Steffen Gay

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers
    Oliver Distler
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland
    Arthritis Res 4:R11. 2002
  2. pmc Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation
    Kimio Masuda
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Gloriastrasse 25, Switzerland
    Arthritis Res 4:R8. 2002
  3. pmc Cartilage destruction in rheumatoid arthritis
    S Gay
    WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, Department of Rheumatology, University Hospital, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Ann Rheum Dis 61:ii87. 2002
  4. doi Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis
    Hossein Hemmatazad
    Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Arthritis Rheum 60:1519-29. 2009
  5. ncbi Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis
    Lars C Huber
    Center of Experimental Rheumatism, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland
    Arthritis Rheum 56:2755-64. 2007
  6. ncbi Galectin 3 and its binding protein in rheumatoid arthritis
    Shiro Ohshima
    Center of Experimental Rheumatology, University Hospital, Zurich, Switzerland
    Arthritis Rheum 48:2788-95. 2003
  7. ncbi Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis
    Oliver Distler
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Circ Res 95:109-16. 2004
  8. ncbi Epigenetics and rheumatoid arthritis: the role of SENP1 in the regulation of MMP-1 expression
    Hanna Maciejewska-Rodrigues
    Center of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse 23 25, Zurich 8091, Switzerland
    J Autoimmun 35:15-22. 2010
  9. doi Expression, regulation, and signaling of the pattern-recognition receptor nucleotide-binding oligomerization domain 2 in rheumatoid arthritis synovial fibroblasts
    Caroline Ospelt
    Center of Experimental Rheumatology, University Hospital Zurich, and Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Arthritis Rheum 60:355-63. 2009
  10. ncbi Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis
    Astrid Jungel
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Arthritis Rheum 50:1468-76. 2004

Detail Information

Publications89

  1. pmc Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers
    Oliver Distler
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland
    Arthritis Res 4:R11. 2002
    ..VEGF appears to be protective against ischemic manifestations when concentrations of VEGF exceed a certain threshold level...
  2. pmc Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation
    Kimio Masuda
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Gloriastrasse 25, Switzerland
    Arthritis Res 4:R8. 2002
    ..Most importantly, the data indicate that the expression of certain genes in RA-SF depends on the stage of proliferation; therefore, the stage needs to be considered in any analysis of differential gene expression in SF...
  3. pmc Cartilage destruction in rheumatoid arthritis
    S Gay
    WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, Department of Rheumatology, University Hospital, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Ann Rheum Dis 61:ii87. 2002
  4. doi Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis
    Hossein Hemmatazad
    Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Arthritis Rheum 60:1519-29. 2009
    ..The purpose of this study was to analyze the silencing of histone deacetylase 7 (HDAC-7) as a possible mechanism by which TSA exerts its antifibrotic function...
  5. ncbi Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis
    Lars C Huber
    Center of Experimental Rheumatism, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland
    Arthritis Rheum 56:2755-64. 2007
    ..In this study, we investigated the antifibrogenic effects of the histone deacetylase inhibitor trichostatin A (TSA) on cytokine-driven fibrotic responses in vitro and in vivo...
  6. ncbi Galectin 3 and its binding protein in rheumatoid arthritis
    Shiro Ohshima
    Center of Experimental Rheumatology, University Hospital, Zurich, Switzerland
    Arthritis Rheum 48:2788-95. 2003
    ....
  7. ncbi Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis
    Oliver Distler
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Circ Res 95:109-16. 2004
    ..Consequently, for therapeutic approaches aiming to improve tissue perfusion in these patients, a controlled expression and timely termination of VEGF signaling appears to be crucial for success of proangiogenic therapies...
  8. ncbi Epigenetics and rheumatoid arthritis: the role of SENP1 in the regulation of MMP-1 expression
    Hanna Maciejewska-Rodrigues
    Center of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse 23 25, Zurich 8091, Switzerland
    J Autoimmun 35:15-22. 2010
    ..This is the first study linking the SUMOylation pathway and the production of MMP-1 to an epigenetic control mechanism mediated through histone acetylation which has a functional consequence for the invasiveness of RASF...
