Research Topics
| Jorge GarbinoSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
Report of a successful treatment of pulmonary Cunninghamella bertholletiae infection with liposomal amphotericin and posaconazole in a child with GvHD and review of the literatureJorge Garbino
Division of Infectious Diseases, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
J Pediatr Hematol Oncol 32:85-7. 2010..Treatment with surgery and liposomal amphotericin B followed by posaconazole successfully treated the infection...
Successful treatment of pulmonary invasive aspergillosis with voriconazole in patients who failed conventional therapyJ Garbino
Division of Infectious Disease, Dept of Internal Medicine, University Hospital Geneva, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Infection 31:241-3. 2003..The incidence of fungal infections, including those due to Aspergillosis species has continued to increase in recent years. Invasive aspergillosis remains an important cause of morbidity and mortality, despite therapeutics interventions...- Invasive aspergillosis: is treatment with "inexpensive" amphotericin B cost saving if "expensive" voriconazole is only used on demand?Jorge Garbino
Infectious Disease Division, Unviersity Hospital Geneva, Geneva, Switzerland
Swiss Med Wkly 136:624-30. 2006..However, the latter is often used as initial treatment due to lower drug acquisition costs. Therefore we performed a cost-effectiveness analysis... - Immunomodulatory therapy in yeast infectionsJorge Garbino
University Hospitals of Geneva, Infectious Diseases Division Clinical Research, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
Expert Rev Anti Infect Ther 5:129-40. 2007..Further preclinical and clinical studies, as well as improving our understanding of immune system functions and dysfunctions, remain a future challenge... - Use of high-dose liposomal amphotericin B: efficacy and toleranceJorge Garbino
Division of Infectious Diseases, University Hospitals of Geneva, Geneva, Switzerland
Acta Biomed 77:19-22. 2006..Based on existing evidence from animal models of invasive fungal infections and the earlyclinical experience, L-AmB used athigher doses for invasive fungal infections is a new treatment option... - Fusarium peritonitis concomitant to kidney transplantation successfully managed with voriconazole: case report and review of the literatureJorge Garbino
Division of Infectious Diseases, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
Transpl Int 18:613-8. 2005..We also review previously reported cases of fusarial infection in solid organ transplant recipients... 
Impact of positive legionella urinary antigen test on patient management and improvement of antibiotic useJ Garbino
Division of Infectious Diseases, Department of Internal Medicine, University of Geneva Hospitals, 1211 Geneva 14, Switzerland
J Clin Pathol 57:1302-5. 2004..To assess the incidence of legionella infection over a 27 month period at a large university hospital...- Respiratory viruses in HIV-infected patients with suspected respiratory opportunistic infectionJorge Garbino
Division of Infectious Diseases, University Hospitals of Geneva, Geneva, Switzerland
AIDS 22:701-5. 2008..To assess the incidence and epidemiological pattern of respiratory viruses in HIV-infected patients and to evaluate their potential clinical impact... - A randomized prospective study of cefepime plus metronidazole with imipenem-cilastatin in the treatment of intra-abdominal infectionsJ Garbino
Division of Infectious Diseases, University Hospitals of Geneva, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Infection 35:161-6. 2007..The aim of this study was to evaluate the efficacy of parenteral cefepime + metronidazole vs imipenem-cilastatin for the treatment of intra-abdominal infections in adult patients... - An unusual cause of vertebral osteomyelitis: Candida speciesJorge Garbino
Division of Infectious Diseases, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
Scand J Infect Dis 35:288-91. 2003..Candida species rarely cause spondylodiscitis. During 3 y, 3 cases of vertebral osteomyelitis due to Candida spp. (Candida albicans and Candida tropicalis) were diagnosed, 2 of which were associated with a spinal epidural abscess... - Absidia posttraumatic infection: successful treatment with posaconazoleJ Garbino
Division of Infectious Diseases, University Hospitals of Geneva, 24, Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
J Infect 51:e135-8. 2005..In the present study, we describe a patient who had severe traumatic injury with an Absidia infection, who developed intolerance to antifungal treatment with amphotericin B, but responded to posaconazole treatment... - Arterial mycotic aneurysm rupture following kidney-pancreatic transplantation with exocrine pancreatic drainage into the bladder: an unusual observationJ Garbino
