M Geiser

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. pmc Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the "relative deposition index": Evidence for clearance through microvasculature
    Christian Mühlfeld
    Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Part Fibre Toxicol 4:7. 2007
  2. pmc Deposition and biokinetics of inhaled nanoparticles
    Marianne Geiser
    Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Part Fibre Toxicol 7:2. 2010
  3. ncbi request reprint Update on macrophage clearance of inhaled micro- and nanoparticles
    Marianne Geiser
    Institute of Anatomy, University of Bern, Bern, Switzerland
    J Aerosol Med Pulm Drug Deliv 23:207-17. 2010
  4. ncbi request reprint The role of macrophages in the clearance of inhaled ultrafine titanium dioxide particles
    Marianne Geiser
    Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Am J Respir Cell Mol Biol 38:371-6. 2008
  5. pmc Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells
    Marianne Geiser
    Institute for Anatomy, University of Bern, Bern, Switzerland
    Environ Health Perspect 113:1555-60. 2005
  6. ncbi request reprint Surface-lining layer of airways in cystic fibrosis mice
    Marianne Geiser
    Institute of Anatomy, Division of Histology, University of Bern, Bühlstr 26, CH 3000 Bern 9, Switzerland
    Am J Physiol Lung Cell Mol Physiol 285:L1277-85. 2003
  7. pmc Influence of airspace geometry and surfactant on the retention of man-made vitreous fibers (MMVF 10a)
    Marianne Geiser
    Institute of Anatomy, Division of Histology, University of Bern, Bern, Switzerland
    Environ Health Perspect 111:895-901. 2003
  8. ncbi request reprint Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer
    Marianne Geiser
    Institute of Anatomy, University of Bern, Bern, Switzerland
    J Appl Physiol (1985) 94:1793-801. 2003
  9. ncbi request reprint Morphological aspects of particle uptake by lung phagocytes
    Marianne Geiser
    Institute of Anatomy, University of Bern, Bern, Switzerland
    Microsc Res Tech 57:512-22. 2002
  10. ncbi request reprint Bioassay for hamster macrophage chemotaxis: application to study particle-lung interactions
    M Geiser
    Institute of Anatomy, University of Bern, Switzerland
    Cell Mol Life Sci 54:179-85. 1998

