Claus W Heizmann

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi Pathologies involving the S100 proteins and RAGE
    C W Heizmann
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Switzerland
    Subcell Biochem 45:93-138. 2007
  2. doi Calcium-regulated intramembrane proteolysis of the RAGE receptor
    Arnaud Galichet
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Biochem Biophys Res Commun 370:1-5. 2008
  3. ncbi S100B protein in clinical diagnostics: assay specificity
    Claus W Heizmann
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Clin Chem 50:249-51. 2004
  4. ncbi S100 proteins: structure, functions and pathology
    Claus W Heizmann
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Front Biosci 7:d1356-68. 2002
  5. ncbi The mechanism by which dietary AGEs are a risk to human health is via their interaction with RAGE: arguing against the motion
    Claus W Heizmann
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Switzerland
    Mol Nutr Food Res 51:1116-9. 2007
  6. ncbi The importance of calcium-binding proteins in childhood diseases
    Claus W Heizmann
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Switzerland
    J Pediatr 147:731-8. 2005
  7. ncbi S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells
    Hsiao Ling Hsieh
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstr 75, CH 8032 Zurich, Switzerland
    Biochem Biophys Res Commun 316:949-59. 2004
  8. doi Site-specific blockade of RAGE-Vd prevents amyloid-beta oligomer neurotoxicity
    Emmanuel Sturchler
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, 8032 Zurich, Switzerland
    J Neurosci 28:5149-58. 2008
  9. ncbi S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains
    Estelle Leclerc
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    J Biol Chem 282:31317-31. 2007
  10. ncbi The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity
    Andrea Mueller
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, Steinwiesstrasse 75, 8032 Zurich
    J Biol Chem 280:29186-93. 2005

Collaborators

Detail Information

Publications73

  1. ncbi Pathologies involving the S100 proteins and RAGE
    C W Heizmann
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Switzerland
    Subcell Biochem 45:93-138. 2007
    ..Finally, the close association of S100 proteins with cardiomyopathy, cancer, inflammation and brain diseases is summarized as well as their use in diagnosis and their potential as drug targets to improve therapies in the future...
  2. doi Calcium-regulated intramembrane proteolysis of the RAGE receptor
    Arnaud Galichet
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Biochem Biophys Res Commun 370:1-5. 2008
    ..These findings reveal new aspects of RAGE regulation and signaling and also provide a new interaction between RAGE and human pathologies...
  3. ncbi S100B protein in clinical diagnostics: assay specificity
    Claus W Heizmann
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Clin Chem 50:249-51. 2004
  4. ncbi S100 proteins: structure, functions and pathology
    Claus W Heizmann
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Front Biosci 7:d1356-68. 2002
    ....
  5. ncbi The mechanism by which dietary AGEs are a risk to human health is via their interaction with RAGE: arguing against the motion
    Claus W Heizmann
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Switzerland
    Mol Nutr Food Res 51:1116-9. 2007
    ..More recently, we also became interested in pathologies involving the Ca2+-binding S100 proteins and AGEs and their association with the multifunctional Receptor for Advanced Glycation Endproducts (RAGE)...
  6. ncbi The importance of calcium-binding proteins in childhood diseases
    Claus W Heizmann
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Switzerland
    J Pediatr 147:731-8. 2005
  7. ncbi S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells
    Hsiao Ling Hsieh
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstr 75, CH 8032 Zurich, Switzerland
    Biochem Biophys Res Commun 316:949-59. 2004
    ..These experiments suggest a common cell surface receptor for S100 proteins on endothelial cells even though intracellular translocation induced by extracellular S100 proteins is specific...
  8. doi Site-specific blockade of RAGE-Vd prevents amyloid-beta oligomer neurotoxicity
    Emmanuel Sturchler
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, 8032 Zurich, Switzerland
    J Neurosci 28:5149-58. 2008
    ....
  9. ncbi S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains
    Estelle Leclerc
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    J Biol Chem 282:31317-31. 2007
    ..Altogether these results highlight the complexity of S100/RAGE cellular signaling...
  10. ncbi The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity
    Andrea Mueller
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, Steinwiesstrasse 75, 8032 Zurich
    J Biol Chem 280:29186-93. 2005
    ..Our data suggest that in oral cancer cells the Ca(2+)- and cell cycle-dependent p53-S100A2 interaction might modulate proliferation...
