G Hasler

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Major depression predicts an increase in long-term body weight variability in young adults
    Gregor Hasler
    Psychiatric University Hospital, Zurich, Switzerland
    Obes Res 13:1991-8. 2005
  2. ncbi request reprint Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism
    Gregor Hasler
    Department of Psychiatry, University Hospital, 8091 Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 141:403-8. 2006
  3. doi request reprint Discovering imaging endophenotypes for major depression
    G Hasler
    Psychiatric University Hospital, University of Berne, Switzerland
    Mol Psychiatry 16:604-19. 2011
  4. ncbi request reprint Toward constructing an endophenotype strategy for bipolar disorders
    Gregor Hasler
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 60:93-105. 2006
  5. pmc Effect of acute psychological stress on prefrontal GABA concentration determined by proton magnetic resonance spectroscopy
    Gregor Hasler
    University of Berne, Psychiatric University Hospital, Bolligenstrasse 111, 3000 Berne 60, Switzerland
    Am J Psychiatry 167:1226-31. 2010
  6. ncbi request reprint Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy
    Gregor Hasler
    Department of Psychiatry, University Hospital, Zurich, Switzerland
    Arch Gen Psychiatry 64:193-200. 2007
  7. pmc Impairments of probabilistic response reversal and passive avoidance following catecholamine depletion
    Gregor Hasler
    Department of Psychiatry, University Hospital, Zurich, Switzerland
    Neuropsychopharmacology 34:2691-8. 2009
  8. pmc Cerebral blood flow in immediate and sustained anxiety
    Gregor Hasler
    Psychiatric University Hospital, 8091 Zurich, Switzerland
    J Neurosci 27:6313-9. 2007
  9. pmc 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, Zurich, Switzerland
    Biol Psychiatry 62:1258-64. 2007
  10. pmc Reward processing after catecholamine depletion in unmedicated, remitted subjects with major depressive disorder
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8 8091, Zurich, Switzerland
    Biol Psychiatry 66:201-5. 2009

Detail Information

Publications39

  1. ncbi request reprint Major depression predicts an increase in long-term body weight variability in young adults
    Gregor Hasler
    Psychiatric University Hospital, Zurich, Switzerland
    Obes Res 13:1991-8. 2005
    ..To test the hypothesis that major depression predicts an increase in long-term body weight variability (BWV)...
  2. ncbi request reprint Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism
    Gregor Hasler
    Department of Psychiatry, University Hospital, 8091 Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 141:403-8. 2006
    ..This study may contribute to understanding of molecular genetic features underlying the appearance of symptom clusters in OCD...
  3. doi request reprint Discovering imaging endophenotypes for major depression
    G Hasler
    Psychiatric University Hospital, University of Berne, Switzerland
    Mol Psychiatry 16:604-19. 2011
    ..Finally, improvements of the phenotypic definition of MDD based on neuroimaging measures will contribute to a new classification system of mood disorders based on etiology and pathophysiology...
  4. ncbi request reprint Toward constructing an endophenotype strategy for bipolar disorders
    Gregor Hasler
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 60:93-105. 2006
    ..Studies to evaluate candidate endophenotypes with respect to specificity, heritability, temporal stability, and prevalence in unaffected relatives are encouraged...
  5. pmc Effect of acute psychological stress on prefrontal GABA concentration determined by proton magnetic resonance spectroscopy
    Gregor Hasler
    University of Berne, Psychiatric University Hospital, Bolligenstrasse 111, 3000 Berne 60, Switzerland
    Am J Psychiatry 167:1226-31. 2010
    ..The effect of acute psychological stress on the human GABA-ergic system is still unknown, however. The purpose of this study was to determine the effect of acute stress on prefrontal GABA levels...
  6. ncbi request reprint Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy
    Gregor Hasler
    Department of Psychiatry, University Hospital, Zurich, Switzerland
    Arch Gen Psychiatry 64:193-200. 2007
    ....
  7. pmc Impairments of probabilistic response reversal and passive avoidance following catecholamine depletion
    Gregor Hasler
    Department of Psychiatry, University Hospital, Zurich, Switzerland
    Neuropsychopharmacology 34:2691-8. 2009
    ....
  8. pmc Cerebral blood flow in immediate and sustained anxiety
    Gregor Hasler
    Psychiatric University Hospital, 8091 Zurich, Switzerland
    J Neurosci 27:6313-9. 2007
    ..This study showed distinct neuronal networks involved in cued fear and contextual anxiety underlying the importance of this distinction for studies on the pathophysiology of anxiety disorders...
  9. pmc 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, Zurich, Switzerland
    Biol Psychiatry 62:1258-64. 2007
    ..For the first time, 5-HT(1A) receptor binding was measured in a sample large enough to permit sensitive comparisons between TLE patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews...
