B Hagenbuch

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi The superfamily of organic anion transporting polypeptides
    B Hagenbuch
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Biochim Biophys Acta 1609:1-18. 2003
  2. ncbi The sodium bile salt cotransport family SLC10
    Bruno Hagenbuch
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091, Zurich, Switzerland
    Pflugers Arch 447:566-70. 2004
  3. ncbi Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties
    Bruno Hagenbuch
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091, Zurich, Switzerland
    Pflugers Arch 447:653-65. 2004
  4. pmc Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X
    B Hagenbuch
    Division of Clinical Pharmacology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Biochem J 345:115-20. 2000
  5. ncbi Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver
    G A Kullak-Ublick
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 120:525-33. 2001
  6. ncbi Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver
    V Cattori
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital Zurich, Switzerland
    FEBS Lett 474:242-5. 2000
  7. ncbi Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3
    V Cattori
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital, 8091 Zurich, Switzerland
    Pflugers Arch 443:188-95. 2001
  8. ncbi The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
    T Gerloff
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    J Biol Chem 273:10046-50. 1998
  9. ncbi Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
    P J Meier
    Department of Medicine, University Hospital, Zurich, Switzerland
    Hepatology 26:1667-77. 1997
  10. pmc Expression cloning of a rat liver Na(+)-independent organic anion transporter
    E Jacquemin
    Department of Medicine, University Hospital, Zurich, Switzerland
    Proc Natl Acad Sci U S A 91:133-7. 1994