Division of Infectious Diseases, University Hospitals of Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
Ann Vasc Surg 15:393-5. 2001.... - Fungemia in HIV-infected patients: a 12-year study in a tertiary care hospitalJ Garbino
Division of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
AIDS Patient Care STDS 15:407-10. 2001..Fungemias in HIV-infected patients have declined significantly since 1996. This coincides with the introduction of highly active antiretroviral therapy (HAART)... - Should we continue using amphotericin B deoxycholate for the treatment of fungal infections? Adverse events and clinical outcomesJorge Garbino
Division of Infectious Diseases, University Hospitals of Geneva, Switzerland
Scand J Infect Dis 38:110-3. 2006..A retrospective review was undertaken to describe adverse events and clinical outcomes in adult patients with IFI treated with only AmBd as initial therapy... - Successful treatment of Paecilomyces lilacinus endophthalmitis with voriconazoleJorge Garbino
Division of Infectious Diseases, University of Geneva Hospitals, Switzerland
Scand J Infect Dis 34:701-3. 2002..lilacinus endophthalmitis who was treated with the new triazole, voriconazole, for 4 months, with a good clinical evolution. This treatment appears to be a valuable new therapeutic option but requires further clinical confirmation... - Impact of enteral versus parenteral nutrition on the incidence of fungal infections: a retrospective study in ICU patients on mechanical ventilation with selective digestive decontaminationJorge Garbino
Division of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
Clin Nutr 23:705-10. 2004..This study tests the hypothesis that the incidence of fungal infections is lower in critically ill patients under mechanical ventilation receiving enteral rather than total parenteral nutrition... - Respiratory viruses in bronchoalveolar lavage: a hospital-based cohort study in adultsJ Garbino
University Hospitals of Geneva, Switzerland
Thorax 64:399-404. 2009..A study was performed to investigate the association between positive viral detection and respiratory infection in an at-risk population... - Prospective epidemiologic survey of patients with community-acquired pneumonia requiring hospitalization in SwitzerlandJ Garbino
Division of Infectious Diseases, Department of Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland
Int J Infect Dis 6:288-93. 2002..The purpose of this paper is to present the main epidemiologic features of patients with CAP requiring hospitalization in our country... - Antibiotic consumption, bacterial resistance and their correlation in a Swiss university hospital and its adult intensive care unitsJutta M Loeffler
Division of Infectious Diseases, Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland
Scand J Infect Dis 35:843-50. 2003..for cephalosporin, in coagulase-negative staphylococci for gentamicin and in Streptococcus pneumoniae for penicillin... - Secular trends of candidemia over 12 years in adult patients at a tertiary care hospitalJorge Garbino
Department of Internal Medicine, University of Geneva Hospital, Switzerland
Medicine (Baltimore) 81:425-33. 2002..Factors independently associated with higher mortality were patient age greater than 65 years, intensive care unit admission, and underlying cancer... - Invasive candidiasis: comparison of management choices by infectious disease and critical care specialistsPhilippe Eggimann
Infection Control Program, University of Geneva Hospitals, 24 rue Micheli-du-Crest, 1211, Geneva 14, Switzerland
Intensive Care Med 31:1514-21. 2005..1% vs. 51%). CONCLUSIONS: These data highlight differences between management approaches for candidiasis in two groups of specialists, particularly in the reported use of antifungals... - Chronic rhinoviral infection in lung transplant recipientsLaurent Kaiser
Central Laboratory of Virology, Division of Infectious Diseases, Department of Internal Medicine, University Hospitals of Geneva, Switzerland
Am J Respir Crit Care Med 174:1392-9. 2006..Lung transplant recipients are particularly at risk of complications from rhinovirus, the most frequent respiratory virus circulating in the community... - Lower respiratory viral illnesses: improved diagnosis by molecular methods and clinical impactJorge Garbino
Department of Medicine, Division of Infectious Diseases, Central Laboratory of Virology, University Hospitals of Geneva, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
Am J Respir Crit Care Med 170:1197-203. 2004..These viruses were associated with high morbidity, particularly in lung transplant recipients... - Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsisStephan Harbarth
Divisions of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