  9. doi Expression, regulation, and signaling of the pattern-recognition receptor nucleotide-binding oligomerization domain 2 in rheumatoid arthritis synovial fibroblasts
    Caroline Ospelt
    Center of Experimental Rheumatology, University Hospital Zurich, and Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Arthritis Rheum 60:355-63. 2009
    ....
  10. ncbi Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis
    Astrid Jungel
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Arthritis Rheum 50:1468-76. 2004
    ..To determine the role and expression of the cytokine/receptor pair interleukin-21 (IL-21)/IL-21 receptor (IL-21R) in rheumatoid arthritis (RA)...
  11. ncbi Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis
    Caroline Ospelt
    Center of Experimental Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
    Arthritis Rheum 58:3684-92. 2008
    ....
  12. ncbi RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3
    Fabia Brentano
    University Hospital, Zurich, Switzerland
    Arthritis Rheum 52:2656-65. 2005
    ....
  13. ncbi Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis
    Jörg H W Distler
    University Hospital Zurich, Zurich, Switzerland
    Arthritis Rheum 52:856-64. 2005
    ..To examine the expression and regulation of interleukin-21 (IL-21) and IL-21 receptor (IL-21R) in patients with systemic sclerosis (SSc; scleroderma)...
  14. ncbi Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis
    Jörg H W Distler
    Center of Experimental Rheumatology and Zurich Center of Integrative Human Physiology, University Hospital Zurich, Gloriastrasse 25, Zurich, Switzerland
    Arthritis Rheum 56:4203-15. 2007
    ..Based on the severely decreased oxygen levels in the skin of patients with SSc, we aimed to investigate the role of hypoxia in the pathogenesis of SSc...
  15. doi DNA hypomethylation in rheumatoid arthritis synovial fibroblasts
    Emmanuel Karouzakis
    Zurich Center of Integrative Human Physiology, University Hospital, Zurich, Switzerland
    Arthritis Rheum 60:3613-22. 2009
    ..We undertook this study to investigate whether the intrinsic activation of RASFs is due to global genomic hypomethylation, an epigenetic modification...
  16. pmc Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis
    Christian A Seemayer
    Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Switzerland
    Am J Pathol 162:1549-57. 2003
    ....
  17. pmc Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis
    Astrid Jungel
    Centre of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Ann Rheum Dis 69:898-902. 2010
    ..To evaluate the decrease of cartilage destruction by a novel orally active and specific matrix metalloproteinase 13 (MMP-13) inhibitor in three different animal models of rheumatoid arthritis (RA)...
  18. doi Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts
    Caroline Ospelt
    University Hospital, Zurich, Switzerland
    Arthritis Rheum 62:1224-35. 2010
    ....
  19. doi Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance
    Fabienne Niederer
    University Hospital Zurich, Zurich, Switzerland
    Arthritis Rheum 64:1771-9. 2012
    ..To investigate the expression and effect of the microRNA-34 (miR-34) family on apoptosis in rheumatoid arthritis synovial fibroblasts (RASFs)...
  20. doi The relationship between plasma microparticles and disease manifestations in patients with systemic sclerosis
    Serena Guiducci
    University Hospital Zurich, Zurich, Switzerland
    Arthritis Rheum 58:2845-53. 2008
    ..The aim of the present study was to analyze the profile of microparticles in the blood of patients with systemic sclerosis (SSc; scleroderma) and healthy controls...
  21. pmc Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation
    Joanna Stanczyk
    Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology, Zurich, Switzerland
    Arthritis Rheum 63:373-81. 2011
    ..The present study was undertaken to examine alterations in expression of miR-203 in RASFs and analyze its role in fibroblast activation...
  22. doi Expression and function of EZH2 in synovial fibroblasts: epigenetic repression of the Wnt inhibitor SFRP1 in rheumatoid arthritis
    Michelle Trenkmann
    Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology, Zurich, Switzerland
    Ann Rheum Dis 70:1482-8. 2011
    ..To study the expression, regulation and function of the histone methyltransferase enhancer of zeste homologue 2 (EZH2) in synovial fibroblasts (SF) from patients with rheumatoid arthritis (RA) and osteoarthritis (OA)...
