Christoph Handschin

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. pmc The role of exercise and PGC1alpha in inflammation and chronic disease
    Christoph Handschin
    Institute of Physiology and Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, CH 8057 Zurich, Switzerland
    Nature 454:463-9. 2008
  2. doi request reprint Peroxisome proliferator-activated receptor-gamma coactivator-1alpha in muscle links metabolism to inflammation
    Christoph Handschin
    Biozentrum, University of Basel, Basel and Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Clin Exp Pharmacol Physiol 36:1139-43. 2009
  3. pmc SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice
    Sokrates Stein
    Cardiovascular Research, Institute of Physiology, Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, and Cardiovascular Center, Cardiology, University Hospital Zurich, CH 8057 Zurich, Switzerland
    Aging (Albany NY) 2:353-60. 2010
  4. pmc Electric pulse stimulation of cultured murine muscle cells reproduces gene expression changes of trained mouse muscle
    Nathalie Burch
    Institute of Physiology and Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
    PLoS ONE 5:e10970. 2010
  5. ncbi request reprint Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:30014-21. 2007
  6. pmc Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 117:3463-74. 2007
  7. pmc AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
    Sibylle Jäger
    Dana Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:12017-22. 2007
  8. ncbi request reprint RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome
    Christian M Matter
    Circulation 115:946-8. 2007
  9. pmc PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
    Marco Sandri
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16260-5. 2006
  10. pmc Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells
    Zhidan Wu
    Diabetes and Metabolism Disease Area, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:14379-84. 2006

Collaborators

  • Ulf Landmesser
  • Marco Toigo
  • Rhonda Bassel-Duby
  • S Cinti
  • Zhidan Wu
  • Christian M Matter
  • Sokrates Stein
  • Zhen Yan
  • Bruce M Spiegelman
  • Jiandie Lin
  • Wenli Yang
  • James Rhee
  • Melina Fan
  • Nathalie Burch
  • Sibylle Jäger
  • Marco Sandri
  • Julie St-Pierre
  • Zoltan Arany
  • Pei Hsuan Wu
  • Michael Podvinec
  • Vamsi K Mootha
  • Pere Puigserver
  • Anne Sophie Arnold
  • Martine Christe
  • Serge Summermatter
  • Gesa Brochmann Santana Santos
  • Flurin Item
  • Urs Boutellier
  • Marcus Cooper
  • Alfred L Goldberg
  • Stewart H Lecker
  • Hongfei Ge
  • Zoltan P Arany
  • Cai Li
  • Christopher B Newgard
  • Peter Tontonoz
  • John M Shelton
  • Ruojing Yang
  • Paul T Tarr
  • Joanne S Ingwall
  • Sherry Chin
  • Ferhaan Ahmad
  • Siming Li
  • Liming Pei
  • Kirsten Hoyer
  • Anthony Rosenzweig
  • Okan Toka
  • Huamei He
  • Takashi Matsui
  • Monia Manieri
  • Igor I Rybkin
  • Marc Uldry
  • Frederick J Schoen
  • Urs A Meyer
  • Hediye Erdjument-Bromage
  • Paul Tempst
  • Julie St Pierre
  • Smita Sihag
  • Richard A Heyman
  • Patricia J Willy
  • Xiaohui Xie
  • Renate Looser
  • Nick Patterson
  • Eric S Lander
  • David Altshuler
  • Ira G Schulman
  • Sibylle Jäeger
  • Dan Arlow

