Research Topics
Genomes and Genes | Benoit R GauthierSummaryAffiliation: University of Geneva Country: Switzerland Publications
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Detail Information
Publications
MicroRNAs: 'ribo-regulators' of glucose homeostasisBenoit R Gauthier
Nat Med 12:36-8. 2006- [Glucose homeostasis ribo-regulated by microRNA]Benoit R Gauthier
Med Sci (Paris) 22:463-5. 2006 - Hepatic nuclear factor-3 (HNF-3 or Foxa2) regulates glucagon gene transcription by binding to the G1 and G2 promoter elementsBenoit R Gauthier
Unite de Diabetologie Clinique, Centre Medical Universitaire, 1211 Geneve 4, Switzerland
Mol Endocrinol 16:170-83. 2002..We suggest that HNF-3 may play a dual role on glucagon gene transcription by 1) inhibiting the transactivation potential of Pax6 on the G1 and G3 elements and 2) direct activation through G1 and G2... 
Synaptotagmins bind calcium to release insulinBenoit R Gauthier
Dept of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
Am J Physiol Endocrinol Metab 295:E1279-86. 2008..Cumulating evidence emphasizes the crucial role of synaptotagmin VII and IX as mediators of glucose-induced insulin secretion...- Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat isletsBenoit R Gauthier
Department of Cell Physiology and Metabolism and Genomics Platform, National Center of Competence in Research Frontiers in Genetics, University of Geneva, 1211 Geneva 4, Switzerland
J Biol Chem 279:31121-30. 2004..In conclusion, loss of PDX1 function alters expression of mitochondrially encoded genes through regulation of TFAM leading to impaired insulin secretion... - Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosisBenoit R Gauthier
Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
FASEB J 22:194-206. 2008..Our results demonstrate that SYTVII is expressed on insulin granules and that only SYTVII alpha is implicated in exocytosis under physiological conditions... - PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppressionBenoit R Gauthier
Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
Cell Metab 10:110-8. 2009..Thus, the genetic control by the beta cell-specific factor Pdx1 of the ubiquitous gene TFAM maintains beta cell mtDNA vital for ATP production and normal GSIS... - The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1Thierry Brun
Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
Hum Mol Genet 17:478-89. 2008..The latter highlights fundamental differences between human and rodent islet physiology and emphasizes the importance of validating results obtained with animal models in human tissues... 
Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stressClare L Kirkpatrick
Department of Cell Physiology and Metabolism, Centre Medical Universitaire, Universite de Geneve, 1 rue Michel Servet, 1211 Geneve 4, Switzerland
J Biol Chem 286:32300-12. 2011..Rat insulin 2 promoter-DN HNF1α mouse islets express lower levels of BiP mRNA, synthesize less insulin, and are sensitized to ER stress relative to matched control mouse islets, suggesting that this mechanism is also operating in vivo...
The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human isletsThierry Brun
Department of Cell Physiology and Metabolism, University Medical Center, Geneva, Switzerland
J Cell Biol 167:1123-35. 2004..We propose that Pax4 is implicated in beta-cell plasticity through the activation of c-myc and potentially protected from apoptosis through Bcl-xL gene expression...- Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin releaseHaiyan Wang
Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, CH 1211 Geneva 4, Switzerland
J Biol Chem 277:17564-70. 2002..These results suggest that Foxa2 is a vital transcription factor evolved to control the expression of genes essential for maintaining beta-cell glucose sensing and glucose homeostasis... - The beta-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6Benoit R Gauthier
Diabetes Unit, Geneva University Hospital, 1211 Geneva 4, Switzerland
Biochem J 403:593-601. 2007..We suggest that cell-specific expression of the glucagon gene may only proceed when Nkx6.1, in combination with Pdx1 and Pax4, are silenced in early alpha-cell precursors... - Transcriptional response of pancreatic beta cells to metabolic stimulation: large scale identification of immediate-early and secondary response genesDominique A Glauser
Fondation pour Recherches Medicales, University of Geneva, Geneva, Switzerland
BMC Mol Biol 8:54. 2007..The identity of these target genes has not been determined, and the sequence of events occurring during beta cell adaptation is still unclear... - In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in miceKai Hui Hu He
Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
Diabetes 60:1705-15. 2011.... - A focus on the role of Pax4 in mature pancreatic islet beta-cell expansion and survival in health and diseaseThierry Brun
Department of Cell Physiology and Metabolism, University Medical Centre, 1211 Geneva 4, Switzerland
J Mol Endocrinol 40:37-45. 2008..This review summarizes promising new published results supporting the important function of Pax4 in mature islet beta-cell physiology and its contribution to pathophysiology when deregulated... - [Pax4, islet plasticity and diabetes]Thierry Brun
, , 1, rue Michel Servet, , Suisse. thierry.brun@ medecine.unige.ch
Med Sci (Paris) 21:358-9. 2005 - Experimental models of transcription factor-associated maturity-onset diabetes of the youngHaiyan Wang
Department of Internal Medicine, Division of Clinical Biochemistry, University Medical Centre, Geneva, Switzerland
Diabetes 51:S333-42. 2002..The presented experimental models are important tools for the elucidation of the beta-cell pathogenesis in MODY syndromes... - Pancreatic insulin content regulation by the estrogen receptor ER alphaPaloma Alonso-Magdalena
Instituto de Bioingenieria, Universidad Miguel Hernandez de Elche, Alicante, Spain
PLoS ONE 3:e2069. 2008..The up-regulation of pancreatic insulin content by ER alpha activation involves ERK1/2. These data may be important to explain the actions of E2 and environmental estrogens in endocrine pancreatic function and blood glucose homeostasis... - Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic isletsKathrin Maedler
Larry L Hillblom Islet Research Center, University of California, Los Angeles, CA, USA
Diabetes 55:2713-22. 2006..These findings indicate that low IL-1beta levels positively influence beta-cell function and turnover through the Fas-FLIP pathway and that IL-1Ra production prevents harmful effects of high IL-1beta concentrations... - The Fas pathway is involved in pancreatic beta cell secretory functionDesiree M Schumann
Clinic of Endocrinology and Diabetes, and Department of Pathology, University Hospital Zurich, CH 8091 Zurich, Switzerland
Proc Natl Acad Sci U S A 104:2861-6. 2007..This led to increased PDX-1 and insulin production independent of changes in cell turnover. The results support a previously undescribed role for the Fas pathway in regulating insulin production and release...