  23. ncbi The role of membrane lipids in the induction of macrophage apoptosis by microparticles
    Lars C Huber
    Center of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse 23, CH 8091, Zurich, Switzerland
    Apoptosis 12:363-74. 2007
    ....
  24. doi Acetaminophen increases blood pressure in patients with coronary artery disease
    Isabella Sudano
    Cardiovascular Center Cardiology University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Circulation 122:1789-96. 2010
    ..Hence, the aim of this study was to evaluate the safety of acetaminophen in patients with coronary artery disease...
  25. doi Angiotensin-converting enzyme inhibition improves vascular function in rheumatoid arthritis
    Andreas J Flammer
    Cardiovascular Centre, Cardiology, University Hospital, Ramistrasse 100, 8091 Zurich, Switzerland
    Circulation 117:2262-9. 2008
    ....
  26. doi Tumor necrosis factor α-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling
    Michelle Trenkmann
    Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Arthritis Rheum 65:916-27. 2013
    ..To elucidate whether the microRNA (miRNA) cluster miR-17-92 contributes to the activated phenotype of rheumatoid arthritis synovial fibroblasts (RASFs)...
  27. pmc The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles
    Jörg H W Distler
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 102:2892-7. 2005
    ..These data provide evidence for a novel mechanism by which vesicles derived from activated or apoptotic immune cells can promote the destructive activity of synovial fibroblasts in rheumatoid arthritis...
  28. ncbi Deficient expression of interleukin-10 receptor alpha chain in rheumatoid arthritis synovium: limitation of animal models of inflammation
    Michel Neidhart
    University Hospital Zurich, Zurich, Switzerland
    Arthritis Rheum 52:3315-8. 2005
  29. doi Inhibitor of DNA binding/differentiation 2 induced by hypoxia promotes synovial fibroblast-dependent osteoclastogenesis
    Mariola Kurowska-Stolarska
    University Hospital Zurich, University of Zurich, Zurich, Switzerland
    Arthritis Rheum 60:3663-75. 2009
    ..To map hypoxic areas in arthritic synovium and to establish the relevance of low oxygen levels to the phenotype of synovial fibroblasts, with special focus on bone degradation...
  30. ncbi Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities
    Fabia Brentano
    University Hospital, Zurich, Switzerland
    Arthritis Rheum 56:2829-39. 2007
    ....
  31. doi Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis
    Britta Maurer
    Center of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse 25, Zurich, Switzerland
    Circulation 120:2367-76. 2009
    ..In this study, we investigated the role of Fos-related antigen-2 (Fra-2), a transcription factor of the activator protein-1 family, in the peripheral vasculopathy of systemic sclerosis and examined the underlying mechanisms...
  32. pmc DREAM is reduced in synovial fibroblasts of patients with chronic arthritic pain: is it a suitable target for peripheral pain management?
    Natasa Reisch
    Center of Experimental Rheumatology, Department of Rheumatology and Institute of Physical Medicine, University Hospital, CH 8091 Zurich, Gloriastrasse 25, Switzerland
    Arthritis Res Ther 10:R60. 2008
    ..Interfering with the trans-repression effect of downstream regulatory element antagonist modulator (DREAM) on the transcription of the opioid dynorphin-encoding prodynorphin (pdyn) gene might enhance pain relief in the periphery...
  33. doi Myeloid related proteins activate Toll-like receptor 4 in human acute coronary syndromes
    Keiko Yonekawa
    Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Switzerland
    Atherosclerosis 218:486-92. 2011
    ..In human ACS, we investigated now whether the pro-inflammatory action of MRPs occurs through TLR4 in monocytes derived from thrombi...
