Benjamin Gantenbein-Ritter

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi request reprint Organ culture bioreactors--platforms to study human intervertebral disc degeneration and regenerative therapy
    Benjamin Gantenbein
    Institute for Surgical Technology and Biomechanics, Medical Faculty, University, Stauffacherstrasse 78, CH 3014 Bern, Switzerland
    Curr Stem Cell Res Ther 10:339-52. 2015
  2. pmc Activation of intervertebral disc cells by co-culture with notochordal cells, conditioned medium and hypoxia
    Benjamin Gantenbein
    Tissue and Organ Mechanobiology, Institute for Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
    BMC Musculoskelet Disord 15:422. 2014
  3. doi request reprint Papain-induced in vitro disc degeneration model for the study of injectable nucleus pulposus therapy
    Samantha C W Chan
    Tissue and Organ Mechanobiology, Institute of Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
    Spine J 13:273-83. 2013
  4. doi request reprint Assessment of the matrix degenerative effects of MMP-3, ADAMTS-4, and HTRA1, injected into a bovine intervertebral disc organ culture model
    Tina Furtwängler
    Institute for Surgical Technology and Biomechanics, University of Bern, Berne, Switzerland Bone and Stem Cell Research Group, Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Zurich, Switzerland and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Spine (Phila Pa 1976) 38:E1377-87. 2013
  5. pmc Region specific response of intervertebral disc cells to complex dynamic loading: an organ culture study using a dynamic torsion-compression bioreactor
    Samantha C W Chan
    Tissue and Organ Mechanobiology group, Institute for Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
    PLoS ONE 8:e72489. 2013
  6. pmc The evolutionary importance of cell ratio between notochordal and nucleus pulposus cells: an experimental 3-D co-culture study
    Benjamin Gantenbein-Ritter
    ARTORG Center for Biomedical Engineering Research, Institute for Surgical Technology and Biomechanics, Medical Faculty, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland
    Eur Spine J 21:S819-25. 2012
  7. doi request reprint Biological response of the intervertebral disc to repetitive short-term cyclic torsion
    Samantha C W Chan
    ARTORG, Institute for Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
    Spine (Phila Pa 1976) 36:2021-30. 2011
  8. pmc Stochastic amplitude-modulated stretching of rabbit flexor digitorum profundus tendons reduces stiffness compared to cyclic loading but does not affect tenocyte metabolism
    Thomas H Steiner
    Institute for Surgical Technology and Biomechanics, University of Bern, Switzerland
    BMC Musculoskelet Disord 13:222. 2012
  9. pmc The effects of dynamic loading on the intervertebral disc
    Samantha C W Chan
    ARTORG Center for Biomedical Engineering, Spine Research Center, Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014 Bern, Switzerland
    Eur Spine J 20:1796-812. 2011
  10. pmc Nonviral Gene Delivery of Growth and Differentiation Factor 5 to Human Mesenchymal Stem Cells Injected into a 3D Bovine Intervertebral Disc Organ Culture System
    Christian Bücher
    Institute for Surgical Technology and Biomechanics, Tissue and Organ Mechanobiology, Medical Faculty, University of Bern, Stauffacherstra e 78, 3014 Bern, Switzerland
    Stem Cells Int 2013:326828. 2013

Collaborators

  • Stephen J Ferguson
  • Lisbet Haglund
  • Karin Wuertz
  • Samantha C W Chan
  • Benjamin Gantenbein
  • Lorin M Benneker
  • Christof Seiler
  • Thomas Geiser
  • Amiq Gazdhar
  • Christian Bücher
  • Tina Furtwängler
  • Thomas H Steiner
  • Svenja Illien-Jünger
  • Sibylle Grad
  • James C Iatridis
  • Jochen Walser
  • Mauricio Reyes
  • Karin Wuertz-Kozak
  • Klaus A Siebenrock
  • Marius J B Keel
  • Elena Calandriello
  • Gregor Bahrenberg
  • Peter J Richards
  • Alexander Bürki