Collaborators

Detail Information

Publications35

  1. ncbi The superfamily of organic anion transporting polypeptides
    B Hagenbuch
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Biochim Biophys Acta 1609:1-18. 2003
    ..In addition, we propose a new species independent and open ended nomenclature and classification system, which is based on divergent evolution and agrees with the guidelines of the Human Genome Nomenclature Committee...
  2. ncbi The sodium bile salt cotransport family SLC10
    Bruno Hagenbuch
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091, Zurich, Switzerland
    Pflugers Arch 447:566-70. 2004
    ..NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT)...
  3. ncbi Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties
    Bruno Hagenbuch
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091, Zurich, Switzerland
    Pflugers Arch 447:653-65. 2004
    ....
  4. pmc Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X
    B Hagenbuch
    Division of Clinical Pharmacology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Biochem J 345:115-20. 2000
    ..Using fluorescence in situ hybridization, the murine Oatp1 gene was mapped to chromosome XA3-A5...
  5. ncbi Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver
    G A Kullak-Ublick
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 120:525-33. 2001
    ..We aimed to characterize the novel OATP-B with respect to tissue distribution and hepatocellular localization and to compare its substrate specificity with those of OATP-A, OATP-C, and OATP8...
  6. ncbi Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver
    V Cattori
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital Zurich, Switzerland
    FEBS Lett 474:242-5. 2000
    ..1 microM) and steroid conjugates. Based on nuclease protection analysis Oatp4 appears to be the predominant transcript in rat liver indicating that rlst-1 plays a minor role in overall hepatic organic anion uptake...
  7. ncbi Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3
    V Cattori
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital, 8091 Zurich, Switzerland
    Pflugers Arch 443:188-95. 2001
    ..Thus, while Oatp4 seems to work in concert with Oatp1 and Oatp2 in the basolateral membrane of rat hepatocytes, Oatp3 is a multispecific transport system in the small intestine...
  8. ncbi The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
    T Gerloff
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    J Biol Chem 273:10046-50. 1998
    ..These results indicate that the sister of P-glycoprotein is the major canalicular bile salt export pump of mammalian liver...
  9. ncbi Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
    P J Meier
    Department of Medicine, University Hospital, Zurich, Switzerland
    Hepatology 26:1667-77. 1997
    ..Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities...
  10. pmc Expression cloning of a rat liver Na(+)-independent organic anion transporter
    E Jacquemin
    Department of Medicine, University Hospital, Zurich, Switzerland
    Proc Natl Acad Sci U S A 91:133-7. 1994
    ....
  11. ncbi Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter
    F Pizzagalli
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Mol Endocrinol 16:2283-96. 2002
    ..Thus, in contrast to most other family members, OATP-F has a more selective substrate preference and may play an important role in the disposition of thyroid hormones in brain and testis...
  12. ncbi Cholestatic expression pattern of sinusoidal and canalicular organic anion transport systems in primary cultured rat hepatocytes
    S J Rippin
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Hepatology 33:776-82. 2001
    ....
  13. ncbi Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver
    M G Ismair
    Division of Clinical Pharmacology Toxicology, Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 121:1185-90. 2001
    ..The smaller isoforms CCK-8 and CCK-4 are rapidly taken up into hepatocytes, metabolized, and excreted into bile. Our aim was to identify and characterize the hepatocellular CCK-8 uptake system...
  14. ncbi Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver1
    V Cattori
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091, Zurich, Switzerland
    Biochim Biophys Acta 1445:154-9. 1999
    ..Both isoforms mediated saturable Na+-dependent transport of taurocholate when expressed in Xenopus laevis oocytes. Analysis of the gene revealed that Ntcp2 is produced by alternative splicing where the last intron is retained...
  15. ncbi Transport of bile acids in hepatic and non-hepatic tissues
    M V St-Pierre
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich CH-8091, Switzerland
    J Exp Biol 204:1673-86. 2001
    ..Recent advances that have fostered a more complete appreciation for the elaborate disposition of bile acids in humans are emphasized...
  16. ncbi Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes
    M Bissig
    Department of Medicine, University Hospital, Zurich, Switzerland
    J Biol Chem 269:3017-21. 1994
    ..Bissig, M., Sorribas, V., Hagenbuch, B., Meier, P. J., and Murer, H. (1994) J. Biol. Chem. 269, 3022-3026)...
  17. pmc Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter
    B Hagenbuch
    Department of Medicine, University Hospital, Zurich, Switzerland
    J Clin Invest 93:1326-31. 1994
    ..Southern blot analysis of genomic DNA from a panel of human/hamster somatic cell hybrids mapped the human NTCP gene to chromosome 14...
  18. ncbi Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
    G A Kullak-Ublick
    Department of Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 109:1274-82. 1995
    ..Based on a recently cloned rat liver organic anion transporter, we attempted to clone the corresponding human liver organic anion transporting polypeptide...
  19. ncbi Transport function and hepatocellular localization of mrp6 in rat liver
    J Madon
    Division of Clinical Pharmacology, Department of Medicine, University Hospital, Zurich, Switzerland
    Mol Pharmacol 57:634-41. 2000
    ....
  20. pmc Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
    B Noe
