Research Topics
| U HeiningerSummaryAffiliation: University Children's Hospital Country: Switzerland Publications
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Detail Information
Publications
A risk-benefit analysis of vaccinationUlrich Heininger
Division of Pediatric Infectious Diseases, University Children s Hospital Basel, P O Box, CH 4005, Basel, Switzerland
Vaccine 27:G9-G12. 2009..Therefore, continuous evaluation of risks and benefits of vaccines is required and results of these need to be communicated broadly to strengthen the confidence in immunisation programmes...- The concept of vaccination failureU Heininger
Division of Infectious Diseases and Vaccines, University Children s Hospital UKBB, PO Box, CH 4031 Basel, Switzerland
Vaccine 30:1265-8. 2012..Here we propose general definitions for types of vaccination failure. In the future, these should be complemented by specific definitions for specific vaccines as needed depending on public health considerations... - Human metapneumovirus infections--biannual epidemics and clinical findings in children in the region of Basel, SwitzerlandUlrich Heininger
University Children s Hospital UKBB, CH 4005 Basel, Switzerland
Eur J Pediatr 168:1455-60. 2009..RSV epidemics usually follow a reciprocal biannual pattern, leading to annually alternating major RSV and hMPV epidemics... - Evaluation of the compliance with recommended procedures in newborns exposed to HBsAg-positive mothers: a multicenter collaborative studyUlrich Heininger
Division of Pediatric Infectious Diseases, University Children s Hospital Basel, Switzerland
Pediatr Infect Dis J 29:248-50. 2010..The purpose of this study was to determine the compliance with official recommendations for prevention of perinatal HBV transmission in hepatitis B surface antigen (HBsAg) exposed infants... - Maternally derived antibodies against Bordetella pertussis antigens pertussis toxin and filamentous hemagglutinin in preterm and full term newbornsUlrich Heininger
Division of Pediatric Infectious Diseases, University Children s Hospital, Basel, Switzerland
Pediatr Infect Dis J 28:443-5. 2009..Transfer ratios increased with gestational age of the newborns. Based on these findings, maternal and neonatal immunization strategies should be considered to protect young infants from pertussis... - Update on pertussis in childrenUlrich Heininger
University Children s Hospital UKBB, PO Box, CH 4005 Basel, Switzerland
Expert Rev Anti Infect Ther 8:163-73. 2010..This apparently requires more than immunization of children--that is, expanding routine immunization into adolescence and adulthood... - Bordetella pertussis and concomitant viral respiratory tract infections are rare in children with cough illnessUlrich Heininger
Department of Pediatric Infectious Diseases, University Children s Hospital Basel, Switzerland
Pediatr Infect Dis J 30:640-4. 2011.... - Preventive medicines: vaccination, prophylaxis of infectious diseases, disinfectantsUlrich Heininger
Universitäts Kinderspital beider Basel, CH 4005 Basel, Switzerland
Handb Exp Pharmacol 205:317-37. 2011.... 
