Jurg Grunenfelder

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi Heat shock protein upregulation lowers cytokine levels after ischemia and reperfusion
    J Grunenfelder
    Clinic for Cardiovascular Surgery, University Hospital, Zurich, Switzerland
    Eur Surg Res 33:383-7. 2001
  2. ncbi Up-regulation of Bcl-2 through hyperbaric pressure transfection of TGF-beta1 ameliorates ischemia-reperfusion injury in rat cardiac allografts
    Jurg Grunenfelder
    Department of Cardiothoracic Surgery, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, California, USA
    J Heart Lung Transplant 21:244-50. 2002
  3. ncbi Genetic polymorphisms of apolipoprotein E4 and tumor necrosis factor beta as predisposing factors for increased inflammatory cytokines after cardiopulmonary bypass
    Jurg Grunenfelder
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
    J Thorac Cardiovasc Surg 128:92-7. 2004
  4. ncbi Increased susceptibility of the left compared to the right ventricle to remote ischemia/reperfusion injury in human C1-inhibitor-overexpressing transgene mice
    Jurg Grunenfelder
    Clinic for Cardiovascular Surgery, University Hospital, Zurich, Switzerland
    J Invest Surg 15:281-6. 2002
  5. ncbi Coronary artery disease in patients with cardiac tumors: preoperative assessment by computed tomography coronary angiography
    Hans Scheffel
    Institute of Diagnostic Radiology, University Hospital Zurich, Raemistr 100, 8091 Zurich, Switzerland
    Interact Cardiovasc Thorac Surg 10:513-8. 2010
  6. ncbi Aortic valve replacement through a minimally invasive approach: preoperative planning, surgical technique, and outcome
    Andre Plass
    Clinic for Cardiovascular Surgery, Zurich, Switzerland
    Ann Thorac Surg 88:1851-6. 2009
  7. ncbi Off-pump surgery for the poor ventricle?
    Maximilian Y Emmert
    Department of Cardiovascular Surgery, University Hospital Zurich, Raemi Street 100, 8091, Zurich, Switzerland
    Heart Vessels 27:258-64. 2012
  8. ncbi Coronary artery imaging with 64-slice computed tomography from cardiac surgical perspective
    Andre Plass
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Ramistr 100, CH 8091 Zurich, Switzerland
    Eur J Cardiothorac Surg 30:109-16. 2006
  9. ncbi Accuracy of dual-source computed tomography coronary angiography: evaluation with a standardised protocol for cardiac surgeons
    Andre Plass
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Raemistr 100, 8091 Zurich, Switzerland
    Eur J Cardiothorac Surg 36:1011-7. 2009
  10. ncbi Feasibility of the Engager™ aortic transcatheter valve system using a flexible over-the-wire design
    Simon H Sündermann
    Division of Cardiac and Vascular Surgery, University Hospital Zurich, Zurich, Switzerland
    Eur J Cardiothorac Surg 42:e48-52. 2012

Detail Information

Publications38

  1. ncbi Heat shock protein upregulation lowers cytokine levels after ischemia and reperfusion
    J Grunenfelder
    Clinic for Cardiovascular Surgery, University Hospital, Zurich, Switzerland
    Eur Surg Res 33:383-7. 2001
    ..The aim of this study is to determine a time-related response of HSP70 expression through topical cardiac warming with correlation to cytokine production...
  2. ncbi Up-regulation of Bcl-2 through hyperbaric pressure transfection of TGF-beta1 ameliorates ischemia-reperfusion injury in rat cardiac allografts
    Jurg Grunenfelder
    Department of Cardiothoracic Surgery, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, California, USA
    J Heart Lung Transplant 21:244-50. 2002
    ..Transforming growth factor (TGF)-beta1 is known to attenuate ischemia-reperfusion injury and inhibits apoptosis of myofibroblasts. We hypothesize that TGF-beta1, prevents bcl-2 cleavage and increased TNF-alpha production...
  3. ncbi Genetic polymorphisms of apolipoprotein E4 and tumor necrosis factor beta as predisposing factors for increased inflammatory cytokines after cardiopulmonary bypass
    Jurg Grunenfelder
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
    J Thorac Cardiovasc Surg 128:92-7. 2004
    ..The aim of the study was to investigate whether the genetic variants of apolipoprotein E (APOE*E4) and tumor necrosis factor beta (TNFB*A329G) affect cytokine release after cardiopulmonary bypass...
