Udo Hasler

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Long term regulation of aquaporin-2 expression in vasopressin-responsive renal collecting duct principal cells
    Udo Hasler
    Division of Nephrology, Fondation pour Recherches Medicales, 64 Avenue de la Roseraie, CH 1211, Geneve 4, Switzerland
    J Biol Chem 277:10379-86. 2002
  2. ncbi request reprint Dual influence of aldosterone on AQP2 expression in cultured renal collecting duct principal cells
    Udo Hasler
    Division of Nephrology, Fondation pour Recherches Medicales, 64 Avenue de la Roseraie, CH 1211, Geneva 4, Switzerland
    J Biol Chem 278:21639-48. 2003
  3. pmc Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells
    Udo Hasler
    Massachusetts General Hospital Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02114 2790, USA
    J Biol Chem 283:26643-61. 2008
  4. ncbi request reprint Tonicity-responsive enhancer binding protein is an essential regulator of aquaporin-2 expression in renal collecting duct principal cells
    Udo Hasler
    Service de Nephrologie, Fondation pour Recherches Medicales, 64 Avenue de la Roseraie, GE 1211, Geneve 4, Switzerland, and Department of Medicine, University of Maryland, Baltimore, USA
    J Am Soc Nephrol 17:1521-31. 2006
  5. pmc NF-kappaB modulates aquaporin-2 transcription in renal collecting duct principal cells
    Udo Hasler
    Service de Nephrologie, Fondation pour Recherches Médicales and University of Geneva, CH 1211, Geneva 4, Switzerland
    J Biol Chem 283:28095-105. 2008
  6. ncbi request reprint Stimulation of Na+ transport by AVP is independent of PKA phosphorylation of the Na-K-ATPase in collecting duct principal cells
    David Mordasini
    Service de Nephrologie, Fondation pour Recherches Medicales, CH 1211 Geneva 4, Switzerland
    Am J Physiol Renal Physiol 289:F1031-9. 2005
  7. ncbi request reprint Extracellular hypotonicity increases Na,K-ATPase cell surface expression via enhanced Na+ influx in cultured renal collecting duct cells
    Manlio Vinciguerra
    Service de Nephrologie, Fondation pour Recherches Medicales, Geneva, Switzerland
    J Am Soc Nephrol 15:2537-47. 2004
  8. pmc Phosphorylation events and the modulation of aquaporin 2 cell surface expression
    Dennis Brown
    MGH Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Nephrol Hypertens 17:491-8. 2008
  9. ncbi request reprint Dual effects of hypertonicity on aquaporin-2 expression in cultured renal collecting duct principal cells
    Udo Hasler
    Division de Nephrologye, Fondation pour Recherches Medicales, 64 Avenue de la Roseraie, Geneve 4, Switzerland, CH 1211
    J Am Soc Nephrol 16:1571-82. 2005
  10. pmc Aldosterone activates NF-kappaB in the collecting duct
    Valerie Leroy
    Foundation for Medical Research, University of Geneva, 64 Avenue de la Roseraie, CH 1211, Geneva 4, Switzerland
    J Am Soc Nephrol 20:131-44. 2009

Detail Information

Publications23

  1. ncbi request reprint Long term regulation of aquaporin-2 expression in vasopressin-responsive renal collecting duct principal cells
    Udo Hasler
    Division of Nephrology, Fondation pour Recherches Medicales, 64 Avenue de la Roseraie, CH 1211, Geneve 4, Switzerland
    J Biol Chem 277:10379-86. 2002
    ..This is the first study that delineates induction and degradation mechanisms of AQP2 endogenously expressed by a renal collecting duct principal cell line...
  2. ncbi request reprint Dual influence of aldosterone on AQP2 expression in cultured renal collecting duct principal cells
    Udo Hasler
    Division of Nephrology, Fondation pour Recherches Medicales, 64 Avenue de la Roseraie, CH 1211, Geneva 4, Switzerland
    J Biol Chem 278:21639-48. 2003
    ..Taken together, our data suggest that aldosterone tightly modulates AQP2 protein expression in cultured mpkCCDC14 cells by increasing AQP2 protein turnover while maintaining low levels of AQP2 mRNA expression...