  34. doi Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
    Joanna Stanczyk
    Center of Experimental Rheumatology, University Hospital Zurich, and Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Arthritis Rheum 58:1001-9. 2008
    ..In this study we investigated the expression, regulation, and function of miR-155 and miR-146a in rheumatoid arthritis (RA) synovial fibroblasts (RASFs) and RA synovial tissue...
  35. doi Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway
    Matthias Brock
    Center for Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Circ Res 104:1184-91. 2009
    ..Taken together, we describe here a novel STAT3-miR-17/92-BMPR2 pathway, thus providing a mechanistic explanation for the loss of BMPR2 in the development of pulmonary hypertension...
  36. ncbi Kappa and delta opioid receptors are expressed but down-regulated in fibroblast-like synoviocytes of patients with rheumatoid arthritis and osteoarthritis
    Hua Shen
    University Hospital Zurich, Zurich, Switzerland
    Arthritis Rheum 52:1402-10. 2005
    ....
  37. ncbi Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands
    Matthias Pierer
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland
    J Immunol 172:1256-65. 2004
    ....
  38. doi SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
    Fabienne Niederer
    Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Ann Rheum Dis 70:1866-73. 2011
    ..To analyse the expression of SIRT1 in synovial tissues and cells of patients with rheumatoid arthritis (RA) and to study the function of SIRT1 in inflammation and apoptosis in RA...
  39. ncbi Dual role of autophagy in stress-induced cell death in rheumatoid arthritis synovial fibroblasts
    Masaru Kato
    Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Arthritis Rheumatol 66:40-8. 2014
    ..To investigate the role of autophagy in the regulation of cell death in rheumatoid arthritis synovial fibroblasts (RASFs)...
  40. ncbi Nucleofection: a new, highly efficient transfection method for primary human keratinocytes*
    Jörg H W Distler
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Exp Dermatol 14:315-20. 2005
    ..In summary, nucleofection is a fast, easy and highly effective alternative for the transfection of primary human keratinocytes, which offers new opportunities for various research applications...
  41. ncbi Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells
    Jörg H W Distler
    Center of Experimental Rheumatology, Dept of Rheumatology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Arthritis Rheum 54:214-25. 2006
    ..The aim of the present study was to examine the mechanisms by which MCP-1 mediates its profibrotic effects in the setting of SSc...
  42. ncbi Effect of losartan, compared with atenolol, on endothelial function and oxidative stress in patients with type 2 diabetes and hypertension
    Andreas J Flammer
    Cardiovascular Center, Cardiology, University Hospital Zurich, Switzerland
    J Hypertens 25:785-91. 2007
    ..We investigated the influence of losartan, compared with atenolol, on endothelial function and oxidative stress in patients with type 2 diabetes and hypertension...
  43. ncbi The L1 retroelement-related p40 protein induces p38delta MAP kinase
    Stefan Kuchen
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital, , Switzerland
    Autoimmunity 37:57-65. 2004
    ..The induction of p38delta appears to be mediated by an ORF1/p40-dependent process. This is the first indication of a p40 mediated transactivation...
  44. doi MicroRNAs in rheumatoid arthritis: potential role in diagnosis and therapy
    Maria Filková
    Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
    BioDrugs 26:131-41. 2012
    ..The aim of the current review is to discuss the available evidence linking the expression of miRNAs to inflammatory and immune response in RA and their potential as biomarkers and the novel targets for treatment in patients with RA...
  45. ncbi Functional characterization of adherent synovial fluid cells in rheumatoid arthritis: destructive potential in vitro and in vivo
    Michel Neidhart
    University Hospital, Zurich, Switzerland
    Arthritis Rheum 48:1873-80. 2003
    ....
  46. ncbi Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes
    Lukas A Altwegg
    Cardiovascular Center, Cardiology, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Eur Heart J 28:941-8. 2007
    ..We investigated whether myeloid-related protein 8/14 complex (MRP8/14) expressed by infiltrating monocytes and granulocytes may represent a mediator and early biomarker of acute coronary syndromes (ACS)...