Detail Information

Publications13

  1. ncbi request reprint Organ culture bioreactors--platforms to study human intervertebral disc degeneration and regenerative therapy
    Benjamin Gantenbein
    Institute for Surgical Technology and Biomechanics, Medical Faculty, University, Stauffacherstrasse 78, CH 3014 Bern, Switzerland
    Curr Stem Cell Res Ther 10:339-52. 2015
    ....
  2. pmc Activation of intervertebral disc cells by co-culture with notochordal cells, conditioned medium and hypoxia
    Benjamin Gantenbein
    Tissue and Organ Mechanobiology, Institute for Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
    BMC Musculoskelet Disord 15:422. 2014
    ..The aim of this study was to determine NC culture conditions (2D/3D, fetal calf serum, oxygen level) that lead to significant IVD cell activation in an indirect co-culture system under normoxia and hypoxia (2% oxygen)...
  3. doi request reprint Papain-induced in vitro disc degeneration model for the study of injectable nucleus pulposus therapy
    Samantha C W Chan
    Tissue and Organ Mechanobiology, Institute of Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
    Spine J 13:273-83. 2013
    ..Proteolytic enzyme digestion of the intervertebral disc (IVD) offers a method to simulate a condition of disc degeneration for the study of cell-scaffold constructs in the degenerated disc...
  4. doi request reprint Assessment of the matrix degenerative effects of MMP-3, ADAMTS-4, and HTRA1, injected into a bovine intervertebral disc organ culture model
    Tina Furtwängler
    Institute for Surgical Technology and Biomechanics, University of Bern, Berne, Switzerland Bone and Stem Cell Research Group, Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Zurich, Switzerland and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Spine (Phila Pa 1976) 38:E1377-87. 2013
    ..In vitro study to develop an intervertebral disc degeneration organ culture model, using coccygeal bovine intervertebral discs (IVDs) and injection of proteolytic enzymes MMP-3, ADAMTS-4, and HTRA1...
  5. pmc Region specific response of intervertebral disc cells to complex dynamic loading: an organ culture study using a dynamic torsion-compression bioreactor
    Samantha C W Chan
    Tissue and Organ Mechanobiology group, Institute for Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
    PLoS ONE 8:e72489. 2013
    ..Cell morphology in the NP of the CCT was changed, as shown by histological evaluation. Our results stress the importance of complex loading on the initiation and progression of disc degeneration. ..
  6. pmc The evolutionary importance of cell ratio between notochordal and nucleus pulposus cells: an experimental 3-D co-culture study
    Benjamin Gantenbein-Ritter
    ARTORG Center for Biomedical Engineering Research, Institute for Surgical Technology and Biomechanics, Medical Faculty, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland
    Eur Spine J 21:S819-25. 2012
    ..Human, cattle, sheep, and goat lose the cells with age, whereas rodents and lagomorphs maintain these throughout their lifetime...
  7. doi request reprint Biological response of the intervertebral disc to repetitive short-term cyclic torsion
    Samantha C W Chan
    ARTORG, Institute for Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
    Spine (Phila Pa 1976) 36:2021-30. 2011
    ..In vitro study of the biological response of the intervertebral disc (IVD) to cyclic torsion by using bovine caudal IVDs...
  8. pmc Stochastic amplitude-modulated stretching of rabbit flexor digitorum profundus tendons reduces stiffness compared to cyclic loading but does not affect tenocyte metabolism
    Thomas H Steiner
    Institute for Surgical Technology and Biomechanics, University of Bern, Switzerland
    BMC Musculoskelet Disord 13:222. 2012
    ..Here, we hypothesized that tenocytes in situ are mechano-responsive to random amplitude modulation of strain...
  9. pmc The effects of dynamic loading on the intervertebral disc
    Samantha C W Chan
    ARTORG Center for Biomedical Engineering, Spine Research Center, Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014 Bern, Switzerland
    Eur Spine J 20:1796-812. 2011
    ..In addition, the parameter space of 'physiological' loading may also be an important factor for the differentiation of stem cells towards most ideally 'discogenic' cells for tissue engineering purpose...
  10. pmc Nonviral Gene Delivery of Growth and Differentiation Factor 5 to Human Mesenchymal Stem Cells Injected into a 3D Bovine Intervertebral Disc Organ Culture System
    Christian Bücher
    Institute for Surgical Technology and Biomechanics, Tissue and Organ Mechanobiology, Medical Faculty, University of Bern, Stauffacherstra e 78, 3014 Bern, Switzerland
    Stem Cells Int 2013:326828. 2013
    ..In this study we demonstrate the potential of GDF5 transfected MSC as a promising approach for clinical translation for disc regeneration...
  11. doi request reprint Intervertebral disc regeneration or repair with biomaterials and stem cell therapy--feasible or fiction?
    Samantha C W Chan
    ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland
    Swiss Med Wkly 142:w13598. 2012
    ..The biological solutions for NP and AF replacement are still more fiction than fact. However, tissue engineering just scratched the tip of the iceberg, more satisfying solutions are yet to be added to the biomedical pipeline...
  12. doi request reprint Confocal imaging protocols for live/dead staining in three-dimensional carriers
    Benjamin Gantenbein-Ritter
    ARTORG, Center for Biomedical Engineering Research, Institute for Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland
    Methods Mol Biol 740:127-40. 2011
    ..Here, we present novel protocols for the staining of 3D tissue (e.g. intervertebral disc tissue) and scaffolds, such as fibrin gels or alginate beads...
  13. doi request reprint Time-lapse microscopy and classification of 2D human mesenchymal stem cells based on cell shape picks up myogenic from osteogenic and adipogenic differentiation
    Christof Seiler
    Institute for Surgical Technology and Biomechanics, University of Bern, Switzerland
    J Tissue Eng Regen Med 8:737-46. 2014
    ..The classification is challenged by cell density, proliferation and possible unknown donor-specific factors, which affect the performance of morphology-based approaches...