W J Gehring

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi Pax 6: mastering eye morphogenesis and eye evolution
    W J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Trends Genet 15:371-7. 1999
  2. ncbi Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development
    L Kammermeier
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Mech Dev 103:71-8. 2001
  3. ncbi A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginal discs
    L P Keegan
    Department of Cell Biology, Basel University Biozentrum, Switzerland
    Mech Dev 63:145-57. 1997
  4. ncbi The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism
    M Seimiya
    Biozentrum University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 127:1879-86. 2000
  5. ncbi Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development
    G Halder
    Biozentrum, University of Basel, Klingelbergstr 70, CH 4056 Basel, Switzerland
    Development 125:2181-91. 1998
  6. pmc Molecular basis for the inhibition of Drosophila eye development by Antennapedia
    S Plaza
    Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    EMBO J 20:802-11. 2001
  7. ncbi A conserved cluster of homeodomain binding sites in the mouse Hoxa-4 intron functions in Drosophila embryos as an enhancer that is directly regulated by Ultrabithorax
    T E Haerry
    Biozentrum, University of Basel, Switzerland
    Dev Biol 186:1-15. 1997
  8. ncbi P-element-mediated enhancer detection: a versatile method to study development in Drosophila
    H J Bellen
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Genes Dev 3:1288-300. 1989
  9. pmc Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila
    T E Haerry
    Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 93:13884-9. 1996
  10. ncbi Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila
    S Leuzinger
    Zoological Institute, University of Basel, Basel, Switzerland
    Development 125:1703-10. 1998

Collaborators

Detail Information

Publications80

  1. ncbi Pax 6: mastering eye morphogenesis and eye evolution
    W J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Trends Genet 15:371-7. 1999
    ..It is proposed that the various eye-types found in metazoa are derived from a common prototype, monophyletically, by a mechanism called intercalary evolution...
  2. ncbi Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development
    L Kammermeier
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Mech Dev 103:71-8. 2001
    ..In contrast, targeted misexpression of ey, but not of toy, resulted in profound axonal abnormalities in the embryonic ventral nerve cord and brain...
  3. ncbi A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginal discs
    L P Keegan
    Department of Cell Biology, Basel University Biozentrum, Switzerland
    Mech Dev 63:145-57. 1997
    ..Testing a reporter gene construct with mutated binding sites in mouse embryos shows that HB1 is also active in the expression domains of posterior Hox genes in the mouse neural tube...
  4. ncbi The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism
    M Seimiya
    Biozentrum University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 127:1879-86. 2000
    ..These results suggest that optix is involved in eye morphogenesis by an eyeless-independent mechanism...
  5. ncbi Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development
    G Halder
    Biozentrum, University of Basel, Klingelbergstr 70, CH 4056 Basel, Switzerland
    Development 125:2181-91. 1998
    ..Recent studies in vertebrate systems indicate that the epistatic relationships among the corresponding vertebrate homologs are very similar to those observed in Drosophila...
  6. pmc Molecular basis for the inhibition of Drosophila eye development by Antennapedia
    S Plaza
    Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    EMBO J 20:802-11. 2001
    ..Using both in vitro and in vivo experiments, we demonstrate that this inhibitory mechanism involves direct protein-protein interactions between the DNA-binding domains of EY and ANTP, resulting in mutual inhibition...
  7. ncbi A conserved cluster of homeodomain binding sites in the mouse Hoxa-4 intron functions in Drosophila embryos as an enhancer that is directly regulated by Ultrabithorax
    T E Haerry
    Biozentrum, University of Basel, Switzerland
    Dev Biol 186:1-15. 1997
    ..The evolutionary and functional conservation of the HB1 elements indicates that not only the homeodomains but also some of their in vivo binding sites are conserved between vertebrates and invertebrates...
  8. ncbi P-element-mediated enhancer detection: a versatile method to study development in Drosophila
    H J Bellen
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Genes Dev 3:1288-300. 1989
    ..In light of our results, we discuss the diversity and complexity of cis-acting regulatory elements in the genome and the general applications of the enhancer detector method for the study of Drosophila development...
  9. pmc Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila
    T E Haerry
    Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 93:13884-9. 1996
    ..These data suggest that HB1 is a potential target for different homeodomain proteins of both vertebrates and invertebrates...