  47. ncbi Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients
    Lars C Huber
    Center of Experimental Rheumatology, University Hospital Zurich, and Zurich Center of Integrative Human Physiology, Zurich, Switzerland
    Arthritis Rheum 56:1087-93. 2007
    ..We undertook this study to investigate the balance of histone acetylase and HDA activity in synovial tissue from RA patients compared with that from patients with osteoarthritis (OA) and normal controls...
  48. ncbi Technology insight: gene transfer and the design of novel treatments for rheumatoid arthritis
    Falk Moritz
    Center of Experimental Rheumatology, Department of Rheumatology, University of Zurich, Switzerland
    Nat Clin Pract Rheumatol 2:153-62. 2006
    ....
  49. doi Epigenetic control in rheumatoid arthritis synovial fibroblasts
    Emmanuel Karouzakis
    Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Nat Rev Rheumatol 5:266-72. 2009
    ....
  50. ncbi Detection of kappa and delta opioid receptors in skin--outside the nervous system
    Souzan Salemi
    Center of Experimental Rheumatology, Department of Rheumatology, Institute of Physical Medicine, University Hospital, Gloriastrasse 25, Zurich, Switzerland
    Biochem Biophys Res Commun 338:1012-7. 2005
    ..We suggest that enhanced expression of DOR and KOR in skin justifies the exploration of selective novel delta and kappa agonists for local pain treatment...
  51. ncbi Bucillamine induces the synthesis of vascular endothelial growth factor dose-dependently in systemic sclerosis fibroblasts via nuclear factor-kappaB and simian virus 40 promoter factor 1 pathways
    Jörg H W Distler
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Mol Pharmacol 65:389-99. 2004
    ..The study provides evidence for a role of NF-kappaB in the transcriptional regulation of the VEGF gene. SA 96 might have positive aspects on the impaired angiogenesis in patients with SSc...
  52. ncbi Expression of transient receptor potential vanilloid 1 (TRPV1) in synovial fibroblasts from patients with osteoarthritis and rheumatoid arthritis
    Andrea Engler
    Center of Experimental Rheumatology, Department of Rheumatology and Institute of Physical Medicine, University Hospital, Gloriastrasse 25, Zurich, Switzerland
    Biochem Biophys Res Commun 359:884-8. 2007
    ..IL-6 protein expression could be antagonized with capsazepine. Thus, we hypothesize that TRPV1 may play a role in non-neuronal mechanisms that might modulate nociception in symptomatic OA and RA patients...
  53. doi The pattern-recognition receptor nucleotide-binding oligomerization domain--containing protein 1 promotes production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts
    Kazuhiro Yokota
    University Hospital Zurich, Zurich Center of Integrative Human Physiology, and University of Zurich, Zurich, Switzerland
    Arthritis Rheum 64:1329-37. 2012
    ..The aim of this study was to analyze the expression, regulation, and function of the PRR NOD-1 in RA synovial fibroblasts (RASFs), and to examine its interaction with other PRRs...
  54. ncbi Selective COX-2 inhibition improves endothelial function in coronary artery disease
    Remy Chenevard
    Cardiovascular Center, Cardiology and Department of Rheumatology, University Hospital Zurich, Switzerland
    Circulation 107:405-9. 2003
    ....
  55. pmc ATP induced brain-derived neurotrophic factor expression and release from osteoarthritis synovial fibroblasts is mediated by purinergic receptor P2X4
    Kerstin Klein
    Center of Experimental Rheumatology, Division of Rheumatology and Institute of Physical Medicine, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 7:e36693. 2012
    ..Here we show a functional role of the purinergic receptor P2X4 and p38 kinase in the ATP-induced expression and release of the neurotrophin BDNF in SF...
  56. doi Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis
    Britta Maurer
    Department of Rheumatology, University Hospital of Zurich, Zurich, Switzerland
    Ann Rheum Dis 71:1382-7. 2012
    ..In this study, the authors evaluated fos-related antigen 2 (Fra-2) transgenic mice as a novel model for systemic sclerosis-associated pulmonary arterial hypertension...
