Alois Gratwohl

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Economics, health care systems and utilization of haematopoietic stem cell transplants in Europe
    Alois Gratwohl
    Division of Hematology, Department of Internal Medicine, Kantonsspital Basel, CH 4031 Basel, Switzerland
    Br J Haematol 117:451-68. 2002
  2. pmc Changes in the use of hematopoietic stem cell transplantation: a model for diffusion of medical technology
    Alois Gratwohl
    Department of Medicine, University Hospital, University of Basel, Switzerland
    Haematologica 95:637-43. 2010
  3. doi request reprint The EBMT activity survey: 1990-2010
    J R Passweg
    EBMT Activity Survey Office, Department of Medicine, Division of Hematology, University Hospital Basel, Basel, Switzerland
    Bone Marrow Transplant 47:906-23. 2012
  4. ncbi request reprint Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: an EBMT analysis of lethal infectious complications and changes over calendar time
    A Gratwohl
    Division of Hematology, University Hospitals, Basel, Switzerland
    Bone Marrow Transplant 36:757-69. 2005
  5. ncbi request reprint Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: transplant activity, long-term data and current results. An analysis by the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplan
    Alois Gratwohl
    Hematology, University Hospital Basel, Switzerland
    Haematologica 91:513-21. 2006
  6. doi request reprint The EBMT activity survey 2008: impact of team size, team density and new trends
    A Gratwohl
    EBMT Activity Survey Office, Hematology, Department of Medicine, University Hospital, Basel, Switzerland
    Bone Marrow Transplant 46:174-91. 2011
  7. ncbi request reprint Current role of stem cell transplantation in chronic myeloid leukaemia
    Alois Gratwohl
    Hematology and Stem Cell Transplant Team, University Hospital, Petersgraben, CH 4031, University of Basel, Basel, Switzerland
    Best Pract Res Clin Haematol 22:431-43. 2009
  8. ncbi request reprint Trends of hematopoietic stem cell transplantation in the third millennium
    Alois Gratwohl
    Hematology, Department of Medicine, University Hospital, Basel, Switzerland
    Curr Opin Hematol 16:420-6. 2009
  9. ncbi request reprint EBMT activity survey 2004 and changes in disease indication over the past 15 years
    A Gratwohl
    Division of Hematology, Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4021 Basel, Switzerland
    Bone Marrow Transplant 37:1069-85. 2006
  10. ncbi request reprint Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a retrospective analysis
    Alois Gratwohl
    Department of Hematology, University Hospital, University of Basel, Basel, Switzerland
    Cancer 115:4715-26. 2009

Detail Information

Publications80

  1. ncbi request reprint Economics, health care systems and utilization of haematopoietic stem cell transplants in Europe
    Alois Gratwohl
    Division of Hematology, Department of Internal Medicine, Kantonsspital Basel, CH 4031 Basel, Switzerland
    Br J Haematol 117:451-68. 2002
    ..Economic strength, team density and hitherto unknown factors influence dissemination of the technology within Europe. These data provide a basis for health care planning, regulatory aspects and future research...
  2. pmc Changes in the use of hematopoietic stem cell transplantation: a model for diffusion of medical technology
    Alois Gratwohl
    Department of Medicine, University Hospital, University of Basel, Switzerland
    Haematologica 95:637-43. 2010
    ..Innovations in hematology spread rapidly. Factors affecting the speed of introduction, international diffusion, and durability of use of innovations are, however, poorly understood...
  3. doi request reprint The EBMT activity survey: 1990-2010
    J R Passweg
    EBMT Activity Survey Office, Department of Medicine, Division of Hematology, University Hospital Basel, Basel, Switzerland
    Bone Marrow Transplant 47:906-23. 2012
    ..The most impressive trend seen is the steady increase of unrelated donor transplantation, in parallel to the availability of unrelated donors through donor registries...
  4. ncbi request reprint Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: an EBMT analysis of lethal infectious complications and changes over calendar time
    A Gratwohl
    Division of Hematology, University Hospitals, Basel, Switzerland
    Bone Marrow Transplant 36:757-69. 2005
    ..Death from infections has been reduced significantly, but it still represents an ongoing risk after HSCT and draws attention to the time beyond the initial period of neutropenia...
  5. ncbi request reprint Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: transplant activity, long-term data and current results. An analysis by the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplan
    Alois Gratwohl
    Hematology, University Hospital Basel, Switzerland
    Haematologica 91:513-21. 2006
    ..HSCT remains an important treatment option for patients with CML. The data describe the current status of this option and the outcome a patient can expect today. They provide an objective basis for decision making...
