Sebastien Gagneux

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Host-pathogen coevolution in human tuberculosis
    Sebastien Gagneux
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute and University of Basel, Basel, Switzerland
    Philos Trans R Soc Lond B Biol Sci 367:850-9. 2012
  2. pmc Two new rapid SNP-typing methods for classifying Mycobacterium tuberculosis complex into the main phylogenetic lineages
    David Stucki
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e41253. 2012
  3. pmc HIV infection disrupts the sympatric host-pathogen relationship in human tuberculosis
    Lukas Fenner
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    PLoS Genet 9:e1003318. 2013
  4. pmc Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes
    Iñaki Comas
    Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, UK
    Nat Genet 44:106-10. 2012
  5. doi request reprint Genetic diversity in Mycobacterium tuberculosis
    Sebastien Gagneux
    Swiss Tropical and Public Health Institute Swiss TPH, University of Basel, Basel, Switzerland
    Curr Top Microbiol Immunol 374:1-25. 2013
  6. ncbi request reprint Prospective study of a serogroup X Neisseria meningitidis outbreak in northern Ghana
    Sébastien P Gagneux
    Swiss Tropical Institute, Socinstrasse 57, 4002 Basel, Switzerland
    J Infect Dis 185:618-26. 2002
  7. pmc Mycobacterium tuberculosis transmission in a country with low tuberculosis incidence: role of immigration and HIV infection
    Lukas Fenner
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    J Clin Microbiol 50:388-95. 2012
  8. pmc Clonal groupings in serogroup X Neisseria meningitidis
    Sebastien Gagneux
    Swiss Tropical Institute, Socinstrasse 57, 4002 Basel, Switzerland
    Emerg Infect Dis 8:462-6. 2002
  9. ncbi request reprint Genetic diversification of Neisseria meningitidis during waves of colonization and disease in the meningitis belt of sub-Saharan Africa
    Julia Leimkugel
    Swiss Tropical Institute, Socinstr 57, 4051 Basel, Switzerland
    Vaccine 25:A18-23. 2007
  10. ncbi request reprint An outbreak of serotype 1 Streptococcus pneumoniae meningitis in northern Ghana with features that are characteristic of Neisseria meningitidis meningitis epidemics
    Julia Leimkugel
    Swiss Tropical Institute, Basel, Switzerland
    J Infect Dis 192:192-9. 2005