  3. pmc Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells
    Udo Hasler
    Massachusetts General Hospital Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02114 2790, USA
    J Biol Chem 283:26643-61. 2008
    ..This may have important implications on adaptational processes governing transcellular water flux and/or cell survival under extreme conditions of hypertonicity...
  4. ncbi request reprint Tonicity-responsive enhancer binding protein is an essential regulator of aquaporin-2 expression in renal collecting duct principal cells
    Udo Hasler
    Service de Nephrologie, Fondation pour Recherches Medicales, 64 Avenue de la Roseraie, GE 1211, Geneve 4, Switzerland, and Department of Medicine, University of Maryland, Baltimore, USA
    J Am Soc Nephrol 17:1521-31. 2006
    ..These findings demonstrate that in collecting duct principal cells, TonEBP plays a central role in regulating AQP2 expression by enhancing AQP2 gene transcription...
  5. pmc NF-kappaB modulates aquaporin-2 transcription in renal collecting duct principal cells
    Udo Hasler
    Service de Nephrologie, Fondation pour Recherches Médicales and University of Geneva, CH 1211, Geneva 4, Switzerland
    J Biol Chem 283:28095-105. 2008
    ..Taken together, these findings indicate that NF-kappaB is an important physiological regulator of AQP2 transcription...
  6. ncbi request reprint Stimulation of Na+ transport by AVP is independent of PKA phosphorylation of the Na-K-ATPase in collecting duct principal cells
    David Mordasini
    Service de Nephrologie, Fondation pour Recherches Medicales, CH 1211 Geneva 4, Switzerland
    Am J Physiol Renal Physiol 289:F1031-9. 2005
    ..Therefore, stimulation of Na-K-ATPase cell surface expression by AVP is dependent on PKA but does not rely on alpha(1)-subunit phosphorylation on serine 943 in the collecting duct principal cells...
  7. ncbi request reprint Extracellular hypotonicity increases Na,K-ATPase cell surface expression via enhanced Na+ influx in cultured renal collecting duct cells
    Manlio Vinciguerra
    Service de Nephrologie, Fondation pour Recherches Medicales, Geneva, Switzerland
    J Am Soc Nephrol 15:2537-47. 2004
    ....
  8. pmc Phosphorylation events and the modulation of aquaporin 2 cell surface expression
    Dennis Brown
    MGH Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Nephrol Hypertens 17:491-8. 2008
    ....
  9. ncbi request reprint Dual effects of hypertonicity on aquaporin-2 expression in cultured renal collecting duct principal cells
    Udo Hasler
    Division de Nephrologye, Fondation pour Recherches Medicales, 64 Avenue de la Roseraie, Geneve 4, Switzerland, CH 1211
    J Am Soc Nephrol 16:1571-82. 2005
    ....
  10. pmc Aldosterone activates NF-kappaB in the collecting duct
    Valerie Leroy
    Foundation for Medical Research, University of Geneva, 64 Avenue de la Roseraie, CH 1211, Geneva 4, Switzerland
    J Am Soc Nephrol 20:131-44. 2009
    ..In summary, aldosterone activates the canonical NF-kappaB pathway in principal cells of the cortical collecting duct by activating the mineralocorticoid receptor and by inducing SGK1...
  11. pmc Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase
    Wei Li
    Center for Systems Biology, Program in Membrane Biology, Division of Nephrology, Dept of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 301:F309-18. 2011
    ..Our study provides an alternative mechanism to regulate AQP2 trafficking, bypassing the VP-vasopressin receptor signaling pathway...
  12. ncbi request reprint Insulin potentiates AVP-induced AQP2 expression in cultured renal collecting duct principal cells
    Mauro Bustamante
    Fondation pour Recherches Medicales, Service of Nephrology, 64 Ave de la Roseraie, CH 1211 Geneva 4, Switzerland
    Am J Physiol Renal Physiol 288:F334-44. 2005
    ..This effect most likely relies on increased AQP2 gene transcription in response to MAPK and PI 3-kinase activation...
