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Genomes and Genes | Markus GlatzelSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
Variant Creutzfeldt-jakob disease: between lymphoid organs and brainMarkus Glatzel
Institute of Neuropathology, Zurich, Switzerland
Trends Microbiol 12:51-3. 2004..A recently published study demonstrated the presence of pathological prion protein in sympathetic ganglia of patients suffering from variant Creutzfeldt-Jakob disease, suggesting that these mechanisms might apply to humans...- The peripheral nervous system and the pathogenesis of prion diseasesMarkus Glatzel
Institute of Neuropathology and National Reference Center for Prion Diseases, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Curr Mol Med 4:355-9. 2004..In this article, we review the state of knowledge on the routes of neuroinvasion used by the infectious agent in order to gain access to the central nervous system upon entry into extracerebral sites... - Testing for prions: a novel protocol for vCJD prevalence studiesMarkus Glatzel
Institute of Neuropathology and National Reference Centre for Prion Diseases, University Hospital of Zurich, , Switzerland
Lancet 364:1196-7. 2004 - Human prion diseases: molecular and clinical aspectsMarkus Glatzel
Institute of Neuropathology and National Reference Center for Prion Diseases, University Hospital Zurich, Zurich, Switzerland
Arch Neurol 62:545-52. 2005..The present review article discusses current concepts and controversies surrounding the basic biological features of prions... - No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesisMarkus Glatzel
Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
J Gen Virol 86:1861-7. 2005..Also, incubation times and clinical course of prion disease, as well as brain infectivity titres at terminal stage, were unaffected. These data rule out neprilysin as a major modulator of PrPSc accumulation and prion pathogenesis... - Immune system and peripheral nerves in propagation of prions to CNSAdriano Aguzzi
Institute of Neuropathology, , Switzerland
Br Med Bull 66:141-59. 2003.... - Heightened incidence of sporadic Creutzfeldt-Jakob disease is associated with a shift in clinicopathological profilesKatharina Stoeck
Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
J Neurol 255:1464-72. 2008.... - Positioning of follicular dendritic cells within the spleen controls prion neuroinvasionMarco Prinz
Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Nature 425:957-62. 2003..This suggests that prion neuroimmune transition occurs between FDCs and sympathetic nerves, and relative positioning of FDCs and nerves controls the efficiency of peripheral prion infection... - Association between deposition of beta-amyloid and pathological prion protein in sporadic Creutzfeldt-Jakob diseaseLaura Debatin
Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland
Neurodegener Dis 5:347-54. 2008.... - Intrinsic resistance of oligodendrocytes to prion infectionMarco Prinz
Institute of Neuropathology, University Hospital of Zurich, CH 8091 Zurich, Switzerland
J Neurosci 24:5974-81. 2004..Hence oligodendrocytes do not support cell-autonomous prion replication, establishment of subclinical disease, and neural spread of prions. Prion resistance sets oligodendrocytes aside from both neurons and astrocytes... - Analysis of prion strains by PrPSc profiling in sporadic Creutzfeldt-Jakob diseaseGaby Schoch
Institute of Neuropathology, , , Switzerland
PLoS Med 3:e14. 2006..Our results show that the co-existence of more than one PrPSc type might be influenced by genetic and brain region-specific determinants. These findings provide valuable insights into the generation of distinct PrPSc types... - Induced prion protein controls immune-activated retroviruses in the mouse spleenMarius Lötscher
Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
PLoS ONE 2:e1158. 2007..The interaction between PrP and ubiquitous endogenous retroviruses may allow new interpretations of TSE pathophysiology and explain the evolutionary conservation of PrP... - Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob diseaseMagdalini Polymenidou