  6. doi request reprint The EBMT activity survey 2008: impact of team size, team density and new trends
    A Gratwohl
    EBMT Activity Survey Office, Hematology, Department of Medicine, University Hospital, Basel, Switzerland
    Bone Marrow Transplant 46:174-91. 2011
    ..54); this connection was even stronger for allogeneic HSCT (R(2)=0.67). These data illustrate status and trends for HSCT in Europe. They provide a rational basis for planning and patient counseling...
  7. ncbi request reprint Current role of stem cell transplantation in chronic myeloid leukaemia
    Alois Gratwohl
    Hematology and Stem Cell Transplant Team, University Hospital, Petersgraben, CH 4031, University of Basel, Basel, Switzerland
    Best Pract Res Clin Haematol 22:431-43. 2009
    ..It is the best option for all patients with failed second-line TKIs, with mutations T315I or with progressive disease. It can always be considered in situations with limited resources...
  8. ncbi request reprint Trends of hematopoietic stem cell transplantation in the third millennium
    Alois Gratwohl
    Hematology, Department of Medicine, University Hospital, Basel, Switzerland
    Curr Opin Hematol 16:420-6. 2009
    ..It has seen major changes in indications and use of transplant techniques. HSCT is a high cost procedure and requires investments; information on trends is essential for patient counselling and healthcare planning...
  9. ncbi request reprint EBMT activity survey 2004 and changes in disease indication over the past 15 years
    A Gratwohl
    Division of Hematology, Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4021 Basel, Switzerland
    Bone Marrow Transplant 37:1069-85. 2006
    ..The decline in HSCT for chronic myeloid leukemia appears to level off for the first time since 1999. These data are informative for patient counselling and decision making for health care professionals...
  10. ncbi request reprint Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a retrospective analysis
    Alois Gratwohl
    Department of Hematology, University Hospital, University of Basel, Basel, Switzerland
    Cancer 115:4715-26. 2009
    ....
  11. ncbi request reprint The EBMT activity survey 2007 with focus on allogeneic HSCT for AML and novel cellular therapies
    A Gratwohl
    Hematology, Department of Medicine, University Hospital, University of Basel, Petersgraben 4, Basel, Switzerland
    Bone Marrow Transplant 43:275-91. 2009
    ..The indications for the latter were cardiovascular disorders (97; 46%), neurological disorders (94; 44%) and tissue repair (21; 10%). These data illustrate the expanding role of cellular therapies...
  12. doi request reprint Allogeneic hematopoietic stem cell transplantation for severe autoimmune diseases
    Alois Gratwohl
    Division of Hematology, Department of Medicine, University Hospital Basel, Basel, Switzerland
    Autoimmunity 41:673-8. 2008
    ..Carefully conducted prospective studies are warranted to define target populations and best technology to be used. Conditions for such studies have been identified by an international expert panel...
  13. ncbi request reprint Results of the EBMT activity survey 2005 on haematopoietic stem cell transplantation: focus on increasing use of unrelated donors
    A Gratwohl
    Hematology, Department of Medicine, University Hospital, Basel, Switzerland
    Bone Marrow Transplant 39:71-87. 2007
    ..These data illustrate the current experience in Europe and form the basis for patient counselling and decisions making at health care institutions...
  14. ncbi request reprint Risk assessment in haematopoietic stem cell transplantation
    Alois Gratwohl
    Haematology, Department of Medicine, University Hospital Basel, CH 4031 Basel, Switzerland
    Best Pract Res Clin Haematol 20:119-24. 2007
  15. ncbi request reprint Why are there regional differences in stem cell transplantation activity? An EBMT analysis
    A Gratwohl
    Department of Hematology, University Hospital Basel, Basel, Switzerland
    Bone Marrow Transplant 42:S7-S10. 2008
    ..These data illustrate that more research is needed to understand the mechanism of HSCT activity and to enable health-care agencies to provide the necessary infrastructure...
  16. ncbi request reprint Activity survey and historical perspective of autologous stem cell transplantation in Europe
    Alois Gratwohl
    European Group for Blood and Marrow Transplantation Activity Survey Hematology, University Hospital Basel, Switzerland
    Semin Hematol 44:220-6. 2007
    ..These numbers emphasize the important role of this type of therapy at its current stage...
