Markus Glatzel

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Variant Creutzfeldt-jakob disease: between lymphoid organs and brain
    Markus Glatzel
    Institute of Neuropathology, Zurich, Switzerland
    Trends Microbiol 12:51-3. 2004
  2. ncbi request reprint The peripheral nervous system and the pathogenesis of prion diseases
    Markus Glatzel
    Institute of Neuropathology and National Reference Center for Prion Diseases, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Curr Mol Med 4:355-9. 2004
  3. ncbi request reprint Testing for prions: a novel protocol for vCJD prevalence studies
    Markus Glatzel
    Institute of Neuropathology and National Reference Centre for Prion Diseases, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    Lancet 364:1196-7. 2004
  4. ncbi request reprint No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis
    Markus Glatzel
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Gen Virol 86:1861-7. 2005
  5. ncbi request reprint Human prion diseases: molecular and clinical aspects
    Markus Glatzel
    Institute of Neuropathology and National Reference Center for Prion Diseases, University Hospital Zurich, Zurich, Switzerland
    Arch Neurol 62:545-52. 2005
  6. ncbi request reprint Immune system and peripheral nerves in propagation of prions to CNS
    Adriano Aguzzi
    Institute of Neuropathology, Universitatsspital Zurich, Switzerland
    Br Med Bull 66:141-59. 2003
  7. doi request reprint Heightened incidence of sporadic Creutzfeldt-Jakob disease is associated with a shift in clinicopathological profiles
    Katharina Stoeck
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    J Neurol 255:1464-72. 2008
  8. ncbi request reprint Intrinsic resistance of oligodendrocytes to prion infection
    Marco Prinz
    Institute of Neuropathology, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    J Neurosci 24:5974-81. 2004
  9. ncbi request reprint Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion
    Marco Prinz
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nature 425:957-62. 2003
  10. doi request reprint Association between deposition of beta-amyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease
    Laura Debatin
    Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland
    Neurodegener Dis 5:347-54. 2008

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Variant Creutzfeldt-jakob disease: between lymphoid organs and brain
    Markus Glatzel
    Institute of Neuropathology, Zurich, Switzerland
    Trends Microbiol 12:51-3. 2004
    ..A recently published study demonstrated the presence of pathological prion protein in sympathetic ganglia of patients suffering from variant Creutzfeldt-Jakob disease, suggesting that these mechanisms might apply to humans...
  2. ncbi request reprint The peripheral nervous system and the pathogenesis of prion diseases
    Markus Glatzel
    Institute of Neuropathology and National Reference Center for Prion Diseases, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Curr Mol Med 4:355-9. 2004
    ..In this article, we review the state of knowledge on the routes of neuroinvasion used by the infectious agent in order to gain access to the central nervous system upon entry into extracerebral sites...
  3. ncbi request reprint Testing for prions: a novel protocol for vCJD prevalence studies
    Markus Glatzel
    Institute of Neuropathology and National Reference Centre for Prion Diseases, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    Lancet 364:1196-7. 2004
  4. ncbi request reprint No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis
    Markus Glatzel
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Gen Virol 86:1861-7. 2005
    ..Also, incubation times and clinical course of prion disease, as well as brain infectivity titres at terminal stage, were unaffected. These data rule out neprilysin as a major modulator of PrPSc accumulation and prion pathogenesis...
  5. ncbi request reprint Human prion diseases: molecular and clinical aspects
    Markus Glatzel
    Institute of Neuropathology and National Reference Center for Prion Diseases, University Hospital Zurich, Zurich, Switzerland
    Arch Neurol 62:545-52. 2005
    ..The present review article discusses current concepts and controversies surrounding the basic biological features of prions...
  6. ncbi request reprint Immune system and peripheral nerves in propagation of prions to CNS
    Adriano Aguzzi
    Institute of Neuropathology, Universitatsspital Zurich, Switzerland
    Br Med Bull 66:141-59. 2003
    ....
