Gosmain Y, Avril I, Mamin A, Philippe J. Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression. J Biol Chem. 2007;282:35024-34 pubmed
..We conclude that Pax-6 and c-Maf interact with G1 to activate basal expression of the glucagon gene. ..
Gosmain Y, Cheyssac C, Heddad Masson M, Dibner C, Philippe J. Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in ?-cell differentiation, glucagon biosynthesis and secretion. Diabetes Obes Metab. 2011;13 Suppl 1:31-8 pubmed publisher
..We conclude that Pax6 independently of Arx and Foxa2 is critical for ?-cell function by coordinating glucagon gene expression as well as glucagon biosynthesis and secretion. ..
Gosmain Y, Katz L, Masson M, Cheyssac C, Poisson C, Philippe J. Pax6 is crucial for ?-cell function, insulin biosynthesis, and glucose-induced insulin secretion. Mol Endocrinol. 2012;26:696-709 pubmed publisher
..We provide further evidence that Pax6 represents a key element of mature ?-cell function. ..
Gosmain Y, Cheyssac C, Masson M, Guerardel A, Poisson C, Philippe J. Pax6 is a key component of regulated glucagon secretion. Endocrinology. 2012;153:4204-15 pubmed publisher
..We propose that Pax6 is not only critical for glucagon biosynthesis but also for glucagon secretion particularly in response to nutrients. ..