Walter Gehring

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster
    K Furukubo-Tokunaga
    Department of Cell Biology, University of Basel, Swtizerland
    Genes Dev 6:1082-96. 1992
  2. ncbi Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans
    R Quiring
    Department of Cell Biology, University of Basel, Switzerland
    Science 265:785-9. 1994
  3. ncbi Cloning and early expression pattern of two melatonin biosynthesis enzymes in the turbot (Scophthalmus maximus)
    Robin Vuilleumier
    Biozentrum, University of Basel, Cell and Developmental Biology, Basel, Switzerland
    Eur J Neurosci 25:3047-57. 2007
  4. ncbi The animal body plan, the prototypic body segment, and eye evolution
    Walter J Gehring
    Biozentrum, University of Basel, Klingelbergstrasse 70, Basel, Switzerland
    Evol Dev 14:34-46. 2012
  5. ncbi The genetic control of eye development and its implications for the evolution of the various eye-types
    Walter J Gehring
    Biozentrum, University of Basel, Switzerland
    Int J Dev Biol 46:65-73. 2002
  6. ncbi Historical perspective on the development and evolution of eyes and photoreceptors
    Walter J Gehring
    Dept Cell Biology, Biozentrum, University of Basel, Switzerland
    Int J Dev Biol 48:707-17. 2004
  7. ncbi The coevolution of blue-light photoreception and circadian rhythms
    Walter Gehring
    Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    J Mol Evol 57:S286-9. 2003
  8. ncbi New perspectives on eye development and the evolution of eyes and photoreceptors
    W J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    J Hered 96:171-84. 2005
  9. ncbi How do Hox transcription factors find their target genes in the nucleus of living cells?
    Walter J Gehring
    Growth and Development, Biozentrum University of Basel, Klingelbergstrasse, Basel, Switzerland
    Biol Aujourdhui 205:75-85. 2011
  10. ncbi Chance and necessity in eye evolution
    Walter J Gehring
    Department of Growth and Development, Biozentrum University of Basel, Switzerland
    Genome Biol Evol 3:1053-66. 2011

Collaborators

Detail Information

Publications79

  1. ncbi In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster
    K Furukubo-Tokunaga
    Department of Cell Biology, University of Basel, Swtizerland
    Genes Dev 6:1082-96. 1992
    ....
  2. ncbi Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans
    R Quiring
    Department of Cell Biology, University of Basel, Switzerland
    Science 265:785-9. 1994
    ....
  3. ncbi Cloning and early expression pattern of two melatonin biosynthesis enzymes in the turbot (Scophthalmus maximus)
    Robin Vuilleumier
    Biozentrum, University of Basel, Cell and Developmental Biology, Basel, Switzerland
    Eur J Neurosci 25:3047-57. 2007
    ..This is in marked contrast with the situation observed with zebrafish Aanat2, indicating that the molecular mechanisms controlling the development of the pineal melatonin system have been modified during the evolution of Teleost...
  4. ncbi The animal body plan, the prototypic body segment, and eye evolution
    Walter J Gehring
    Biozentrum, University of Basel, Klingelbergstrasse 70, Basel, Switzerland
    Evol Dev 14:34-46. 2012
    ..Since Pax6 is involved in eye development in all bilaterian phyla, this argues strongly for a monophyletic origin of the metazoan eye. With the same tool box of transcription factors all the different eye-types can be constructed...
  5. ncbi The genetic control of eye development and its implications for the evolution of the various eye-types
    Walter J Gehring
    Biozentrum, University of Basel, Switzerland
    Int J Dev Biol 46:65-73. 2002
    ....
  6. ncbi Historical perspective on the development and evolution of eyes and photoreceptors
    Walter J Gehring
    Dept Cell Biology, Biozentrum, University of Basel, Switzerland
    Int J Dev Biol 48:707-17. 2004
    ....
  7. ncbi The coevolution of blue-light photoreception and circadian rhythms
    Walter Gehring
    Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    J Mol Evol 57:S286-9. 2003
    ..The oceans and the 24-h light-dark cycle therefore provided an optimal setting for an early evolutionary relationship between blue-light photoreception and circadian rhythmicity...
  8. ncbi New perspectives on eye development and the evolution of eyes and photoreceptors
    W J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    J Hered 96:171-84. 2005
    ..These two hypotheses, the cellular differentiation and the symbiont hypothesis, are not mutually exclusive and are the subject of further investigations...