  7. doi request reprint Heightened incidence of sporadic Creutzfeldt-Jakob disease is associated with a shift in clinicopathological profiles
    Katharina Stoeck
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    J Neurol 255:1464-72. 2008
    ....
  8. ncbi request reprint Intrinsic resistance of oligodendrocytes to prion infection
    Marco Prinz
    Institute of Neuropathology, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    J Neurosci 24:5974-81. 2004
    ..Hence oligodendrocytes do not support cell-autonomous prion replication, establishment of subclinical disease, and neural spread of prions. Prion resistance sets oligodendrocytes aside from both neurons and astrocytes...
  9. ncbi request reprint Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion
    Marco Prinz
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nature 425:957-62. 2003
    ..This suggests that prion neuroimmune transition occurs between FDCs and sympathetic nerves, and relative positioning of FDCs and nerves controls the efficiency of peripheral prion infection...
  10. doi request reprint Association between deposition of beta-amyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease
    Laura Debatin
    Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland
    Neurodegener Dis 5:347-54. 2008
    ....
  11. pmc Analysis of prion strains by PrPSc profiling in sporadic Creutzfeldt-Jakob disease
    Gaby Schoch
    Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland
    PLoS Med 3:e14. 2006
    ..Comparability of classifications is hampered by disparity of applied methods and inter-observer variability...
  12. pmc Induced prion protein controls immune-activated retroviruses in the mouse spleen
    Marius Lötscher
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    PLoS ONE 2:e1158. 2007
    ..The interaction between PrP and ubiquitous endogenous retroviruses may allow new interpretations of TSE pathophysiology and explain the evolutionary conservation of PrP...
  13. ncbi request reprint Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease
    Magdalini Polymenidou
    Institute of Neuropathology, University Hospital Zurich, Switzerland
    Lancet Neurol 4:805-14. 2005
    ..On digestion with proteinase K, type 1 and type 2 PrP(Sc) display unglycosylated core fragments of 21 kDa and 19 kDa, resulting from cleavage around amino acids 82 and 97, respectively...
  14. pmc A case-control study of sporadic Creutzfeldt-Jakob disease in Switzerland: analysis of potential risk factors with regard to an increased CJD incidence in the years 2001-2004
    Jessica Ruegger
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    BMC Public Health 9:18. 2009
    ..In 2001, the observed annual mortality from Creutzfeldt-Jakob disease (CJD) in Switzerland increased from less than 1.5 to 2.6 per million inhabitants. An underlying cause could not be identified...
  15. pmc Strain fidelity of chronic wasting disease upon murine adaptation
    Christina J Sigurdson
    Universitatsspital Zurich, Institute of Neuropathology, Department of Pathology, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Virol 80:12303-11. 2006
    ..These findings indicate that the salient strain-specific properties of CWD are encoded by agent-intrinsic components rather than by host factors...
  16. ncbi request reprint vCJD tissue distribution and transmission by transfusion--a worst-case scenario coming true?
    Adriano Aguzzi
    Institute of Neuropathology, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    Lancet 363:411-2. 2004
  17. ncbi request reprint Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease
    Markus Glatzel
    Institute of Neuropathology and National Reference Center for Prion Diseases, University Hospital of Zurich, Zurich, Switzerland
    N Engl J Med 349:1812-20. 2003
    ..Understanding the distribution of PrPSc in Creutzfeldt-Jakob disease is important for classification and diagnosis and perhaps even for prevention...
  18. ncbi request reprint Human prion diseases: epidemiology and integrated risk assessment
    Markus Glatzel
    Institute of Neuropathology and National Reference Center for Prion Diseases, Switzerland
    Lancet Neurol 2:757-63. 2003
    ..In addition, we present the design and current status of a Swiss population-wide study of subclinical vCJD prevalence...
