P GONCZY

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. ncbi Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III
    P GONCZY
    Max Planck Institute for Cell Biology and Genetics, Dresden, Germany
    Nature 408:331-6. 2000
  2. ncbi zyg-8, a gene required for spindle positioning in C. elegans, encodes a doublecortin-related kinase that promotes microtubule assembly
    P GONCZY
    Swiss Institute for Experimental Cancer Research, Lausanne
    Dev Cell 1:363-75. 2001
  3. ncbi Nuclear envelope: torn apart at mitosis
    PIERRE GONCZY
    ISREC Swiss Institute for Experimental Cancer Research, 155, Ch des Boveresses, CH 1066, Epalinges Lausanne, Switzerland
    Curr Biol 12:R242-4. 2002
  4. ncbi Mechanisms of spindle positioning: focus on flies and worms
    PIERRE GONCZY
    Swiss Institute for Experimental Cancer Research ISREC, 155 ch des Boveresses, CH 1066 Epalinges Lausanne, Switzerland
    Trends Cell Biol 12:332-9. 2002
  5. ncbi Centrosomes: hooked on the nucleus
    PIERRE GONCZY
    ISREC, 155, Ch des Boveresses, CH 1066 Epalinges Lausanne, Switzerland
    Curr Biol 14:R268-70. 2004
  6. ncbi [Mechanisms of cell division: lessons from a nematode]
    PIERRE GONCZY
    ISREC, 155, chemin des Bouveresses, CH 1066 Epalinges Lausanne, Suisse
    Med Sci (Paris) 19:735-42. 2003
  7. ncbi Centrosomes promote timely mitotic entry in C. elegans embryos
    Virginie Hachet
    Swiss Institute for Experimental Cancer Research ISREC, and School of Life Sciences, Swiss Federal Institute of Technology EPFL, CH 1066 Lausanne, Switzerland
    Dev Cell 12:531-41. 2007
  8. ncbi RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos
    Katayoun Afshar
    Swiss Institute for Experimental Cancer Research ISREC, 1066 Epalinges Lausanne, Switzerland
    Cell 119:219-30. 2004
  9. ncbi Coupling of cortical dynein and G alpha proteins mediates spindle positioning in Caenorhabditis elegans
    Tu Nguyen-Ngoc
    Swiss Institute for Experimental Cancer Research ISREC, Swiss Federal Institute of Technology EPFL, School of Life Sciences, Lausanne, Switzerland CH 1066
    Nat Cell Biol 9:1294-302. 2007
  10. ncbi Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos
    Michael Brauchle
    ISREC Swiss Institute for Experimental Cancer Research, 155, Ch des Boveresses, CH 1066 Epalinges Lausanne, Switzerland
    Curr Biol 13:819-27. 2003

Collaborators

  • A A Hyman
  • DAVID SIDEROVSKI
  • Alexey L Khodjakov
  • S J Jones
  • K Oegema
  • R R Copley
  • P Bork
  • B F McEwen
  • Stephan W Grill
  • M Glotzer
  • BRUCE A BOWERMAN
  • Jadranka Loncarek
  • Katayoun Afshar
  • Yemima Budirahardja
  • Sebastian Leidel
  • Petr Strnad
  • Jean Michel Bellanger
  • Coralie Canard
  • Marie Delattre
  • Karine Baumer
  • Kelly Colombo
  • Daiju Kitagawa
  • Gregor Kohlmaier
  • Tu Nguyen-Ngoc
  • Virginie Hachet
  • Moira M Cockell
  • Remi Sonneville
  • Francis S Willard
  • Michael Brauchle
  • S Pichler
  • Yu Chung Tse
  • Michael E Werner
  • Coralie Busso
  • Isabelle Fl├╝ckiger
  • Brian D Dynlacht
  • Xing Meng
  • Alexander Spektor
  • Mette M Mogensen
  • Jennifer B Phillips
  • J Clayton Carter
  • Tatiana Vinogradova
  • Ursula Euteneuer
  • Lorenzo Cerutti
  • Christopher A Johnston
  • Christopher R McCudden
  • Randall J Kimple
  • R Schnabel
  • A Pozniakowski
  • A Ashford
  • H Schnabel