  57. ncbi Synovial activation in rheumatoid arthritis
    Caroline Ospelt
    Center of Experimental Rheumatology, University Hospital, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Front Biosci 9:2323-34. 2004
    ..Thanks to new techniques in basic research, novel insights into the cellular and molecular mechanisms of the pathogenesis of RA were gained and led to the development of new, specific therapeutic strategies...
  58. doi Toll-like receptors and rheumatoid arthritis
    Fabia Brentano
    Department of Rheumatology, University Hospital Zurich, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Methods Mol Biol 517:329-43. 2009
    ..These results suggest an important role for TLR2, 3, and 4 in the activation of synovial fibroblasts in RA leading to chronic inflammation and joint destruction...
  59. ncbi The SCID mouse model: novel therapeutic targets - lessons from gene transfer
    Matthias Pierer
    WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, Department of Rheumatology, University Hospital, Gloriastrasse 25, 8091, Zurich, Switzerland
    Springer Semin Immunopathol 25:65-78. 2003
    ..Modulation of both pathways by gene transfer approaches in the SCID mouse model is a feasible method aimed at identifying novel targets for the prevention of cartilage destruction in RA...
  60. ncbi Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors
    Britta Maurer
    Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Ann Rheum Dis 72:2039-46. 2013
    ..To assess whether the discrepancy between the strong antifibrotic effects of tyrosine kinase inhibitors (TKIs) in animal models and the inconsistent results in clinical studies might be related to the activation levels of drug targets...
  61. doi Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts
    Emmanuel Karouzakis
    University Hospital, Zurich, Switzerland
    Arthritis Rheum 64:1809-17. 2012
    ..The aim of this study was to investigate whether increased polyamine metabolism is associated with a decreased level of S-adenosyl methionine (SAM), causing global DNA hypomethylation...
  62. doi Epigenetic modifications: novel therapeutic strategies for systemic sclerosis?
    Astrid Jungel
    Center of Experimental Rheumatology, University Hospital Zurich, Zurich Center of Integrative Human Physiology, Switzerland
    Expert Rev Clin Immunol 7:475-80. 2011
    ..In vitro and in vivo experiments demonstrate that the use of epigenetic-based drugs on these cells is able to reverse their activated phenotype...
  63. pmc MicroRNA-18a enhances the interleukin-6-mediated production of the acute-phase proteins fibrinogen and haptoglobin in human hepatocytes
    Matthias Brock
    Center of Experimental Rheumatology, University Zurich, Switzerland
    J Biol Chem 286:40142-50. 2011
    ..Our data reveal, for the first time, a microRNA-mediated positive feedback loop of IL-6 signal transduction leading to an enhanced acute-phase response in human hepatocytes...
  64. ncbi Molecular and cellular basis of rheumatoid joint destruction
    Emmanuel Karouzakis
    Center of Experimental Rheumatology, University Hospital Zurich, Switzerland
    Immunol Lett 106:8-13. 2006
    ..e. TLRs), a unique communication network of microparticles and epigenetic changes (e.g. L1 retroelements)...
  65. ncbi Cellular actors, Toll-like receptors, and local cytokine profile in acute coronary syndromes
    Christophe A Wyss
    Department of Cardiology, Cardiovascular Center, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Eur Heart J 31:1457-69. 2010
    ..We characterized leucocytes and TLR expression within coronary thrombi and compared cytokine levels from the site of coronary occlusion with aortic blood (AB) in ACS patients...
  66. doi What can we learn from epigenetics in the year 2009?
    Astrid Jungel
    Center of Experimental Rheumatology, University Hospital and Zurich Center of Integrative Human Physiology, Switzerland
    Curr Opin Rheumatol 22:284-92. 2010
    ..Even though current therapies with biologics such as tumor necrosis factor-alpha blockers yield significant improvement for the patients, the disease is not curable yet. Therefore, we need novel strategies for better therapies...