Am J Med 115:529-35. 2003..To examine the effect of inappropriate initial antimicrobial therapy on the prognosis of patients with sepsis who were enrolled in a clinical trial of an immunomodulating agent conducted in 108 hospitals in North America and Europe... - Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000Oscar Marchetti
Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Clin Infect Dis 38:311-20. 2004..krusei remained rare (2%). Fluconazole consumption increased significantly (P<.001). Despite increasing high-risk activities, the incidence of candidemia remained unchanged, and no shift to resistant species occurred... - A prospective hospital-based study of the clinical impact of non-severe acute respiratory syndrome (Non-SARS)-related human coronavirus infectionJorge Garbino
Division of Infectious Diseases, University Hospitals of Geneva, Geneva, 1211, Switzerland
Clin Infect Dis 43:1009-15. 2006..CONCLUSIONS: The recently discovered HCoVs NL63 and HKU1 contribute significantly to the overall spectrum of coronavirus infection. Our study also suggests that coronaviruses contribute to respiratory symptoms in most cases... - Epidemiology of Candida species infections in critically ill non-immunosuppressed patientsPhilippe Eggimann
Medical Clinic II, the Medical Intensive Care Unit and the Infection Control Programme, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
Lancet Infect Dis 3:685-702. 2003..Management of invasive candidiasis in these patients will be addressed in the December issue of The Lancet Infectious Diseases... - Prevention of severe Candida infections in nonneutropenic, high-risk, critically ill patients: a randomized, double-blind, placebo-controlled trial in patients treated by selective digestive decontaminationJorge Garbino
Division of Infectious Diseases, Department of Internal Medicine, University of Geneva Hospitals, 1211 Geneva 14, Switzerland
Intensive Care Med 28:1708-17. 2002..41% placebo). CONCLUSIONS: Prophylactic use of fluconazole in a selected group of mechanically ventilated patients at high risk for infection reduces the incidence of Candida infections, in particular candidemia... - Respiratory viruses and severe lower respiratory tract complications in hospitalized patientsJorge Garbino
Division of Infectious Diseases, University Hospitals of Geneva, Geneva, Switzerland
Chest 125:1033-9. 2004..CONCLUSION: Respiratory viruses recovered in BAL samples of immunocompromised patients are associated with severe lower respiratory complications. In lung transplant recipients, we observed a persisting impairment of pulmonary function... - Management of Candida species infections in critically ill patientsPhilippe Eggimann
Medical Clinic II and Intensive Care Unit, and the Infection Control Programme, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
Lancet Infect Dis 3:772-85. 2003..Among critically ill patients, azole prophylaxis is effective and is not associated with acquisition of resistance; it must be restricted to highly selected groups of patients at high risk only... - Infection and rejection in liver transplant patients: a 10-year Swiss single-centre experienceJorge Garbino
Division of Infectious Diseases, University Hospitals of Geneva, 1211 Geneva 14, Switzerland
Swiss Med Wkly 135:587-93. 2005..Following OLT, rejection is associated with a higher incidence of infection, mainly of viral origin, concurrent with increased immunosuppressive therapy... - Short parenteral antibiotic treatment for adult septic arthritis after successful drainageIlker Uckay
Orthopedic Surgery Service, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 4, rue Gabrielle Perret Gentil, 1211 Geneva 14, Switzerland Infectious Diseases Service, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland Electronic address
Int J Infect Dis 17:e199-205. 2013..To assess the risk factors for recurrence of septic arthritis with an emphasis on the duration of antibiotic treatment, to gather data for a prospective study on an optimized antibiotic treatment in adults with septic arthritis... - Emerging invasive zygomycosis in a tertiary care center: epidemiology and associated risk factorsJuan Ambrosioni
Division of Infectious Diseases, University of Geneva Hospitals and Faculty of Medicine, 4 rue Gabrielle Perret Gentil, Geneva 14, Switzerland
Int J Infect Dis 14:e100-3. 2010..Presented herein is our investigation of the epidemiological factors associated with an increasing incidence of the disease at the University of Geneva Hospitals, Geneva, Switzerland, over the past five years... - Cefepime versus imipenem-cilastatin for treatment of nosocomial pneumonia in intensive care unit patients: a multicenter, evaluator-blind, prospective, randomized studyG Zanetti
Division of Infectious Diseases, Department of Microbiology, and Intensive Care Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Antimicrob Agents Chemother 47:3442-7. 2003..aeruginosa. Selection of a single agent for therapy of nosocomial pneumonia should be guided by local resistance patterns... 