  4. ncbi Increased susceptibility of the left compared to the right ventricle to remote ischemia/reperfusion injury in human C1-inhibitor-overexpressing transgene mice
    Jurg Grunenfelder
    Clinic for Cardiovascular Surgery, University Hospital, Zurich, Switzerland
    J Invest Surg 15:281-6. 2002
    ..Inhibition of the classic complement cascade may be a promising therapeutic approach for myocardial protection in reperfusion injury...
  5. ncbi Coronary artery disease in patients with cardiac tumors: preoperative assessment by computed tomography coronary angiography
    Hans Scheffel
    Institute of Diagnostic Radiology, University Hospital Zurich, Raemistr 100, 8091 Zurich, Switzerland
    Interact Cardiovasc Thorac Surg 10:513-8. 2010
    ..Our results indicate that CTCA provides a high diagnostic performance for diagnosing significant CAD in patients with primary cardiac tumors. CTCA may thus be used as a filter test prior to surgery...
  6. ncbi Aortic valve replacement through a minimally invasive approach: preoperative planning, surgical technique, and outcome
    Andre Plass
    Clinic for Cardiovascular Surgery, Zurich, Switzerland
    Ann Thorac Surg 88:1851-6. 2009
    ....
  7. ncbi Off-pump surgery for the poor ventricle?
    Maximilian Y Emmert
    Department of Cardiovascular Surgery, University Hospital Zurich, Raemi Street 100, 8091, Zurich, Switzerland
    Heart Vessels 27:258-64. 2012
    ..92.8%; PS-OR = 0.75; p = 0.50). OPCAB in patients with severely decreased EF is safe and feasible. It may even benefit these patients in regard to non-cardiac complications and does not come at cost of less complete revascularization...
  8. ncbi Coronary artery imaging with 64-slice computed tomography from cardiac surgical perspective
    Andre Plass
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Ramistr 100, CH 8091 Zurich, Switzerland
    Eur J Cardiothorac Surg 30:109-16. 2006
    ..64-Slice computed tomography (CT) has been introduced with high expectations. This study illustrates the value of 64-slice CT for the diagnosis of significant coronary artery stenoses when images are analysed by cardiovascular surgeons...
  9. ncbi Accuracy of dual-source computed tomography coronary angiography: evaluation with a standardised protocol for cardiac surgeons
    Andre Plass
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Raemistr 100, 8091 Zurich, Switzerland
    Eur J Cardiothorac Surg 36:1011-7. 2009
    ....
  10. ncbi Feasibility of the Engager™ aortic transcatheter valve system using a flexible over-the-wire design
    Simon H Sündermann
    Division of Cardiac and Vascular Surgery, University Hospital Zurich, Zurich, Switzerland
    Eur J Cardiothorac Surg 42:e48-52. 2012
    ..The aim was to investigate the safety and feasibility of the redesigned Engager™ transcatheter aortic valve implantation (TAVI) system...
  11. ncbi Assessment of inflammatory response to transfemoral transcatheter aortic valve implantation compared to transapical and surgical procedures: a pilot study
    Barbara E Stähli
    Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    J Invasive Cardiol 24:407-11. 2012
    ..Surgical aortic valve replacement (AVR) has been associated with systemic inflammatory reactions. Yet, the role of inflammation following transcatheter aortic valve implantation (TAVI) has not been fully elucidated...
  12. ncbi Total arterial off-pump surgery provides excellent outcomes and does not compromise complete revascularization
    Maximilian Y Emmert
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
    Eur J Cardiothorac Surg 41:e25-31. 2012
    ..The feasibility of OPCAB-TAR with specific regards to the complete revascularization (CR) in patients with multi-vessel disease was evaluated...
  13. ncbi Titanium plate osteosynthesis for the correction of severe sternal deformity in a 13-year-old boy
    Andre Plass
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
    Interact Cardiovasc Thorac Surg 7:935-7. 2008
    ..Sternal plate osteosynthesis represents an excellent alternative for the correction of difficult sternal closures and deformities in adults as well as in children...
  14. ncbi Assessment of coronary sinus anatomy between normal and insufficient mitral valves by multi-slice computertomography for mitral annuloplasty device implantation
    Andre Plass
    Clinic for Cardiovascular Surgery, University Hospital, Raemistr 100, 8091 Zurich, Switzerland
    Eur J Cardiothorac Surg 33:583-9. 2008
    ..We evaluate the feasibility of non-invasive assessment to determine CS anatomy and its relation to MV annulus and coronary arteries by multi-slice CT (MSCT) in normal and insufficient MV...
  15. ncbi Low-dose CT coronary angiography for the prediction of myocardial ischaemia
    Paul Stolzmann
    Institute of Diagnostic Radiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Eur Radiol 20:56-64. 2010
    ..Low-dose CTCA is reliable for ruling out functionally relevant CAD, but is a poor predictor of myocardial ischaemia...