Institute of Neuropathology, University Hospital Zurich, Switzerland
Lancet Neurol 4:805-14. 2005.... - A case-control study of sporadic Creutzfeldt-Jakob disease in Switzerland: analysis of potential risk factors with regard to an increased CJD incidence in the years 2001-2004Jessica Ruegger
Department of Neurology, University Hospital Zurich, Zurich, Switzerland
BMC Public Health 9:18. 2009..In 2001, the observed annual mortality from Creutzfeldt-Jakob disease (CJD) in Switzerland increased from less than 1.5 to 2.6 per million inhabitants. An underlying cause could not be identified... - Strain fidelity of chronic wasting disease upon murine adaptationChristina J Sigurdson
, Institute of Neuropathology, Department of Pathology, Schmelzbergstrasse 12, , Switzerland
J Virol 80:12303-11. 2006..These findings indicate that the salient strain-specific properties of CWD are encoded by agent-intrinsic components rather than by host factors... - Human prion diseases: epidemiology and integrated risk assessmentMarkus Glatzel
Institute of Neuropathology and National Reference Center for Prion Diseases, Switzerland
Lancet Neurol 2:757-63. 2003..In addition, we present the design and current status of a Swiss population-wide study of subclinical vCJD prevalence... - vCJD tissue distribution and transmission by transfusion--a worst-case scenario coming true?Adriano Aguzzi
Institute of Neuropathology, , , Switzerland
Lancet 363:411-2. 2004 - Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob diseaseMarkus Glatzel
Institute of Neuropathology and National Reference Center for Prion Diseases, University Hospital of Zurich, Zurich, Switzerland
N Engl J Med 349:1812-20. 2003..Extraneural PrPSc appears to correlate with a long duration of disease... - Prions--role of the peripheral nervous systemMarkus Glatzel
Institute of Neuropathology, Zurich University Hospital, Switzerland
Virus Res 82:53. 2002 - Prion infections, blood and transfusionsAdriano Aguzzi
Department of Pathology, Zurich University, Switzerland
Nat Clin Pract Neurol 2:321-9. 2006..Novel diagnostic strategies, which might include the use of surrogate markers of prion infection, along with prion removal strategies, might help to control the risk of iatrogenic prion spread through blood transfusions... - Analysis of the prion protein in primates reveals a new polymorphism in codon 226 (Y226F)Markus Glatzel
Institute of Neuropathology, University Hospital Zurich, Switzerland
Biol Chem 383:1021-5. 2002..A modulatory effect of this polymorphism on the development of prion disease is possible because codon 226 is close to the suggested binding side of the factor X, which has been invoked as a determinant of the prion species barrier... - Oral prion infection requires normal numbers of Peyer's patches but not of enteric lymphocytesMarco Prinz
Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland
Am J Pathol 162:1103-11. 2003..Although susceptibility to prion infection following oral challenge correlates with the number of PPs, it is remarkably independent of the number of PP-associated lymphocytes... - Serial EEG findings in sporadic and iatrogenic Creutzfeldt-Jakob diseaseHeinz Gregor Wieser
Department of Neurology, Zurich University Hospital, Zurich, Switzerland
Clin Neurophysiol 115:2467-78. 2004..To study temporal and spatial development of EEG patterns in sporadic and iatrogenic Creutzfeldt-Jakob disease patients... - Incidence of Creutzfeldt-Jakob disease in SwitzerlandMarkus Glatzel
Institute of Neuropathology and National Reference Center for Prion Diseases, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland
Lancet 360:139-41. 2002..Several scenarios could account for the increase in CJD, including improved reporting, iatrogenic transmission, and transmission of a prion zoonosis... - Progressive scoliosis in central core diseaseKirsten D Mertz
Institute of Neuropathology, University Hospital Zurich, Switzerland
Eur Spine J 14:900-5. 2005..Although scoliosis is a common feature in CCD, the correct diagnosis can be missed in scoliosis patients. Therefore, we recommend a muscle biopsy in patients with scoliosis, unexplained muscle weakness and multiple joint problems... - Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993-2002Jesus de Pedro-Cuesta