  17. ncbi request reprint Predictability of hematopoietic stem cell transplantation rates
    Alois Gratwohl
    University Hospital Basel, CH 4031 Basel, Switzerland
    Haematologica 92:1679-86. 2007
    ..Hematopoietic stem cell transplantation (HSCT) is a complex and expensive procedure. Trends in the use of this procedure have appeared erratic in the past. Information on future needs is essential for health care administrators...
  18. ncbi request reprint The EBMT activity survey 2006 on hematopoietic stem cell transplantation: focus on the use of cord blood products
    A Gratwohl
    Hematology, Department of Medicine, University Hospital Basel, Basel, Switzerland
    Bone Marrow Transplant 41:687-705. 2008
    ..Numbers of autologous HSCT remained similar in most main indications. This data provide an update of the current HSCT experience in Europe...
  19. ncbi request reprint Does early stem-cell transplantation have a role in chronic myeloid leukaemia? For the proposal
    Alois Gratwohl
    Haematology and Stem Cell Transplant Team, University Hospital, CH 4031 Basel, Switzerland
    Lancet Oncol 6:721-2. 2005
    ..In this debate, Alois Gratwohl and Gianantonio Rosti present opposing arguments as to whether there is still a role for early HSCT in CML.
  20. ncbi request reprint Change in stem cell source for hematopoietic stem cell transplantation (HSCT) in Europe: a report of the EBMT activity survey 2003
    A Gratwohl
    Hematology, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Bone Marrow Transplant 36:575-90. 2005
    ..In 2003, bone marrow remains a significant source of stem cells in some European countries for autologous HSCT and for nonmalignant disorders in allogeneic HSCT...
  21. ncbi request reprint [Chronic myeloid leukemia]
    A Gratwohl
    Hematologie, Hôpital universitaire de Bâle
    Rev Med Suisse 1:1631-5. 2005
  22. ncbi request reprint Hematopoietic stem cell transplantation in Europe 1998
    A Gratwohl
    Division of Hematology, Department of Internal Medicine, Kantonsspital Basel, CH 4031 Basel, Switzerland
    Hematol J 1:333-50. 2000
    ..Information on these changes is essential for interpretation of current data, patient counseling and health care planning...
  23. ncbi request reprint Female donors influence transplant-related mortality and relapse incidence in male recipients of sibling blood and marrow transplants
    A Gratwohl
    Division of Hematology, Department of Internal Medicine, Kantonsspital Basel, Switzerland
    Hematol J 2:363-70. 2001
    ....
  24. ncbi request reprint Current trends in hematopoietic stem cell transplantation in Europe
    Alois Gratwohl
    Division of Hematology, Department of Internal Medicine and Department of Research, Kantonsspital Basel, Switzerland
    Blood 100:2374-86. 2002
    ..Despite marked changes in the rapidly developing field of HSCT, this information on current use, trends, and midterm predictions forms a rational basis for patient counseling and health care planning...
  25. ncbi request reprint Graft-versus-host disease and outcome in HLA-identical sibling transplantations for chronic myeloid leukemia
    Alois Gratwohl
    Division of Hematology, Department of Internal Medicine, Kantonsspital Basel, Basel, Switzerland
    Blood 100:3877-86. 2002
    ..These data clarify the role of GvHD in posttransplantation outcome. Considerations for long-term outcome are essential when short-term data of interventions on GvHD are analyzed...
  26. doi request reprint Introduction of a quality management system and outcome after hematopoietic stem-cell transplantation
    Alois Gratwohl
    European Group for Blood and Marrow Transplantation Activity Survey Office, University Hospital, Basel, Switzerland
    J Clin Oncol 29:1980-6. 2011
    ..We therefore tested the hypothesis that the introduction of JACIE improved patient survival...
  27. ncbi request reprint [New developments in hematopoietic stem cell transplantation]
    A Gratwohl
    Abteilung für Hämatologie, Departement Innere Medizin, Kantonsspital, Basel
    Ther Umsch 59:571-6. 2002
    ..Diagnosis and age as sole criteria no longer suffice. Hematopoetic stem cell transplantation might serve in the future as a model for stem cell transplants for other organs...
  28. doi request reprint H-Y as a minor histocompatibility antigen in kidney transplantation: a retrospective cohort study
    Alois Gratwohl
    Department of Haematology, University Hospital Basel, Switzerland
    Lancet 372:49-53. 2008
    ..By contrast, in kidney transplantation, the role of H-Y as a minor histocompatibility antigen has been disputed. We aimed to investigate whether an immunological H-Y effect occurs in kidney transplantation...