[Influenza in children--an epidemiological problem]U Heininger
Pädiatrische Infektiologie und Vakzinologie, Universitäts Kinderspital beider Basel UKBB, Basel
Ther Umsch 64:643-7. 2007..However, the need for repeated yearly vaccination as well as suboptimal acceptance of influenza immunization amongst physicians and the public are significant hurdles, which would need to be overcome...- Prevalence of nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) in children a multicenter cross-sectional studyUlrich Heininger
University Children s Hospital, Basel, Switzerland
Pediatr Infect Dis J 26:544-6. 2007..7 years, interquartile range 1.3-10.4 years) and 562 (41.3%) grew S. aureus. Only one isolate was MRSA (0.18%) which encoded mecA and femA genes as well as SCCmec type IV, whereas Panton-Valentine leukocidin (PVL) was absent... - Long-term safety and effectiveness of lopinavir/ritonavir in antiretroviral-experienced HIV-1-infected childrenChristoph Rudin
Division of Infectious Diseases, University Children s Hospital, Basel, Switzerland
Arch Dis Child 95:478-81. 2010..To evaluate the long-term safety and effectiveness of lopinavir/ritonavir (LPV/r) in a population-based cohort of HIV-1-infected children... - Recent progress in clinical and basic pertussis researchU Heininger
University Children s Hospital UKBB, PO Box, 4005 Basel, Switzerland
Eur J Pediatr 160:203-13. 2001..CONCLUSION: The major achievements in the field of pertussis research are reviewed and discussed. They have great impact on the current and future practice of paediatric, adolescent and adult medicine... - Pertussis: an old disease that is still with usU Heininger
University Children s Hospital, Basel, Switzerland
Curr Opin Infect Dis 14:329-35. 2001..The present review provides an update on recent progress... - Lemierre syndrome and nosocomial transmission of Fusobacterium necrophorum from patient to physicianJ Bonhoeffer
Paediatric Infectious Diseases and Vaccines, University Children s Hospital Basel, Switzerland
Klin Padiatr 222:464-6. 2010..Human-to-human transmission of Fusobacterium necrophorum has not been described before... - The role of Bordetella infections in patients with acute exacerbation of chronic bronchitisJ Bonhoeffer
University Children s Hospital Basel, P O Box, CH 4005 Basel, Switzerland
Infection 33:13-7. 2005..Bordetella pertussis, which causes whooping cough, has not been studied in this context. We aimed to assess the role of Bordetella infections in patients with AECB... - Booster immunization with a hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated poliovirus vaccine and Haemophilus influenzae type b conjugate combination vaccine in the second year of life: safety, immunogenicity and persistenceU Heininger
University Children s Hospital, Division for Pediatric Infectious Diseases and Vaccinology, Basel, Switzerland
Vaccine 25:1055-63. 2007.... - Built environment, parents' perception, and children's vigorous outdoor playBettina Bringolf-Isler
Swiss Tropical and Public Health Institute, Basel, Switzerland
Prev Med 50:251-6. 2010..To evaluate the combined effects and relative importance of socio-cultural factors as well as parents' subjectively perceived and objectively assessed environment on time children spent vigorously playing outdoors... - Seroprevalence of varicella-zoster virus immunoglobulin G antibodies in Swiss adolescents and risk factor analysis for seronegativityU Heininger
University Children s Hospital, Basel, Switzerland
Pediatr Infect Dis J 20:775-8. 2001..Little is known about the seroprevalence of anti-varicella-zoster virus (VZV) serum antibodies in adolescents in Switzerland as in most other European countries... - Long-term safety and effectiveness of ritonavir, nelfinavir, and lopinavir/ritonavir in antiretroviral-experienced HIV-infected childrenChristoph Rudin
Division of Infectious Diseases, University Children s Hospital, Basel, Switzerland
Pediatr Infect Dis J 27:431-7. 2008..To evaluate the long-term safety and effectiveness of ritonavir, nelfinavir, and lopinavir/ritonavir in antiretroviral-experienced, initially protease inhibitor (PI)-naive, human immunodeficiency virus (HIV)-1-infected children... - Prospective study on central venous line associated bloodstream infectionsMine Wagner
University Children s Hospital Basel UKBB, PO Box CH 4005, Basel, Switzerland