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 94:10346-50. 1997
    ..They indicate that oatp2 may play an especially important role in the brain accumulation and toxicity of digoxin and in the hepatobiliary and renal excretion of cardiac glycosides from the body...
  21. ncbi Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha
    D Jung
    Division of Clinical Pharmacology and Toxicology, University Hospital, CH 8091 Zurich, Switzerland
    J Biol Chem 276:37206-14. 2001
    ..These data support a role for HNF1 alpha as a global regulator of liver-specific bile salt and organic anion transporter genes...
  22. pmc Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system
    B Hagenbuch
    Department of Medicine, University Hospital, Zurich, Switzerland
    Proc Natl Acad Sci U S A 88:10629-33. 1991
    ..Northern blot analysis with the cloned probe revealed crossreactivity with mRNA species from rat kidney and intestine as well as from liver tissues of mouse, guinea pig, rabbit, and man...
  23. ncbi Characterization of the mouse bile salt export pump overexpressed in the baculovirus system
    J Noe
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital, , Switzerland
    Hepatology 33:1223-31. 2001
    ..Given that bile salts activate selected PKC isoforms in hepatocytes, including the alpha isoform, the phosphorylation of mBsep by PKCalpha may represent a point of regulation for this transporter that is mediated by its own substrate...
  24. ncbi Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta
    M V St-Pierre
    Department of Medicine, Institute of Clinical Pathology, University Hospital, CH 8091 Zurich, Switzerland
    J Clin Endocrinol Metab 87:1856-63. 2002
    ..These findings suggest a physiological role for OATP-B in the placental uptake of fetal-derived sulfated steroids...
  25. pmc Stable expression and functional characterization of a Na+-taurocholate cotransporting green fluorescent protein in human hepatoblastoma HepG2 cells
    G A Kullak-Ublick
    Divisions of Clinical Pharmacology Toxicology, Department of Medicine, University Hospital, CH 8091, Zurich, Switzerland
    Cytotechnology 34:1-9. 2000
    ..We conclude that the Ntcp-EGFP fusion proteinfollows the sorting route of Ntcp, is functionallyidentical to Ntcp and could be used to monitor proteintrafficking in living HepG2 cells...
  26. ncbi Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene
    Diana Jung
    Division of Gastroenterology and Hepatology, Dept of Internal Medicine, Univ Hospital, CH 8091 Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 286:G752-61. 2004
    ..Bile acids may regulate NTCP/Ntcp indirectly by modulating the capacity of nuclear factors to activate gene expression...
  27. ncbi Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells
    Oscar Briz
    Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    Mol Pharmacol 61:853-60. 2002
    ..These results suggest a role for carriers of organic anions and cations in Bamet-R2 and Bamet-UD2 uptake, which may determine their ability to accumulate in liver tumor cells and/or be taken up and efficiently excreted by hepatocytes...
  28. ncbi Functional characterization of the mouse organic-anion-transporting polypeptide 2
    Jessica E van Montfoort
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Ramistr 100, CH 8091 Zurich, Switzerland
    Biochim Biophys Acta 1564:183-8. 2002
    ..Northern blot analysis demonstrated a predominant expression in the liver with additional signals in kidney and brain. Using fluorescence in situ hybridization, the Oatp2 gene (gene symbol Slc21a5) was mapped to chromosome 6G1-G3...
  29. ncbi Identification of phalloidin uptake systems of rat and human liver
    Fabienne Meier-Abt
    Department of Medicine, Division of Clinical Pharmacology and Toxicology, University Hospital, Ramistr 100, CH 8091, Zurich, Switzerland
    Biochim Biophys Acta 1664:64-9. 2004
    ..Therefore, we conclude that rat Oatp1b2 as well as human OATP1B1 and OATP1B3 are responsible for phalloidin uptake into rat and human hepatocytes...
  30. ncbi Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver
    Pascal Frei
    Division of Clinical Pharmacology and Toxicology, Dept of Medicine, Univ Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 288:G771-8. 2005
    ..We conclude that NaPi-IIb is most probably involved in the reabsorption of P(i) from primary hepatic bile and thus might play an important role in the regulation of biliary P(i) concentration...
  31. ncbi Cellular entry of thyroid hormones by organic anion transporting polypeptides
    Bruno Hagenbuch
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Best Pract Res Clin Endocrinol Metab 21:209-21. 2007
    ..OATP4A1 is expressed in the placenta and could be important for maternal thyroid hormone transport to the developing fetus...
  32. pmc Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport
    Chunshan Gui
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biochemistry 47:9090-7. 2008
    ..In conclusion, we have identified three amino acid residues (Y537, S545, and T550) in TM10 of OATP1B3 that are important for CCK-8 transport...
  33. pmc Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3
    Chunshan Gui
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, USA
    Eur J Pharmacol 584:57-65. 2008
    ..In summary, these results demonstrate that pregnane X receptor ligands, by inhibiting or stimulating OATP-mediated uptake, can lead to drug-drug interactions at the transporter level...
  34. ncbi Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain
    Robert D Huber
    Univ Hospital, Dept of Internal Medicine, Institute of Clinical Pharmacology and Toxicology, 8091 Zurich, Switzerland
    Am J Physiol Cell Physiol 292:C795-806. 2007
    ....
  35. ncbi Transport of xenobiotics across the blood-brain barrier
    Bruno Hagenbuch
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    News Physiol Sci 17:231-4. 2002
    ..Members of the drug transporter families MDR, MRP, and OATP have been identified in the BBB, and a detailed characterization of the involved proteins is now required to target drugs more efficiently to the brain...