  19. ncbi request reprint Analysis of the prion protein in primates reveals a new polymorphism in codon 226 (Y226F)
    Markus Glatzel
    Institute of Neuropathology, University Hospital Zurich, Switzerland
    Biol Chem 383:1021-5. 2002
    ..A modulatory effect of this polymorphism on the development of prion disease is possible because codon 226 is close to the suggested binding side of the factor X, which has been invoked as a determinant of the prion species barrier...
  20. ncbi request reprint Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau
    Valérie Künzi
    Institute of Neuropathology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Neurosci 22:7471-7. 2002
    ..The coincidence of tau and prion pathology resembled Gerstmann-Sträussler-Scheinker syndrome. These findings identify tau pathology as a possible end stretch of prion-induced neurodegeneration...
  21. ncbi request reprint Prions--role of the peripheral nervous system
    Markus Glatzel
    Institute of Neuropathology, Zurich University Hospital, Switzerland
    Virus Res 82:53. 2002
  22. ncbi request reprint Prion infections, blood and transfusions
    Adriano Aguzzi
    Department of Pathology, Zurich University, Switzerland
    Nat Clin Pract Neurol 2:321-9. 2006
    ..Novel diagnostic strategies, which might include the use of surrogate markers of prion infection, along with prion removal strategies, might help to control the risk of iatrogenic prion spread through blood transfusions...
  23. pmc Oral prion infection requires normal numbers of Peyer's patches but not of enteric lymphocytes
    Marco Prinz
    Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland
    Am J Pathol 162:1103-11. 2003
    ..Although susceptibility to prion infection following oral challenge correlates with the number of PPs, it is remarkably independent of the number of PP-associated lymphocytes...
  24. ncbi request reprint Serial EEG findings in sporadic and iatrogenic Creutzfeldt-Jakob disease
    Heinz Gregor Wieser
    Department of Neurology, Zurich University Hospital, Zurich, Switzerland
    Clin Neurophysiol 115:2467-78. 2004
    ..To study temporal and spatial development of EEG patterns in sporadic and iatrogenic Creutzfeldt-Jakob disease patients...
  25. ncbi request reprint Incidence of Creutzfeldt-Jakob disease in Switzerland
    Markus Glatzel
    Institute of Neuropathology and National Reference Center for Prion Diseases, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Lancet 360:139-41. 2002
    ..Several scenarios could account for the increase in CJD, including improved reporting, iatrogenic transmission, and transmission of a prion zoonosis...
  26. ncbi request reprint Progressive scoliosis in central core disease
    Kirsten D Mertz
    Institute of Neuropathology, University Hospital Zurich, Switzerland
    Eur Spine J 14:900-5. 2005
    ..Although scoliosis is a common feature in CCD, the correct diagnosis can be missed in scoliosis patients. Therefore, we recommend a muscle biopsy in patients with scoliosis, unexplained muscle weakness and multiple joint problems...
  27. pmc Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993-2002
    Jesus de Pedro-Cuesta
    Instituto de Salud Carlos III, Centro Nacional de Epidemiologia, Departamento de Epidemiologia Aplicada, Calle Sinesio Delgado 6, 28029, Madrid, Spain
    BMC Public Health 6:278. 2006
    ..The objective of this study was to describe the diagnostic panorama of human transmissible spongiform encephalopathies across 11 countries...
  28. doi request reprint Transport and distribution of 3-hydroxyglutaric acid before and during induced encephalopathic crises in a mouse model of glutaric aciduria type 1
    Britta Keyser
    Children s Hospital, Department of Biochemistry, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Biochim Biophys Acta 1782:385-90. 2008
    ..The data demonstrate that under conditions mimicking encephalopathic crises the blood-brain barrier appears to remain intact...
  29. ncbi request reprint Genetic prion disease: the EUROCJD experience
    Gabor G Kovacs
    Austrian Reference Centre for Human Prion Diseases OERPE, Vienna, Austria
    Hum Genet 118:166-74. 2005
    ..Application of genetic screening in clinical practice has the advantage of early diagnosis and may lead to the identification of a risk of a TSE...