Arch Dis Child 96:827-31. 2011..To prospectively assess the incidence rates and characteristics of central venous line associated bloodstream infections (CLABSI) in one institution... - Compliance with antenatal screening for hepatitis B surface antigen carrier status in pregnant women and consecutive procedures in exposed newbornsKirsten Beckers
Department of Internal Medicine, Spital Zofingen, Zofingen, Switzerland
Eur J Pediatr 163:654-7. 2004..This will require improved communication between neonatology units and care-providing paediatricians in private practices... - Adverse events following immunization: perception and evidenceJan Bonhoeffer
University Children s Hospital, Basel, Switzerland
Curr Opin Infect Dis 20:237-46. 2007..The aim of this article is to highlight the evidence on new and ongoing vaccine safety concerns in the light of several vaccines recently licensed and others made available and recommended more widely... - Clinical findings and unusual epidemiologic characteristics of human metapneumovirus infections in children in the region of Basel, SwitzerlandGurli Baer
University Children s Hospital UKBB, P O Box CH 4005, Basel, Switzerland
Eur J Pediatr 167:63-9. 2008..In conclusion, hMPV leads to endemic and epidemic respiratory disease with features similar to those of RSV and should be considered in the differential diagnosis of upper and lower respiratory tract disease... - The development of standardized case definitions and guidelines for adverse events following immunizationKatrin S Kohl
Vaccine 25:5671-4. 2007 - No temporal association between influenza outbreaks and invasive pneumococcal infectionsAndre Michael Toschke
Institute for Social Pediatrics and Adolescent Medicine, Ludwig Maximilians University Munich, Munich, Germany
Arch Dis Child 93:218-20. 2008..To assess whether the influenza peak in populations precedes the annual peak for invasive pneumococcal infections (IPI) in winter... - Vaccinated students with negative enzyme immunoassay results show positive measles virus-specific antibody levels by immunofluorescence and plaque neutralisation testsAnnedore Tischer
National Reference Centre Measles, Mumps, Rubella, Robert Koch Institute, Berlin, Germany
J Clin Virol 38:204-9. 2007..In 2003 and 2004, in contrast to previous years, surprisingly many negative results (33% and 54%, respectively) were observed... - Metaanalysis of vaccine effectiveness in varicella outbreaksOtmar Bayer
Institute for Social Paediatrics and Adolescent Medicine, Ludwig Maximilians University, Heiglhofstr 63, 81377 Munich, Germany
Vaccine 25:6655-60. 2007..Waning might also be an issue with the newly recommended two dose vaccination schedule. Sustained surveillance for varicella outbreaks in populations with varicella immunization programs therefore is mandatory... - Three-year surveillance of intussusception in children in SwitzerlandMichael Buettcher
Division of Pediatric Infectious Diseases, University Children s Hospital Basel, PO Box 4005, Basel, Switzerland
Pediatrics 120:473-80. 2007..We attempted to obtain baseline data on the incidence of intussusception and its association with gastroenteritis in a cross-sectional observational study in children... - Assessment of immunization status in hospitalized children followed by counseling of parents and primary care physicians improves vaccination coverage: an interventional studyBeda Muehleisen
Division of Pediatric Infectious Diseases, Basel University Children s Hospital, Basel, Switzerland
J Pediatr 151:704-6, 706.e1-2. 2007..One month after hospital discharge, significantly more children in the intervention group (27%) than the controls (8%) had received catch-up immunizations (P < .001)... - [Protection with influenza vaccine from bird flu?]Ulrich Heininger
Universitätskinderspital beider Basel UKBB, Schweiz
Med Monatsschr Pharm 30:418. 2007 - Attitudes of pediatricians regarding influenza self-immunization: a survey in a Swiss university children's hospitalUlrich Heininger
Division of Pediatric Infectious Diseases, University Children s Hospital Basel, PO Box CH 4005, Basel, Switzerland
Pediatr Infect Dis J 22:391-4. 2003..To assess the attitude toward influenza immunization of doctors among physicians in our hospital... - Comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthmaDouglas M Fleming
Northfield Health Centre, Birmingham, United Kingdom
Pediatr Infect Dis J 25:860-9. 2006..There was no evidence of a significant increase in adverse pulmonary outcomes for CAIV-T compared with TIV. CAIV-T had a significantly greater relative efficacy of 35% compared with TIV in this high-risk population... 