  16. ncbi Impact of coronary disease after aortic valve replacement
    Jurg Grunenfelder
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Asian Cardiovasc Thorac Ann 17:248-52. 2009
    ..This suggests that coronary artery disease has a negative impact on postoperative myocardial recovery...
  17. ncbi Intramyocardial transplantation and tracking of human mesenchymal stem cells in a novel intra-uterine pre-immune fetal sheep myocardial infarction model: a proof of concept study
    Maximilian Y Emmert
    Swiss Centre for Regenerative Medicine, University of Zurich, Zurich, Switzerland
    PLoS ONE 8:e57759. 2013
    ....
  18. ncbi Negative microbiological results are not mandatory in deep sternal wound infections before wound closure
    Hector Rodriguez Cetina Biefer
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
    Eur J Cardiothorac Surg 42:306-10; discussion 310. 2012
    ..To define the outcome of treatment for deep sternal wound infections (DSWIs) using direct wound closure (DC) or vacuum-assisted therapy (VAT) based on negative vs. positive microbiological results...
  19. ncbi Acute haemodynamic changes after percutaneous mitral valve repair: relation to mid-term outcomes
    Oliver Gaemperli
    Andreas Gruntzig Laboratories, Cardiovascular Center, University Hospital Zurich, Ramistrasse 100, Zurich, Switzerland
    Heart 98:126-32. 2012
    ..Percutaneous mitral valve repair (MVR) using the Evalve MitraClip has been recently introduced as a potential alternative to surgical MVR...
  20. ncbi Transcatheter aortic valve implantation (TAVI) outcome according to standardized endpoint definitions by the Valve Academic Research Consortium (VARC)
    Barbara E Stähli
    Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Rämistress 100, 8091 Zurich, Switzerland
    J Invasive Cardiol 23:307-12. 2011
    ..Transcatheter aortic valve implantation (TAVI) has become an accepted treatment option for severe aortic stenosis (AS) in high-risk individuals. Yet, current results are difficult to compare given the lack of standardized definitions...
  21. ncbi The potential value of hybrid positron emission tomography/dual-source computed tomography imaging in coronary bypass surgery
    Andre Plass
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
    Heart Surg Forum 14:E283-90. 2011
    ....
  22. ncbi Left atrial appendage clip occlusion: early clinical results
    Sacha P Salzberg
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Switzerland
    J Thorac Cardiovasc Surg 139:1269-74. 2010
    ..Few means are available for safe, effective, and durable left atrial appendage occlusion. A new clip device was evaluated with regard to safety and effectiveness for epicardial left atrial appendage occlusion...
  23. ncbi Sixteen-channel multidetector row computed tomography versus coronary angiography in a surgical view
    Andre Plass
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Switzerland
    Heart Surg Forum 9:E572-8. 2006
    ..Sixteen-multidetector row computed tomography (MDCT) represents an alternative depiction of coronary vessels...
  24. ncbi Real-time left ventricular pressure-volume loops during percutaneous mitral valve repair with the MitraClip system
    Oliver Gaemperli
    Andreas Grüntzig Cardiac Catheterization Laboratories, University Hospital Zurich, Zurich, Switzerland
    Circulation 127:1018-27. 2013
    ..However, its effects on left ventricular loading conditions and contractility have not been investigated yet...
  25. ncbi Is off-pump superior to conventional coronary artery bypass grafting in diabetic patients with multivessel disease?
    Maximilian Y Emmert
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
    Eur J Cardiothorac Surg 40:233-9. 2011
    ..In this study, the safety, feasibility, and completeness of revascularization for this subset of patients was assessed...
  26. ncbi Stem cell-based transcatheter aortic valve implantation: first experiences in a pre-clinical model
    Maximilian Y Emmert
    Swiss Center for Regenerative Medicine, University and University Hospital Zurich, Zurich, Switzerland
    JACC Cardiovasc Interv 5:874-83. 2012
    ....
  27. ncbi Formation of pseudoaneurysm after aortic valve replacement without previous endocarditis: a case-control study
    Frank Enseleit
    Clinic of Cardiology, University Hospital Zurich, and Institute for Social and Preventive Medicine, University of Zurich, Zurich, Switzerland
    J Am Soc Echocardiogr 23:741-6. 2010
    ..The aim of this study was to identify the predisposing factors for pseudoaneurysm formation after aortic valve replacement without previous endocarditis...