  11. ncbi S100A16, a novel calcium-binding protein of the EF-hand superfamily
    Emmanuel Sturchler
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    J Biol Chem 281:38905-17. 2006
    ..Finally, we investigated S100A16 intracellular localization in human glioblastoma cells. The protein was found to accumulate within nucleoli and to translocate to the cytoplasm in response to Ca(2+) stimulation...
  12. ncbi Metal-free MIRAS phasing: structure of apo-S100A3
    Peer R E Mittl
    Institute of Biochemistry, University of Zurich, Winterthurer Strasse 190, 8057 Zurich, Switzerland
    Acta Crystallogr D Biol Crystallogr 58:1255-61. 2002
    ..The C-terminal canonical EF-hand loop shows an extended conformation and a different helix arrangement to other S100/metal complex crystal structures...
  13. ncbi Mass spectrometry: a tool for enhanced detection of hemoglobin variants
    Peter Kleinert
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, Zurich, Switzerland
    Clin Chem 54:69-76. 2008
    ..In our laboratory, we routinely apply chromatographic methods. To ascertain whether Hb variants are missed with our procedures, we additionally analyzed all samples with mass spectrometry (MS)...
  14. ncbi Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart
    Roland Kiewitz
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstr 75, CH 8032, Zurich, Switzerland
    Biochem Biophys Res Commun 306:550-7. 2003
    ..Our results support a regulatory role of S100A1 in the contraction-relaxation cycle in the human heart...
  15. ncbi S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)
    Ingo Marenholz
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zürich Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Biochem Biophys Res Commun 322:1111-22. 2004
    ..An update of the S100 nomenclature is included, because some of the recently identified S100 genes and pseudogenes had to be renamed...
  16. ncbi The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution
    Gunter Fritz
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, Universitat Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    J Biol Chem 277:33092-8. 2002
    ..Zn(2+) binding induces a large conformational change in S100A3 perturbing the hydrophobic interface between two S100A3 subunits, as shown by size exclusion chromatography and CD spectroscopy...
  17. ncbi S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells
    Hsiao Ling Hsieh
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstr 75, CH 8032 Zurich, Switzerland
    J Cell Sci 115:3149-58. 2002
    ..These experiments suggest that different S100 proteins utilize distinct translocation pathways, which might lead them to certain subcellular compartments in order to perform their physiological tasks in the same cellular environment...
  18. ncbi Effect of glycosylation on the protein pattern in 2-D-gel electrophoresis
    Peter Kleinert
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Zurich, Switzerland
    Proteomics 7:15-22. 2007
    ..This study contradicts the commonly accepted assumption that the multiple protein spots of Trf observed in 2-D-PAGE are due, as in AGP, to the glycosylation of the protein...
  19. ncbi Expression analysis of S100 proteins and RAGE in human tumors using tissue microarrays
    Hsiao Ling Hsieh
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Switzerland
    Biochem Biophys Res Commun 307:375-81. 2003
    ..This suggests a possible role of RAGE-mediated signal transduction in the development of these particular cancers...
  20. ncbi S100A16, a ubiquitously expressed EF-hand protein which is up-regulated in tumors
    Ingo Marenholz
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Zurich, Switzerland
    Biochem Biophys Res Commun 313:237-44. 2004
    ..S100A16 was mapped within the S100 gene cluster on human chromosome 1q21, a region that is frequently rearranged in tumors...
  21. ncbi Analysis of minor hemoglobins by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Karin Zurbriggen
    Division of Hematology, University of Zurich, Zurich, Switzerland
    Clin Chem 51:989-96. 2005
    ..Here we describe a method for identification of the globin chains and their posttranslational modifications contained in the Hb fractions...
  22. ncbi S100A1-deficient male mice exhibit increased exploratory activity and reduced anxiety-related responses
    Gabriele E Ackermann
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Biochim Biophys Acta 1763:1307-19. 2006
    ..In avoidance-approach tests, predominantly male S100A1KO mice showed reduced anxiety-like responses and enhanced explorative activities. We conclude that S100A1 plays a role in modulating innate fear and exploration of novel stimuli...
  23. ncbi Calcium, troponin, calmodulin, S100 proteins: from myocardial basics to new therapeutic strategies
    Marcus C Schaub
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Biochem Biophys Res Commun 369:247-64. 2008
    ..Some of these sensor proteins are critically involved in certain diseases and are now used in clinical diagnostics...