Early appearance of bactericidal antibodies after polysaccharide challenge of toddlers primed with a group C meningococcal conjugate vaccine: what is its role in the maintenance of protection?Theodore F Tsai
Wyeth Research, 500 Arcola Rd, Collegeville, Pennsylvania 19426, USA
Clin Vaccine Immunol 13:854-61. 2006..The majority of toddlers previously immunized with MCC and challenged 1 year later with PS antigen mounted protective levels of bactericidal antibody within 2 to 4 days...- Pertussis immunisation in adolescents and adults--Bordetella pertussis epidemiology should guide vaccination recommendationsUlrich Heininger
University Children s Hospital UKBB, PO Box, CH 4005 Basel, Switzerland
Expert Opin Biol Ther 6:685-97. 2006..pertussis could be eliminated... - Acceptance and timeliness of standard vaccination in children with chronic neurological deficits in north-western SwitzerlandBettina Ute Tillmann
Department of Neuropaediatrics, University Children s Hospital, P O Box, 4005 Basel, Switzerland
Eur J Pediatr 164:320-5. 2005..Therefore, vaccination should be promoted as part of the consultation during a routine appointment with the specialist... - New pertussis vaccination strategies beyond infancy: recommendations by the global pertussis initiativeKevin D Forsyth
Department of Paediatraics and Child Health, Flinders Medical Center, Flinders University, Adelaide, South Australia, Australia
Clin Infect Dis 39:1802-9. 2004..The Global Pertussis Initiative, an expert scientific forum, was established to address the ongoing problems associated with pertussis disease worldwide... - Prevalence of nosocomial infections in Swiss children's hospitalsKathrin Mühlemann
University Hospital, Bern, Switzerland
Infect Control Hosp Epidemiol 25:765-71. 2004..To acquire data on pediatric nosocomial infections (NIs), which are associated with substantial morbidity and mortality and for which data are scarce... - [Shock behavior state after vaccination in children--should you continue vaccination?]Ulrich Heininger
Abt Pädiatrische Infektiologie, Universitäts Kinderspital beider Basel, Schweiz
Med Monatsschr Pharm 27:279. 2004 - The Brighton Collaboration-enhancing vaccine safetyJan Bonhoeffer
Division of Pediatrics Infectious Diseases and Vaccines, University Children's Hospital, P.O. Box 8, 4005 Basel, Switzerland
Vaccine 22:2046. 2004 - Comparison of pulsed field gel electrophoresis patterns of Bordetella pertussis isolates from unvaccinated children with severe or mild pertussisUlrich Heininger
University Hospital for Children and Adolescents, Erlangen, Germany
Pediatr Infect Dis J 23:211-7. 2004..mild illness. CONCLUSIONS: Differences in virulence of circulating B. pertussis strains can be absent or might not correlate with specific PFGE patterns. Other methods should be evaluated to identify differences in virulence... - An update on the prevention of influenza in children and adolescentsUlrich Heininger
University Children s Hospital UKBB, PO Box, 4005, Basel, Switzerland
Eur J Pediatr 162:828-36. 2003..Recently, neuraminidase inhibitors with curative and preventive efficacy against influenza virus types A and B have become available. They serve as second line weapons for influenza prophylaxis under specific circumstances... - The Brighton Collaboration: enhancing comparability of vaccine safety dataKatrin S Kohl
Centers for Disease Control and Prevention, National Immunization Program, 1600 Clifton Rd, Mailstop E-61, Atlanta, GA 30333, USA
Pharmacoepidemiol Drug Saf 12:335-40. 2003 - Protection against vaccine-preventable diseases in medical studentsGurli Baer
Division of Pediatric Infectious Diseases, University Children's Hospital Basel, CH-4005 Basel, Switzerland
Pediatr Infect Dis J 22:373-4. 2003 - The Brighton Collaboration: addressing the need for standardized case definitions of adverse events following immunization (AEFI)Jan Bonhoeffer
University Children s Hospital Basel, Basel, Switzerland
Vaccine 21:298-302. 2002..Comparability requires the availability of standardized case definitions for adverse events following immunization (AEFI) and guidelines for case determination, recording and data presentation... - Shortage of vaccines: USA, Europe, who next?Ulrich Heininger
Arch Dis Child 87:9. 2002 - Seroprevalence and immunization history of selected vaccine preventable diseases in medical studentsGurli Baer
Division of Pediatric Infectious Diseases, University Children's Hospital Basel, P.O. Box 8, CH-4005 Basel, Switzerland
Vaccine 23:2016-20. 2005..In conclusion, the great majority of medical students had immunization gaps. Systematic immunization programmes for medical students should be implemented... - Prospective surveillance of hospitalisations associated with varicella-zoster virus infections in children and adolescentsJan Bonhoeffer