Recurrent bacteremia with Helicobacter cinaedi: case report and review of the literatureIlker Uckay
Division of Infectious Diseases, Department of Medicine, University Hospital of Geneva, Switzerland
BMC Infect Dis 6:86. 2006..Helicobacter cinaedi is a rare pathogen in humans, occurring mostly in immuno-compromised patients, with a high potential for recurrence. We describe a case of a patient with lymphoma hospitalized for chemotherapy...- Upper and lower respiratory tract viral infections and acute graft rejection in lung transplant recipientsP M Soccal
Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva
Clin Infect Dis 51:163-70. 2010.... - Caspofungin in the treatment of oropharyngeal candidiasisJ Garbino
Division of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
Int J Clin Pract 57:143-4. 2003..Therapy with caspofungin was then initiated (70 mg loading dose, followed by 50 mg/day). The patient responded favourably to caspofungin, with complete resolution of signs and symptoms... - Group A beta-hemolytic streptococcus meningitis: clinical and microbiological features of nine casesR Sommer
Division of Infectious Diseases, University Hospital of Geneva, Switzerland
Clin Infect Dis 29:929-31. 1999..Our observations suggest that GAS meningitis in adults is associated with neurosurgical conditions and/or an upper respiratory tract infection... - Lack of effect of combination antibiotic therapy on mortality in patients with pneumococcal sepsisS Harbarth
Division of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
Eur J Clin Microbiol Infect Dis 24:688-90. 2005..Overall, in contrast to recently published reports, these results suggest that combination antibiotic therapy does not decrease mortality after severe pneumococcal sepsis... - Severe Mycoplasma hominis infections in two renal transplant patientsP Rohner
Service des Maladies Infectieuses, Hopitaux Universitaire de Geneve, 1211 Geneve 14, Switzerland
Eur J Clin Microbiol Infect Dis 23:203-4. 2004..Effective treatment with doxycycline was administered only after definitive identification of Mycoplasma hominis was achieved. For this identification, the new genetic amplification-sequencing method was invaluable... - Atypical infections in tsunami survivorsChristian Garzoni
University Hospitals of Geneva, Geneva, Switzerland
Emerg Infect Dis 11:1591-3. 2005..Treating these infections is challenging from a clinical and microbiologic point of view... - Secular trends of nocardia infection over 15 years in a tertiary care hospitalR Matulionyte
Division of Infectious Diseases, Department of Internal Medicine, University of Geneva Hospitals, 1211Geneva, Switzerland
J Clin Pathol 57:807-12. 2004..Imipenem should be used as an alternative treatment for severely ill patients, and the sulfa combination for less severe infections... - Disseminated Rhizopus microsporus infection cured by salvage allogeneic hematopoietic stem cell transplantation, antifungal combination therapy, and surgical resectionO Lebeau
Department of Medicine, Hematology Division, University Hospital Geneva, Geneva, Switzerland
Transpl Infect Dis 12:269-72. 2010..New combination antifungal therapies might sufficiently control disseminated zygomycosis to allow allo-HSCT to be performed, assuring life-saving immune recovery. Surgery appears to be necessary for definite cure of these infections... - Anti-inflammatory response after infusion of p55 soluble tumor necrosis factor receptor fusion protein for severe sepsisVincent L Butty
