Affiliation: University of Bern
- Activation of intervertebral disc cells by co-culture with notochordal cells, conditioned medium and hypoxiaBenjamin Gantenbein
Tissue and Organ Mechanobiology, Institute for Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
BMC Musculoskelet Disord 15:422. 2014..The aim of this study was to determine NC culture conditions (2D/3D, fetal calf serum, oxygen level) that lead to significant IVD cell activation in an indirect co-culture system under normoxia and hypoxia (2% oxygen)...
- Stochastic amplitude-modulated stretching of rabbit flexor digitorum profundus tendons reduces stiffness compared to cyclic loading but does not affect tenocyte metabolismThomas H Steiner
Institute for Surgical Technology and Biomechanics, University of Bern, Switzerland
BMC Musculoskelet Disord 13:222. 2012..Here, we hypothesized that tenocytes in situ are mechano-responsive to random amplitude modulation of strain...
- The evolutionary importance of cell ratio between notochordal and nucleus pulposus cells: an experimental 3-D co-culture studyBenjamin Gantenbein-Ritter
ARTORG Center for Biomedical Engineering Research, Institute for Surgical Technology and Biomechanics, Medical Faculty, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland
Eur Spine J 21:S819-25. 2012..Human, cattle, sheep, and goat lose the cells with age, whereas rodents and lagomorphs maintain these throughout their lifetime...
- Biological response of the intervertebral disc to repetitive short-term cyclic torsionSamantha C W Chan
ARTORG, Institute for Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
Spine (Phila Pa 1976) 36:2021-30. 2011..In vitro study of the biological response of the intervertebral disc (IVD) to cyclic torsion by using bovine caudal IVDs...
- Intervertebral disc regeneration or repair with biomaterials and stem cell therapy--feasible or fiction?Samantha C W Chan
ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland
Swiss Med Wkly 142:w13598. 2012..The biological solutions for NP and AF replacement are still more fiction than fact. However, tissue engineering just scratched the tip of the iceberg, more satisfying solutions are yet to be added to the biomedical pipeline...
- Papain-induced in vitro disc degeneration model for the study of injectable nucleus pulposus therapySamantha C W Chan
Tissue and Organ Mechanobiology, Institute of Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
Spine J 13:273-83. 2013..Proteolytic enzyme digestion of the intervertebral disc (IVD) offers a method to simulate a condition of disc degeneration for the study of cell-scaffold constructs in the degenerated disc...