Martin Hausmann

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. doi request reprint MIP-3α expression in macrophages is NOD dependent
    M Hausmann
    Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland
    Digestion 85:192-201. 2012
  2. pmc BCL-2 modifying factor (BMF) is a central regulator of anoikis in human intestinal epithelial cells
    Martin Hausmann
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital of Zurich, 8091 Zurich, Switzerland
    J Biol Chem 286:26533-40. 2011
  3. pmc (GT)N dinucleotide repeat polymorphism of haem oxygenase-1 promotor region is not associated with inflammatory bowel disease risk or disease course
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 153:81-5. 2008
  4. ncbi request reprint 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells
    Reinhold Altmann
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Biochem Pharmacol 74:612-22. 2007
  5. ncbi request reprint Role of soluble factors and three-dimensional culture in in vitro differentiation of intestinal macrophages
    Tanja Spoettl
    Department of Internal Medicine I, University of Regensburg, Regensburg 93042, Germany
    World J Gastroenterol 13:1032-41. 2007
  6. ncbi request reprint Cell-cell contacts prevent anoikis in primary human colonic epithelial cells
    Claudia Hofmann
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Gastroenterology 132:587-600. 2007
  7. doi request reprint Gene expression profiles of mucosal fibroblasts from strictured and nonstrictured areas of patients with Crohn's disease
    Markus Lang
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Inflamm Bowel Dis 15:212-23. 2009
  8. ncbi request reprint Physiological role of macrophage inflammatory protein-3 alpha induction during maturation of intestinal macrophages
    Martin Hausmann
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Immunol 175:1389-98. 2005
  9. doi request reprint Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients
    Katrin Kosovac
    University of Regensburg, Department of Internal Medicine I, Regensburg, Germany
    Inflamm Bowel Dis 16:1311-21. 2010
  10. doi request reprint Specific differences in migratory function of myofibroblasts isolated from Crohn's disease fistulae and strictures
    Johannes K H Meier
    Department of Cranio Maxillo Facial Surgery, University of Regensburg, Germany
    Inflamm Bowel Dis 17:202-12. 2011