  10. ncbi Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila
    S Leuzinger
    Zoological Institute, University of Basel, Basel, Switzerland
    Development 125:1703-10. 1998
    ....
  11. ncbi Direct regulatory interaction of the eyeless protein with an eye-specific enhancer in the sine oculis gene during eye induction in Drosophila
    T Niimi
    Biozentrum University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 126:2253-60. 1999
    ....
  12. ncbi Spatial and temporal targeting of gene expression in Drosophila by means of a tetracycline-dependent transactivator system
    B Bello
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 125:2193-202. 1998
    ..This provides the basis of a versatile binary system for controlling gene expression in Drosophila, with an additional level of regulation as compared to the general method using the yeast transcription factor GAL4...
  13. ncbi The structure of the homeodomain and its functional implications
    W J Gehring
    University of Basel, Switzerland
    Trends Genet 6:323-9. 1990
    ..Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution...
  14. pmc Functional specificity of the Antennapedia homeodomain
    K Furukubo-Tokunaga
    Department of Cell Biology, Biozentrum der Universitat Basel, Switzerland
    Proc Natl Acad Sci U S A 90:6360-4. 1993
    ....
  15. ncbi Exploring the homeobox
    W J Gehring
    Biozentrum, University of Basel, Switzerland
    Gene 135:215-21. 1993
    ..The homeodomain essentially consists of four alpha-helices, a helix-turn-helix motif, and a flexible N-terminal arm. Base-specific contacts are made by both the recognition helix and the N-terminal arm.(ABSTRACT TRUNCATED AT 250 WORDS)..
  16. ncbi P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila
    C Wilson
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Genes Dev 3:1301-13. 1989
    ..Therefore, the enhancer detection system is an efficient method of screening for genes primarily on the basis of their expression pattern and then rapidly analyzing those of particular interest at the molecular and genetic levels...
  17. pmc The homeotic gene Sex Combs Reduced of Drosophila: gene structure and embryonic expression
    P K LeMotte
    Biozentrum, University of Basel, Switzerland
    EMBO J 8:219-27. 1989
    ..Expression begins at gastrulation and is eventually apparent in three tissues, epidermis, nervous system and visceral mesoderm, though there are clear contrasts in the domains of expression in these three tissues...
  18. ncbi Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans
    R Quiring
    Department of Cell Biology, University of Basel, Switzerland
    Science 265:785-9. 1994
    ....
  19. ncbi Regional repression of a Drosophila POU box gene in the endoderm involves inductive interactions between germ layers
    M Affolter
    Biozentrum, University of Basel, Switzerland
    Development 117:1199-210. 1993
    ....
  20. ncbi The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered
    J Montagne
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Development 122:2589-97. 1996
    ..We propose that DSRF acts at a key step between regulatory genes that define the early positional values in the developing wing disc and the subsequent localized expression of intervein-specific structural genes...
  21. ncbi Gene duplication and recruitment of a specific tropomyosin into striated muscle cells in the jellyfish Podocoryne carnea
    H Groger
    Institute of Zoology, University of Basel, CH 4051 Basel, Switzerland
    J Exp Zool 285:378-86. 1999
    ..J. Exp. Zool. (Mol. Dev. Evol.) 285:378-386, 1999...
  22. ncbi The master control gene for morphogenesis and evolution of the eye
    W J Gehring
    Biozentrum, University of Basel, Switzerland
    Genes Cells 1:11-5. 1996
    ..The finding of Pax-6 from flatworms to humans suggests that eyeless is a universal master control gene and that the various types of eyes in the various animal phyla may have evolved from a single prototype...
  23. ncbi Characterization and expression analysis of an ancestor-type Pax gene in the hydrozoan jellyfish Podocoryne carnea
    H Groger
    Institute of Zoology, University of Basel, Switzerland
    Mech Dev 94:157-69. 2000
    ..The expression data indicate that Pax-B is involved in nerve cell differentiation...
  24. pmc In vivo analysis of scaffold-associated regions in Drosophila: a synthetic high-affinity SAR binding protein suppresses position effect variegation
    F Girard
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    EMBO J 17:2079-85. 1998
    ..This suppression required MATH20 expression at an early larval developmental stage. Our data suggest an involvement of the high AT-rich SARs in higher order chromatin structure and gene expression...
