G Gabbiani

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Regulation of alpha-smooth muscle actin and CRBP-1 expression by retinoic acid and TGF-beta in cultured fibroblasts
    G Xu
    Department of Pathology, University of Geneva-CMU, 1 rue Michel Servet, Geneva 4, Switzerland
    J Cell Physiol 187:315-25. 2001
  2. ncbi request reprint Keloids and hypertrophic scars of Caucasians show distinctive morphologic and immunophenotypic profiles
    M Santucci
    Dipartimento di Patologia Umana ed Oncologia, , Italy
    Virchows Arch 438:457-63. 2001
  3. pmc Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation
    B Hinz
    Department of Pathology, University of Geneva, Geneva, Switzerland
    Am J Pathol 159:1009-20. 2001
  4. ncbi request reprint The myofibroblast in wound healing and fibrocontractive diseases
    G Gabbiani
    Department of Pathology, CMU University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Pathol 200:500-3. 2003
  5. ncbi request reprint The cellular derivation and the life span of the myofibroblast
    G Gabbiani
    CMU Department of Pathology, University of Geneva, Switzerland
    Pathol Res Pract 192:708-11. 1996
  6. ncbi request reprint Cultured porcine coronary artery smooth muscle cells. A new model with advanced differentiation
    T Christen
    Department of Pathology, University of Geneva CMU, Geneva, Switzerland
    Circ Res 85:99-107. 1999
  7. ncbi request reprint Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins
    O Skalli
    Department of Pathology, University of Geneva, Switzerland
    Lab Invest 60:275-85. 1989
  8. pmc Characterization of stromal cells with myoid features in lymph nodes and spleen in normal and pathologic conditions
    M F Toccanier-Pelte
    Department of Pathology, University of Geneva, Switzerland
    Am J Pathol 129:109-18. 1987
  9. pmc Alpha-smooth muscle actin expression upregulates fibroblast contractile activity
    B Hinz
    Department of Pathology, CMU, University of Geneva, 1211 Geneva 4, Switzerland
    Mol Biol Cell 12:2730-41. 2001
  10. pmc Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis
    S L Vyalov
    Department of Pathology, Centre Medical Universitaire, Geneva, Switzerland
    Am J Pathol 143:1754-65. 1993

Collaborators

  • Boris Hinz
  • A Desmouliere
  • R B Low
  • D Mastrangelo
  • J W Fischer
  • C A Jahoda
  • A Orlandi
  • M L Bochaton-Piallat
  • T Christen
  • P Neuville
  • V B Dugina
  • G Xu
  • V Dugina
  • S Ribault
  • B Czernobilsky
  • A M Costa
  • S Clement
  • C Chaponnier
  • M Santucci
  • G van Eys
  • M Redard
  • A Iu Aleksandrova
  • Iu M Vasil'ev
  • L Borgognoni
  • L Fontao
  • F Gabbiani
  • B Tuchweber
  • F Ramaekers
  • A Parlakian
  • L Rubbia-Brandt
  • A W Clowes
  • V Verin
  • M Chevallie
  • D Prus
  • D Paulin
  • S Peyrol
  • E Camenzind
  • P Debruyne
  • V Calenda
  • T Pedrazzini
  • C Pellieux
  • M Adham
  • M Bochaton-Piallat
  • M M Clowes
  • Y Popowski
  • B Lifschitz-Mercer
  • D Andreutti
  • J Rosenbaum
  • U M Reali
  • J Vasiliev
  • S Rensen
  • O Skalli
  • S L Vyalov
  • Y Kapanci
  • M F Toccanier-Pelte
  • W Schurch
  • D Montandon
  • T A Seemayer
  • G Bussolati
  • P Gugliotta
  • G Pizzolato
  • M C Peclet
  • F Babai
  • B Pittet
  • R Lagace
  • M F Pelte
  • T Seemayer
  • L Orci
  • M Ravazzola