  9. ncbi How do Hox transcription factors find their target genes in the nucleus of living cells?
    Walter J Gehring
    Growth and Development, Biozentrum University of Basel, Klingelbergstrasse, Basel, Switzerland
    Biol Aujourdhui 205:75-85. 2011
    ..These direct measurements solve an old enigma of how Hox transcription factors find their target genes in the nucleus of live cells...
  10. ncbi Chance and necessity in eye evolution
    Walter J Gehring
    Department of Growth and Development, Biozentrum University of Basel, Switzerland
    Genome Biol Evol 3:1053-66. 2011
    ..In the course of evolution, a series of similar prototypic segments gradually undergoes cephalization anteriorly and caudalization posteriorly through diversification of the Hox genes...
  11. ncbi Isolation and characterization of drosocrystallin, a lens crystallin gene of Drosophila melanogaster
    H Janssens
    Biozentrum, University of Basel, Klingelbergstrasse 70, Basel, CH 4056, Switzerland
    Dev Biol 207:204-14. 1999
    ....
  12. ncbi The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism
    M Seimiya
    Biozentrum University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 127:1879-86. 2000
    ..These results suggest that optix is involved in eye morphogenesis by an eyeless-independent mechanism...
  13. ncbi The master control gene for morphogenesis and evolution of the eye
    W J Gehring
    Biozentrum, University of Basel, Switzerland
    Genes Cells 1:11-5. 1996
    ..The finding of Pax-6 from flatworms to humans suggests that eyeless is a universal master control gene and that the various types of eyes in the various animal phyla may have evolved from a single prototype...
  14. ncbi Direct regulatory interaction of the eyeless protein with an eye-specific enhancer in the sine oculis gene during eye induction in Drosophila
    T Niimi
    Biozentrum University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 126:2253-60. 1999
    ....
  15. ncbi The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered
    J Montagne
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Development 122:2589-97. 1996
    ..We propose that DSRF acts at a key step between regulatory genes that define the early positional values in the developing wing disc and the subsequent localized expression of intervein-specific structural genes...
  16. ncbi Gene duplication and recruitment of a specific tropomyosin into striated muscle cells in the jellyfish Podocoryne carnea
    H Groger
    Institute of Zoology, University of Basel, CH 4051 Basel, Switzerland
    J Exp Zool 285:378-86. 1999
    ..J. Exp. Zool. (Mol. Dev. Evol.) 285:378-386, 1999...
  17. ncbi Pax 6: mastering eye morphogenesis and eye evolution
    W J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Trends Genet 15:371-7. 1999
    ..It is proposed that the various eye-types found in metazoa are derived from a common prototype, monophyletically, by a mechanism called intercalary evolution...
  18. ncbi Characterization and expression analysis of an ancestor-type Pax gene in the hydrozoan jellyfish Podocoryne carnea
    H Groger
    Institute of Zoology, University of Basel, Switzerland
    Mech Dev 94:157-69. 2000
    ..The expression data indicate that Pax-B is involved in nerve cell differentiation...
  19. ncbi PAX-6 in development and evolution
    P Callaerts
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Annu Rev Neurosci 20:483-532. 1997
    ..We discuss the implications of these findings for our understanding of the development and evolution of eyes and nervous systems...
  20. ncbi Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development
    L Kammermeier
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Mech Dev 103:71-8. 2001
    ..In contrast, targeted misexpression of ey, but not of toy, resulted in profound axonal abnormalities in the embryonic ventral nerve cord and brain...
  21. ncbi A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginal discs
    L P Keegan
    Department of Cell Biology, Basel University Biozentrum, Switzerland
    Mech Dev 63:145-57. 1997
    ..Testing a reporter gene construct with mutated binding sites in mouse embryos shows that HB1 is also active in the expression domains of posterior Hox genes in the mouse neural tube...
  22. ncbi A conserved cluster of homeodomain binding sites in the mouse Hoxa-4 intron functions in Drosophila embryos as an enhancer that is directly regulated by Ultrabithorax
    T E Haerry
    Biozentrum, University of Basel, Switzerland
    Dev Biol 186:1-15. 1997
    ..The evolutionary and functional conservation of the HB1 elements indicates that not only the homeodomains but also some of their in vivo binding sites are conserved between vertebrates and invertebrates...