  67. ncbi Antirheumatic drugs and gene signatures
    Caroline Ospelt
    University Hospital Zurich, Center of Experimental Rheumatology, Gloriastrasse 23, Zurich, CH 8091, Switzerland
    Curr Opin Investig Drugs 8:385-9. 2007
    ..This review discusses the strengths and weaknesses of microarray technology and gives an overview of gene expression studies currently performed in the field of antiheumatic therapies...
  68. ncbi Detection of synovial macrophages in an experimental rabbit model of antigen-induced arthritis: ultrasmall superparamagnetic iron oxide-enhanced MR imaging
    Amelie M Lutz
    Institute of Diagnostic Radiology and Center for Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Radiology 233:149-57. 2004
    ..To evaluate intravenously administered ultrasmall superparamagnetic iron oxide (USPIO) as a marker of macrophage activity in an experimental rabbit model of antigen-induced arthritis...
  69. ncbi Gene analysis for exploring the effects of drugs in rheumatoid arthritis
    Caroline Ospelt
    University Hospital, Zurich, Switzerland
    Arthritis Rheum 52:2248-56. 2005
  70. ncbi S100A4 (Mts1): is there any relation to the pathogenesis of rheumatoid arthritis?
    Ladislav Senolt
    Center of Experimental Rheumatology, Univ Hosp Zürich, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Autoimmun Rev 5:129-31. 2006
    ..Since several phenomena are similar between rheumatoid arthritis and malignant tumors it can be hypothesized that S100A4 contributes to the invasive and tumor-like behavior of rheumatoid arthritis synovium...
  71. ncbi The role of Toll-like receptor signalling in the pathogenesis of arthritis
    Fabia Brentano
    Center of Experimental Rheumatology, University Hospital, CH 8091 Zurich, Switzerland
    Cell Immunol 233:90-6. 2005
    ..In this review, recent studies on TLR signal transduction pathways activated by corresponding ligands are summarized and evidence for a possible role of TLR signalling in the pathogenesis of rheumatoid arthritis is discussed...
  72. ncbi Gene targeting: roadmap to future therapies
    Lars C Huber
    WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies, Department of Rheumatology, University Hospital, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Curr Rheumatol Rep 6:323-5. 2004
  73. ncbi Absence of inducible retroviruses from synovial fibroblasts and synovial fluid cells of patients with rheumatoid arthritis
    Christian A Seemayer
    University Hospital, University of Zurich, Zurich, Switzerland
    Arthritis Rheum 46:2811-3. 2002
  74. ncbi Expression and localization of opioid receptors in muscle satellite cells: no difference between fibromyalgia patients and healthy subjects
    Souzan Salemi
    University Hospital Zurich, Switzerland
    Arthritis Rheum 48:3291-3. 2003
  75. ncbi Epigenetic deregulation in rheumatoid arthritis
    Emmanuel Karouzakis
    Center for Experimental Rheumatology, University Hospital Zurich, Gloriastrasse, Zurich, Switzerland
    Adv Exp Med Biol 711:137-49. 2011
    ..In conclusion, we discuss the possible use of epigenetic therapy and describe future experiments that can elucidate further the epigenetic changes observed in the disease...
  76. doi The role of resident synovial cells in destructive arthritis
    Caroline Ospelt
    Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology, Gloriastrasse 23, CH 8091 Zurich, Switzerland
    Best Pract Res Clin Rheumatol 22:239-52. 2008
    ..Most importantly, by producing matrix-degrading molecules they contribute strongly to the destructive mechanisms operative in RA...
  77. ncbi Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis
    Jörg H W Distler
    University Hospital, Zurich, Switzerland
    Arthritis Rheum 50:10-23. 2004
  78. ncbi Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis
    David Hurlimann
    Cardiology Department, University Hospital, Zurich, Switzerland
    Circulation 106:2184-7. 2002
    ..Hence, the aim of the present study was to assess the effect of chronic antiinflammatory treatment with the anti-TNF-alpha antibody infliximab on disease activity and endothelial function in patients with active RA...
