Philippe A Halban

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment
    Philippe A Halban
    Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland
    Diabetes Care 37:1751-8. 2014
  2. doi A new paradigm for improved co-ordination and efficacy of European biomedical research: taking diabetes as a model
    P A Halban
    Department of Genetic Medicine and Development, University of Geneva Medical Centre, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Diabetologia 56:439-43. 2013
  3. pmc Current status of islet cell replacement and regeneration therapy
    Philippe A Halban
    Department of Genetic Medicine and Development, University of Geneva, University Medical Center, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Clin Endocrinol Metab 95:1034-43. 2010
  4. ncbi Regulation of insulin secretion by phosphatidylinositol-4,5-bisphosphate
    Alejandra Tomas
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Traffic 11:123-37. 2010
  5. ncbi Signaling pathways implicated in the stimulation of beta-cell proliferation by extracellular matrix
    Geraldine Parnaud
    Department of Genetic Medicine and Development, University of Geneva University Medical Center, Geneva, Switzerland
    Mol Endocrinol 23:1264-71. 2009
  6. doi Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells
    Sabine Rütti
    Department of Genetic Medicine and Development, University Medical Center, University of Geneva, Geneva, Switzerland Electronic address
    FEBS Lett 588:15-20. 2014
  7. ncbi β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment
    Philippe A Halban
    Department of Genetic Medicine and Development P A H, University of Geneva, Geneva, Switzerland Department of Medicine K S P, Section of Endocrinology, University of Chicago, Chicago, IL 60637 Center for Genomics and Personalized Medicine Research and Center for Diabetes Research D W B, Wake Forest University, Winston Salem, NC 27106 Department of Medicine Endocrinology and Global Diabetes Institute M A H, Albert Einstein College of Medicine, Bronx, NY 10461 Department of Clinical Sciences, Lund University C L, Lund, Sweden Department of Endocrinology K J M, Indiana University, Indianapolis, IN 46202 Division of Diabetes A C P, Endocrinology and Metabolism, Vanderbilt University School of Medicine, Nashville, TN 37232 Kovler Diabetes Center C J R, Department of Medicine, University of Chicago, Chicago, IL 60637 Naomi Berrie Diabetes Center L S, Columbia University, New York, NY 10027 and Joslin Diabetes Center G C W, Harvard Medical School, Boston, MA 02215
    J Clin Endocrinol Metab 99:1983-92. 2014
  8. doi Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion
    Fabienne Jaques
    Department of Genetic Medicine and Development, University of Geneva Medical Center, 1211 Geneva 4, Switzerland
    Endocrinology 149:2494-505. 2008
  9. pmc Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion
    Karim Bouzakri
    Department of Genetic Medicine and Development, University Medical Center, University of Geneva, CH 1211 Geneva 4, Switzerland
    J Biol Chem 284:27892-8. 2009
  10. ncbi Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity
    Domenico Bosco
    Surgical Research Unit, Department of Surgery, Cell Isolation and Transplantation Center, CMU, Geneva University Hospitals, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    J Endocrinol 194:21-9. 2007

Detail Information

Publications28

  1. ncbi β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment
    Philippe A Halban
    Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland
    Diabetes Care 37:1751-8. 2014
    ..This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment...
  2. doi A new paradigm for improved co-ordination and efficacy of European biomedical research: taking diabetes as a model
    P A Halban
    Department of Genetic Medicine and Development, University of Geneva Medical Centre, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Diabetologia 56:439-43. 2013
    ....
  3. pmc Current status of islet cell replacement and regeneration therapy
    Philippe A Halban
    Department of Genetic Medicine and Development, University of Geneva, University Medical Center, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Clin Endocrinol Metab 95:1034-43. 2010
    ..However, the various approaches are at an early stage of preclinical development and should not be offered to patients until shown to be safe as well as more efficacious than existing therapy...
  4. ncbi Regulation of insulin secretion by phosphatidylinositol-4,5-bisphosphate
    Alejandra Tomas
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Traffic 11:123-37. 2010
    ....