  25. ncbi Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments
    K M Cadigan
    Biozentrum, University of Basel, Switzerland
    Genes Dev 8:899-913. 1994
    ..In addition to demonstrating the role of slp in maintaining segment polarity, our results suggest that slp works in, or parallel with, the ptc/hh signal transduction pathway to regulate wg transcription...
  26. ncbi Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated
    L Pick
    Department of Cell Biology, University of Basel, Switzerland
    Genes Dev 4:1224-39. 1990
    ..We suggest that ftz protein acts in combination with germ layer-restricted transcription factors directly and positively to regulate the transcription of its own gene...
  27. ncbi Isolation and characterization of drosocrystallin, a lens crystallin gene of Drosophila melanogaster
    H Janssens
    Biozentrum, University of Basel, Klingelbergstrasse 70, Basel, CH 4056, Switzerland
    Dev Biol 207:204-14. 1999
    ....
  28. ncbi Dominant-negative form of the Pax6 homolog eyeless for tissue-specific loss-of-function studies in the developing eye and brain in drosophila
    T Niimi
    Department of Cell Biology, Biozentrum, Basel, Switzerland
    Genesis 34:74-5. 2002
  29. ncbi The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen
    Y Yamamoto
    Biozentrum, University of Basel, Switzerland
    Development 124:3385-94. 1997
    ..Together, our data suggest that these two proteins are involved in a common regulatory pathway and highlight possible interactions between Pc-G-mediated silencing and DNA replication in Drosophila...
  30. pmc Analysis of a fushi tarazu autoregulatory element: multiple sequence elements contribute to enhancer activity
    A F Schier
    Biozentrum, Universitat, Basel, Switzerland
    EMBO J 12:1111-9. 1993
    ..The D. virilis AE is functional in D. melanogaster. The sequence motifs identified here are candidate elements contributing to the target specificity of the homeodomain protein ftz...
  31. pmc Functional redundancy: the respective roles of the two sloppy paired genes in Drosophila segmentation
    K M Cadigan
    Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 91:6324-8. 1994
    ..We propose that the slp proteins are biochemically equivalent and that the greater requirement for slp1 in some functions can be explained in large part by its earlier expression...
  32. ncbi The location, modification, and function of the fushi tarazu protein during Drosophila embryogenesis
    H M Krause
    Department of Cell Biology, University of Basel, Switzerland
    Prog Clin Biol Res 284:105-23. 1988
    ..In this paper, we demonstrate that embryonic ftz protein binds to a specific region within the ftz enhancer element. The potential relationship between these observations is discussed...
  33. pmc Detection in situ of genomic regulatory elements in Drosophila
    C J O'Kane
    Department of Cell Biology, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 84:9123-7. 1987
    ..The P-lacZ fusion gene is, therefore, an efficient tool for the recovery of elements that may regulate gene expression in Drosophila and for the generation of a wide variety of cell-type-specific markers...
  34. pmc Structural organization and sequence of the homeotic gene Antennapedia of Drosophila melanogaster
    S Schneuwly
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstr 70, CH 4056 Basel, Switzerland
    EMBO J 5:733-9. 1986
    ..Functional implications of the complex structure with respect to development and its relation to the mutant phenotypes are discussed...
  35. pmc The interaction with DNA of wild-type and mutant fushi tarazu homeodomains
    A Percival-Smith
    University of Basel, Department of Cell Biology, Switzerland
    EMBO J 9:3967-74. 1990
    ..These three points of contact allowed us to propose a crude orientation of the ftz HD within the protein-DNA complex. We find that the ftz HD and the Antp HD peptides contact DNA in a similar way...
  36. pmc The eyeless homeodomain is dispensable for eye development in Drosophila
    C Punzo
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Genes Dev 15:1716-23. 2001
    ..This result suggests distinct functions mediated differentially by the two DNA-binding domains of eyeless...
  37. ncbi PAX-6 in development and evolution
    P Callaerts
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Annu Rev Neurosci 20:483-532. 1997
    ..We discuss the implications of these findings for our understanding of the development and evolution of eyes and nervous systems...
  38. ncbi The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain
    G Gibson
    Department of Cell Biology, Biozentrum, Basel, Switzerland
    Cell 62:1087-103. 1990
    ..The remaining sequences contribute to the potency with which the proteins act in different cells and are to a limited extent functionally transferable from one protein to the other...