  24. ncbi Detection of a novel variant human hemoglobin by electrospray ionization mass spectrometry
    Heinz Troxler
    Division of Clinical Chemistry and Biochemistry, Division of Nephrology, Division of Hematology, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, Zurich, CH 8032, Switzerland
    Biochem Biophys Res Commun 292:1044-7. 2002
    ..The carrier was found to be heterozygous for the new hemoglobin variant. These results illustrate the power of ESI mass spectrometry for hemoglobin analysis...
  25. ncbi Effects of creatine supplementation in cystic fibrosis: results of a pilot study
    Christian P Braegger
    Divisions of Gastroenterology and Nutrition and Clinical Chemistry and Biochemistry, University Children s Hospital, Steinwiesstrasse 75, Zurich CH 8032, Switzerland
    J Cyst Fibros 2:177-82. 2003
    ..Creatine supplementation has been shown to increase phosphocreatine levels, thus promoting muscle growth and strength in athletes and having protective effects in neuromuscular disorders...
  26. ncbi Ca2+-binding S100 proteins in the central nervous system
    C W Heizmann
    Department of Pediatrics, University of Zurich, Switzerland
    Neurochem Res 24:1097-100. 1999
    ..Their protein structures, localizations, and association with brain pathology as well as their potential use in clinical diagnostics will be discussed...
  27. ncbi Filter paper cards contaminated with EMLA cream produce artefacts on acylcarnitine analysis
    T Kuster
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Zurich, Switzerland
    J Inherit Metab Dis 27:707-9. 2004
    ..This interference prevents the proper quantification of the two short-chain acylcarnitines when samples are analysed without derivatization...
  28. ncbi Purification and characterization of the recombinant human calcium-binding S100 proteins CAPL and CACY
    M Pedrocchi
    Department of Pediatrics, University of Zurich, Switzerland
    Biochemistry 33:6732-8. 1994
    ..The Ca(2+)-induced difference spectra of CAPL are about 3 times smaller than those of CACY, suggesting that the additional Tyr84 in CACY is much more sensitive to Ca2+ than the two Tyr residues conserved in both proteins...
  29. ncbi Subcellular distribution of S100 proteins in tumor cells and their relocation in response to calcium activation
    A Mueller
    Department of Pediatrics, University of Zurich, Switzerland
    Histochem Cell Biol 111:453-9. 1999
    ..These findings support the hypothesis that S100 proteins could play a crucial role in the regulation of Ca2+ homeostasis in cancer cells...
  30. ncbi Free 3-nitrotyrosine in exhaled breath condensates of children fails as a marker for oxidative stress in stable cystic fibrosis and asthma
    Silva Celio
    Division of Respiratory Medicine, University Children s Hospital Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Nitric Oxide 15:226-32. 2006
    ..HPLC analyses provided similar concentration ranges for EBC 3-NT when compared with GC-NICI-MS. Our study has clearly demonstrated that free 3-NT in EBC fails as a marker for oxidative stress in children with stable CF and asthma...
  31. ncbi The multifunctional S100 protein family
    Claus W Heizmann
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Zurich, Switzerland
    Methods Mol Biol 172:69-80. 2002
  32. ncbi S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart
    D Engelkamp
    Department of Pediatrics, University of Zurich, Switzerland
    Biochemistry 31:10258-64. 1992
    ..Interestingly, the expression pattern of S100 alpha, CACY, and CAPL in human tissues differs significantly from that in rodent tissues...
  33. ncbi Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily
    B W Schafer
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstrasse 75, CH 8032 Zurich, the Institute of Pharmacology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol Chem 275:30623-30. 2000
    ..The two Cu(2+)-binding sites likely share ligands of the EF-hands. The potential role of S100A5 in copper homeostasis is discussed...
  34. ncbi Binding of Ca2+ and Zn2+ to human nuclear S100A2 and mutant proteins
    C Franz
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, CH 8032 Zurich, Switzerland
    J Biol Chem 273:18826-34. 1998
    ....
  35. ncbi Mass spectrometric analysis of human transferrin in different body fluids
    Peter Kleinert
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Zurich, Switzerland
    Clin Chem Lab Med 41:1580-8. 2003
    ..Additionally, samples from alcohol consumers that were found with turbidimetric immunoassay to contain increased levels of carbohydrate-deficient transferrin were analyzed...
  36. ncbi Intracellular Ca2+ and Zn2+ levels regulate the alternative cell density-dependent secretion of S100B in human glioblastoma cells
    G E Davey
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland
    J Biol Chem 276:30819-26. 2001
    ..On the other hand, secretion did not decrease by treatment with brefeldin A, supporting the view that this process is independent of the endoplasmic reticulum-Golgi classical secretion pathway...
