P Giannakopoulos

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi Presenilin-1 expression in Pick's disease
    P Giannakopoulos
    Department of Psychiatry, Clinic of Geriatric Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, CH 1225 Geneva, Switzerland
    Acta Neuropathol 98:488-92. 1999
  2. ncbi Impaired processing of famous faces in Alzheimer's disease is related to neurofibrillary tangle densities in the prefrontal and anterior cingulate cortex
    P Giannakopoulos
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Dement Geriatr Cogn Disord 11:336-41. 2000
  3. ncbi Neural substrates of spatial and temporal disorientation in Alzheimer's disease
    P Giannakopoulos
    Department of Psychiatry, Clinic of Geriatric Psychiatry, HUG Belle Idée, Geneva, Switzerland
    Acta Neuropathol 100:189-95. 2000
  4. ncbi Differential distribution of presenilin-1, Bax, and Bcl-X(L) in Alzheimer's disease and frontotemporal dementia
    P Giannakopoulos
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Acta Neuropathol 98:141-9. 1999
  5. ncbi Neuroanatomic correlates of visual agnosia in Alzheimer's disease: a clinicopathologic study
    P Giannakopoulos
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Neurology 52:71-7. 1999
  6. ncbi Selective vulnerability of neocortical association areas in Alzheimer's disease
    P Giannakopoulos
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Microsc Res Tech 43:16-23. 1998
  7. ncbi Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts
    P Giannakopoulos
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Brain Res Brain Res Rev 25:217-45. 1997
  8. ncbi Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study
    P Giannakopoulos
    Department of Psychiatry, University of Geneva School of Medicine, Chene Bourg, Switzerland
    Acta Neuropathol 95:387-94. 1998
  9. ncbi Working memory load-related electroencephalographic parameters can differentiate progressive from stable mild cognitive impairment
    P Missonnier
    Clinical Neurophysiology and Neuroimaging Unit, Division of Neuropsychiatry, Department of Psychiatry, University Hospitals of Geneva, 2 Chemin du Petit Bel Air, 1225 Chene Bourg, Geneva, Switzerland
    Neuroscience 150:346-56. 2007
  10. ncbi Postnatal distribution of cpp32/caspase 3 mRNA in the mouse central nervous system: an in situ hybridization study
    F De Bilbao
    Department of Psychiatry, University Hospital of Geneva, Switzerland
    J Comp Neurol 409:339-57. 1999