  28. ncbi Aortic no-touch technique makes the difference in off-pump coronary artery bypass grafting
    Maximilian Y Emmert
    Clinic for Cardiovascular Surgery, University of Zurich, Zurich, Switzerland
    J Thorac Cardiovasc Surg 142:1499-506. 2011
    ..We evaluate the impact of partial aortic clamping (PC) versus a no-touch technique using either the HEARTSTRING system (HS) or total arterial revascularization (TAR) on the incidence of stroke...
  29. ncbi Evaluation of biological aortic valve prostheses by dual source computer tomography and anatomic measurements for potential transapical valve-in-valve procedure
    Jurg Grunenfelder
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Ramistr 100, 8091 Zurich, Switzerland
    Interact Cardiovasc Thorac Surg 7:195-9; discussion 199-200. 2008
    ..These measurements represent a prerequisite for preoperative planning and increase the awareness to detect potential procedural problems of the valve-in-valve concept...
  30. ncbi Transcatheter based electromechanical mapping guided intramyocardial transplantation and in vivo tracking of human stem cell based three dimensional microtissues in the porcine heart
    Maximilian Y Emmert
    Swiss Centre for Regenerative Medicine, University of Zurich, Zurich, Switzerland
    Biomaterials 34:2428-41. 2013
    ..The concept of 3D cellular self-assembly represents a promising application format as a next generation technology for cell-based myocardial regeneration...
  31. ncbi Multimodality preoperative planning and postoperative follow-up of a hybrid cardiac intervention
    Andre Plass
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
    Heart Surg Forum 11:E375-7. 2008
    ..This approach could be further improved by increasing the installations of hybrid operating rooms...
  32. ncbi New transverse plate fixation system for complicated sternal wound infection after median sternotomy
    Andre Plass
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
    Ann Thorac Surg 83:1210-2. 2007
    ..In this report the technical concept has been described in detail in 1 patient. This new sternal fixation technique is safe and easy to handle and broadens the spectrum for closure of complicated sternal wound infections or dehiscence...
  33. ncbi Isolated cleft in the posterior mitral valve leaflet: a congenital form of mitral regurgitation
    Christophe A Wyss
    Clinic for Cardiology, University Hospital, 8091 Zurich, Switzerland
    Clin Cardiol 32:553-60. 2009
    ..Isolated congenital cleft of the posterior leaflet of the mitral valve is a rare cause of mitral regurgitation (MR). This study describes the clinical, echocardiographic, and intraoperative findings as well as treatment options...
  34. ncbi Tissue engineering of functional trileaflet heart valves from human marrow stromal cells
    Simon P Hoerstrup
    Department of Cardiovascular Surgery, University Hospital, Zurich, Switzerland
    Circulation 106:I143-50. 2002
    ..The feasibility of creating tissue engineered heart valves (TEHV) from MSC as an alternative cell source, and the impact of a biomimetic in vitro environment on tissue differentiation was investigated...
  35. ncbi A new source for cardiovascular tissue engineering: human bone marrow stromal cells
    Alexander Kadner
    Clinic for Cardiovascular Surgery, University Hospital, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Eur J Cardiothorac Surg 21:1055-60. 2002
    ..We studied the feasibility of using MSC as an alternative cell source for cardiovascular tissue engineering...
  36. ncbi A single bicaval venous cannula used for optimization of endoscopic robotically assisted procedures of the heart
    Jurg Grunenfelder
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
    Heart Surg Forum 6:393-5. 2003
    ..The cannula shows sufficient flow characteristics for cardiopulmonary bypass. Subsequent suturing of the atrial septum defect was achieved without complications in the 4 experimental animals...
  37. ncbi Effects of tacrolimus or sirolimus on proliferation of vascular smooth muscle and endothelial cells
    Christian M Matter
    Cardiovascular Research, Institute of Physiology, Zurich University and CardioVascular Center, University Hospital Zurich, Switzerland
    J Cardiovasc Pharmacol 48:286-92. 2006
    ..However, tacrolimus exerts markedly less antiproliferative effects on EC compared with sirolimus. In combination with its potent antiinflammatory effects, tacrolimus may represent a promising compound for the use in drug-eluting stents...
  38. ncbi Dynamic cine imaging of the mitral valve with 16-MDCT: a feasibility study
    Hatem Alkadhi
    Department of Medical Radiology, Institute of Diagnostic Radiology, University Hospital Zurich, Zurich 8091, Switzerland
    AJR Am J Roentgenol 185:636-46. 2005
    ..Perpendicular long-axis reconstructions yield images of superior quality when compared with the short-axis reconstructions and enable a determination of its functional morphology...