  10. pmc Reward processing after catecholamine depletion in unmedicated, remitted subjects with major depressive disorder
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8 8091, Zurich, Switzerland
    Biol Psychiatry 66:201-5. 2009
    ..We investigated whether performance on a reward processing task differs between fully remitted patients with major depressive disorder (MDD) and healthy control subjects after catecholamine depletion...
  11. doi request reprint Altered cerebral gamma-aminobutyric acid type A-benzodiazepine receptor binding in panic disorder determined by [11C]flumazenil positron emission tomography
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Arch Gen Psychiatry 65:1166-75. 2008
    ..However, the results of previous neuroimaging studies are in disagreement, possibly because of experimental design limitations related to sample size, matching between patients and controls, and confounding medication effects...
  12. pmc Prefrontal cortical gamma-aminobutyric Acid levels in panic disorder determined by proton magnetic resonance spectroscopy
    Gregor Hasler
    Department of Psychiatry, University Hospital, Zurich, Switzerland
    Biol Psychiatry 65:273-5. 2009
    ..The current study is the first MRS study to compare GABA concentrations between unmedicated PD subjects and control subjects in the prefrontal cortex (PFC)...
  13. ncbi request reprint Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy
    Gregor Hasler
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Biol Psychiatry 58:969-73. 2005
    ..As a result, the current study investigates whether GABA levels in the prefrontal cortex differ between unmedicated subjects with remitted major depressive disorder (rMDD) and healthy control subjects...
  14. ncbi request reprint Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 200, MSC 2670, Bethesda, MD 20892 2670, USA
    Psychiatry Res 135:121-32. 2005
    ....
  15. ncbi request reprint Treatment of depressive disorders with and without medication - a naturalistic study
    G Hasler
    Psychiatric Department, Zurich University Hospital, Switzerland
    Pharmacopsychiatry 35:235-8. 2002
    ..Our assumption was that this sample is more representative for subjects treated for depressive disorders than subjects included in controlled trials...
  16. ncbi request reprint [The University of Rhode Island Change Assessment Scale (URICA)]
    Gregor Hasler
    Universitäts Spital Zürich, Psychiatrische Poliklinik, Zurich, Schweiz
    Psychother Psychosom Med Psychol 53:406-11. 2003
    ..In addition, there was evidence for the predictive and concordant validity of the instrument. We conclude that the FEVER is a valid instrument to assess the motivational dimension of therapeutic change of complex problem behavior...
  17. ncbi request reprint Patient satisfaction with outpatient psychiatric treatment: the role of diagnosis, pharmacotherapy, and perceived therapeutic change
    Gregor Hasler
    Psychiatric Department, Zurich University Hospital, Switzerland
    Can J Psychiatry 49:315-21. 2004
    ..To investigate the influence of diagnosis, type of treatment, and perceived therapeutic change on patient satisfaction following psychiatric treatment for nonpsychotic, nonsubstance-related disorders...
  18. ncbi request reprint Discovering endophenotypes for major depression
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
    Neuropsychopharmacology 29:1765-81. 2004
    ....
  19. ncbi request reprint Application of Prochaska's transtheoretical model of change to patients with eating disorders
    Gregor Hasler
    Psychiatric Department, Zurich University Hospital, Zurich, Switzerland
    J Psychosom Res 57:67-72. 2004
    ..The aim of this study was to assess stages of change in patients with eating disorders and to analyze their correlations with clinical characteristics and treatment processes using Prochaska's transtheoretical model of change...
  20. ncbi request reprint The association between short sleep duration and obesity in young adults: a 13-year prospective study
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Sleep 27:661-6. 2004
    ..The objective of this study was to test the hypothesis that short sleep duration is associated with obesity and weight gain during young adulthood...
  21. pmc Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Arch Gen Psychiatry 65:521-31. 2008
    ..An instructive paradigm for more directly investigating the relationship between catecholaminergic function and depression has involved the mood response to experimental catecholamine depletion (CD)...
  22. ncbi request reprint Depressive symptoms during childhood and adult obesity: the Zurich Cohort Study
    G Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institutes of Health, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Mol Psychiatry 10:842-50. 2005
    ..Whether the results of this study are limited to populations with elevated levels of psychopathology remains to be tested...
  23. ncbi request reprint The associations between psychopathology and being overweight: a 20-year prospective study
    G Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Psychol Med 34:1047-57. 2004
    ..The purpose of this study was to test the hypothesis that being overweight is associated with a range of psychiatric conditions including minor and atypical depressive disorders, binge eating, and aggression...
  24. ncbi request reprint Excessive daytime sleepiness in young adults: a 20-year prospective community study
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institutes of Health, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:521-9. 2005
    ..The aim of this study was to explore associations between self-reported EDS, sleep disorder symptoms, major depression, and anxiety in a longitudinal community study of young adults...