Collaborators

Detail Information

Publications30

  1. doi request reprint MIP-3α expression in macrophages is NOD dependent
    M Hausmann
    Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland
    Digestion 85:192-201. 2012
    ..We therefore investigated the influence of NOD2 ligation of IMAC differentiation and functional MIP-3α induction...
  2. pmc BCL-2 modifying factor (BMF) is a central regulator of anoikis in human intestinal epithelial cells
    Martin Hausmann
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital of Zurich, 8091 Zurich, Switzerland
    J Biol Chem 286:26533-40. 2011
    ..BMF knockdown supports survival of IEC. BMF is induced in human IEC by the loss of cell attachment and is likely to play an important role in the regulation of IEC survival...
  3. pmc (GT)N dinucleotide repeat polymorphism of haem oxygenase-1 promotor region is not associated with inflammatory bowel disease risk or disease course
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 153:81-5. 2008
    ..Our data indicate that (GT)(n) dinucleotide repeats of the HO-1 promotor region have no significance for the pathophysiology and disease course of IBD...
  4. ncbi request reprint 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells
    Reinhold Altmann
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Biochem Pharmacol 74:612-22. 2007
    ..Highest activity of 13-HODE dehydrogenase is found in colonic epithelial cells (CECs). We therefore investigated whether 13-Oxo-ODE is a new endogenous ligand of PPARgamma in CECs...
  5. ncbi request reprint Role of soluble factors and three-dimensional culture in in vitro differentiation of intestinal macrophages
    Tanja Spoettl
    Department of Internal Medicine I, University of Regensburg, Regensburg 93042, Germany
    World J Gastroenterol 13:1032-41. 2007
    ..To examine the factor(s) involved in differentiation of intestinal macrophages (IMACs) using a recently established in vitro model...
  6. ncbi request reprint Cell-cell contacts prevent anoikis in primary human colonic epithelial cells
    Claudia Hofmann
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Gastroenterology 132:587-600. 2007
    ..In contrast to the established role of cell-matrix contact, the role of cell-cell contacts as a physiologic survival factor for CECs is less clear...
  7. doi request reprint Gene expression profiles of mucosal fibroblasts from strictured and nonstrictured areas of patients with Crohn's disease
    Markus Lang
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Inflamm Bowel Dis 15:212-23. 2009
    ..We aimed to investigate differences in gene expression profiles between CLPF isolated from normal, inflamed and strictured areas of CD patients...
  8. ncbi request reprint Physiological role of macrophage inflammatory protein-3 alpha induction during maturation of intestinal macrophages
    Martin Hausmann
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Immunol 175:1389-98. 2005
    ..MIP-3alpha is induced during the differentiation of monocytes into IMAC. Our data suggest that MIP-3alpha expression could be involved in the recruitment of CD45R0+ cells into the lamina propria...
  9. doi request reprint Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients
    Katrin Kosovac
    University of Regensburg, Department of Internal Medicine I, Regensburg, Germany
    Inflamm Bowel Dis 16:1311-21. 2010
    ....
  10. doi request reprint Specific differences in migratory function of myofibroblasts isolated from Crohn's disease fistulae and strictures
    Johannes K H Meier
    Department of Cranio Maxillo Facial Surgery, University of Regensburg, Germany
    Inflamm Bowel Dis 17:202-12. 2011
    ..The behavior of CD-CLPFs isolated from fistulae and strictures was now investigated in detail...
  11. ncbi request reprint Evidence for a differential expression of fibronectin splice forms ED-A and ED-B in Crohn's disease (CD) mucosa
    Julia Brenmoehl
    Department of Internal Medicine I, University of Regensburg, 93042, Regensburg, Germany
    Int J Colorectal Dis 22:611-23. 2007
    ..We, therefore, investigated changes in FN or integrin expression that could be relevant for CLPF migration...
  12. ncbi request reprint A new organotypic model to study cell interactions in the intestinal mucosa
    Tanja Spottl
    Department of Internal Medicine I, University of Regensburg, Germany
    Eur J Gastroenterol Hepatol 18:901-9. 2006
    ..Here we describe a more organotypic model to study cell interactions in the intestinal mucosa...
  13. doi request reprint Knock-out of β-glucosidase 2 has no influence on dextran sulfate sodium-induced colitis
    Michael Scharl
    Division of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
    Digestion 84:156-67. 2011
    ..The aim of this study was to investigate whether Gba2 knock-out (Gba2(-/-)) affects the extent of dextran sulfate sodium (DSS)-induced colitis in mice...
  14. ncbi request reprint Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer
    Nicole Deutscher
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Int J Colorectal Dis 21:573-81. 2006
    ..The aim of this study was to investigate the expression profiling of IL-11Ralpha and its downstream signaling cascade in colonic adenoma and carcinoma...
  15. doi request reprint Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis
    Susanne Bentz
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 300:G598-607. 2011