  30. ncbi request reprint Creutzfeldt-Jakob disease and inclusion body myositis: abundant disease-associated prion protein in muscle
    Gabor G Kovacs
    Institute of Neurology, University of Vienna, and Austrian Reference Centre for Human Prion Diseases, Vienna, Austria
    Ann Neurol 55:121-5. 2004
    ..Extraneural PrP(C)-PrP(Sc) conversion in Creutzfeldt-Jakob disease appears to become prominent when PrP(C) is abundantly available as substrate, as in inclusion body myositis muscle...
  31. ncbi request reprint Understanding the natural variability of prion diseases
    Markus Geissen
    Institute of Neuropathology, Universitatsklinikum Hamburg Eppendorf, 20246 Hamburg, Germany
    Vaccine 25:5631-6. 2007
    ..Current classification systems are based on the assessment of clinical presentation, genetic investigations, neuropathological findings and biochemical analysis of PrP(Sc)...
  32. ncbi request reprint Clinical and radiological mimicry of vCJD in a valine homozygous PrP(Sc) type 1 sCJD patient
    Andrea O Rossetti
    J Neurol 250:491-3. 2003
  33. doi request reprint Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis
    Sabrina Jabs
    University Medical Center Hamburg Eppendorf, Children s Hospital Biochemistry, Hamburg, Germany
    J Neurochem 106:1415-25. 2008
    ....
  34. pmc Accumulation of mutant neuroserpin precedes development of clinical symptoms in familial encephalopathy with neuroserpin inclusion bodies
    Giovanna Galliciotti
    Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Am J Pathol 170:1305-13. 2007
    ....
  35. ncbi request reprint 3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3
    Franziska Stellmer
    Department of Pediatrics, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Mol Med (Berl) 85:763-70. 2007
    ..The data demonstrate for the first time the membrane translocation of 3OH-GA mediated by NaDC3 and the cis-inhibitory effect on OCT2-mediated transport of cations...
  36. ncbi request reprint The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis
    Silke Walter
    Department of Neurology, Saarland University Hospital, Homburg, Germany
    Cell Physiol Biochem 17:167-72. 2006
    ..Thus, the key innate immune receptor, CD14, may be of pathophysiological relevance in experimental autoimmune encephalomyelitis and multiple sclerosis...
  37. ncbi request reprint Cerebrovascular P-glycoprotein expression is decreased in Creutzfeldt-Jakob disease
    Silke Vogelgesang
    Department of Neuropathology, University of Greifswald, 17487, Greifswald, Germany
    Acta Neuropathol 111:436-43. 2006
    ....
  38. ncbi request reprint Sporadic Creutzfeldt-Jakob disease: a comparison of pathological findings and diffusion weighted imaging
    Heike Russmann
    Dept of Neurology, Centre Hospitalier Universitaire Vaudois, Route de Bugnon 11, CH 1011 Lausanne, Switzerland
    J Neurol 252:338-42. 2005
    ..The characteristic focal involvement and extension of lesions of the cortex and the basal ganglia bilaterally shown by DWI may be an argument for the spreading of the disease per contiguitatem...
  39. ncbi request reprint Comment on "Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy"
    Christina Sigurdson
    Vet Pathol 42:107. 2005
  40. ncbi request reprint Immunochemical detection of prion protein on dipsticks prepared with crystalline bacterial cell-surface layers
    Dirk Völkel
    Baxter BioScience, Vienna, Austria
    Transfusion 43:1677-82. 2003
    ..The pathologic protein is detected by Western blot analysis or ELISA methods. The bovine spongiform encephalopathy crisis and occurrence of a new variant of CJD has increased demand for rapid and simple assays...
  41. ncbi request reprint Mimicry of variant Creutzfeldt-Jakob disease by sporadic Creutzfeldt-Jakob disease: importance of the pulvinar sign
    Andrea O Rossetti
    Arch Neurol 61:445-6. 2004