  23. ncbi Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development
    G Halder
    Biozentrum, University of Basel, Klingelbergstr 70, CH 4056 Basel, Switzerland
    Development 125:2181-91. 1998
    ..Recent studies in vertebrate systems indicate that the epistatic relationships among the corresponding vertebrate homologs are very similar to those observed in Drosophila...
  24. ncbi Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila
    T E Haerry
    Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 93:13884-9. 1996
    ..These data suggest that HB1 is a potential target for different homeodomain proteins of both vertebrates and invertebrates...
  25. ncbi Spatial and temporal targeting of gene expression in Drosophila by means of a tetracycline-dependent transactivator system
    B Bello
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 125:2193-202. 1998
    ..This provides the basis of a versatile binary system for controlling gene expression in Drosophila, with an additional level of regulation as compared to the general method using the yeast transcription factor GAL4...
  26. ncbi Empty spiracles, a gap gene containing a homeobox involved in Drosophila head development
    U Walldorf
    Department of Cell Biology, University of Basel, Switzerland
    EMBO J 11:2247-59. 1992
    ..In addition to a homeodomain, the N-terminal portion of the predicted protein sequence is very proline-rich, whereas the C-terminus has an acidic profile consistent with the role of the ems gene product as a transcription factor...
  27. ncbi In vivo analysis of scaffold-associated regions in Drosophila: a synthetic high-affinity SAR binding protein suppresses position effect variegation
    F Girard
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    EMBO J 17:2079-85. 1998
    ..This suppression required MATH20 expression at an early larval developmental stage. Our data suggest an involvement of the high AT-rich SARs in higher order chromatin structure and gene expression...
  28. ncbi The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen
    Y Yamamoto
    Biozentrum, University of Basel, Switzerland
    Development 124:3385-94. 1997
    ..Together, our data suggest that these two proteins are involved in a common regulatory pathway and highlight possible interactions between Pc-G-mediated silencing and DNA replication in Drosophila...
  29. ncbi Functional redundancy: the respective roles of the two sloppy paired genes in Drosophila segmentation
    K M Cadigan
    Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 91:6324-8. 1994
    ..We propose that the slp proteins are biochemically equivalent and that the greater requirement for slp1 in some functions can be explained in large part by its earlier expression...
  30. ncbi The eyeless homeodomain is dispensable for eye development in Drosophila
    C Punzo
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Genes Dev 15:1716-23. 2001
    ..This result suggests distinct functions mediated differentially by the two DNA-binding domains of eyeless...
  31. ncbi The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain
    G Gibson
    Department of Cell Biology, Biozentrum, Basel, Switzerland
    Cell 62:1087-103. 1990
    ..The remaining sequences contribute to the potency with which the proteins act in different cells and are to a limited extent functionally transferable from one protein to the other...
  32. ncbi Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated
    L Pick
    Department of Cell Biology, University of Basel, Switzerland
    Genes Dev 4:1224-39. 1990
    ..We suggest that ftz protein acts in combination with germ layer-restricted transcription factors directly and positively to regulate the transcription of its own gene...
  33. ncbi The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development
    M Affolter
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Development 120:743-53. 1994
    ..Thus, the DSRF gene might play a role in the proper formation and maintenance of the trachea...
  34. ncbi Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex
    M Mlodzik
    Biozentrum, University of Basel, Switzerland
    EMBO J 7:2569-78. 1988
    ..The posterior domain is part of the posterior midgut primordium (endoderm), that invaginates and later contacts the endoderm cells from the anterior midgut invagination...
  35. ncbi The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors
    U Grossniklaus
    Biozentrum, University of Basel, Switzerland
    Genes Dev 6:1030-51. 1992
    ..The two genes appear to share an enhancer element situated upstream of slp1 that acts on both the proximal slp1 promoter and the distal slp2 promoter...
  36. ncbi DNA binding properties of the purified Antennapedia homeodomain
    M Affolter
    Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 87:4093-7. 1990
    ..The DNA binding properties of the Antp HD and prokaryotic DNA binding domains that share a helix-turn-helix motif are compared...
  37. ncbi Dominant-negative form of the Pax6 homolog eyeless for tissue-specific loss-of-function studies in the developing eye and brain in drosophila
    T Niimi
    Department of Cell Biology, Biozentrum, Basel, Switzerland
    Genesis 34:74-5. 2002
  38. ncbi Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments
    K M Cadigan
    Biozentrum, University of Basel, Switzerland
    Genes Dev 8:899-913. 1994
    ..In addition to demonstrating the role of slp in maintaining segment polarity, our results suggest that slp works in, or parallel with, the ptc/hh signal transduction pathway to regulate wg transcription...