Detail Information

Publications22

  1. ncbi request reprint Regulation of alpha-smooth muscle actin and CRBP-1 expression by retinoic acid and TGF-beta in cultured fibroblasts
    G Xu
    Department of Pathology, University of Geneva-CMU, 1 rue Michel Servet, Geneva 4, Switzerland
    J Cell Physiol 187:315-25. 2001
    ..The characterization of these pathways will be helpful for the design of drugs influencing wound healing...
  2. ncbi request reprint Keloids and hypertrophic scars of Caucasians show distinctive morphologic and immunophenotypic profiles
    M Santucci
    Dipartimento di Patologia Umana ed Oncologia, , Italy
    Virchows Arch 438:457-63. 2001
    ....
  3. pmc Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation
    B Hinz
    Department of Pathology, University of Geneva, Geneva, Switzerland
    Am J Pathol 159:1009-20. 2001
    ..Our results support the assumption that mechanical tension is crucial for myofibroblast modulation and for the maintenance of their contractile activity...
  4. ncbi request reprint The myofibroblast in wound healing and fibrocontractive diseases
    G Gabbiani
    Department of Pathology, CMU University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Pathol 200:500-3. 2003
    ..These factors also play important roles in the development of fibrocontractive changes, such as those observed in liver cirrhosis, renal fibrosis, and stroma reaction to epithelial tumours...
  5. ncbi request reprint The cellular derivation and the life span of the myofibroblast
    G Gabbiani
    CMU Department of Pathology, University of Geneva, Switzerland
    Pathol Res Pract 192:708-11. 1996
    ..The possibility exists that an altered regulation of this process leads to the development of a hypertrophic scar...
  6. ncbi request reprint Cultured porcine coronary artery smooth muscle cells. A new model with advanced differentiation
    T Christen
    Department of Pathology, University of Geneva CMU, Geneva, Switzerland
    Circ Res 85:99-107. 1999
    ..This model should be a useful complement to in vivo studies of SMC differentiation and of pathological situations such as restenosis and atheromatosis...
  7. ncbi request reprint Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins
    O Skalli
    Department of Pathology, University of Geneva, Switzerland
    Lab Invest 60:275-85. 1989
    ....
  8. pmc Characterization of stromal cells with myoid features in lymph nodes and spleen in normal and pathologic conditions
    M F Toccanier-Pelte
    Department of Pathology, University of Geneva, Switzerland
    Am J Pathol 129:109-18. 1987
    ..It is concluded that a subset of reticular cells in lymph nodes and spleen, as well as pericytes and endothelial cells in high endothelium venules display cytoskeletal features suggesting a myoid differentiation and function...
  9. pmc Alpha-smooth muscle actin expression upregulates fibroblast contractile activity
    B Hinz
    Department of Pathology, CMU, University of Geneva, 1211 Geneva 4, Switzerland
    Mol Biol Cell 12:2730-41. 2001
    ..This took place in the absence of any change in smooth muscle or nonmuscle myosin heavy-chain expression. Our results indicate that an increased alpha-SMA expression is sufficient to enhance fibroblast contractile activity...
  10. pmc Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis
    S L Vyalov
    Department of Pathology, Centre Medical Universitaire, Geneva, Switzerland
    Am J Pathol 143:1754-65. 1993
    ..In such a modulation a possible role of cytokines, particularly of transforming growth factor-beta, is considered...
  11. ncbi request reprint Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes
    O Skalli
    Department of Pathology, University of Geneva, Switzerland
    J Histochem Cytochem 37:315-21. 1989
    ..In SMC and pericytes, alpha-sm actin was localized in microfilament bundles, strengthening the assumption that it is the functional isoform in these cell types and supporting the assumption that pericytes exert contractile functions...