Detail Information

Publications27

  1. ncbi Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III
    P GONCZY
    Max Planck Institute for Cell Biology and Genetics, Dresden, Germany
    Nature 408:331-6. 2000
    ....
  2. ncbi zyg-8, a gene required for spindle positioning in C. elegans, encodes a doublecortin-related kinase that promotes microtubule assembly
    P GONCZY
    Swiss Institute for Experimental Cancer Research, Lausanne
    Dev Cell 1:363-75. 2001
    ..Our findings demonstrate that ZYG-8 is a MAP crucial for proper spindle positioning in C. elegans, and indicate that the function of the Doublecortin domain in modulating microtubule dynamics is conserved across metazoan evolution...
  3. ncbi Nuclear envelope: torn apart at mitosis
    PIERRE GONCZY
    ISREC Swiss Institute for Experimental Cancer Research, 155, Ch des Boveresses, CH 1066, Epalinges Lausanne, Switzerland
    Curr Biol 12:R242-4. 2002
    ..The findings of two recent studies suggest a novel mechanism for nuclear envelope breakdown in which cytoplasmic dynein anchored on the outside of the nucleus generates tension, thus triggering tearing of the nuclear envelope...
  4. ncbi Mechanisms of spindle positioning: focus on flies and worms
    PIERRE GONCZY
    Swiss Institute for Experimental Cancer Research ISREC, 155 ch des Boveresses, CH 1066 Epalinges Lausanne, Switzerland
    Trends Cell Biol 12:332-9. 2002
    ..This article discusses recent findings that indicate how this mechanism might be used for spindle positioning during Drosophila and Caenorhabditis elegans development...
  5. ncbi Centrosomes: hooked on the nucleus
    PIERRE GONCZY
    ISREC, 155, Ch des Boveresses, CH 1066 Epalinges Lausanne, Switzerland
    Curr Biol 14:R268-70. 2004
    ..The results suggest a novel mechanism for the tight coupling between these two organelles, and shed new light on its biological significance...
  6. ncbi [Mechanisms of cell division: lessons from a nematode]
    PIERRE GONCZY
    ISREC, 155, chemin des Bouveresses, CH 1066 Epalinges Lausanne, Suisse
    Med Sci (Paris) 19:735-42. 2003
    ..Together, these experimental approaches contribute to a better understanding of the mechanisms orchestrating spatial cell division control in metazoan organisms...
  7. ncbi Centrosomes promote timely mitotic entry in C. elegans embryos
    Virginie Hachet
    Swiss Institute for Experimental Cancer Research ISREC, and School of Life Sciences, Swiss Federal Institute of Technology EPFL, CH 1066 Lausanne, Switzerland
    Dev Cell 12:531-41. 2007
    ..Together, our findings support a model in which centrosomes serve as integrative centers for mitotic regulators and thus trigger mitotic entry in a timely fashion...
  8. ncbi RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos
    Katayoun Afshar
    Swiss Institute for Experimental Cancer Research ISREC, 1066 Epalinges Lausanne, Switzerland
    Cell 119:219-30. 2004
    ..Our findings suggest a mechanism in which RIC-8 favors generation of Galpha free from Gbetagamma and enables GPR-1/2 to mediate asymmetric cell division...
  9. ncbi Coupling of cortical dynein and G alpha proteins mediates spindle positioning in Caenorhabditis elegans
    Tu Nguyen-Ngoc
    Swiss Institute for Experimental Cancer Research ISREC, Swiss Federal Institute of Technology EPFL, School of Life Sciences, Lausanne, Switzerland CH 1066
    Nat Cell Biol 9:1294-302. 2007
    ..Together with microtubule dynamics, this allows pulling forces to be exerted and proper cell division to be achieved...
  10. ncbi Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos
    Michael Brauchle
    ISREC Swiss Institute for Experimental Cancer Research, 155, Ch des Boveresses, CH 1066 Epalinges Lausanne, Switzerland
    Curr Biol 13:819-27. 2003
    ..How anterior-posterior (A-P) polarity cues control this asynchrony remains to be elucidated...
  11. doi Mechanisms of asymmetric cell division: flies and worms pave the way
    PIERRE GONCZY
    Swiss Institute for Experimental Cancer Research ISREC, Swiss Federal Institute of Technology EPFL, School of Life Sciences, Lausanne, Switzerland
    Nat Rev Mol Cell Biol 9:355-66. 2008
    ..Lessons learned from these two model organisms also apply to cells that divide asymmetrically in other metazoans, such as self-renewing stem cells in mammals...
  12. ncbi OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P(1) blastomere of C. elegans embryos
    S Pichler
    Max Planck Institute for Cell Biology and Genetics, D 01307 Dresden, Germany
    Development 127:2063-73. 2000
    ..Our results show that ooc-3 is required to form the cortical domains essential for polarity after cell division...
  13. ncbi lis-1 is required for dynein-dependent cell division processes in C. elegans embryos
    Moira M Cockell
    Swiss Institute for Experimental Cancer Research ISREC, Ch des Boveresses 155, 1066 Epalinges Lausanne, Switzerland
    J Cell Sci 117:4571-82. 2004
    ..These results suggest that dynein and Lis1, albeit functioning in identical processes, are targeted partially independently of one another...
  14. ncbi Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans
    Remi Sonneville