  29. ncbi request reprint On the distinction between males and females
    A Gratwohl
    Haematology and Stem Cell Transplantation Unit, University of Basel, CH 4031, Basel, Switzerland
    Lancet 362:590-1. 2003
  30. doi request reprint The EBMT activity survey 2009: trends over the past 5 years
    H Baldomero
    EBMT Activity Survey Office, Department of Medicine, Division of Hematology, University Hospital Basel, Basel, Switzerland
    Bone Marrow Transplant 46:485-501. 2011
    ..01, two sided). These data illustrate the status and trends of HST in Europe...
  31. ncbi request reprint Hematopoetic stem cell transplantation for solid tumors in Europe
    A Gratwohl
    Division of Hematology, Department of Internal Medicine, Kantonsspital Basel, Switzerland
    Ann Oncol 15:653-60. 2004
    ..Transplant numbers have changed substantially over the last decade, few controlled studies are available and different opinions prevail. Objective information on current practice is needed...
  32. ncbi request reprint Overview of transplant activity in Europe
    Alois Gratwohl
    Division of Hematology, Department of Internal Medicine, Kantonsspital Basel, Switzerland
    Hematol J 5:S29-33. 2004
    ..As such, it provides up-to-date information for patients, treating physicians and health-care officials...
  33. doi request reprint European survey on clinical use of cord blood for hematopoietic and non-hematopoietic indications
    Alois Gratwohl
    EBMT Activity Survey Office, Hematology, Department of Medicine, University Hospital, Basel, Switzerland
    Transfus Apher Sci 42:265-75. 2010
    ..3 (range 0.1-234.6) and a proportion of CB amongst allogeneic HSCT from 0.7% to 18.2% (median 5.4%). These data document the established role of CB HSCT in Europe but point to significant differences in its use...
  34. pmc Hematopoietic stem cell transplantation: a global perspective
    Alois Gratwohl
    European Group for Blood andMarrow Transplantation, Transplant Activity Survey Office, Department of Hematology, University Hospital Basel, Basel, Switzerland
    JAMA 303:1617-24. 2010
    ..Hematopoietic stem cell transplantation (HSCT) requires significant infrastructure. Little is known about HSCT use and the factors associated with it on a global level...
  35. ncbi request reprint Evolution of hematopoietic stem cell transplantation in Eastern and Western Europe from 1990 to 2003. A report from the EBMT activity survey
    Alois Gratwohl
    Division of Hematology, Department of Internal Medicine, University Hospital Basel, CH 4031 Basel, Switzerland
    Croat Med J 45:689-94. 2004
    ..Another important factor seems to be the access to the therapeutic procedure. These data provide a basis for health care planning...
  36. ncbi request reprint Risk assessment for patients with chronic myeloid leukemia before allogeneic blood or marrow transplantation
    Alois Gratwohl
    Hematology, University Hospitals Basel, Switzerland
    Haematologica 90:151. 2005
  37. pmc Late altered organ function in very long-term survivors after allogeneic hematopoietic stem cell transplantation: a paired comparison with their HLA-identical sibling donor
    Alicia Rovo
    Department of Hematology, University Hospital of Basel, Basel, Switzerland
    Haematologica 96:150-5. 2011
    ..The study objective was to assess health status of very long-term survivors in comparison with their respective human leukocyte antigen-identical sibling donors...
  38. doi request reprint Infection prevention strategies in a stem cell transplant unit: impact of change of care in isolation practice and routine use of high dose intravenous immunoglobulins on infectious complications and transplant related mortality
    Nathan Cantoni
    Division of Hematology, University Hospital Basel, Basel, Switzerland
    Eur J Haematol 83:130-8. 2009
    ..Nursing in 'live islands' and routine high dose intravenous immunoglobulins after allogeneic hematopoietic stem cell transplantation were abandoned by many teams in view of limited evidence and high costs...
  39. ncbi request reprint Human leukocyte antigen DR15 is associated with reduced relapse rate and improved survival after human leukocyte antigen-identical sibling hematopoietic stem cell transplantation
    Martin Stern
    Department of Hematology, University Hospital, Basel, Switzerland
    Biol Blood Marrow Transplant 12:1169-75. 2006
    ..This adds to the growing list of links between DR15 and immune reactions in hematopoiesis...