  39. ncbi Molecular basis for the inhibition of Drosophila eye development by Antennapedia
    S Plaza
    Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    EMBO J 20:802-11. 2001
    ..Using both in vitro and in vivo experiments, we demonstrate that this inhibitory mechanism involves direct protein-protein interactions between the DNA-binding domains of EY and ANTP, resulting in mutual inhibition...
  40. ncbi Regional repression of a Drosophila POU box gene in the endoderm involves inductive interactions between germ layers
    M Affolter
    Biozentrum, University of Basel, Switzerland
    Development 117:1199-210. 1993
    ....
  41. ncbi Exploring the homeobox
    W J Gehring
    Biozentrum, University of Basel, Switzerland
    Gene 135:215-21. 1993
    ..The homeodomain essentially consists of four alpha-helices, a helix-turn-helix motif, and a flexible N-terminal arm. Base-specific contacts are made by both the recognition helix and the N-terminal arm.(ABSTRACT TRUNCATED AT 250 WORDS)..
  42. ncbi Functional specificity of the Antennapedia homeodomain
    K Furukubo-Tokunaga
    Department of Cell Biology, Biozentrum der Universitat Basel, Switzerland
    Proc Natl Acad Sci U S A 90:6360-4. 1993
    ....
  43. ncbi Structural organization and sequence of the homeotic gene Antennapedia of Drosophila melanogaster
    S Schneuwly
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstr 70, CH 4056 Basel, Switzerland
    EMBO J 5:733-9. 1986
    ..Functional implications of the complex structure with respect to development and its relation to the mutant phenotypes are discussed...
  44. ncbi The interaction with DNA of wild-type and mutant fushi tarazu homeodomains
    A Percival-Smith
    University of Basel, Department of Cell Biology, Switzerland
    EMBO J 9:3967-74. 1990
    ..These three points of contact allowed us to propose a crude orientation of the ftz HD within the protein-DNA complex. We find that the ftz HD and the Antp HD peptides contact DNA in a similar way...
  45. ncbi The homeobox in perspective
    W J Gehring
    Biozentrum, University of Basel, Switzerland
    Trends Biochem Sci 17:277-80. 1992
    ..Their mechanism of action can now be studied at the molecular level and their occurrence seems to be much more universal than originally anticipated...
  46. ncbi Identification of target genes of the homeotic gene Antennapedia by enhancer detection
    J T Wagner-Bernholz
    Biozentrum, University of Basel, Switzerland
    Genes Dev 5:2467-80. 1991
    ..Our analysis of several enhancer-detector strains suggests that the basic patterning information in the antennal and leg imaginal discs is very similar...
  47. ncbi Homeodomain proteins and the regulation of gene expression
    M Affolter
    Biozentrum, University of Basel, Switzerland
    Curr Opin Cell Biol 2:485-95. 1990
  48. ncbi The structure of the homeodomain and its functional implications
    W J Gehring
    University of Basel, Switzerland
    Trends Genet 6:323-9. 1990
    ..Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution...
  49. ncbi Fruit flies with additional expression of the elongation factor EF-1 alpha live longer
    J C Shepherd
    Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 86:7520-1. 1989
    ..Here we show that Drosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies...
  50. ncbi P-element-mediated enhancer detection: a versatile method to study development in Drosophila
    H J Bellen
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Genes Dev 3:1288-300. 1989
    ..In light of our results, we discuss the diversity and complexity of cis-acting regulatory elements in the genome and the general applications of the enhancer detector method for the study of Drosophila development...
  51. ncbi P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila
    C Wilson
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Genes Dev 3:1301-13. 1989
    ..Therefore, the enhancer detection system is an efficient method of screening for genes primarily on the basis of their expression pattern and then rapidly analyzing those of particular interest at the molecular and genetic levels...
  52. ncbi The homeotic gene Sex Combs Reduced of Drosophila: gene structure and embryonic expression
    P K LeMotte
    Biozentrum, University of Basel, Switzerland
    EMBO J 8:219-27. 1989
    ..Expression begins at gastrulation and is eventually apparent in three tissues, epidermis, nervous system and visceral mesoderm, though there are clear contrasts in the domains of expression in these three tissues...
  53. ncbi Comparison of homeobox-containing genes of the honeybee and Drosophila
    U Walldorf
    Department of Cell Biology, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 86:9971-5. 1989
    ....