Division of Paediatric Infectious Diseases, University Children's Hospital, P.O. Box, 4005, Basel, Switzerland
Eur J Pediatr 164:366-70. 2005..CONCLUSION: This study describes a sizeable hospitalisation and complication rate of varicella-zoster virus infections and provides a solid basis for future immunisation recommendations in Switzerland... - Health care-associated rotavirus illness in pediatric inpatients in Germany, Austria, and SwitzerlandIvo M Foppa
Department of Epidemiology and Biostatistics, Arnold School of Public Health, Columbia, SC 29208, USA
Infect Control Hosp Epidemiol 27:633-5. 2006..The effectiveness of vaccination against RV from 2 months of age onward remains to be evaluated... - Compliance with recommended immunizations in adolescentsUlrich Heininger
University Children s Hospital UKBB, P O Box CH 4005, Basel, Switzerland
Eur J Pediatr 165:671-6. 2006..The goal of this study was to determine compliance with official standard immunization recommendations in adolescents attending secondary schools in the city of Erlangen, Germany... - Seroprevalence of Varicella-Zoster virus IgG antibodies in Swiss children during the first 16 months of ageUlrich Heininger
Division of Pediatric Infectious Diseases, University Children s Hospital Basel, P O Box CH 4005, Basel, Switzerland
Vaccine 24:3258-60. 2006..To investigate the persistence of maternal IgG antibodies against Varicella-Zoster virus (VZV) in infants and young children... - Immunization rates and timely administration in pre-school and school-aged childrenUlrich Heininger
University Children s Hospital UKBB, P O Box, 4005 Basel, Switzerland
Eur J Pediatr 165:124-9. 2006..This may lead to fatal disease in individuals, epidemics in the community, and threatens national and international targets of disease elimination, such as measles and congenital rubella syndrome... - Influenza vaccination among healthcare workers in a university children's hospitalTerhi Tapiainen
University Children's Hospital, PO Box, CH-4005 Basel, Switzerland
Infect Control Hosp Epidemiol 26:855-8. 2005..Active promotion and educational efforts were successful in increasing the immunization rate of physicians but not nurses and other HCWs... - How do physicians immunize their own children? Differences among pediatricians and nonpediatriciansKlara M Posfay-Barbe
Centre for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Switzerland
Pediatrics 116:e623-33. 2005..Physicians are known to exert a direct influence on immunization rates by answering questions and clarifying misconceptions. Yet, it is unknown how they immunize their own children... - Evaluation of the Brighton Collaboration case definition of acute intussusception during active surveillanceTerhi Tapiainen
University Children Hospital, Division of Pediatrics Infectious Diseases and Vaccines, Post Box, 4005 Basel, Switzerland
Vaccine 24:1483-7. 2006..In conclusion, the case definition was useful and applicable to assess the background rate of intussusception in the light of potential future rotavirus immunization... - Fever following immunizationTerhi Tapiainen
University Children's Hospital, Postfach, CH-4005 Basel, Switzerland
Expert Rev Vaccines 4:419-27. 2005..A recent analysis by the Brighton Collaboration has provided a standardized case definition for fever, the use of which should be strongly encouraged... - Reliability of varicella history in children and adolescentsUlrich Heininger
University Children s Hospital Basel, Switzerland
Swiss Med Wkly 135:252-5. 2005..Our goal was to determine positive and negative predictive values of varicella history in a prospective cross-sectional study... - Health burden of pertussis in infants and childrenDavid P Greenberg
University of Pittsburgh School of Medicine, Division of Allergy, Immunology and Infectious Diseases, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
Pediatr Infect Dis J 24:S39-43. 2005.... - Defining pertussis epidemiology: clinical, microbiologic and serologic perspectivesJames D Cherry
David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Pediatr Infect Dis J 24:S25-34. 2005..In particular, polymerase chain reaction and single serum serology are 2 techniques that should be more widely adopted... - Comparative phenotypic analysis of the Bordetella parapertussis isolate chosen for genomic sequencingUlrich Heininger
Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles School of Medicine, University of California-Los Angeles, Los Angeles, California 90095-1747, USA
Infect Immun 70:3777-84. 2002..pertussis (by lack of motility and cytotoxicity to a macrophage-like cell line). These results begin to provide phenotypes that can be related to genetic differences identified in the genomic sequences of bordetellae...