mass spectrometry
    Andreas J Hülsmeier
    Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mol Cell Proteomics 6:2132-8. 2007
    ..This multiple reaction monitoring LC-MS/MS method can be extended to multiple glycoproteins, thereby enabling a glycoproteomics survey of N-glycosylation site occupancies in biological samples...
  27. ncbi request reprint O-Linked glycosylation in Acanthamoeba polyphaga mimivirus
    Andreas J Hülsmeier
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, Zurich 8057, Switzerland
    Glycobiology 24:703-14. 2014
    ..We sequenced 26 previously undescribed O-glycans, most of which contain glucose as their reducing end saccharide. These data will facilitate future studies on the functional significance of glycosylation in Mimivirus. ..