    ISREC Swiss Institute for Experimental Cancer Research Boveresses, CH 1066 Epalinges Lausanne, Switzerland
    Development 131:3527-43. 2004
    ....
  15. doi PLK-1 asymmetry contributes to asynchronous cell division of C. elegans embryos
    Yemima Budirahardja
    Swiss Institute for Experimental Cancer Research ISREC Sciences, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
    Development 135:1303-13. 2008
    ....
  16. ncbi ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos
    Jean Michel Bellanger
    Swiss Institute for Experimental Cancer Research ISREC, Swiss Federal Institute of Technology EPFL, School of Life Sciences, Lausanne, Switzerland
    J Cell Sci 120:2963-73. 2007
    ..Taken together, these findings indicate that ZYG-9-TAC-1 and ZYG-8 act in a partially redundant manner to ensure correct microtubule assembly throughout the cell cycle of early C. elegans embryos...
  17. ncbi Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos
    Kelly Colombo
    Swiss Institute for Experimental Cancer Research ISREC, 1066 Epalinges Lausanne, Switzerland
    Science 300:1957-61. 2003
    ..Thus, the extent of net pulling forces may depend on cortical Galpha activity, which is regulated by anterior-posterior polarity cues through GPR-1/2...
  18. ncbi Sequential protein recruitment in C. elegans centriole formation
    Marie Delattre
    Swiss Institute for Experimental Cancer Research, School of Life Sciences ISREC, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
    Curr Biol 16:1844-9. 2006
    ..Several of these proteins have homologs in other metazoans, and we expect the assembly pathway that stems from our work to be conserved...
  19. ncbi TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos
    Jean Michel Bellanger
    Swiss Institute for Experimental Cancer Research ISREC, CH 1066, Epalinges Lausanne, Switzerland
    Curr Biol 13:1488-98. 2003
    ..While a large body of work has made important contributions to our understanding of the mechanisms governing microtubule dynamics in vitro, much remains to be learned about how these mechanisms operate in vivo...
  20. pmc Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos
    Katayoun Afshar
    Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Swiss Federal Institute of Technology EPFL, Lausanne CH 1015, Switzerland
    Development 137:237-47. 2010
    ..Our findings provide the first insights into the role of a member of the PP6 family of phosphatases in metazoan development...
  21. ncbi SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells
    Sebastian Leidel
    Swiss Institute for Experimental Cancer Research ISREC, CH 1066 Epalinges Lausanne, Switzerland
    Nat Cell Biol 7:115-25. 2005
    ..Therefore, HsSAS-6 is also required for centrosome duplication, indicating that the function of SAS-6-related proteins has been widely conserved during evolution...
  22. ncbi SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle
    Sebastian Leidel
    Swiss Institute for Experimental, Cancer Research ISREC, CH 1066 Epalinges, Lausanne, Switzerland
    Dev Cell 4:431-9. 2003
    ..Additional evidence indicates that SAS-4 is recruited to the daughter centriole or a closely associated structure. These findings identify SAS-4 recruitment as a key step in the centrosome duplication cycle...
  23. pmc Overly long centrioles and defective cell division upon excess of the SAS-4-related protein CPAP
    Gregor Kohlmaier
    Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
    Curr Biol 19:1012-8. 2009
    ..This in turn leads to multipolar spindle assembly and cytokinesis defects. Overall, our findings suggest that centriole length must be carefully regulated to restrict procentriole number and thus ensure accurate cell division...
  24. doi Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos
    Daiju Kitagawa
    Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Swiss Federal Institute of Technology EPFL, CH 1015 Lausanne, Switzerland
    Dev Cell 17:900-7. 2009
    ..Overall, our findings establish that phosphorylation of the evolutionarily conserved protein SAS-6 is critical for centriole formation and thus for faithful cell division...
  25. doi Mechanisms of procentriole formation
    Petr Strnad
    Swiss Institute for Experimental Cancer Research ISREC, Swiss Federal Institute of Technology EPFL, School of Life Sciences, Lausanne, Switzerland
    Trends Cell Biol 18:389-96. 2008
    ..Here, we review recent findings that provide important mechanistic insights into how a single procentriole forms next to each centriole once per cell cycle, thus ensuring that one centrosome becomes two...
  26. doi Coupling the cell cycle to development
    Yemima Budirahardja
    Swiss Institute for Experimental Cancer Research ISREC Sciences, Swiss Federal Institute of Technology, Lausanne, Switzerland
    Development 136:2861-72. 2009
    ....
  27. pmc Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle
    Petr Strnad
    Swiss Institute for Experimental Cancer Research, Swiss Federal Institute of Technology, School of Life Sciences, CH 1066 Lausanne, Switzerland
    Dev Cell 13:203-13. 2007
    ....