  37. ncbi Clustered organization of S100 genes in human and mouse
    K Ridinger
    Department of Pediatrics, University of Zurich, Switzerland
    Biochim Biophys Acta 1448:254-63. 1998
    ..Further studies on the genomic organization of the S100 genes including various species could generate new insights into gene regulatory processes and phylogenetic relationships...
  38. ncbi Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation
    R Wicki
    Department of Pediatrics, University of Zurich, Switzerland
    Cell Calcium 22:243-54. 1997
    ..Since transcription of a number of known tumor suppressor genes is also repressed by methylation, our observation is consistent with the suggestion that S100A2 might have a tumor suppressor function...
  39. ncbi Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry
    E C Ilg
    Department of Pediatrics, University of Zurich, Switzerland
    Biochem Biophys Res Commun 225:146-50. 1996
    ..Interestingly, a sequence comparison of S100A12 with all known human S100 proteins revealed that S100A12 is the most divergent of the S100 proteins...
  40. ncbi The S100 family of EF-hand calcium-binding proteins: functions and pathology
    B W Schafer
    Department of Pediatrics, University of Zurich, Switzerland
    Trends Biochem Sci 21:134-40. 1996
    ..Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging...
  41. ncbi Amino acid sequence analysis of human S100A7 (psoriasin) by tandem mass spectrometry
    D M Bürgisser
    Department of Pediatrics, University of Zurich, Switzerland
    Biochem Biophys Res Commun 217:257-63. 1995
    ..Interestingly, a sequence comparison of S100A7 with all known human S100 proteins showed that S100A7 is the most divergent of all S100 proteins...
  42. ncbi Purification and cation binding properties of the recombinant human S100 calcium-binding protein A3, an EF-hand motif protein with high affinity for zinc
    U G Föhr
    Department of Pediatrics, University of Zurich, Switzerland
    J Biol Chem 270:21056-61. 1995
    ..Since no Zn(2+)-binding motif of known structure was identified in the primary sequence of S100A3, the results are suggestive for a novel Zn(2+)-binding motif...
  43. ncbi S100A1, a new marker for acute myocardial ischemia
    R Kiewitz
    Division of Clinical Chemistry and Biochemistry, University of Zurich, Zurich, Switzerland
    Biochem Biophys Res Commun 274:865-71. 2000
    ..We suggest that S100A1 should be included in combinatorial measurements as an early diagnostic marker for ischemic coronary diseases...
  44. ncbi Transcriptional regulation of S100A1 and expression during mouse heart development
    R Kiewitz
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Switzerland
    Biochim Biophys Acta 1498:207-19. 2000
    ..The regulatory elements identified in the mouse S100A1 promoter correspond well with the observed expression pattern and suggest that S100A1 has an important function during heart muscle development...
  45. ncbi Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family
    B W Schafer
    University of Zurich, Department of Pediatrics, Switzerland
    Genomics 25:638-43. 1995
    ..The new nomenclature should facilitate and further the understanding of this protein family and be easily expandable to other species...
  46. ncbi S100A1 deficiency results in prolonged ventricular repolarization in response to sympathetic activation
    G E Ackermann
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Gen Physiol Biophys 27:127-42. 2008
    ....
  47. ncbi Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family
    R Wicki
    Department of Pediatrics, University of Zurich, Switzerland
    Biochem Biophys Res Commun 227:594-9. 1996
    ..Furthermore, we characterized the cDNA sequence coding for the mouse homolog of S100A13. Similar to the putative human protein, mouse S100A13 is composed of 98 amino acids displaying a homology of 86.7% compared to human S100A13...
  48. ncbi Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions
    R Boni
    Department of Dermatology, University of Zurich, Switzerland
    Br J Dermatol 137:39-43. 1997
    ..These findings are important for correct interpretation of staining patterns, when S100 antibodies are used as markers for melanoma or other tumours...
  49. ncbi S100A13. Biochemical characterization and subcellular localization in different cell lines
    K Ridinger
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, 8032 Zurich, Switzerland
    J Biol Chem 275:8686-94. 2000
    ..These data suggest diverse functions for this protein in signal transduction...
  50. ncbi Specific citrullination causes assembly of a globular S100A3 homotetramer: a putative Ca2+ modulator matures human hair cuticle
    Kenji Kizawa
    Basic Research Laboratory, Kanebo Cosmetics Inc, 5 3 28 Kotobuki cho, Odawara 250 0002, Japan
    J Biol Chem 283:5004-13. 2008
    ..High concentrations of S100A3 homotetramer might provide the millimolar level of Ca2+ required for hair cuticular barrier formation...