    ..We conclude that induced colitis in TKTL1(-/-) mice was more severe compared with WT. This indicates a role of TKTL1 during mucosal repair and restoration...
  16. ncbi request reprint IL-15 protects intestinal epithelial cells
    Florian Obermeier
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Eur J Immunol 36:2691-9. 2006
    ..According to this, endogenously produced IL-15 in chronic colitis does not only act as a proinflammatory cytokine but has at the same time the potential to reduce mucosal damage by preventing IEC apoptosis...
  17. ncbi request reprint Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells
    Stephan Kiessling
    Department of Internal Medicine I, University of Regensburg, Germany
    J Biol Chem 279:10304-15. 2004
    ..The beneficial effects of IL-11 therapy are likely to be mediated by CEC via activation of the Akt-survival pathway, mediating antiapoptotic effects to support mucosal integrity...
  18. ncbi request reprint Serum soluble TNF receptor I and II levels correlate with disease activity in IBD patients
    Tanja Spoettl
    Department of Internal Medicine I, University of Regensburg, Germany
    Inflamm Bowel Dis 13:727-32. 2007
    ..Soluble TNF receptors I and II (sTNF-RI + II) are released by proteolytic cleavage of the extracellular domains of these receptors. Soluble TNF-Rs act as TNF antagonists and can inhibit TNFalpha-mediated proinflammatory effects...
  19. ncbi request reprint Immune-non immune networks in intestinal inflammation
    Martin Hausmann
    Clinic for Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital Zurich, Switzerland
    Curr Drug Targets 9:388-94. 2008
    ....
  20. doi request reprint Sphingomyelin induces cathepsin D-mediated apoptosis in intestinal epithelial cells and increases inflammation in DSS colitis
    Anne Fischbeck
    Institute of Food Chemistry, University of Muenster and NRW Graduate School of Chemistry, Muenster, Germany
    Gut 60:55-65. 2011
    ..Damage of the epithelial barrier was detected in patients with inflammatory bowel disease (IBD) due to increased rates of intestinal epithelial cell (IEC) apoptosis...
  21. pmc Expression of growth factor receptors and targeting of EGFR in cholangiocarcinoma cell lines
    Ling Xu
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    BMC Cancer 10:302. 2010
    ..The aim of this study was to determine the expression of seven growth factor receptors in CC cell lines and to assess the effect of blocking the EGFR receptor in vitro...
  22. doi request reprint NAT1 genotypes do not predict response to mesalamine in patients with ulcerative colitis
    M Hausmann
    Department of Internal Medicine, University Hospital of Zurich, Switzerland
    Z Gastroenterol 46:259-65. 2008
    ..5-ASA treatment causes side effects in up to 10 % of patients with ulcerative colitis (UC). We therefore determined genetic variations of NAT1 in patients with UC and looked for a possible association with the clinical response to 5-ASA...
  23. pmc Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation
    Jana Fritsche
    Department of Hematology and Oncology, University of Regensburg, Regensburg, Germany
    Immunology 110:450-7. 2003
    ..Therefore only MADDAM, but not decysin is a suitable marker for human monocyte-derived DC...
  24. pmc Cathepsin D is up-regulated in inflammatory bowel disease macrophages
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Clin Exp Immunol 136:157-67. 2004
    ..This study shows that expression of cathepsin D is induced in inflammation-associated IMACs. The presence of cathepsin D might contribute to the mucosal damage in IBD...
  25. pmc Glycoprotein (gp) 96 expression: induced during differentiation of intestinal macrophages but impaired in Crohn's disease
    K Schreiter
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Gut 54:935-43. 2005
    ..It is a chaperone with a binding domain for peptides generated by proteasomal degradation. During cellular stress, peptide loaded gp96 can be released and presented to T cells by antigen presenting cells (APCs)...
  26. pmc Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo
    K Menzel
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Clin Exp Immunol 146:169-80. 2006
    ..Inhibition of CTSD as well as CTSB/CTSL is followed by an amelioration of experimental colitis. The prevention of mucosal damage by cathepsin inhibition could represent a new approach for the therapy of IBD...
  27. pmc Monocyte chemoattractant protein-1 (MCP-1) inhibits the intestinal-like differentiation of monocytes
    T Spoettl
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 145:190-9. 2006
    ..It may be speculated that MCP-1 could play a role in the disturbed IMAC differentiation in IBD mucosa...
  28. pmc Subtractive screening reveals up-regulation of NADPH oxidase expression in Crohn's disease intestinal macrophages
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 125:48-55. 2001
    ..In IBD macrophage-oxidative burst activity is increased and NADPH oxidase mRNA induced. Inhibition of NADPH oxidase could be a new therapeutical target in IBD and reduce mucosal tissue damage in active IBD...
  29. ncbi request reprint T-cell co-stimulatory molecules are upregulated on intestinal macrophages from inflammatory bowel disease mucosa
    G Rogler
    Department of Internal Medicine I, University of Regensburg, Germany
    Eur J Gastroenterol Hepatol 11:1105-11. 1999
    ....
  30. pmc Glucocorticoid receptor isoform expression does not predict steroid treatment response in IBD
    M Hausmann
    Gut 56:1328-9. 2007