  54. ncbi The location, modification, and function of the fushi tarazu protein during Drosophila embryogenesis
    H M Krause
    Department of Cell Biology, University of Basel, Switzerland
    Prog Clin Biol Res 284:105-23. 1988
    ..In this paper, we demonstrate that embryonic ftz protein binds to a specific region within the ftz enhancer element. The potential relationship between these observations is discussed...
  55. ncbi Heat shock protein synthesis and thermotolerance in Cataglyphis, an ant from the Sahara desert
    W J Gehring
    Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 92:2994-8. 1995
    ..These findings are interpreted as preadaption of the ants prior to exposure to high temperatures...
  56. ncbi Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
    G Halder
    Biozentrum, University of Basel, Switzerland
    Science 267:1788-92. 1995
    ..Because homologous genes are present in vertebrates, ascidians, insects, cephalopods, and nemerteans, ey may function as a master control gene throughout the metazoa...
  57. ncbi Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila
    F Hirth
    Laboratory of Neurobiology, University of Basel, Switzerland
    Neuron 15:769-78. 1995
    ....
  58. ncbi Expression, modification, and localization of the fushi tarazu protein in Drosophila embryos
    H M Krause
    Department of Cell Biology, University of Basel, Switzerland
    Genes Dev 2:1021-36. 1988
    ..Post-translational modification may influence the biochemical properties and functions of the ftz protein during embryogenesis...
  59. ncbi Stage-specific phosphorylation of the fushi tarazu protein during Drosophila development
    H M Krause
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    EMBO J 8:1197-204. 1989
    ..Interestingly we find that the endogenous ftz protein is also phosphorylated at multiple sites and that different subsets of the phosphoisoforms occur during different stages of development...
  60. ncbi Analysis of a fushi tarazu autoregulatory element: multiple sequence elements contribute to enhancer activity
    A F Schier
    Biozentrum, Universitat, Basel, Switzerland
    EMBO J 12:1111-9. 1993
    ..The D. virilis AE is functional in D. melanogaster. The sequence motifs identified here are candidate elements contributing to the target specificity of the homeodomain protein ftz...
  61. ncbi Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila
    S Leuzinger
    Zoological Institute, University of Basel, Basel, Switzerland
    Development 125:1703-10. 1998
    ....
  62. ncbi Misexpression screen in Drosophila melanogaster aiming to reveal novel factors involved in formation of body parts
    Nicole C Grieder
    Biozentrum der Universitat Basel, Abteilung Zellbiologie, CH 4056 Basel, Switzerland
    Genetics 175:1707-18. 2007
    ..In the other line, the arista is transformed into a tubular structure, resembling an abnormal leg. We found that ectopic expression of abrupt was responsible for this potential transformation of the arista...
  63. ncbi Differential microarray analysis of Drosophila mushroom body transcripts using chemical ablation
    Masatomo Kobayashi
    Graduate School of Life and Environmental Sciences and Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305-8572, Japan
    Proc Natl Acad Sci U S A 103:14417-22. 2006
    ..These results provide important information not only on the repertoire of genes that control MB development but also on the repertoire of neural factors that may have important physiological functions in MB plasticity...
  64. ncbi Differential interactions of eyeless and twin of eyeless with the sine oculis enhancer
    Claudio Punzo
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 129:625-34. 2002
    ..Altogether, these results suggest a differential requirement for EY and TOY to specify the development of the two types of adult visual systems, namely the compound eye and the ocellus...
  65. ncbi Evolution and functional diversity of jellyfish opsins
    Hiroshi Suga
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Curr Biol 18:51-5. 2008
    ..The expression of specific opsins in the eyes suggests a role in vision, whereas that in the gonads suggests a role in light-controlled release of gametes...
  66. ncbi The YPWM motif links Antennapedia to the basal transcriptional machinery
    Frederic Prince
    Biozentrum, University of Basel, Klingelberstrasse 70, CH 4056 Basel, Switzerland
    Development 135:1669-79. 2008
    ..BIP2 is a TATA-binding protein associated factor (also known as dTAFII3) that links ANTP to the basal transcriptional machinery...
  67. ncbi Cross-regulatory protein-protein interactions between Hox and Pax transcription factors
    Serge Plaza
    Centre National de la Recherche Scientifique Centre de Biologie du Developpement, 118 route de Narbonne, Bâtiment 4R3, 31062 Toulouse, France
    Proc Natl Acad Sci U S A 105:13439-44. 2008
    ..These results demonstrate that the homeodomain supports multiple molecular regulatory functions in addition to protein-DNA and protein-RNA interactions; it is also involved in protein-protein interactions...
