- Gosmain Y, Avril I, Mamin A, Philippe J. Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression. J Biol Chem. 2007;282:35024-34 pubmed..We conclude that Pax-6 and c-Maf interact with G1 to activate basal expression of the glucagon gene. ..
- Gosmain Y, Katz L, Masson M, Cheyssac C, Poisson C, Philippe J. Pax6 is crucial for ?-cell function, insulin biosynthesis, and glucose-induced insulin secretion. Mol Endocrinol. 2012;26:696-709 pubmed publisher..We provide further evidence that Pax6 represents a key element of mature ?-cell function. ..
- Gosmain Y, Cheyssac C, Masson M, Guerardel A, Poisson C, Philippe J. Pax6 is a key component of regulated glucagon secretion. Endocrinology. 2012;153:4204-15 pubmed publisher..We propose that Pax6 is not only critical for glucagon biosynthesis but also for glucagon secretion particularly in response to nutrients...