Department of Anesthesiology, Pharmacology and Surgical Intensive Care, Geneva University Hospital, 1211 Geneva 14, Switzerland
Eur Cytokine Netw 14:15-9. 2003..Therefore, peripheral inflammatory processes might not have been significantly modified by the treatment. This might account for the lack of efficacy this treatment in septic patients.. - Candida parapsilosis endocarditis: a comparative review of the literatureC Garzoni
Division of Infectious Diseases, University Hospitals of Geneva, 24 Rue Micheli du Crest, Geneva 14, Switzerland
Eur J Clin Microbiol Infect Dis 26:915-26. 2007..Few patients received the newer antifungal agents, and it would appear that more experience is required for their use in the treatment of C. parapsilosis endocarditis... - Disseminated histoplasmosis in an HIV-infected patient discovered by routine blood smear stainingR Matulionyte
Division of Infectious Diseases, University of Geneva Hospitals, 24, rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
Eur J Clin Microbiol Infect Dis 24:361-3. 2005 - Nocardiosis: updated clinical review and experience at a tertiary centerJ Ambrosioni
Division of Infectious Diseases, Faculty of Medicine, University Hospitals of Geneva, 4 rue Gabrielle Perret Gentil, 1211 Geneva 14, Switzerland
Infection 38:89-97. 2010..We report the epidemiologic characteristics of Nocardia spp. observed in our institution and discuss the risk factors, clinical features, diagnosis, and management of the disease... - Invasive fusariosis with prolonged fungemia in a patient with acute lymphoblastic leukemia: case report and review of the literatureM Jossi
Infectious Diseases Division, University Hospitals of Geneva, 24 Rue Micheli du Crest, Geneva 14, Switzerland
Int J Infect Dis 14:e354-6. 2010..A review of the literature for Fusariumspp fungemia was carried out... - A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasisJan Pachl
Charles University, Prague, Czech Republic
Clin Infect Dis 42:1404-13. 2006..3; 95% CI, 1.4-3.8; P = .001). Mycograb was well tolerated. CONCLUSIONS: Mycograb plus lipid-associated amphotericin B produced significant clinical and culture-confirmed improvement in outcome for patients with invasive candidiasis... - Oral nystatin as antifungal prophylaxis in critically ill patients: an old SDD tool to be renewed?Philippe Eggimann
Intensive Care Med 31:1466-8. 2005 - New drugs, old drugs - dear drugs, cheap drugsBernard Hirschel
Swiss Med Wkly 132:301-2. 2002 - Unusual pathogens and multidrug-resistant bacteria in tsunami survivorsJorge Garbino
Clin Infect Dis 42:889-90; author reply 890-1. 2006 - Treatment options of invasive fungal infections in adultsUrsula Fluckiger
Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland
Swiss Med Wkly 136:447-63. 2006..Amphotericin B deoxycholate is recommended as initial therapy for the empirical therapy in patients with neutropenia and persistent fever with close monitoring of adverse events... - Cladophialophora bantiana: a rare cause of fungal brain abscess. Clinical aspects and new therapeutic optionsChristian Garzoni
Infectious Diseases Division, University Hospital of Bern, Bern
Med Mycol 46:481-6. 2008..We discuss clinical, microbiological and practical pharmacological aspects and review current and evolving treatment options... - Long-term risk of atypical fungal infection after near-drowning episodesChristian Garzoni
Pediatrics 119:417; author reply 417-8. 2007 - Is anti-tumor necrosis factor therapy associated with increased mortality in patients with severe sepsis caused by pneumonia?Stephan Harbarth
J Infect Dis 189:1743. 2004