  51. ncbi Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes
    Daisuke Matsubara
    Department of Human Pathology, School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 96:844-57. 2005
    ..Thus, the present study demonstrates involvement of S100A2 and S100A4 in the progression of lung adenocarcinomas and an inverse association between S100A4 and p53 expression, and provides a list of targets regulated by S100A2 and S100A4...
  52. ncbi Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase
    Shibani Bhattacharya
    Department of Biochemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232 8725, USA
    Biochemistry 42:14416-26. 2003
    ..These structural studies, in combination with available biochemical data, have been used to develop a model for calcium-induced activation of NDR kinase by S100B...
  53. ncbi Implications on zinc binding to S100A2
    Michael Koch
    Department of Biology, University of Konstanz, Universitatsstrasse 10, Postfach M665, 78457 Konstanz, Germany
    Biochim Biophys Acta 1773:457-70. 2007
    ..These findings imply that S100A2 is regulated by both Zn2+ and Ca2+, and suggest that Zn2+ might deactivate S100A2 by inhibiting response to intracellular Ca2+ signals...
  54. pmc The extracellular region of the receptor for advanced glycation end products is composed of two independent structural units
    Brian M Dattilo
    Department of Biochemistry, Center for Structural Biology, 465 21st Avenue South, 5140 BIOSCI MRBIII, Vanderbilt University, Nashville, Tennessee 37232 8725, USA
    Biochemistry 46:6957-70. 2007
    ..The implications of these results are discussed with respect to models for RAGE signaling...
  55. pmc Structural and functional insights into RAGE activation by multimeric S100B
    Thorsten Ostendorp
    Fachbereich Biologie, Mathematisch Naturwissenschaftliche Sektion, Universitat Konstanz, Konstanz, Germany
    EMBO J 26:3868-78. 2007
    ..The structural and the binding data suggest that tetrameric S100B triggers RAGE activation by receptor dimerisation...
  56. ncbi Expression and purification of the soluble isoform of human receptor for advanced glycation end products (sRAGE) from Pichia pastoris
    Thorsten Ostendorp
    Fachbereich Biologie, Mathematisch Naturwissenschaftliche Sektion, Universitat Konstanz, Germany
    Biochem Biophys Res Commun 347:4-11. 2006
    ..The identity of the protein was confirmed by mass spectrometry and Western blot. The protein was N-glycosylated and 95-98% pure as judged by SDS-PAGE...
  57. pmc Purification, crystallization and preliminary X-ray diffraction studies on human Ca2+-binding protein S100B
    Thorsten Ostendorp
    Fachbereich Biologie, Universitat Konstanz, Postfach M665, Universitatsstrasse 10, 78467 Konstanz, Germany
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:673-5. 2005
    ..9 A and belong to space group P2(1), with unit-cell parameters a = 63.4, b = 81.6, c = 71.5 A, alpha = 90, beta = 107, gamma = 90 degrees. Preliminary analysis of the X-ray data indicate that there are four homodimers per asymmetric unit...
  58. ncbi S100A4 regulates E-cadherin expression in oral squamous cell carcinoma
    Makiko Moriyama-Kita
    Department of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medicine, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Cancer Lett 230:211-8. 2005
    ..Interestingly, vascular endothelial growth factor-C was up-regulated in OSC-19/S100A4 cells. In summary, S100A4-mediated regulation of E-cadherin expression may play an important mechanism in invasion and metastasis of oral SCC...
  59. ncbi Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma
    Hue H Luu
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA
    Cancer Lett 229:135-48. 2005
    ..Our findings provide evidence that, while S100A6 is commonly overexpressed in human osteosarcoma, loss of its expression correlates with a metastatic phenotype...
  60. ncbi Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles
    Kenji Kizawa
    Basic Research Laboratory, Kanebo Ltd, 5 3 28 Kotobuki cho, Odawara 250 0002, Japan
    Biochem Biophys Res Commun 299:857-62. 2002
    ..This is the first report on biochemical characteristics of S100A3 in hair cuticle...
  61. ncbi Detection of S100B, S100A6 and galectin-3 ligands in meningiomas as markers of aggressiveness
    Sabine Hancq
    Department of Neurosurgery, Erasmus University Hospital, Brussels, Belgium
    Int J Oncol 25:1233-40. 2004
    ..Our results thus suggest that the galectin-3-binding sites and S100B (and S100A6 to a lesser extent) could play a role in the aggressiveness characterizing atypical meningiomas...