  25. pmc Asthma and panic in young adults: a 20-year prospective community study
    Gregor Hasler
    National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, 15K North Drive, Room 200, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Respir Crit Care Med 171:1224-30. 2005
    ..Psychologic factors are increasingly recognized to influence the onset and course of asthma. Previous cross-sectional community-based studies have provided evidence for a relatively specific association between asthma and panic...
  26. ncbi request reprint Asthma and body weight change: a 20-year prospective community study of young adults
    G Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Int J Obes (Lond) 30:1111-8. 2006
    ..The objectives of these analyses were to examine the temporal relationships of this association and to explore the role of childhood depression as an explanatory factor...
  27. ncbi request reprint Reduced hippocampal 5HT1A PET receptor binding and depression in temporal lobe epilepsy
    William H Theodore
    Clinical Epilepsy Section, National Institute of Neurological Diseases and Stroke NIH, Bethesda, MD 20892, USA
    Epilepsia 48:1526-30. 2007
    ..Depression is common in people with epilepsy, and reduced 5HT1A binding has been reported in patients with primary depressive disorders...
  28. ncbi request reprint Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study
    Gregor Hasler
    Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    Biol Psychiatry 61:617-25. 2007
    ..While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions...
  29. doi request reprint Impact of emotion on cognition in trauma survivors: what is the role of posttraumatic stress disorder?
    C Mueller-Pfeiffer
    Department of Psychiatry, University Hospital, Zurich, Switzerland
    J Affect Disord 126:287-92. 2010
    ..We investigated the influence of trauma exposure and the presence of anxiety/stress disorders on the impact of emotional distractors on cognitive performance...
  30. ncbi request reprint Outcome of psychiatric treatment: what is relevant for our patients?
    Gregor Hasler
    Psychiatric Department, Zurich University Hospital, Zurich, Switzerland
    Compr Psychiatry 45:199-205. 2004
    ..The use of measures that include dimensions such as personal growth, purpose of life, and positive relations with others may record important changes in these patients...
  31. ncbi request reprint [Establishing and changing therapeutic goals in psychiatric-psychotherapeutic treatment]
    G Hasler
    Universitatsspital Zurich, Psychiatrische Poliklinik, Culmannstrasse 8, CH 8091 Zurich
    Nervenarzt 73:54-8. 2002
    ..The point in time of goal-setting, the achievability of treatment goals, and the patient's handling of unattained goals appear to be of particular significance...
  32. pmc Temporal lobe epilepsy, depression, and hippocampal volume
    Sadat Shamim
    EEG Section, NINDS, NIH, Bethesda, Maryland, USA
    Epilepsia 50:1067-71. 2009
    ..To evaluate the relationship between hippocampal volume loss, depression, and epilepsy...
  33. ncbi request reprint Does weight gain induce cortical and trabecular bone regain in anorexia nervosa? A two-year prospective study
    Gabriella Milos
    Department of Psychiatry, University Hospital of Zurich, Culmannstrasse 8, 8091, Zurich, Switzerland
    Bone 41:869-74. 2007
    ..The course of bone density and structure at different locations was different, and, despite weight increase, bone regain appeared to need different time periods...
  34. pmc Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories
    Anthony Pinto
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
    Psychiatry Res 160:83-93. 2008
    ..The results support investigation of this multidimensional model in OCD genetic linkage studies...
  35. pmc The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers
    Jonathan P Roiser
    Department of Imaging Neuroscience, Institute of Neurology, London, UK
    Neuropsychopharmacology 33:1992-2006. 2008
    ..These data suggest that 5-HT may play an important role in mediating automatic negative attentional biases in major depression, as well as resilience against negative distracting stimuli in never-depressed individuals...
  36. ncbi request reprint The analytical epidemiology of obsessive-compulsive disorder: risk factors and correlates
    Leonardo F Fontenelle
    Anxiety and Depression Research Program, Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro RJ, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 32:1-15. 2008
    ....
  37. ncbi request reprint Obsessive-compulsive symptoms in sibling pairs concordant for obsessive-compulsive disorder
    Priscila Chacon
    Department of Psychiatry, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Am J Med Genet B Neuropsychiatr Genet 144:551-5. 2007
    ..76; P = 0.01). Familial factors seem to contribute to specific OCD phenotypic components such as age at onset of OCS and specific dimensions. The obvious influence of gender is as yet unexplained...
  38. ncbi request reprint Evaluating endophenotypes for psychiatric disorders
    Gregor Hasler
    Rev Bras Psiquiatr 28:91-2. 2006
  39. ncbi request reprint What is the optimal way to subdivide obsessive-compulsive disorder?
    Maria Alice de Mathis
    Department of Psychiatry, University of Sao Paulo Medical School, Brazil
    CNS Spectr 11:762-8, 771-4, 776-9. 2006
    ....