Collaborators

Detail Information

Publications24

  1. pmc Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the "relative deposition index": Evidence for clearance through microvasculature
    Christian Mühlfeld
    Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Part Fibre Toxicol 4:7. 2007
    ..abstract:..
  2. pmc Deposition and biokinetics of inhaled nanoparticles
    Marianne Geiser
    Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Part Fibre Toxicol 7:2. 2010
    ..We emphasize the importance for quantitative analyses and the use of particle doses derived from real world exposures...
  3. ncbi request reprint Update on macrophage clearance of inhaled micro- and nanoparticles
    Marianne Geiser
    Institute of Anatomy, University of Bern, Bern, Switzerland
    J Aerosol Med Pulm Drug Deliv 23:207-17. 2010
    ....
  4. ncbi request reprint The role of macrophages in the clearance of inhaled ultrafine titanium dioxide particles
    Marianne Geiser
    Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Am J Respir Cell Mol Biol 38:371-6. 2008
    ....
  5. pmc Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells
    Marianne Geiser
    Institute for Anatomy, University of Bern, Bern, Switzerland
    Environ Health Perspect 113:1555-60. 2005
    ..Particles within cells are not membrane bound and hence have direct access to intracellular proteins, organelles, and DNA, which may greatly enhance their toxic potential...
  6. ncbi request reprint Surface-lining layer of airways in cystic fibrosis mice
    Marianne Geiser
    Institute of Anatomy, Division of Histology, University of Bern, Bühlstr 26, CH 3000 Bern 9, Switzerland
    Am J Physiol Lung Cell Mol Physiol 285:L1277-85. 2003
    ..Hence, there were no signs of any ultrastructural abnormalities in the surface-lining layer of young adult Cftrtm1HGU/Cftrtm1HGU mice before infection with CF-related pathogens...
  7. pmc Influence of airspace geometry and surfactant on the retention of man-made vitreous fibers (MMVF 10a)
    Marianne Geiser
    Institute of Anatomy, Division of Histology, University of Bern, Bern, Switzerland
    Environ Health Perspect 111:895-901. 2003
    ..We found a substantial number of particle profiles within alveolar blood capillaries. Fiber length and alveolar geometry appear to be important limiting factors for the submersion of vitreous fibers into the lungs' surface lining layer...
  8. ncbi request reprint Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer
    Marianne Geiser
    Institute of Anatomy, University of Bern, Bern, Switzerland
    J Appl Physiol (1985) 94:1793-801. 2003
    ....
  9. ncbi request reprint Morphological aspects of particle uptake by lung phagocytes
    Marianne Geiser
    Institute of Anatomy, University of Bern, Bern, Switzerland
    Microsc Res Tech 57:512-22. 2002
    ....
  10. ncbi request reprint Bioassay for hamster macrophage chemotaxis: application to study particle-lung interactions
    M Geiser
    Institute of Anatomy, University of Bern, Switzerland
    Cell Mol Life Sci 54:179-85. 1998
    ..6-fold. Thus, the stimulus for macrophage recruitment to the site of deposited polystyrene particles in hamster airways could not be demonstrated using this bioassay...
  11. ncbi request reprint Does lack of Cftr gene lead to developmental abnormalities in the lung?
    M Geiser
    Institute of Anatomy, University of Bern, Switzerland
    Exp Lung Res 26:551-64. 2000
    ..In other words, our data do not supply any significant evidence that the lack of the Cftr gene is accompanied by any developmental abnormalities in the lung, at least as far as the parameters studied are concerned...
  12. ncbi request reprint Retention of Teflon particles in hamster lungs: a stereological study
    M Geiser
    Institute of Anatomy, University of Bern, Switzerland
    J Aerosol Med 13:43-55. 2000
    ..It was this displacement that enabled subsequent interaction with macrophages. Refined knowledge of particle retention may help us to better understand the biological response to inhaled particles...
  13. ncbi request reprint Efficiency of airway macrophage recovery by bronchoalveolar lavage in hamsters: a stereological approach
    M Geiser
    Institute of Anatomy, University of Bern, Switzerland
    Eur Respir J 8:1712-8. 1995
    ..This is an aspect which has to be considered in studies performed with macrophages obtained by BAL, since they could represent a functionally different macrophage population...
  14. ncbi request reprint Electron energy loss spectroscopy for analysis of inhaled ultrafine particles in rat lungs
    Nadine Kapp
    Institute of Anatomy, University of Bern, Buhlstrasse 26, CH 3000 Bern 9, Switzerland
    Microsc Res Tech 63:298-305. 2004
    ..Electron energy loss spectroscopy and related analytical methods were found to be suitable to identify and localize ultrafine titanium dioxide particles within chemically fixed and resin-embedded lung tissue...
  15. ncbi request reprint [The mucociliary system of the lung--role of surfactants]
    P Gehr
    Abteilung für Histologie, Universitat Bern
    Schweiz Med Wochenschr 130:691-8. 2000
    ..We therefore consider surfactant to be a primary immune barrier...
  16. ncbi request reprint Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated X rays
    J A Laissue
    Institute of Pathology, University of Bern, Switzerland
    Int J Cancer 78:654-60. 1998
    ..Correlation of those grades with radiation doses shows that loss of tissue structure was confined to beam-crossing regions and that only minor damage was done to zones of the brain irradiated unidirectionally...
  17. doi request reprint Cellular responses after exposure of lung cell cultures to secondary organic aerosol particles
    Annina Gaschen
    Institute of Anatomy, University of Bern, 3012 Bern, Switzerland
    Environ Sci Technol 44:1424-30. 2010
    ..In addition, cellular responses were found to correlate with particle number concentration, as interleukin-8 production was increased in pig explants exposed to TMB-SOA with high particle numbers...
  18. doi request reprint Aspiration toxicology of hydrocarbons and lamp oils studied by in vitro technology
    S Schneider
    Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Toxicol In Vitro 27:1089-101. 2013
    ..8%. Effects of RME-based combustibles differed between the cell models. Our results confirm data from animal experiments and give new insights into the mechanisms underlying the adverse health effects observed...
  19. ncbi request reprint A novel exposure system for the efficient and controlled deposition of aerosol particles onto cell cultures
    Melanie Savi
    Institute of Anatomy, University of Bern, Bern, Switzerland
    Environ Sci Technol 42:5667-74. 2008
    ..In situ analyses of the lung cells, e.g., the ciliary beat frequency, indicative of the defense capability of the cells, are complemented by off-line biochemical, physiological, and morphological cell analyses...
  20. ncbi request reprint Combined determination of the chemical composition and of health effects of secondary organic aerosols: the POLYSOA project
    Urs Baltensperger
    Laboratory of Atmospheric Chemistry, Paul Scherrer Institut PSI, Villigen CH 5232, Switzerland
    J Aerosol Med Pulm Drug Deliv 21:145-54. 2008
    ..Thus, these first results indicate that SOA, in concentrations comparable to environmental concentrations, may induce distinct effects in lung cells...
  21. ncbi request reprint Estimation of particle number by stereology: an update
    Luis M Cruz-Orive
    Department of Mathematics, Statistics and Computation, Faculty of Sciences, University of Cantabria, Santander, Spain
    J Aerosol Med 17:197-212. 2004
    ..The present paper constitutes a detailed survey of the latest advances, and it illustrates methods and formulae alike by way of a real example stemming from an earlier study on particle retention and clearance...
  22. pmc In vivo particle uptake by airway macrophages in healthy volunteers
    Neil E Alexis
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, 104 Mason Farm Rd, Chapel Hill, NC 27599 7310, USA
    Am J Respir Cell Mol Biol 34:305-13. 2006
    ..Further, macrophage recruitment and phagocytosis-modifying agents are factors in vivo that likely affect particle uptake and its time course...
  23. ncbi request reprint Electron energy-loss spectroscopy as a tool for elemental analysis in biological specimens
    Nadine Kapp
    Department of Veterinary Anatomy, Veterinary School, Univeristy of Bern, Switzerland
    Methods Mol Biol 369:431-47. 2007
    ..Ultrafine, 22-nm titanium dioxide particles are used in an inhalation study in rats to investigate the distribution of nanoparticles in lung tissue...