Instituto de Salud Carlos III, Centro Nacional de Epidemiologia, Departamento de Epidemiologia Aplicada, Calle Sinesio Delgado 6, 28029, Madrid, Spain
BMC Public Health 6:278. 2006..The objective of this study was to describe the diagnostic panorama of human transmissible spongiform encephalopathies across 11 countries... - Transport and distribution of 3-hydroxyglutaric acid before and during induced encephalopathic crises in a mouse model of glutaric aciduria type 1Britta Keyser
Children s Hospital, Department of Biochemistry, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Biochim Biophys Acta 1782:385-90. 2008..The data demonstrate that under conditions mimicking encephalopathic crises the blood-brain barrier appears to remain intact... - Genetic prion disease: the EUROCJD experienceGabor G Kovacs
Austrian Reference Centre for Human Prion Diseases OERPE, Vienna, Austria
Hum Genet 118:166-74. 2005..Application of genetic screening in clinical practice has the advantage of early diagnosis and may lead to the identification of a risk of a TSE... - Creutzfeldt-Jakob disease and inclusion body myositis: abundant disease-associated prion protein in muscleGabor G Kovacs
Institute of Neurology, University of Vienna, and Austrian Reference Centre for Human Prion Diseases, Vienna, Austria
Ann Neurol 55:121-5. 2004..Extraneural PrP(C)-PrP(Sc) conversion in Creutzfeldt-Jakob disease appears to become prominent when PrP(C) is abundantly available as substrate, as in inclusion body myositis muscle... - Understanding the natural variability of prion diseasesMarkus Geissen
Institute of Neuropathology, Universitatsklinikum Hamburg Eppendorf, 20246 Hamburg, Germany
Vaccine 25:5631-6. 2007..Current classification systems are based on the assessment of clinical presentation, genetic investigations, neuropathological findings and biochemical analysis of PrP(Sc)... - Clinical and radiological mimicry of vCJD in a valine homozygous PrP(Sc) type 1 sCJD patientAndrea O Rossetti
J Neurol 250:491-3. 2003 - Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosisSabrina Jabs
University Medical Center Hamburg Eppendorf, Children s Hospital Biochemistry, Hamburg, Germany
J Neurochem 106:1415-25. 2008.... - Accumulation of mutant neuroserpin precedes development of clinical symptoms in familial encephalopathy with neuroserpin inclusion bodiesGiovanna Galliciotti
Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Am J Pathol 170:1305-13. 2007.... - 3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3Franziska Stellmer
Department of Pediatrics, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
J Mol Med (Berl) 85:763-70. 2007..The data demonstrate for the first time the membrane translocation of 3OH-GA mediated by NaDC3 and the cis-inhibitory effect on OCT2-mediated transport of cations... - The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosisSilke Walter
Department of Neurology, Saarland University Hospital, Homburg, Germany
Cell Physiol Biochem 17:167-72. 2006..Thus, the key innate immune receptor, CD14, may be of pathophysiological relevance in experimental autoimmune encephalomyelitis and multiple sclerosis... - Cerebrovascular P-glycoprotein expression is decreased in Creutzfeldt-Jakob diseaseSilke Vogelgesang
Department of Neuropathology, University of Greifswald, 17487, Greifswald, Germany
Acta Neuropathol 111:436-43. 2006.... - Sporadic Creutzfeldt-Jakob disease: a comparison of pathological findings and diffusion weighted imagingHeike Russmann
Dept of Neurology, Centre Hospitalier Universitaire Vaudois, Route de Bugnon 11, CH 1011 Lausanne, Switzerland
J Neurol 252:338-42. 2005..The characteristic focal involvement and extension of lesions of the cortex and the basal ganglia bilaterally shown by DWI may be an argument for the spreading of the disease per contiguitatem... - Comment on "Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy"Christina Sigurdson
Vet Pathol 42:107. 2005 - Mimicry of variant Creutzfeldt-Jakob disease by sporadic Creutzfeldt-Jakob disease: importance of the pulvinar signAndrea O Rossetti
Arch Neurol 61:445-6. 2004