  40. ncbi request reprint Cellular senescence of white blood cells in very long-term survivors after allogeneic hematopoietic stem cell transplantation: the role of chronic graft-versus-host disease and female donor sex
    Gabriela M Baerlocher
    Department of Hematology, University Hospital, University of Bern, Bern, Switzerland
    Blood 114:219-22. 2009
    ..If this hypothesis can be confirmed, identification of recipients at risk for cellular senescence could become part of monitoring long-term survivors after hematopoietic stem cell transplantation...
  41. doi request reprint Evidence for a bidirectional relationship between cytomegalovirus replication and acute graft-versus-host disease
    Nathan Cantoni
    Division of Hematology, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    Biol Blood Marrow Transplant 16:1309-14. 2010
    ..65, P < .01). These data confirm that GVHD and its therapy can induce CMV replication. They further demonstrate the reciprocal novel finding that patients are at significantly increased risk of developing aGVHD during CMV replication...
  42. doi request reprint Large granular lymphocyte expansion after allogeneic hematopoietic stem cell transplant is associated with a cytomegalovirus reactivation and shows an indolent outcome
    Sabine Nann-Rütti
    Department of Hematology, University Hospital of Basel, Basel, Switzerland
    Biol Blood Marrow Transplant 18:1765-70. 2012
    ..Our data indicate that such expansions may be considered as an expression of chronic stimulation, triggered by CMV reactivation rather than a malignant transformation...
  43. doi request reprint Aplastic anemia and concomitant autoimmune diseases
    Magnus P Stalder
    Basel Stem Cell Transplant Team, University Hospital Basel, Basel, Switzerland
    Ann Hematol 88:659-65. 2009
    ..In 13 patients in which AID occurred after first-line therapy, the median time to the AID was 7 years (range 3 months-27.5 years)...
  44. ncbi request reprint Spermatogenesis in long-term survivors after allogeneic hematopoietic stem cell transplantation is associated with age, time interval since transplantation, and apparently absence of chronic GvHD
    Alicia Rovo
    Hematology Department, Division of Hematology, University Hospital, Basel Petersgraben 4, CH 4031 Basel, Switzerland
    Blood 108:1100-5. 2006
    ..In conclusion, men who are long-term survivors, who were younger than 25 years at HSCT, and who apparently do not have chronic GvHD have a reasonable likelihood of spermatogenesis even when conditioned with standard-dose TBI...
  45. ncbi request reprint Lung resection in hematologic patients with pulmonary invasive fungal disease
    Christian A Nebiker
    Division of Thoracic Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    Chest 142:988-95. 2012
    ..Pulmonary invasive fungal disease is a frequent complication in patients with hematologic malignancies. Surgical resection in addition to antifungal therapy is an option for selected cases but often feared because of immunosuppression...
  46. doi request reprint Patient and product factors affecting platelet transfusion results
    Dominik Heim
    Hematology, University Hospital, Basel, Switzerland
    Transfusion 48:681-7. 2008
    ..Optimizing PLT transfusions is in the interest of not only patient safety but also economic importance. Only few studies have evaluated factors associated with transfusion results...
  47. doi request reprint Comparison of transfusion efficacy of amotosalen-based pathogen-reduced platelet components and gamma-irradiated platelet components
    Joerg Peter Sigle
    Blood Transfusion Center Swiss Red Cross, Hematology, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Transfusion 53:1788-97. 2013
    ..However, PR-PLTs and conventional PCs often differed in various factors besides PR. We compared transfusion efficacy of single-donor apheresis PCs treated with PR or gamma irradiation...
  48. ncbi request reprint Leukocyte count and risk of thrombosis in patients undergoing haematopoietic stem cell transplantation or intensive chemotherapy
    Nadina Stoffel
    University Hospital Basel, Basel, Switzerland
    Thromb Haemost 103:1228-32. 2010
    ..In three cohorts of patients undergoing intensive cytoreductive treatment for haematological malignancy, leukocyte count was strongly associated with development of thrombotic complications...
  49. ncbi request reprint Premature cardiovascular disease after allogeneic hematopoietic stem-cell transplantation
    Andre Tichelli
    Division of Hematology, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Blood 110:3463-71. 2007
    ..Thus, long-term survivors after allogeneic HSCT are at high risk for premature arterial vascular disease. HSCT might favor the emergence of established risk factors, such as hypertension, diabetes, and dyslipidemia...