  5. ncbi Signaling pathways implicated in the stimulation of beta-cell proliferation by extracellular matrix
    Geraldine Parnaud
    Department of Genetic Medicine and Development, University of Geneva University Medical Center, Geneva, Switzerland
    Mol Endocrinol 23:1264-71. 2009
    ..Conversely, inhibition of the MAPK pathway increased beta-cell proliferation, indicating a counterregulatory restraining role for this signaling pathway...
  6. doi Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells
    Sabine Rütti
    Department of Genetic Medicine and Development, University Medical Center, University of Geneva, Geneva, Switzerland Electronic address
    FEBS Lett 588:15-20. 2014
    ..Knockdown of TBC1D1 in beta-cells resulted in increased basal and glucose-stimulated insulin release, decreased proliferation but no change in apoptosis. ..
  7. ncbi β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment
    Philippe A Halban
    Department of Genetic Medicine and Development P A H, University of Geneva, Geneva, Switzerland Department of Medicine K S P, Section of Endocrinology, University of Chicago, Chicago, IL 60637 Center for Genomics and Personalized Medicine Research and Center for Diabetes Research D W B, Wake Forest University, Winston Salem, NC 27106 Department of Medicine Endocrinology and Global Diabetes Institute M A H, Albert Einstein College of Medicine, Bronx, NY 10461 Department of Clinical Sciences, Lund University C L, Lund, Sweden Department of Endocrinology K J M, Indiana University, Indianapolis, IN 46202 Division of Diabetes A C P, Endocrinology and Metabolism, Vanderbilt University School of Medicine, Nashville, TN 37232 Kovler Diabetes Center C J R, Department of Medicine, University of Chicago, Chicago, IL 60637 Naomi Berrie Diabetes Center L S, Columbia University, New York, NY 10027 and Joslin Diabetes Center G C W, Harvard Medical School, Boston, MA 02215
    J Clin Endocrinol Metab 99:1983-92. 2014
    ..This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment...
  8. doi Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion
    Fabienne Jaques
    Department of Genetic Medicine and Development, University of Geneva Medical Center, 1211 Geneva 4, Switzerland
    Endocrinology 149:2494-505. 2008
    ....
  9. pmc Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion
    Karim Bouzakri
    Department of Genetic Medicine and Development, University Medical Center, University of Geneva, CH 1211 Geneva 4, Switzerland
    J Biol Chem 284:27892-8. 2009
    ..We thus identify MAP4K4 as a key upstream mediator of TNF-alpha action on the beta cell, making it a potential therapeutic target for preservation of beta cell function in type 2 diabetes...
  10. ncbi Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity
    Domenico Bosco
    Surgical Research Unit, Department of Surgery, Cell Isolation and Transplantation Center, CMU, Geneva University Hospitals, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    J Endocrinol 194:21-9. 2007
    ....
  11. ncbi Blockade of beta1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix
    Geraldine Parnaud
    Department of Genetic Medicine and Development, University Medical Center, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Diabetes 55:1413-20. 2006
    ..Our findings indicate that outside-in signaling via engagement of beta1 integrins by laminin-5 is an important component of normal beta-cell function...
  12. pmc Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion
    Dieter Rondas
    Department of Genetic Medicine and Development, University of Geneva, CH 1211 Geneva 4, Switzerland
    J Biol Chem 287:2423-36. 2012
    ....
  13. pmc Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle
    Karim Bouzakri
    Department of Genetic Medicine and Development, University Medical Center, University of Geneva, Geneva, Switzerland
    Diabetes 60:1111-21. 2011
    ..Type 2 diabetes is characterized by insulin resistance with a relative deficiency in insulin secretion. This study explored the potential communication between insulin-resistant human skeletal muscle and primary (human and rat) β-cells...
  14. doi Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function
    Eva Hammar
    Department of Genetic Medicine and Development, University of Geneva, University Medical Center, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Endocrinology 150:2072-9. 2009
    ..Furthermore, they indicate that inhibition of this pathway might be one of the mechanisms by which the extracellular matrix exerts its beneficial effects on pancreatic beta-cell function...
  15. doi Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells
    Karim Bouzakri
    University Medical Center, Department of Genetic Medicine and Development, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Diabetes 57:1195-204. 2008
    ..The aim of this study was to investigate the expression and potential role of AS160 in beta-cells...