  79. ncbi Synovial cell activation
    Joanna Stanczyk
    Center of Experimental Rheumatology and World Health Organization Collaborating Center for Molecular Biology and Novel Therapeutic Strategies, Department of Rheumatology, University Hospital Zurich, Switzerland
    Curr Opin Rheumatol 18:262-7. 2006
    ..This review presents recent findings in the field of synovial fibroblast biology contributing to knowledge of the pathogenesis of rheumatoid arthritis...
  80. ncbi Antisense strategies in degenerative joint diseases: sense or nonsense?
    Lars C Huber
    Center of Experimental Rheumatology, WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, University of Zurich, University Hospital Zurich, Gloriastr 23, CH 8091 Zurich, Switzerland
    Adv Drug Deliv Rev 58:285-99. 2006
    ..To introduce these therapies in clinical practice, however, several hurdles still have to be overcome...
  81. ncbi Detection of interleukin 1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha in skin of patients with fibromyalgia
    Souzan Salemi
    Center of Experimental Rheumatology, Department of Rheumatology and Institute of Physical Medicine, University Hospital, Zurich, Switzerland
    J Rheumatol 30:146-50. 2003
    ..To determine if abnormal collagen metabolism is correlated with neurogenic inflammation, a potential activator of collagen metabolism, in patients with fibromyalgia (FM)...
  82. ncbi Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: locally increased interleukin-6 and serum amyloid A but decreased C-reactive protein
    Willibald Maier
    Division of Cardiology, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Circulation 111:1355-61. 2005
    ..Acute myocardial infarction (AMI) is associated with inflammation. However, it remains unclear whether it originates from the ruptured plaque or represents a systemic process...
  83. doi Innate immunity, epigenetics and autoimmunity in rheumatoid arthritis
    Hanna Maciejewska Rodrigues
    Center of Experimental Rheumatology, University Hospital Zurich Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, Gloriastrasse 23 25, CH 8091 Zurich, Switzerland
    Mol Immunol 47:12-8. 2009
    ..The recent findings in the field of innate immunity, epigenetics and autoimmunity related to the pathogenesis of RA are in the scope of this review...
  84. pmc Proteinases in the joint: clinical relevance of proteinases in joint destruction
    Yvonne Rengel
    Center of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse, CH 8091 Zurich, Switzerland
    Arthritis Res Ther 9:221. 2007
    ..Despite disappointing early results with synthetic inhibitors of MMPs, there is still much scope for developing effective and safe MMPs inhibitors, and consequently to deliver new options to inhibit joint destruction...
  85. ncbi Toll-like receptors direct antimicrobial immune responses--and driving arthritis?
    Diego Kyburz
    Center of Experimental Rheumatology, Division of Rheumatology, University Hospital of Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland
    Curr Rheumatol Rep 5:407-8. 2003
  86. ncbi FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis
    Jörg Schedel
    Center of Experimental Rheumatology, WHO Collaborating Center for Molecular Biology, University Hospital of Zurich, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Arthritis Rheum 46:1512-8. 2002
    ..We undertook this study to examine the expression of FLIP in RA, osteoarthritic (OA), and normal synovial tissues...
  87. pmc 7th meeting of the Global Arthritis Research Network
    Matthias Brock
    Department of Rheumatology, University Hospital, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Arthritis Res Ther 13:303. 2011
    ....
  88. ncbi The molecular control of angiogenesis
    Oliver Distler
    WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, University Hospital Zurich, CH 8091, Switzerland
    Int Rev Immunol 21:33-49. 2002
    ..Although initial results are promising, much more work has to be done to consider anti-angiogenic or pro-angiogenic approaches as reliable therapeutic tools...
  89. pmc Role of MicroRNAs in Fibrosis
    Serena Vettori
    Center of Experimental Rheumatology, ZIHP, University Hospital Zurich, Gloriastrasse 25, CH 8091 Zurich, Switzerland
    Open Rheumatol J 6:130-9. 2012
    ..This review provides a comprehensive overview of microRNAs regulating profibrotic pathways and extracellular matrix synthesis. The potential of miRNA for targeted therapeutic approaches in fibrotic disorders is also discussed...