  39. ncbi Expression, modification, and localization of the fushi tarazu protein in Drosophila embryos
    H M Krause
    Department of Cell Biology, University of Basel, Switzerland
    Genes Dev 2:1021-36. 1988
    ..Post-translational modification may influence the biochemical properties and functions of the ftz protein during embryogenesis...
  40. ncbi Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
    G Halder
    Biozentrum, University of Basel, Switzerland
    Science 267:1788-92. 1995
    ..Because homologous genes are present in vertebrates, ascidians, insects, cephalopods, and nemerteans, ey may function as a master control gene throughout the metazoa...
  41. ncbi New perspectives on eye development and the evolution of eyes and photoreceptors
    W J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    J Hered 96:171-84. 2005
    ..These two hypotheses, the cellular differentiation and the symbiont hypothesis, are not mutually exclusive and are the subject of further investigations...
  42. pmc Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex
    M Mlodzik
    Biozentrum, University of Basel, Switzerland
    EMBO J 7:2569-78. 1988
    ..The posterior domain is part of the posterior midgut primordium (endoderm), that invaginates and later contacts the endoderm cells from the anterior midgut invagination...
  43. ncbi Homeodomain proteins and the regulation of gene expression
    M Affolter
    Biozentrum, University of Basel, Switzerland
    Curr Opin Cell Biol 2:485-95. 1990
  44. ncbi The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development
    M Affolter
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Development 120:743-53. 1994
    ..Thus, the DSRF gene might play a role in the proper formation and maintenance of the trachea...
  45. ncbi Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila
    F Hirth
    Laboratory of Neurobiology, University of Basel, Switzerland
    Neuron 15:769-78. 1995
    ....
  46. pmc Stage-specific phosphorylation of the fushi tarazu protein during Drosophila development
    H M Krause
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    EMBO J 8:1197-204. 1989
    ..Interestingly we find that the endogenous ftz protein is also phosphorylated at multiple sites and that different subsets of the phosphoisoforms occur during different stages of development...
  47. pmc Comparison of homeobox-containing genes of the honeybee and Drosophila
    U Walldorf
    Department of Cell Biology, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 86:9971-5. 1989
    ....
  48. ncbi Effects of ectopic expression of caudal during Drosophila development
    M Mlodzik
    Department of Cell Biology, Biozentrum der Universitat, Basel, Switzerland
    Development 109:271-7. 1990
    ....
  49. pmc Fruit flies with additional expression of the elongation factor EF-1 alpha live longer
    J C Shepherd
    Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 86:7520-1. 1989
    ..Here we show that Drosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies...
  50. pmc Heat shock protein synthesis and thermotolerance in Cataglyphis, an ant from the Sahara desert
    W J Gehring
    Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 92:2994-8. 1995
    ..These findings are interpreted as preadaption of the ants prior to exposure to high temperatures...
  51. pmc Empty spiracles, a gap gene containing a homeobox involved in Drosophila head development
    U Walldorf
    Department of Cell Biology, University of Basel, Switzerland
    EMBO J 11:2247-59. 1992
    ..In addition to a homeodomain, the N-terminal portion of the predicted protein sequence is very proline-rich, whereas the C-terminus has an acidic profile consistent with the role of the ems gene product as a transcription factor...
  52. ncbi P-element-mediated enhancer detection applied to the study of oogenesis in Drosophila
    U Grossniklaus
    Department of Cell Biology, University of Basel, Switzerland
    Development 107:189-200. 1989
    ..On the basis of our results, we suggest new strategies, which are not primarily based on the generation of mutants, to screen for and isolated female sterile genes...
  53. pmc DNA binding properties of the purified Antennapedia homeodomain
    M Affolter
    Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 87:4093-7. 1990
    ..The DNA binding properties of the Antp HD and prokaryotic DNA binding domains that share a helix-turn-helix motif are compared...
  54. ncbi The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors
    U Grossniklaus
    Biozentrum, University of Basel, Switzerland
    Genes Dev 6:1030-51. 1992
    ..The two genes appear to share an enhancer element situated upstream of slp1 that acts on both the proximal slp1 promoter and the distal slp2 promoter...
