Research Topics
Genomes and Genes | J GotzSummaryAffiliation: University of Zurich Country: Switzerland Publications
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Detail Information
Publications
Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic miceStefan Kins
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
Am J Pathol 163:833-43. 2003..Our findings imply that PP2A is a negative regulator of the ERK and JNK signaling pathways in vivo, suggesting that in AD, tau hyperphosphorylation may be caused in part by PP2A dysfunction...
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrilsJ Gotz
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
Science 293:1491-5. 2001..NFTs were composed of twisted filaments and occurred in 6-month-old mice as early as 18 days after Abeta42 injections. Our data support the hypothesis that Abeta42 fibrils can accelerate NFT formation in vivo...- Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapyJ Gotz
Division of Psychiatry Research, University of Zurich, August Forel Str 1, Ch 8008 Zurich, Switzerland
Mol Psychiatry 9:664-83. 2004..This review aims to discuss the suitability and limitations of the various animal models and their contribution to an understanding of the pathophysiology of AD and related disorders... - Tau and transgenic animal modelsJ Gotz
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008, Zurich, Switzerland
Brain Res Brain Res Rev 35:266-86. 2001..These models link neurofibrillary lesion formation to neuronal loss, provide an in vivo model in which therapies can be assessed, and may contribute to determine the relationship between Abeta production and tau pathology... - Oligodendroglial tau filament formation in transgenic mice expressing G272V tauJ Gotz
Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
Eur J Neurosci 13:2131-40. 2001..These results establish that expression of the G272V mutation in mice causes oligodendroglial fibrillary lesions that are similar to those seen in human tauopathies... - In vivo analysis of wild-type and FTDP-17 tau transgenic miceJ Gotz
Department of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
Ann N Y Acad Sci 920:126-33. 2000..We have now extended our initial studies by introducing exonic mutations including G2t 2V and PS01L into the tau gene in order to achieve a more advanced FTDP-17 associated phenotype... - Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture modelsJürgen Götz
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
Int J Dev Neurosci 22:453-65. 2004..These mechanisms may be partially shared between sporadic Alzheimer's disease, the familial forms and frontotemporal dementia. Eventually, Alzheimer's disease may be redefined based on biochemical events rather than phenotype... - Tau filament formation in transgenic mice expressing P301L tauJ Gotz
Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
J Biol Chem 276:529-34. 2001..Together, our results show that expression of the P301L mutation in mice causes neuronal lesions that are similar to those seen in human tauopathies... - Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during developmentJ Gotz
Department of Psychiatry Research, University of Zurich, Switzerland
Mech Dev 93:83-93. 2000..Cytosolic concentrations of beta-catenin were low. Our results suggest that Calpha is required for stabilization of E-cadherin/beta-catenin complexes at the plasma membrane... - Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic miceJ Gotz
Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
Neuroreport 12:2007-16. 2001..CA1 neurons phosphorylated tau at more epitopes than dentate gyrus neurons, suggesting that tau phosphorylation is cell type-specific, a possible explanation for the spatial distribution of neurofibrillary tangles... - Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic miceS Kins
Division of Psychiatry Research, , , Switzerland
J Biol Chem 276:38193-200. 2001..Our results also show that reduced PP2A activity is associated with altered compartmentalization and ubiquitination of tau, resembling a key pathological finding in AD... - Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic miceL Pennanen
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Genes Brain Behav 5:369-79. 2006..In addition, a modest disinhibition of exploratory behavior at 6 months of age was confirmed in the open field and the elevated O-maze and was more pronounced during aging... - Immature human NT2 cells grafted into mouse brain differentiate into neuronal and glial cell typesA Ferrari
Division of Psychiatry Research, University of Z rich, Zurich, Switzerland
FEBS Lett 486:121-5. 2000.... - Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit CalphaJ Gotz
Institut fur Molekularbiologie, Abteilung I, Universitat Zurich, Honggerberg, 8093 Zurich, Switzerland
Proc Natl Acad Sci U S A 95:12370-5. 1998..While the primary germ layers ectoderm and endoderm are formed, mesoderm is not formed in degenerating embryos... - Saitohin gene is not associated with Alzheimer's diseaseJ R Streffer
Division of Psychiatry Research, University of Zurich, Switzerland
J Neurol Neurosurg Psychiatry 74:362-3. 2003....