  68. ncbi Involvement of winged eye encoding a chromatin-associated bromo-adjacent homology domain protein in disc specification
    Tomonori Katsuyama
    Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    Proc Natl Acad Sci U S A 102:15918-23. 2005
    ..These findings suggest that wge functions in the determination of disc-specific identity, downstream of Hox genes...
  69. ncbi Expression of COPI components during development of Drosophila melanogaster
    Nicole C Grieder
    Biozentrum der Universitat Basel, Abteilung Zellbiologie, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Gene Expr Patterns 6:11-21. 2005
    ....
  70. ncbi Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies
    Yasuko Onuma
    Department of Life Sciences, Core Research for Evolution Science and Technology Project, University of Tokyo, Komaba, Meguro ku, Tokyo 153 8902, Japan
    Proc Natl Acad Sci U S A 99:2020-5. 2002
    ..These findings indicate that the gene regulatory cascade is similar in vertebrates and invertebrates...
  71. ncbi HOX genes in the sepiolid squid Euprymna scolopes: implications for the evolution of complex body plans
    Patrick Callaerts
    Department of Biology and Biochemistry, University of Houston, Houston, TX 77204-5513, USA
    Proc Natl Acad Sci U S A 99:2088-93. 2002
    ..Furthermore, our phylogenetic analysis and in particular the identification of Post-1 and Post-2 homologs support the Lophotrochozoan clade...
  72. ncbi Conversion of a postocellar into an ocellar region as a transdetermination event occurring in adult ribbonworms
    Michel Tarpin
    Laboratoire de Biologie Cellulaire et Moleculaire, UFR des Sciences Exactes et Naturelles, E A 3306, Universite de Reims Champagne Ardenne, B P 1039, F 51 687 Reims Cedex 2, France
    Mech Dev 118:39-44. 2002
    ....
  73. ncbi Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in Drosophila head development
    Corinne Benassayag
    Centre de Biologie du Développement CNRS and Institut d Exploration Fonctionnelle du Génome, 118 route de Narbonne, Bâtiment 4R3, F 31062 Toulouse cedex 04, France
    Development 130:575-86. 2003
    ..The direct functional antagonism between PB and EY proteins suggests a novel crosstalk mechanism integrating known selector functions in Drosophila head morphogenesis...
  74. ncbi Analysis of the eye developmental pathway in Drosophila using DNA microarrays
    Lydia Michaut
    Biozentrum, University of Basel, CH-4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 100:4024-9. 2003
    ..As expected, genes already known to act downstream of eyeless during eye development were identified, together with a group of genes that were not yet associated with eye formation...
  75. ncbi Functional divergence between eyeless and twin of eyeless in Drosophila melanogaster
    Claudio Punzo
    Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Development 131:3943-53. 2004
    ..These results suggest distinct functions of the two DNA-binding domains of TOY and EY, and significant evolutionary divergence between the two Drosophila Pax6 genes...
  76. ncbi Functional analysis of the chicken delta1-crystallin enhancer activity in Drosophila reveals remarkable evolutionary conservation between chicken and fly
    Jorge Blanco
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 132:1895-905. 2005
    ..As PAX6 and PAX2 proteins derive from the same ancestor, we propose that during evolution Pax6 function in vertebrate lens development was retained by Pax2 in Drosophila...
  77. ncbi Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog
    Tobias Pauli
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 132:2771-82. 2005
    ..Our results strengthen the general assumption that feedback loops among the genes of the retinal determination network are crucial for proper development of eyes and ocelli...
  78. ncbi DNA-binding characteristics of cnidarian Pax-C and Pax-B proteins in vivo and in vitro: no simple relationship with the Pax-6 and Pax-2/5/8 classes
    Serge Plaza
    Biozentrum, University of Basel, CH-4056 Basel, Switzerland
    J Exp Zoolog B Mol Dev Evol 299:26-35. 2003
    ....
  79. ncbi Central projections of photoreceptor axons originating from ectopic eyes in Drosophila
    Jason Clements
    Laboratory of Developmental Genetics, Vlaams Instituut voor Biotechnologie VIB and Center for Human Genetics, Katholieke Universiteit Leuven, Herestraat 49 bus 602, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 105:8968-73. 2008
    ....