  16. ncbi Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells
    Pascale Ribaux
    Department of Genetic Medicine and Development, University Medical Center, 1211, Geneva 4, Switzerland
    Endocrinology 148:5582-90. 2007
    ..It is concluded that ECM induces expression of cytokines including CXCL1 with amplification by IL-1 acting via a positive autocrine feedback loop...
  17. ncbi Pro-survival role of gelsolin in mouse beta-cells
    Barbara Yermen
    Department of Genetic Medicine and Development, University Medical Center, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Diabetes 56:80-7. 2007
    ..In summary, our results show for the first time that gelsolin plays a pro-survival role in pancreatic beta-cells...
  18. pmc Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin
    Dieter Rondas
    Department of Genetic Medicine and Development, University Medical Center, University of Geneva, Geneva, Switzerland
    Diabetes 60:1146-57. 2011
    ..This led us to study the role of two key focal adhesion proteins, focal adhesion kinase (FAK) and paxillin, in GSIS...
  19. doi Munc 18-1 and granuphilin collaborate during insulin granule exocytosis
    Alejandra Tomas
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva 4, Switzerland
    Traffic 9:813-32. 2008
    ....
  20. ncbi Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway
    Alejandra Tomas
    Department of Genetic Medicine and Development, University of Geneva Medical School, Switzerland
    J Cell Sci 119:2156-67. 2006
    ..Taken together, these data demonstrate that F-actin reorganization prior to insulin secretion requires gelsolin and plays a role in the glucose-dependent MAPK signal transduction that regulates beta-cell insulin secretion...
  21. pmc In vitro proliferation of adult human beta-cells
    Sabine Rütti
    Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland
    PLoS ONE 7:e35801. 2012
    ..Liraglutide increases beta-cell proliferation only in the non-sorted cell population and only on BCEC. However, it cannot be excluded that human beta-cells may proliferate to a greater extent in situ in response to natural stimuli...
  22. ncbi Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines
    Valérie Lilla
    Louis Jeantet Research Laboratories, University Medical Center, 1211 Geneva 4, Switzerland
    Endocrinology 144:1368-79. 2003
    ..These two sublines should be useful for identification of the genes and mechanisms involved in regulated insulin secretion of the pancreatic beta-cell...
  23. ncbi Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways
    Eva Hammar
    Department of Genetic Medecine and Development, University Medical Center, Geneva, Switzerland
    Diabetes 53:2034-41. 2004
    ..In summary, this study provides evidence for activation of signaling pathways and gene expression by extracellular matrix leading to improved beta-cell survival...
  24. pmc Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway
    Philippe A Halban
    Louis Jeantet Research Laboratories, University Medical Center, 1211 Geneva 4, Switzerland
    Mol Biol Cell 14:1195-203. 2003
    ..Thus, in primary islet cells, unprocessed (mutant) proinsulin is sorted to the regulated pathway and then retained in secretory granules as efficiently as fully processed insulin...
  25. pmc Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome
    Alexandra C Nica
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland
    Genome Res 23:1554-62. 2013
    ..This first molecular blueprint of the human beta cell offers biological insight into its differentiated function, including expression of key genes associated with both major types of diabetes. ..
  26. ncbi Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine
    Philippe A Halban
    Department of Genetic Medicine and Development, University Medical Centre, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Nat Cell Biol 6:1021-5. 2004
    ..It is also critical to ensure that any surrogate or regenerated beta cells have perfectly regulated insulin production, which is essential for physiological glucose homeostasis...
  27. ncbi Activation of NF-kappaB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells
    Eva B Hammar
    Department of Genetic Medicine and Development, University Medical Center, University Hospital, 1211 Geneva 4, Switzerland
    J Biol Chem 280:30630-7. 2005
    ..It is proposed that transient and moderate NF-kappaB activity is essential for proper function of the pancreatic beta cell...
  28. ncbi Diabetes research investment in the European Union
    Philippe A Halban
    Department of Genetic Medicine and Development, University Medical Centre, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Nat Med 12:70-2. 2006