  50. pmc Persistence of recipient-type endothelium after allogeneic hematopoietic stem cell transplantation
    Regula J Mueller
    Laboratory for Transplantation Immunology, University Hospital, Zurich, Switzerland
    Haematologica 96:119-27. 2011
    ..For this reason, we investigated the level of endothelial cell chimerism after allogeneic hematopoietic stem cell transplantation in order to delineate the role of hematopoietic stem cells in endothelial replacement...
  51. ncbi request reprint Increasing use of reduced intensity conditioning transplants: report of the 2001 EBMT activity survey
    A Gratwohl
    Division of Hematology, Department of Internal Medicine, Kantonsspital Basel, Switzerland
    Bone Marrow Transplant 30:813-31. 2002
    ..These data document the current status of blood and marrow transplantation in Europe and indicate a marked change towards RIC HSCT in allogeneic transplantation...
  52. pmc Quantitative and qualitative differences in use and trends of hematopoietic stem cell transplantation: a Global Observational Study
    Alois Gratwohl
    The European Group for Blood and Marrow Transplantation EBMT Transplant Activity Survey Office, University Hospital, Basel, Switzerland
    Haematologica 98:1282-90. 2013
    ....
  53. pmc Severe events in donors after allogeneic hematopoietic stem cell donation
    Joerg Halter
    Hematology, Department of Medicine, University Hospital Basel, Basel, Switzerland
    Haematologica 94:94-101. 2009
    ..Scattered reports of severe complications and a recent controversy on hematopoietic malignancies after granulocyte colony-stimulating factor administration have challenged this opinion...
  54. ncbi request reprint Influence of donor/recipient sex matching on outcome of allogeneic hematopoietic stem cell transplantation for aplastic anemia
    Martin Stern
    University Hospital, Department of Hematology, Basel, Switzerland
    Transplantation 82:218-26. 2006
    ..An increased rejection of male grafts in female recipients is not reported for solid organ or stem cell transplants and the role of H-Y as transplantation antigen has been controversial...
  55. doi request reprint Prospective change control analysis of transfer of platelet concentrate production from a specialized stem cell transplantation unit to a blood transfusion center
    Joerg Peter Sigle
    Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland
    J Clin Apher 27:178-82. 2012
    ..We wanted to demonstrate that neither quality nor transfusion outcome was affected...
  56. doi request reprint Initial cord blood unit volume affects mononuclear cell and CD34+ cell-processing efficiency in a non-linear fashion
    Sandrine Meyer-Monard
    Basel University Hospital, Basel, Switzerland
    Cytotherapy 14:215-22. 2012
    ..It is now suggested for use for adults as well, a fact that increases the pressure to obtain units with high cellularity. Therefore, the optimization of UCB processing is a priority...
  57. doi request reprint Hematopoietic progenitor cell colony growth differentiates chronic myelomonocytic leukemia from reactive monocytosis
    Angelika Birrer
    Department of Hematology, University Hospital, Basel, Switzerland
    Eur J Haematol 81:267-72. 2008
    ..None of the patients with reactive monocytosis showed either leukemic or pseudonormal growth. With a specificity of 100% and a sensitivity of 89%, the CFU-C assay has a unique potential to distinguish CMML from reactive monocytosis...
  58. ncbi request reprint Hematopoietic stem cell transplantation in Switzerland: a comprehensive quality control report on centre effect
    Jakob Passweg
    Haematology, University Hospital, Geneva HUG, Switzerland
    Swiss Med Wkly 140:326-34. 2010
    ..Haematopoietic stem cell transplantation (HSCT) requires significant infrastructure and represents a cost-intensive procedure. It therefore qualifies as a prime target for such a policy...
  59. ncbi request reprint Effect of beta-blockers, Ca2+ antagonists, and benzodiazepines on bleeding incidence in patients with chemotherapy induced thrombocytopenia
    Christine Rysler
    Stem Cell Transplant Team, University Hospital, Basel, Switzerland
    Platelets 21:77-83. 2010
    ..In conclusion, therapy with Beta-1-adrenoreceptor antagonists, Ca(2+) antagonists, and benzodiazepines did not appear to significantly increase the risk for hemorrhagic complications in patients with iatrogenic severe thrombocytopenia...