  62. ncbi S100A6 overexpression within astrocytes associated with impaired axons from both ALS mouse model and human patients
    Daphne Hoyaux
    Laboratory of Histopathology, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    J Neuropathol Exp Neurol 61:736-44. 2002
    ..Although these results do not give any clue about the beneficial or detrimental role played by S100A6, its induction may be assumed to appropriately serve some function(s)...
  63. doi N(epsilon)-carboxymethyllysine-modified proteins are unable to bind to RAGE and activate an inflammatory response
    Timo M Buetler
    Nestle Research Center, Lausanne, Switzerland
    Mol Nutr Food Res 52:370-8. 2008
    ..Thus, CML probably does not form the necessary structure(s) to interact with RAGE and activate an inflammatory signaling cascade in RAGE-expressing cells...
  64. ncbi Postnatal maturation of the dog stria vascularis-- an immunohistochemical study
    Angélique G Coppens
    Laboratory of Anatomy and Embryology, Veterinary Anatomy, Free University of Brussels, Brussels, Belgium
    Anat Rec A Discov Mol Cell Evol Biol 270:82-92. 2003
    ..This study may form a basis for future investigations about spontaneous cochleosaccular degeneration in dogs. This species is an important companion animal, and a possible model for the study of comparable diseases in humans...
  65. ncbi Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family
    Agnieszka Pietas
    Institute of Pathology, University Hospital Charite, Berlin, Germany
    Genomics 79:513-22. 2002
    ....
  66. ncbi Correlation of S100A4 expression with invasion and metastasis in oral squamous cell carcinoma
    Makiko Moriyama-Kita
    Department of Experimental Therapeutics, Cancer Research Institute, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 0934, Japan
    Oral Oncol 40:496-500. 2004
    ..01). These results lead us to conclude that S100A4 expression status may be a useful prognostic factor in patients with invasive and metastatic oral SCCs...
  67. ncbi The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer
    Ulrike Stein
    Department of Surgery and Surgical Oncology, Robert Rössle Cancer Hospital, Charite Campus Buch, Berlin, Germany
    Gastroenterology 131:1486-500. 2006
    ..Our aim was to elucidate the impact of gain-of-function beta-catenin on the metastasis-associated gene S100A4 in human colon cancer cell lines and tumors...
  68. ncbi An update of the S100 nomenclature
    Ingo Marenholz
    Pediatric Pneumology and Immunology, Charité Medical Faculty, Berlin, Germany
    Biochim Biophys Acta 1763:1282-3. 2006
    ..Here we present the official and updated nomenclature of this protein family, approved by the HGNC (HUGO gene nomenclature committee) and ECS (European Calcium Society)...
  69. ncbi Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene
    Christina EL Naaman
    Department of Molecular Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK2100 Copenhagen, Denmark
    Oncogene 23:3670-80. 2004
    ..Taken together, these observations indicate that spontaneous tumors in S100A4-/- mice are a result of functional destabilization of p53 tumor suppressor gene...
  70. ncbi Differential expression of S100 proteins in the developing human hippocampus and temporal cortex
    Wood Yee Chan
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    Microsc Res Tech 60:600-13. 2003
    ....
  71. ncbi Dissimilar effect of perming and bleaching treatments on cuticles: advanced hair damage model based on elution and oxidation of S100A3 protein
    Kenji Kizawa
    Basic Research Laboratory, Kanebo Cosmetics Inc, 5 3 28 Kotobuki cho, Odawara 250 0002, Japan
    J Cosmet Sci 56:219-26. 2005
    ..Here we present a more comprehensive model of hair damage based on a diverse mechanism of cuticle delamination...
  72. ncbi Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton
    Nathalie Belot
    Laboratory of Histopathology, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Biochim Biophys Acta 1600:74-83. 2002
    ..All these activities, which result in the stimulation of cell motility, contribute to the understanding of the extracellular role of S100A4...
  73. ncbi Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models
    Alain Boom
    Laboratory of Histology, Neuroanatomy and Neuropathology, School of Medicine, Universite Libre de Bruxelles, 808, Route de Lennik, Bldg GE, 1070 Brussels, Belgium
    Biochim Biophys Acta 1742:161-8. 2004
    ..Coupling the knowledge that biometals such as zinc are highly concentrated in the amyloid deposits in AD and S100A6 having a high affinity for Zn(2+) may suggest that S100A6 plays a role in AD neuropathology...