Collaborators

Detail Information

Publications33

  1. ncbi Presenilin-1 expression in Pick's disease
    P Giannakopoulos
    Department of Psychiatry, Clinic of Geriatric Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, CH 1225 Geneva, Switzerland
    Acta Neuropathol 98:488-92. 1999
    ..These data suggest that as previously shown in AD, low cellular expression of PS-1 may be associated with increased neuronal loss and cellular degeneration...
  2. ncbi Impaired processing of famous faces in Alzheimer's disease is related to neurofibrillary tangle densities in the prefrontal and anterior cingulate cortex
    P Giannakopoulos
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Dement Geriatr Cogn Disord 11:336-41. 2000
    ..In agreement with previous studies, they also indicate that SP densities are not a good pathological correlate of neuropsychological deficits in AD...
  3. ncbi Neural substrates of spatial and temporal disorientation in Alzheimer's disease
    P Giannakopoulos
    Department of Psychiatry, Clinic of Geriatric Psychiatry, HUG Belle Idée, Geneva, Switzerland
    Acta Neuropathol 100:189-95. 2000
    ..These observations are discussed with respect to the notion of global corticocortical disconnection in AD...
  4. ncbi Differential distribution of presenilin-1, Bax, and Bcl-X(L) in Alzheimer's disease and frontotemporal dementia
    P Giannakopoulos
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Acta Neuropathol 98:141-9. 1999
    ..In FTD, neurons containing PS-1 are preserved, further supporting a neuroprotective role for this protein in other neurodegenerative disorders...
  5. ncbi Neuroanatomic correlates of visual agnosia in Alzheimer's disease: a clinicopathologic study
    P Giannakopoulos
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Neurology 52:71-7. 1999
    ..To examine the neuroanatomic correlates of visual agnosia in AD...
  6. ncbi Selective vulnerability of neocortical association areas in Alzheimer's disease
    P Giannakopoulos
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Microsc Res Tech 43:16-23. 1998
    ..Moreover, recent data on pathological correlates of apraxia in AD are examined in the light of the hypothesis of global corticocortical disconnection in this disorder...
  7. ncbi Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts
    P Giannakopoulos
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Brain Res Brain Res Rev 25:217-45. 1997
    ..These observations are discussed in the light of the hypothesis of global corticocortical disconnection and with respect to the notion of selective neuronal vulnerability in Alzheimer's disease...
  8. ncbi Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study
    P Giannakopoulos
    Department of Psychiatry, University of Geneva School of Medicine, Chene Bourg, Switzerland
    Acta Neuropathol 95:387-94. 1998
    ....
  9. ncbi Working memory load-related electroencephalographic parameters can differentiate progressive from stable mild cognitive impairment
    P Missonnier
    Clinical Neurophysiology and Neuroimaging Unit, Division of Neuropsychiatry, Department of Psychiatry, University Hospitals of Geneva, 2 Chemin du Petit Bel Air, 1225 Chene Bourg, Geneva, Switzerland
    Neuroscience 150:346-56. 2007
    ..They also show that P200 latency during the two-back task may be a simple and promising EEG marker of rapid cognitive decline in MCI...
  10. ncbi Postnatal distribution of cpp32/caspase 3 mRNA in the mouse central nervous system: an in situ hybridization study
    F De Bilbao
    Department of Psychiatry, University Hospital of Geneva, Switzerland
    J Comp Neurol 409:339-57. 1999
    ..Moreover, the prevention of cell death by Bcl-2 likely is not linked to the regulation of caspase mRNA levels...
  11. ncbi Clinical validity of A beta-protein deposition staging in brain aging and Alzheimer disease
    G Gold
    Department of Psychiatry, , University of Geneva School of Medicine, Switzerland
    J Neuropathol Exp Neurol 60:946-52. 2001
    ....
  12. doi Microvascular changes in late-life schizophrenia and mood disorders: stereological assessment of capillary diameters in anterior cingulate cortex
    L Sinka
    Department of Psychiatry, University Hospitals and School of Medicine of Geneva, Belle Idee, Geneva, Switzerland
    Neuropathol Appl Neurobiol 38:696-709. 2012
    ..Here, we analysed morphological parameters of capillaries in this area in elderly cases affected by these psychiatric disorders...
  13. ncbi Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
    P Giannakopoulos
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Neurology 60:1495-500. 2003
    ..To examine the relationship between stereologic estimates of AD-related pathology and severity of cognitive deficits in brain aging...
  14. ncbi Cortical microinfarcts and demyelination affect cognition in cases at high risk for dementia
    E Kovari
    Department of Psychiatry, University of Geneva School of Medicine, Chene Bourg, Switzerland
    Neurology 68:927-31. 2007
    ..To investigate the possible synergistic effect of microvascular lesions with mild Alzheimer disease (AD) pathology in mixed cases...
  15. pmc Neuropathological analysis of lacunes and microvascular lesions in late-onset depression
    M Santos
    Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Geneva, Switzerland
    Neuropathol Appl Neurobiol 36:661-72. 2010
    ..More recently, we showed that thalamic and basal ganglia lacunes are associated with post-stroke depression and may affect emotional regulation. The present study examines whether this is also the case for late-onset depression...
  16. doi Clusterin expression during fetal and postnatal CNS development in mouse
    Y Charnay
    Division of Neuropsychiatry, Department of Psychiatry, University Hospitals of Geneva, 2, Ch du petit Bel Air, CH 1225 Chene Bourg, Geneva, Switzerland
    Neuroscience 155:714-24. 2008
    ..Although the lack of this protein does not significantly alter basic aspects of the CNS development, it may have a negative impact on neuronal development in certain motor nuclei...