  60. doi request reprint DV-ICE, intensive induction and early transplantation for adult patients with acute lymphoblastic leukemia: a phase II study
    Christine Dudler
    University of Basel, University Hospital, Switzerland
    Eur J Haematol 83:512-8. 2009
    ..The role of induction intensity, first remission hematopoietic stem cell transplantation (HSCT) and maintenance chemotherapy continues to be discussed. We tested a strategy of high intensity treatment of short duration followed by HSCT...
  61. pmc Human acute myeloid leukemia CD34+CD38- stem cells are susceptible to allorecognition and lysis by single KIR-expressing natural killer cells
    Ulrich Langenkamp
    Experimental Hematology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Haematologica 94:1590-4. 2009
    ..These results show that alloreactive natural killer cells have the potential to detect and target leukemic stem cells, and thus to improve the treatment outcome in acute myeloid leukemia...
  62. ncbi request reprint Cutaneous graft-versus-host disease: a guide for the dermatologist
    Peter Hausermann
    Department of Dermatology, University Hospital Basel, Basel, Switzerland
    Dermatology 216:287-304. 2008
    ....
  63. doi request reprint Good manufacturing practice-compliant cell sorting and large-scale expansion of single KIR-positive alloreactive human natural killer cells for multiple infusions to leukemia patients
    Uwe Siegler
    Experimental Hematology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Cytotherapy 12:750-63. 2010
    ..The introduction of NK cell-based immunotherapy to current treatment options in acute myeloid leukemia (AML) requires NK cell products with high anti-leukemic efficacy optimized for clinical use...
  64. pmc Donor characteristics affecting graft failure, graft-versus-host disease, and survival after unrelated donor transplantation with reduced-intensity conditioning for hematologic malignancies
    Jakob R Passweg
    University Hospital Basel, Basel, Switzerland
    Biol Blood Marrow Transplant 17:1869-73. 2011
    ..33, P = .002). Donor age, parity, and donor sex match were not associated with transplantation outcome. Donor-recipient HLA matching is the only donor characteristic predictive for survival after RIC regimens for hematologic malignancies...
  65. doi request reprint Pathogen-inactivation of platelet components with the INTERCEPT Blood System ™: a cohort study
    Laura Infanti
    Blood Transfusion Center, Swiss Red Cross, Basel, Switzerland
    Transfus Apher Sci 45:175-81. 2011
    ..INTERCEPT treatment is used to reduce platelet transfusion associated bacterial infections. Limited data are available in Switzerland...
  66. ncbi request reprint Quality-adjusted survival analysis shows differences in outcome after immunosuppression or bone marrow transplantation in aplastic anemia
    Romaine Viollier
    Transplantation Unit, University Hospitals of Basel, Petersgraben 4, 4031 Basel, Switzerland
    Ann Hematol 84:47-55. 2005
    ..43, p=0.056). In conclusion, survival, event-free survival, and Q-TWiST are similar. BMT-treated patients had longer periods free from symptoms, while IS-treated patients needed closer medical care, transfusion support, and medications...
  67. doi request reprint Leukemic cluster growth in culture is an independent risk factor for acute myeloid leukemia and short survival in patients with myelodysplastic syndrome
    Michael Bernimoulin
    Department of Hematology, University Hospital, Basel, Switzerland
    Acta Haematol 119:226-35. 2008
    ..CFU-C assays have a significant predictive value in addition to established prognostic factors in MDS. Leukemic growth identifies a subpopulation of MDS patients with poor prognosis...
  68. doi request reprint ABO blood group-incompatible living donor kidney transplantation: a prospective, single-centre analysis including serial protocol biopsies
    Tobias Oettl
    Clinic for Transplantation Immunology and Nephrology, University Hospital, Basel, Switzerland
    Nephrol Dial Transplant 24:298-303. 2009
    ..The present prospective single-centre study was aimed at these issues...
  69. ncbi request reprint Association of TNFd and IL-10 polymorphisms with mortality in unrelated hematopoietic stem cell transplantation
    Florence Bettens
    Transplantation Immunology Unit LNRH, University Hospital, Geneva, Switzerland
    Transplantation 81:1261-7. 2006
    ..In this study, we have determined the role of TNFa, TNFd, IL-10, IL-1, IL-1Ra, and IL-4R polymorphisms in patients transplanted with HSC of an unrelated donor...