Detail Information

Publications28

  1. pmc Host-pathogen coevolution in human tuberculosis
    Sebastien Gagneux
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute and University of Basel, Basel, Switzerland
    Philos Trans R Soc Lond B Biol Sci 367:850-9. 2012
    ..In summary, the biology and the epidemiology of human TB have been shaped by the long-standing association between MTBC and its human host...
  2. pmc Two new rapid SNP-typing methods for classifying Mycobacterium tuberculosis complex into the main phylogenetic lineages
    David Stucki
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e41253. 2012
    ..Furthermore, both methods are rapid, flexible and comparably inexpensive...
  3. pmc HIV infection disrupts the sympatric host-pathogen relationship in human tuberculosis
    Lukas Fenner
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    PLoS Genet 9:e1003318. 2013
    ..In summary, these findings support a model for TB in which the stable relationship between the human host and its locally adapted M. tuberculosis is disrupted by HIV infection...
  4. pmc Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes
    Iñaki Comas
    Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, UK
    Nat Genet 44:106-10. 2012
    ..Our findings support a role for compensatory evolution in the global epidemics of MDR TB...
  5. doi request reprint Genetic diversity in Mycobacterium tuberculosis
    Sebastien Gagneux
    Swiss Tropical and Public Health Institute Swiss TPH, University of Basel, Basel, Switzerland
    Curr Top Microbiol Immunol 374:1-25. 2013
    ..Given the complexity of the host-pathogen interaction in tuberculosis, systems approaches will be key to define the role of MTBC diversity in the fight against one of humankind's most important pathogens. ..
  6. ncbi request reprint Prospective study of a serogroup X Neisseria meningitidis outbreak in northern Ghana
    Sébastien P Gagneux
    Swiss Tropical Institute, Socinstrasse 57, 4002 Basel, Switzerland
    J Infect Dis 185:618-26. 2002
    ..The occurrence of serogroup X outbreaks argues for the inclusion of this serogroup into a multivalent conjugate vaccine against N. meningitidis...
  7. pmc Mycobacterium tuberculosis transmission in a country with low tuberculosis incidence: role of immigration and HIV infection
    Lukas Fenner
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    J Clin Microbiol 50:388-95. 2012
    ..Continued access to health services and clinical follow-up will be essential to control TB in this population...
  8. pmc Clonal groupings in serogroup X Neisseria meningitidis
    Sebastien Gagneux
    Swiss Tropical Institute, Socinstrasse 57, 4002 Basel, Switzerland
    Emerg Infect Dis 8:462-6. 2002
    ..During the last decade, these bacteria have caused meningitis outbreaks in Niger and Ghana. These results support the development of a comprehensive conjugate vaccine that would include serogroup X polysaccharide...
  9. ncbi request reprint Genetic diversification of Neisseria meningitidis during waves of colonization and disease in the meningitis belt of sub-Saharan Africa
    Julia Leimkugel
    Swiss Tropical Institute, Socinstr 57, 4051 Basel, Switzerland
    Vaccine 25:A18-23. 2007
    ....
  10. ncbi request reprint An outbreak of serotype 1 Streptococcus pneumoniae meningitis in northern Ghana with features that are characteristic of Neisseria meningitidis meningitis epidemics
    Julia Leimkugel
    Swiss Tropical Institute, Basel, Switzerland
    J Infect Dis 192:192-9. 2005
    ..These epidemics are generally caused by Neisseria meningitidis, an organism that is considered to be uniquely capable of causing meningitis epidemics...
  11. pmc Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis
    Lukas Fenner
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Antimicrob Agents Chemother 56:3047-53. 2012
    ..Our study also supports a role for epistatic interactions between different drug resistance mutations and strain genetic backgrounds in M. tuberculosis drug resistance...
  12. pmc "Pseudo-Beijing": evidence for convergent evolution in the direct repeat region of Mycobacterium tuberculosis
    Lukas Fenner
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    PLoS ONE 6:e24737. 2011
    ..We used three alternative genotyping techniques to revisit the phylogenetic classification of M. tuberculosis complex (MTBC) strains exhibiting the typical "Beijing" spoligotyping pattern...
  13. pmc First insights into the phylogenetic diversity of Mycobacterium tuberculosis in Nepal
    Bijaya Malla
    Swiss Tropical and Public Health Institute Swiss TPH, Basel, Switzerland
    PLoS ONE 7:e52297. 2012
    ..Tuberculosis (TB) is a major public health problem in Nepal. Strain variation in Mycobacterium tuberculosis may influence the outcome of TB infection and disease. To date, the phylogenetic diversity of M. tuberculosis in Nepal is unknown...
  14. pmc Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes
    Lukas Fenner
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    PLoS ONE 7:e34186. 2012
    ..The aim of this study was to compare characteristics of TB in HIV-negative and HIV-infected patients diagnosed in Switzerland, and between coinfected patients enrolled and not enrolled in the national Swiss HIV Cohort Study (SHCS)...
  15. pmc Drug resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua New Guinea
    Marie Ballif
    Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland
    BMC Microbiol 12:191. 2012
    ..We report for the first time M. tuberculosis mutations associated with resistance to first and second-line anti-TB drugs in Madang, PNG. A molecular cluster analysis was performed to identify M. tuberculosis transmission in that region...
  16. pmc Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologies
    Iñaki Comas
    Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, UK
    PLoS ONE 4:e7815. 2009
    ..Our findings have implications for strain typing in other genetically monomorphic bacteria...
  17. pmc Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved
    Iñaki Comas
    Medical Research Council, National Institute for Medical Research, London, UK
    Nat Genet 42:498-503. 2010
    ..These findings are consistent with strong purifying selection acting on these epitopes, implying that MTBC might benefit from recognition by human T cells...
  18. pmc Clonal waves of Neisseria colonisation and disease in the African meningitis belt: eight- year longitudinal study in northern Ghana
    Julia Leimkugel
    Swiss Tropical Institute, Basel, Switzerland
    PLoS Med 4:e101. 2007
    ....
  19. pmc The heterogeneous evolution of multidrug-resistant Mycobacterium tuberculosis
    Borna Muller
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland
    Trends Genet 29:160-9. 2013
    ..tuberculosis. Improved knowledge of these factors will help better predict the future trajectory of MDR-TB, and contribute to the development of new tools and strategies to combat this growing public health threat...
  20. pmc Novel Mycobacterium tuberculosis complex isolate from a wild chimpanzee
    Mireia Coscollá
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Emerg Infect Dis 19:969-76. 2013
    ..Exploring this diversity is crucial to the understanding of the biology and evolutionary history of this widespread infectious disease...
  21. pmc Single nucleotide polymorphisms in Mycobacterium tuberculosis and the need for a curated database
    David Stucki
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Tuberculosis (Edinb) 93:30-9. 2013
    ..We then review some of the analytical challenges involved in processing SNP data, and end with a list of features, which should be included in a new SNP database for MTBC...
  22. pmc Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa
    Borna Muller
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland
    PLoS ONE 8:e70919. 2013
    ..Since 2010, ethambutol has been replaced by cycloserine or terizidone. The effect of standardized treatment on the acquisition of XDR-TB is not currently known...
  23. pmc The past and future of tuberculosis research
    Iñaki Comas
    Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK
    PLoS Pathog 5:e1000600. 2009
    ..We argue here, however, that new multidisciplinary approaches--especially the integration of epidemiology with systems biology in what we call "systems epidemiology"--will be required to eliminate TB...
  24. pmc A role for systems epidemiology in tuberculosis research
    Iñaki Comas
    Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK
    Trends Microbiol 19:492-500. 2011
    ..Such a multidisciplinary approach might be best described as 'systems epidemiology' in an effort to overcome the traditional boundaries between basic biology and classical epidemiology...
  25. pmc Old and new selective pressures on Mycobacterium tuberculosis
    Daniela Brites
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Infect Genet Evol 12:678-85. 2012
    ..Here we discuss how the emergence of HIV/TB and drug resistance could impact the long-term balance between MTBC and its human host, and how these changes might influence the future evolutionary trajectory of MTBC...
  26. pmc Evaluation of customised lineage-specific sets of MIRU-VNTR loci for genotyping Mycobacterium tuberculosis complex isolates in Ghana
    Adwoa Asante-Poku
    Bacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland
    PLoS ONE 9:e92675. 2014
    ..Here, we evaluated the discriminatory power of a "customized MIRU12" loci format proposed previously by Comas et al. based on the standard 24 loci defined by Supply et al. for VNTR-typing of MTBC in Ghana...
  27. ncbi request reprint Evolution of drug resistance in tuberculosis: recent progress and implications for diagnosis and therapy
    Andrej Trauner
    Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002, Basel, Switzerland
    Drugs 74:1063-72. 2014
    ..In particular, the use of whole genome sequencing combined with surveillance efforts in the field could provide a powerful instrument to prevent future epidemics of drug-resistant tuberculosis. ..