  55. ncbi In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster
    K Furukubo-Tokunaga
    Department of Cell Biology, University of Basel, Swtizerland
    Genes Dev 6:1082-96. 1992
    ....
  56. ncbi Identification of target genes of the homeotic gene Antennapedia by enhancer detection
    J T Wagner-Bernholz
    Biozentrum, University of Basel, Switzerland
    Genes Dev 5:2467-80. 1991
    ..Our analysis of several enhancer-detector strains suggests that the basic patterning information in the antennal and leg imaginal discs is very similar...
  57. ncbi The homeobox in perspective
    W J Gehring
    Biozentrum, University of Basel, Switzerland
    Trends Biochem Sci 17:277-80. 1992
    ..Their mechanism of action can now be studied at the molecular level and their occurrence seems to be much more universal than originally anticipated...
  58. pmc Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development
    T Eggert
    Institut für Allgemeine Genetik 240, Universitat Hohenheim, Garbenstrasse 70, D 70593 Stuttgart, Germany
    Proc Natl Acad Sci U S A 95:2343-8. 1998
    ..Therefore DRx could be considered as a homolog of vertebrate Rx genes. The Rx genes might be involved in brain patterning processes and specify eye fields in different phyla...
  59. pmc Transgenic planarian lines obtained by electroporation using transposon-derived vectors and an eye-specific GFP marker
    C González-Estévez
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 100:14046-51. 2003
    ..Transgenesis will be an important tool to dissect developmental molecular mechanisms in planarian regeneration, development and stem cell biology, and may also be an entry point to analyze the biology of parasitic Platyhelminthes...
  60. ncbi twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development
    T Czerny
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell 3:297-307. 1999
    ..Toy is therefore required for initiation of ey expression in the embryo and acts through Ey to activate the eye developmental program...
  61. pmc Notch signaling and the determination of appendage identity
    S Kurata
    Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Proc Natl Acad Sci U S A 97:2117-22. 2000
    ..Therefore, Notch is involved in a common regulatory pathway for the determination of the various Drosophila appendages...
  62. pmc Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila
    B Hauck
    Institut für Allgemeine Genetik 240, Universitat Hohenheim, Garbenstrasse 30, D 70593 Stuttgart, Germany
    Proc Natl Acad Sci U S A 96:564-9. 1999
    ..This transactivator recently has been identified as twin of eyeless, the second Pax-6 gene in Drosophila...
  63. pmc Developmentally regulated Drosophila gene family encoding the fork head domain
    U Hacker
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Federal Republic of Germany
    Proc Natl Acad Sci U S A 89:8754-8. 1992
    ..The FD gene products presumably represent a family of transcription factors that, like the previously identified DNA-binding proteins, contribute to early developmental decisions in cell fates during embryogenesis...
  64. pmc The des(1-6)antennapedia homeodomain: comparison of the NMR solution structure and the DNA-binding affinity with the intact Antennapedia homeodomain
    Y Q Qian
    Institut fur Molekularbiologie und Biophysik, Eidgenössiche Technische Hochschule Hönggerberg, Zurich, Switzerland
    Proc Natl Acad Sci U S A 91:4091-5. 1994
    ....
  65. pmc Genetic control of development of the mushroom bodies, the associative learning centers in the Drosophila brain, by the eyeless, twin of eyeless, and Dachshund genes
    M Kurusu
    Institute of Biological Sciences, University of Tsukuba, Tsukuba 305 8572, Japan
    Proc Natl Acad Sci U S A 97:2140-4. 2000
    ..These data argue for a distinct combinatorial code of regulatory genes for MBs as compared with eye development and suggest conserved roles of Pax6 homologs in the genetic programs of the olfactory learning centers of complex brains...
  66. ncbi Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene
    A F Schier
    Biozentrum der Universitat Basel, Switzerland
    Nature 356:804-7. 1992
    ..This down-regulatory effect is specifically suppressed in vivo by the DNA-binding specificity mutant ftzQ50K. These results establish a direct positive autoregulatory feedback mechanism in the regulation of this homeobox gene...
  67. pmc Distamycin-induced inhibition of homeodomain-DNA complexes
    A Dorn
    Pharma Division, F Hoffmann La Roche Ltd, Basel, Switzerland
    EMBO J 11:279-86. 1992
    ....