  70. pmc Haematopoietic stem cell transplantation for vasculitis including Behcet's disease and polychondritis: a retrospective analysis of patients recorded in the European Bone Marrow Transplantation and European League Against Rheumatism databases and a review
    Thomas Daikeler
    Department of Rheumatology, University of Basle, Petersgraben 4, CH 4031 Basle, Switzerland
    Ann Rheum Dis 66:202-7. 2007
    ..To evaluate the feasibility of haematopoietic stem cell transplantation (HSCT) in vasculitis...
  71. ncbi request reprint Hematopoietic stem cell transplantation activity in Europe 1999
    A Gratwohl
    Division of Hematology, Department of Internal Medicine, Kantonsspital Basel, Switzerland
    Bone Marrow Transplant 27:899-916. 2001
    ..Reasons therefore are discussed. These data reflect the most recent changes in utilisation and document current status of blood and marrow transplantation in Europe...
  72. doi request reprint Respiratory syncytial virus infection in patients with hematological diseases: single-center study and review of the literature
    Nina Khanna
    Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Basel, Switzerland
    Clin Infect Dis 46:402-12. 2008
    ..Respiratory syncytial virus (RSV) causes significant mortality in patients with hematological diseases, but diagnosis and treatment are uncertain...
  73. ncbi request reprint Reconstitution of dendritic and natural killer-cell subsets after allogeneic stem cell transplantation: effects of endogenous flt3 ligand
    Elena Chklovskaia
    Department of Research, University Hospital Basel, Basel, Switzerland
    Blood 103:3860-8. 2004
    ..Our results demonstrate that endogenous FL has distinct effects on the kinetics of reconstitution of DCs and NK cells and have potential implications for the modulation of immune responses after allogeneic SCT...
  74. ncbi request reprint The allele burden of JAK2 mutations remains stable over several years in patients with myeloproliferative disorders
    Alexandre Theocharides
    Experimental Hematology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Haematologica 93:1890-3. 2008
    ..Our data suggest that in untreated myeloproliferative disorders patients, from whom samples at diagnosis are not available, the JAK2 allele burden determined at later stages could be equally informative...
  75. doi request reprint Female-versus-male alloreactivity as a model for minor histocompatibility antigens in hematopoietic stem cell transplantation
    M Stern
    Department of Hematology, University Hospital, Basel, Switzerland
    Am J Transplant 8:2149-57. 2008
    ..These data define the role of H-Y mismatching in allogeneic HSCT and support the current practice of avoiding female donors for male patients, if possible...
  76. doi request reprint Allogeneic hematopoietic SCT for patients with autoimmune diseases
    T Daikeler
    Department of Rheumatology, University of Basel, University Hospital, Basel CH 4031, Switzerland
    Bone Marrow Transplant 44:27-33. 2009
    ..However, allogeneic HSCT can induce remission in patients suffering from refractory AD. These data provide the basis for carefully conducted prospective trials...
  77. ncbi request reprint Haematopoietic stem cell transplantation (HSCT) in Europe 2002. Changes in indication and impact of team density. A report of the EBMT activity survey
    A Gratwohl
    Department of Internal Medicine, Division of Hematology, Kantonsspital Basel, Basel, Switzerland
    Bone Marrow Transplant 34:855-75. 2004
    ..These data describe current practice for blood and marrow transplantation in Europe and give some hints about mechanisms involved in HSCT rates...
  78. doi request reprint A survey on cellular and engineered tissue therapies in europe in 2008
    Ivan Martin
    Department of Surgery and of Biomedicine, University Hospital, Basel, Switzerland
    Tissue Eng Part A 16:2419-27. 2010
    ..This data collection platform is expected to capture and foresee trends for novel cellular therapies in Europe, and warrants further consolidation and extension...
  79. ncbi request reprint Hematopoietic stem cell transplantation for hematological malignancies in Europe
    A Gratwohl
    Division of Hematology, Department of Internal Medicine, Kantonsspital Basel, Switzerland
    Leukemia 17:941-59. 2003
    ..These data give an overview of the current status of HSCT for hematological malignancies in Europe and provide objective information for health-care providers and patient counselling...
  80. ncbi request reprint Haematopoietic stem cell transplantation in Switzerland. Report from the Swiss Transplant Working Group Blood and Marrow Transplantation (STABMT) Registry 1997-2003
    J Passweg
    Division of Haematology, University Hospital, Geneva, Switzerland
    Swiss Med Wkly 136:50-8. 2006
    ..Outcome depended on indication, donor type, stem cell source and age of patient. HSCT is an established therapy in Switzerland. These data describe current practice and outcome...