Detail Information

Publications21

  1. pmc The role of exercise and PGC1alpha in inflammation and chronic disease
    Christoph Handschin
    Institute of Physiology and Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, CH 8057 Zurich, Switzerland
    Nature 454:463-9. 2008
    ..We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise...
  2. doi request reprint Peroxisome proliferator-activated receptor-gamma coactivator-1alpha in muscle links metabolism to inflammation
    Christoph Handschin
    Biozentrum, University of Basel, Basel and Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Clin Exp Pharmacol Physiol 36:1139-43. 2009
    ..Accordingly, modulation of PGC-1alpha activity in skeletal muscle may have a broad range of therapeutic effects. Here, recent advances in the understanding of the role of muscle PGC-1alpha in health and disease are reviewed...
  3. pmc SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice
    Sokrates Stein
    Cardiovascular Research, Institute of Physiology, Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, and Cardiovascular Center, Cardiology, University Hospital Zurich, CH 8057 Zurich, Switzerland
    Aging (Albany NY) 2:353-60. 2010
    ..In conclusion, endogenous SIRT1 diminishes endothelial activation in ApoE-/- mice, but does not affect endothelium-dependent vasodilatation...
  4. pmc Electric pulse stimulation of cultured murine muscle cells reproduces gene expression changes of trained mouse muscle
    Nathalie Burch
    Institute of Physiology and Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
    PLoS ONE 5:e10970. 2010
    ..This system will be useful for the study of the molecular mechanisms that regulate exercise adaptation in muscle...
  5. ncbi request reprint Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:30014-21. 2007
    ..Our data demonstrate a critical role for PGC-1alpha in maintenance of normal fiber type composition and of muscle fiber integrity following exertion...
  6. pmc Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 117:3463-74. 2007
    ..These data clearly illustrate a causal role for muscle PGC-1alpha in maintenance of glucose homeostasis and highlight an unexpected cytokine-mediated crosstalk between skeletal muscle and pancreatic islets...
  7. pmc AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
    Sibylle Jäger
    Dana Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:12017-22. 2007
    ..These data indicate that AMPK phosphorylation of PGC-1alpha initiates many of the important gene regulatory functions of AMPK in skeletal muscle...
  8. ncbi request reprint RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome
    Christian M Matter
    Circulation 115:946-8. 2007
  9. pmc PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
    Marco Sandri
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16260-5. 2006
    ..Thus, the high levels of PGC-1alpha in dark and exercising muscles can explain their resistance to atrophy, and the rapid fall in PGC-1alpha during atrophy should enhance the FoxO-dependent loss of muscle mass...
  10. pmc Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells
    Zhidan Wu
    Diabetes and Metabolism Disease Area, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:14379-84. 2006
    ..Our results, together with previous findings, strongly suggest that TORCs play a key role in linking these external signals to the transcriptional program of adaptive mitochondrial biogenesis by activating PGC-1alpha gene transcription...
  11. ncbi request reprint Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism
    James Rhee
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    J Biol Chem 281:14683-90. 2006
    ..These data point to a crucial role for the PGC-1alpha/HNF4alpha partnership in hepatic lipoprotein metabolism...
  12. ncbi request reprint Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:505-15. 2005
    ..These data show that PGC-1alpha links nutritional status to heme biosynthesis and acute hepatic porphyria...
  13. pmc Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK
    Melina Fan
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 18:278-89. 2004
    ..The discovery of p160MBP as a PGC-1alpha regulator has important implications for the understanding of energy balance and diabetes...
  14. pmc Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
    Vamsi K Mootha
    The Eli and Edythe L Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139 1561, USA
    Proc Natl Acad Sci U S A 101:6570-5. 2004
    ....
  15. pmc Identification of the xenosensors regulating human 5-aminolevulinate synthase
    Michael Podvinec
    Division of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 101:9127-32. 2004
    ..Understanding the direct effects of drugs on heme synthesis is of clinical interest, particularly in patients with hepatic porphyrias...
  16. ncbi request reprint Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR
    Christoph Handschin
    Department of Cell Biology, Dana Farber Cancer Institute, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    Arch Biochem Biophys 433:387-96. 2005
    ..In this review, functional interactions between these nuclear receptors as well as the consequences on physiology and pathophysiology of the liver are discussed...
  17. ncbi request reprint Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids
    Christoph Handschin
    Division of Pharmacology Neurobiology, Biozentrum of the University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Arch Biochem Biophys 434:75-85. 2005
    ..Thus, besides the importance of HNF4alpha in CYP7A1 regulation in all species, birds and mammals use different signaling pathways to adjust CYP7A1 levels after exposure to xenobiotics...
  18. ncbi request reprint Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 120:261-73. 2005
    ..These data suggest a mechanism through which dietary saturated fats can stimulate hyperlipidemia and atherogenesis...
  19. ncbi request reprint Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle
    Zoltan Arany
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Metab 1:259-71. 2005
    ..As mice lacking PGC-1alpha age, cardiac dysfunction becomes evident in vivo. These data indicate that PGC-1alpha is vital for the heart to meet increased demands for ATP and work in response to physiological stimuli...
  20. ncbi request reprint Metabolic control through the PGC-1 family of transcription coactivators
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Metab 1:361-70. 2005
    ..These actions also raise new opportunities for the development of novel therapeutics...
  21. pmc An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:7111-6. 2003
    ..Furthermore, these data suggest an autofeedback loop whereby the calcium-signaling pathway may result in a stable induction of PGC-1alpha, contributing to the relatively stable nature of muscle fiber-type determination...