  68. pmc NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein
    Y Q Qian
    Institut fur Molekularbiologie und Biophysik, Eidgenössiche Technische Hochschule Hönggerberg, Zurich, Switzerland
    Proc Natl Acad Sci U S A 89:10738-42. 1992
    ....
  69. pmc Protein--DNA contacts in the structure of a homeodomain--DNA complex determined by nuclear magnetic resonance spectroscopy in solution
    G Otting
    Institut für Molekularbiologie und Biophysik ETH Hönggerberg, Zurich, Switzerland
    EMBO J 9:3085-92. 1990
    ....
  70. pmc Functional specificity of the homeodomain protein fushi tarazu: the role of DNA-binding specificity in vivo
    A F Schier
    Biozentrum der Universitat, Basel, Switzerland
    Proc Natl Acad Sci U S A 90:1450-4. 1993
    ..These results are discussed in the light of recent observations on the mechanism of action of the yeast homeodomain protein alpha 2...
  71. ncbi Homeodomain proteins in development and therapy
    A Dorn
    Pharma Division, Preclinical Research, F Hoffmann La Roche Ltd, Basel, Switzerland
    Pharmacol Ther 61:155-84. 1994
    ..It has been demonstrated that chimeric peptide molecules encompassing pAntp are also captured by cultured neurons and conveyed to their nuclei. This may be of enormous interest for the internalization of drugs...
  72. ncbi Nuclear magnetic resonance solution structure of the fushi tarazu homeodomain from Drosophila and comparison with the Antennapedia homeodomain
    Y Q Qian
    Institut fur Molekularbiologie und Biophysik, ETH Honggerberg, Zurich, Switzerland
    J Mol Biol 238:333-45. 1994
    ..Another difference is that the Antp homeodomain is more stable with respect to thermal denaturation, with denaturation temperatures at pH 4.8 of 27 degrees C and 48 degrees C, respectively, for ftz and Antp...
  73. pmc spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo
    R P Kühnlein
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
    EMBO J 13:168-79. 1994
    ....
  74. ncbi A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans
    W McGinnis
    Cell 37:403-8. 1984
    ..Apparently at least a part of these developmental switch genes from Drosophila is highly conserved during evolution, and might perform an analogous function in many metazoans ...
  75. ncbi Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila
    W McGinnis
    Cell 38:675-80. 1984
    ..Mo-10 has been mapped to the proximal portion of mouse chromosome 6, and its position in relationship to genes known to influence mouse morphogenesis is discussed...
  76. pmc Isolation and sequence-specific DNA binding of the Antennapedia homeodomain
    M Muller
    Biozentrum der Universitat Basel, Switzerland
    EMBO J 7:4299-304. 1988
    ..It selectively binds to the same sites as a longer Antp polypeptide and a full-length fushi tarazu (ftz) protein. Therefore, the homeodomain represents the DNA-binding domain of the homeotic proteins...
  77. ncbi The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors
    Y Q Qian
    Institut für Molekularbiologie und Biophysik Eidgenössische Technische Hochschule Hönggerberg, Zurich, Switzerland
    Cell 59:573-80. 1989
    ..The elongation of the third helix by the fourth helix is a structured element that so far appears to be unique to the Antennapedia homeodomain...
  78. ncbi Expression of homeotic mutations in duplicated and regenerated antennae of Drosophila melanogaster
    W J Gehring
    J Embryol Exp Morphol 33:459-69. 1975
    ..Both duplicated and regenerated antennae showed at least a partial transformation into leg structures which indicates that the mutant gene is expressed during proliferation in culture...
  79. ncbi Determination of the three-dimensional structure of the Antennapedia homeodomain from Drosophila in solution by 1H nuclear magnetic resonance spectroscopy
    M Billeter
    Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule Honggerberg, Zurich, Switzerland
    J Mol Biol 214:183-97. 1990
    ..The helices enclose a structurally well-defined molecular core of hydrophobic amino acid side-chains...
  80. ncbi RNA binding and translational suppression by bicoid
    R Rivera-Pomar
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Nature 379:746-9. 1996
    ..This suggests that bcd may act in the region-specific control of cad mRNA translation. Here we report that bcd binds through its homeodomain to cad mRNA in vitro, and exerts translational control through a bcd-binding region of cad mRNA...