  17. ncbi Aging and working memory: early deficits in EEG activation of posterior cortical areas
    P Missonnier
    Neuroimaging Unit, University Hospitals of Geneva, Geneva, Switzerland
    J Neural Transm 111:1141-54. 2004
    ..The present results are consistent with the hypothesis of decreased brain reserve in the elderly and provide evidence for age-related deficits in the recruitment of posterior cortical neurons with increasing working memory load...
  18. pmc Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates
    A Costanza
    Department of Psychiatry, University Hospitals and Faculty of Medicine, University of Geneva School of Medicine, Geneva, Switzerland
    Neuropathol Appl Neurobiol 37:570-84. 2011
    ....
  19. ncbi In vivo study of motoneuron death induced by nerve injury in mice deficient in the caspase 1/ interleukin-1 beta-converting enzyme
    F De Bilbao
    University Hospital Geneva, Department of Psychiatry, 2, chemin du Petit Bel Air, 1225, Geneva, Switzerland
    Neuroscience 98:573-83. 2000
    ..Similar results were obtained in interleukin-1 beta-converting enzyme-deficient and wild-type mice, indicating that the interleukin-1 beta-converting enzyme may not be required for caspase 3 activation...
  20. ncbi Re-evaluating the role of vascular changes in the differential diagnosis of Alzheimer's disease and vascular dementia
    G Gold
    Department of Geriatric, University of Geneva School of Medicine, Geneva, Switzerland
    Eur Neurol 40:121-9. 1998
    ..It may be time to reevaluate the dichotomy between AD and VaD...
  21. doi EEG anomalies in adult ADHD subjects performing a working memory task
    P Missonnier
    Clinical Neurophysiology and Neuroimaging Unit, Division of Neuropsychiatry, Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland
    Neuroscience 241:135-46. 2013
    ..ADHD cases may successfully face WM needs depending on the preservation of sustained theta ERS and prolonged increase of alpha ERS at later post-stimulus time points...
  22. ncbi A laser microprobe mass analysis of trace elements in brain mineralizations and capillaries in Fahr's disease
    C Bouras
    Department of Psychiatry, University of Geneva School of Medicine, Chene Bourg, Switzerland
    Acta Neuropathol 92:351-7. 1996
    ....
  23. ncbi Cell death is prevented in thalamic fields but not in injured neocortical areas after permanent focal ischaemia in mice overexpressing the anti-apoptotic protein Bcl-2
    F De Bilbao
    University Hospital Geneva, Department of Psychiatry, 2, chemin du Petit Bel Air, 1225 Geneva, Switzerland
    Eur J Neurosci 12:921-34. 2000
    ....
  24. ncbi Anterior cingulate cortex pathology in schizophrenia and bipolar disorder
    C Bouras
    Division of Neuropsychiatry, HUG Belle Idée, Geneva, Switzerland
    Acta Neuropathol 102:373-9. 2001
    ..The neuroanatomical and functional significance of these findings are discussed in the light of current hypotheses regarding the role of areas 24 and 24sg in schizophrenia and bipolar disorder...
  25. doi Cognitive impairment in late-onset depression. Limited to a decrement in information processing resources?
    C Delaloye
    Division of Geriatric Psychiatry, University Hospitals of Geneva, Geneva, Switzerland
    Eur Neurol 60:149-54. 2008
    ..In order to address this issue, we analyzed processing resources in LOD to see if their decrease explains higher-level cognition (episodic memory and naming capacity) deficits...
  26. ncbi Neuropathological analysis of an asymptomatic adult case with Dandy-Walker variant
    G Notaridis
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Neuropathol Appl Neurobiol 32:344-50. 2006
    ..The preservation of the cortical cytoarchitecture as well as the paucity of additional neurodevelopmental changes may explain the absence of clinical expression...
  27. ncbi Inhibition of post-ischemic brain injury by clusterin overexpression
    P Wehrli
    Nat Med 7:977-9. 2001
  28. ncbi Lipoprotein lipase and endothelial lipase expression in mouse brain: regional distribution and selective induction following kainic acid-induced lesion and focal cerebral ischemia
    E Paradis
    Department of Medical Biology, Faculty of Medicine, Laval University, Ste Foy PQ, Canada
    Neurobiol Dis 15:312-25. 2004
    ..These results show that LPL and EL transcripts are selectively upregulated in function of the type of brain injury. LPL and EL could thus fulfill a function in the pathophysiological response of the brain to injury...
  29. ncbi Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease
    T Bussiere
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Box 1639, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 112:75-91. 2002
    ....
  30. ncbi Decreased infarct size after focal cerebral ischemia in mice chronically infected with Toxoplasma gondii
    D Arsenijevic
    Department of Medicine, Division of Physiology, University of Fribourg, Chemin du Musee 5, 1700 Fribourg, Switzerland
    Neuroscience 150:537-46. 2007
    ..Overall, these findings indicate that chronic toxoplasmosis decisively influences both the inflammatory molecular events and outcome of cerebral ischemia...
  31. ncbi The role of stimulus type in age-related changes of visual working memory
    U Leonards
    Division de Neuropsychiatrie, Departement de Psychiatrie, Hôpitaux Universitaires de Genève Belle Idée, 2, chemin du Petit Bel Air, 1225 Chêne Bourg GE, Switzerland
    Exp Brain Res 146:172-83. 2002
    ....
  32. ncbi Stereological analysis of neuropil threads in the hippocampal formation: relationships with Alzheimer's disease neuronal pathology and cognition
    P Giannakopoulos
    Division of Old Age Psychiatry, University of Lausanne School of Medicine, 1008 Prilly, Lausanne, Switzerland
    Neuropathol Appl Neurobiol 33:334-43. 2007
    ..In terms of clinicopathological correlations, NT length in the hippocampal formation does not represent an independent marker of dementia severity...
  33. ncbi Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease
    T Bussiere
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 117:577-92. 2003
    ....