  13. pmc Calcium-sensing receptor attenuates AVP-induced aquaporin-2 expression via a calmodulin-dependent mechanism
    Mauro Bustamante
    Service of Nephrology, Fondation pour Recherches Medicales, 64 Ave de la Roseraie, CH 1211 Geneve 4, Switzerland
    J Am Soc Nephrol 19:109-16. 2008
    ....
  14. pmc A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2
    Paula Nunes
    Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Physiol Cell Physiol 295:C1476-87. 2008
    ..These results support the idea that, in addition to its role in reducing AQP2 endocytosis, VP increases AQP2 exocytosis...
  15. doi request reprint Controlled aquaporin-2 expression in the hypertonic environment
    Udo Hasler
    Service de Nephrologie, Fondation pour Recherches Medicales, 64 Ave de la Roseraie, CH 1211, Geneva 4, Switzerland
    Am J Physiol Cell Physiol 296:C641-53. 2009
    ..Intracellular mechanisms governing these events are discussed and the biological relevance of altered AQP2 expression by hypertonicity is outlined...
  16. pmc Intracellular Na+ controls cell surface expression of Na,K-ATPase via a cAMP-independent PKA pathway in mammalian kidney collecting duct cells
    Manlio Vinciguerra
    Division de Néphrologie, Fondation pour Recherches Medicales, CH 1211 Geneve 4, Switzerland
    Mol Biol Cell 14:2677-88. 2003
    ..These findings suggest that Na,K-ATPase may be recruited to the cell membrane following an increase in [Na+]i through cAMP-independent PKA activation that is itself dependent on proteasomal activity...
  17. pmc Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling
    Elena A Zalyapin
    Program in Membrane Biology and Nephrology Division, MGH Center for Systems Biology, Boston, Massachusetts 02114, USA
    Kidney Int 74:1557-67. 2008
    ..While the gradient is important for urinary concentration, it may also play a substantial role in fine-tuning of the vasopressin response through the V2R...
  18. doi request reprint Aquaporin-2 abundance in the renal collecting duct: new insights from cultured cell models
    Udo Hasler
    Service de Nephrologie, Fondation pour Recherches Medicales, 1211 Geneva 4, Switzerland
    Am J Physiol Renal Physiol 297:F10-8. 2009
    ..These examples illustrate how cross talk between various stimuli regulates AQP2 abundance in collecting duct principal cells and consequently contributes to maintenance of body water homeostasis...
  19. pmc Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus
    Richard Bouley
    Massachusetts General Hospital Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Semin Nephrol 28:266-78. 2008
    ....
  20. ncbi request reprint Posttranscriptional control of aquaporin-2 abundance by vasopressin in renal collecting duct principal cells
    Udo Hasler
    Service de Nephrologie, Fondation pour Recherches Medicales, 64 Ave de la Roseraie, CH 1211, Geneve 4, Switzerland
    Am J Physiol Renal Physiol 290:F177-87. 2006
    ....
  21. pmc The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells
    Hua Jenny Lu
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 295:F290-4. 2008
    ..The potential role of S261 phosphorylation/dephosphorylation in vasopressin action remains to be determined...
  22. ncbi request reprint Interplay between TonEBP and calcineurin-NFATc signaling pathways: a means of optimizing water reabsorption? Focus on "Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress"
    Udo Hasler
    Am J Physiol Cell Physiol 292:C1581-2. 2007
  23. ncbi request reprint Cytokines and sodium induce protein kinase A-dependent cell-surface Na,K-ATPase recruitment via dissociation of NF-kappaB/IkappaB/protein kinase A catalytic subunit complex in collecting duct principal cells
    Manlio Vinciguerra
    Service of Nephrology, Foundation for Medical Research, Geneva, Switzerland
    J Am Soc Nephrol 16:2576-85. 2005
    ....