J Gotz

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. pmc Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice
    Stefan Kins
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Am J Pathol 163:833-43. 2003
  2. ncbi Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
    J Gotz
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Science 293:1491-5. 2001
  3. ncbi Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy
    J Gotz
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, Ch 8008 Zurich, Switzerland
    Mol Psychiatry 9:664-83. 2004
  4. ncbi Tau and transgenic animal models
    J Gotz
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008, Zurich, Switzerland
    Brain Res Brain Res Rev 35:266-86. 2001
  5. ncbi Oligodendroglial tau filament formation in transgenic mice expressing G272V tau
    J Gotz
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Eur J Neurosci 13:2131-40. 2001
  6. ncbi In vivo analysis of wild-type and FTDP-17 tau transgenic mice
    J Gotz
    Department of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Ann N Y Acad Sci 920:126-33. 2000
  7. ncbi Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models
    Jürgen Götz
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Int J Dev Neurosci 22:453-65. 2004
  8. ncbi Tau filament formation in transgenic mice expressing P301L tau
    J Gotz
    Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    J Biol Chem 276:529-34. 2001
  9. ncbi Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development
    J Gotz
    Department of Psychiatry Research, University of Zurich, Switzerland
    Mech Dev 93:83-93. 2000
  10. ncbi Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice
    J Gotz
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neuroreport 12:2007-16. 2001

Collaborators

Detail Information

Publications15

  1. pmc Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice
    Stefan Kins
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Am J Pathol 163:833-43. 2003
    ..Our findings imply that PP2A is a negative regulator of the ERK and JNK signaling pathways in vivo, suggesting that in AD, tau hyperphosphorylation may be caused in part by PP2A dysfunction...
  2. ncbi Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
    J Gotz
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Science 293:1491-5. 2001
    ..NFTs were composed of twisted filaments and occurred in 6-month-old mice as early as 18 days after Abeta42 injections. Our data support the hypothesis that Abeta42 fibrils can accelerate NFT formation in vivo...
  3. ncbi Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy
    J Gotz
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, Ch 8008 Zurich, Switzerland
    Mol Psychiatry 9:664-83. 2004
    ..This review aims to discuss the suitability and limitations of the various animal models and their contribution to an understanding of the pathophysiology of AD and related disorders...
  4. ncbi Tau and transgenic animal models
    J Gotz
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008, Zurich, Switzerland
    Brain Res Brain Res Rev 35:266-86. 2001
    ..These models link neurofibrillary lesion formation to neuronal loss, provide an in vivo model in which therapies can be assessed, and may contribute to determine the relationship between Abeta production and tau pathology...
  5. ncbi Oligodendroglial tau filament formation in transgenic mice expressing G272V tau
    J Gotz
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Eur J Neurosci 13:2131-40. 2001
    ..These results establish that expression of the G272V mutation in mice causes oligodendroglial fibrillary lesions that are similar to those seen in human tauopathies...
  6. ncbi In vivo analysis of wild-type and FTDP-17 tau transgenic mice
    J Gotz
    Department of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Ann N Y Acad Sci 920:126-33. 2000
    ..We have now extended our initial studies by introducing exonic mutations including G2t 2V and PS01L into the tau gene in order to achieve a more advanced FTDP-17 associated phenotype...
  7. ncbi Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models
    Jürgen Götz
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Int J Dev Neurosci 22:453-65. 2004
    ..These mechanisms may be partially shared between sporadic Alzheimer's disease, the familial forms and frontotemporal dementia. Eventually, Alzheimer's disease may be redefined based on biochemical events rather than phenotype...
  8. ncbi Tau filament formation in transgenic mice expressing P301L tau
    J Gotz
    Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    J Biol Chem 276:529-34. 2001
    ..Together, our results show that expression of the P301L mutation in mice causes neuronal lesions that are similar to those seen in human tauopathies...
  9. ncbi Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development
    J Gotz
    Department of Psychiatry Research, University of Zurich, Switzerland
    Mech Dev 93:83-93. 2000
    ..Cytosolic concentrations of beta-catenin were low. Our results suggest that Calpha is required for stabilization of E-cadherin/beta-catenin complexes at the plasma membrane...
  10. ncbi Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice
    J Gotz
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neuroreport 12:2007-16. 2001
    ..CA1 neurons phosphorylated tau at more epitopes than dentate gyrus neurons, suggesting that tau phosphorylation is cell type-specific, a possible explanation for the spatial distribution of neurofibrillary tangles...
  11. ncbi Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice
    S Kins
    Division of Psychiatry Research, , , Switzerland
    J Biol Chem 276:38193-200. 2001
    ..Our results also show that reduced PP2A activity is associated with altered compartmentalization and ubiquitination of tau, resembling a key pathological finding in AD...
  12. ncbi Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice
    L Pennanen
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Genes Brain Behav 5:369-79. 2006
    ..In addition, a modest disinhibition of exploratory behavior at 6 months of age was confirmed in the open field and the elevated O-maze and was more pronounced during aging...
  13. ncbi Immature human NT2 cells grafted into mouse brain differentiate into neuronal and glial cell types
    A Ferrari
    Division of Psychiatry Research, University of Z rich, Zurich, Switzerland
    FEBS Lett 486:121-5. 2000
    ....
  14. pmc Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha
    J Gotz
    Institut fur Molekularbiologie, Abteilung I, Universitat Zurich, Honggerberg, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 95:12370-5. 1998
    ..While the primary germ layers ectoderm and endoderm are formed, mesoderm is not formed in degenerating embryos...
  15. pmc Saitohin gene is not associated with Alzheimer's disease
    J R Streffer
    Division of Psychiatry Research, University of Zurich, Switzerland
    J Neurol Neurosurg Psychiatry 74:362-3. 2003
    ....