  12. ncbi request reprint Mechanisms of neointima formation and remodeling in the porcine coronary artery
    T Christen
    Department of Pathology, University of Geneva, Divisions of Cardiology, University Hospital Geneva, Geneva, Switzerland
    Circulation 103:882-8. 2001
    ..The adventitial reaction observed after PTCA evolves with a chronology independent of that of neointima formation and probably corresponds to a myofibroblastic reaction...
  13. pmc Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. II. Rhabdomyosarcomas
    O Skalli
    Department of Pathology, University of Geneva, Switzerland
    Am J Pathol 130:515-31. 1988
    ..The presence of alpha-smooth muscle actin in 1 case of rhabdomyosarcoma suggests that this actin isoform may be expressed during skeletal muscle differentiation...
  14. ncbi request reprint Angiotensin II stimulates alpha-skeletal actin expression in cadiomyocytes in vitro and in vivo in the absence of hypertension
    S Clement
    University of Geneva CMU, Department of Pathology, Switzerland
    Differentiation 69:66-74. 2001
    ..Angiotensin II increases also the expression of alpha-smooth muscle actin in sarcomeres of cardiomyocytes as well as in fibroblastic cells present within the culture...
  15. ncbi request reprint Cultured arterial smooth muscle cells maintain distinct phenotypes when implanted into carotid artery
    M L Bochaton-Piallat
    Department of Pathology, University of Geneva, Geneva, Switzerland
    Arterioscler Thromb Vasc Biol 21:949-54. 2001
    ..Our results reinforce the notion of arterial SMC phenotypic heterogeneity and suggest that in our model, heterogeneity is controlled genetically and not by the local environment...
  16. ncbi request reprint Early activation of hepatic stellate cells and perisinusoidal extracellular matrix changes during ex vivo pig liver perfusion
    A M Costa
    Research Group for Liver Study, INSERM E99 17, Victor Segalen University, Bordeaux, France
    J Submicrosc Cytol Pathol 33:231-40. 2001
    ..These results are compatible with the view that HSC function as liver specific pericytes participating in the regulation of sinusoidal blood pressure...
  17. ncbi request reprint Focal adhesion features during myofibroblastic differentiation are controlled by intracellular and extracellular factors
    V Dugina
    Moscow State University, 119899 Moscow, Russia
    J Cell Sci 114:3285-96. 2001
    ..The organisation of this structure is regulated by intracellularly and extracellularly originated forces...
  18. ncbi request reprint [Effect of actomyosin contractility on focal contacts of myofibroblasts and structure of stress fibers]
    V B Dugina
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    Tsitologiia 44:48-55. 2002
    ..Thus, actin-myosin contractility controls the structure of "supermature" focal contacts of myofibroblasts and alpha-SMA expression in stress fibers...
  19. ncbi request reprint Alpha-smooth muscle actin-positive myofibroblasts in endometrial stroma are not a reliable criterion for the diagnosis of well differentiated endometrioid adenocarcinoma in small tissue samples
    B Czernobilsky
    Laboratory of Pathology, Patho-Lab, Ness-Ziona, Israel
    Int J Gynecol Pathol 20:232-8. 2001
    ....
  20. ncbi request reprint Smooth muscle alpha-actin is a marker for hair follicle dermis in vivo and in vitro
    C A Jahoda
    Department of Biological Sciences, University of Dundee, Scotland
    J Cell Sci 99:627-36. 1991
    ....
  21. ncbi request reprint Chimeric smooth muscle-specific enhancer/promoters: valuable tools for adenovirus-mediated cardiovascular gene therapy
    S Ribault
    Cardiovascular Gene Therapy Laboratory, , Strasbourg, France
    Circ Res 88:468-75. 2001
    ..These results indicate that such vectors can be useful for the treatment of hyperproliferative vascular disorders...
  22. ncbi request reprint Cardiac myxoma cells exhibit embryonic endocardial stem cell features
    A Orlandi
    Institute of Anatomic Pathology, Tor Vergata University of Rome, Italy
    J Pathol 209:231-9. 2006
    ....