K Frei

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi request reprint Ex vivo malignant glioma cells are sensitive to Fas (CD95/APO-1) ligand-mediated apoptosis
    K Frei
    Department of Neurosurgery, University Hospital Zurich, Switzerland
    J Neuroimmunol 87:105-13. 1998
  2. ncbi request reprint IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    H P Eugster
    Department of Internal Medicine, University Hospital Zurich, Switzerland
    Eur J Immunol 28:2178-87. 1998
  3. ncbi request reprint Superantigen overcomes resistance of IL-6-deficient mice towards MOG-induced EAE by a TNFR1 controlled pathway
    H P Eugster
    Section of Clinical Immunology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 31:2302-12. 2001
  4. ncbi request reprint Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis
    U C Sahrbacher
    Departement of Internal Medicine, University Hospital Zurich, Switzerland
    Eur J Immunol 28:1332-8. 1998
  5. ncbi request reprint Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice
    U Malipiero
    Department of Neurosurgery, University Hospital Zurich, Switzerland
    Eur J Immunol 27:3151-60. 1997
  6. ncbi request reprint Differential effects of TNF and LTalpha in the host defense against M. bovis BCG
    M Bopst
    Institute of Toxicology, Swiss Federal Institute of Technology, Schwerzenbach, Switzerland
    Eur J Immunol 31:1935-43. 2001
  7. pmc Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice
    R Bachmann
    Institute of Neurology, University of Vienna, Schwarzspanierstrasse 17, 1090 Wien, Austria
    Am J Pathol 154:1417-22. 1999
  8. ncbi request reprint Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1
    H P Eugster
    Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Eur J Immunol 29:626-32. 1999
  9. ncbi request reprint Reduced antilisterial activity of TNF-deficient bone marrow-derived macrophages is due to impaired superoxide production
    M Muller
    Novartis Pharma Research Basel, Switzerland
    Eur J Immunol 29:3089-97. 1999
  10. ncbi request reprint Down-regulation of occludin expression in astrocytes by tumour necrosis factor (TNF) is mediated via TNF type-1 receptor and nuclear factor-kappaB activation
    M Wachtel
    Institute of Biochemistry, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Neurochem 78:155-62. 2001

Collaborators

  • H Lassmann
  • C Agresti
  • M Kopf
  • F Winkler
  • Jurg Tschopp
  • H P Eugster
  • A Fontana
  • M Muller
  • R Bachmann
  • M Wachtel
  • M Bopst
  • H Bluethmann
  • U C Sahrbacher
  • U Malipiero
  • I Garcia
  • M Le Hir
  • S Wyss
  • M F Bolliger
  • S M Gloor
  • M L Olleros
  • T Rülicke
  • W Pfister
  • R Guler
  • U Koedel
  • H Ishihara
  • D Frohlich
  • R Althaus
  • F Lechner
  • M Hahne
  • K S Spanaus

Detail Information

Publications11

  1. ncbi request reprint Ex vivo malignant glioma cells are sensitive to Fas (CD95/APO-1) ligand-mediated apoptosis
    K Frei
    Department of Neurosurgery, University Hospital Zurich, Switzerland
    J Neuroimmunol 87:105-13. 1998
    ..These results suggest that Fas targeting by FasL but not by alpha-Fas antibodies may provide a promising approach for locoregional glioma treatment...
  2. ncbi request reprint IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    H P Eugster
    Department of Internal Medicine, University Hospital Zurich, Switzerland
    Eur J Immunol 28:2178-87. 1998
    ..Taking into account recent studies on the role of VCAM-1 in the entry of Th1 cells into the CNS, the absence of VCAM-1 on endothelial cells in IL-6-/- mice may explain their resistance to EAE...
  3. ncbi request reprint Superantigen overcomes resistance of IL-6-deficient mice towards MOG-induced EAE by a TNFR1 controlled pathway
    H P Eugster
    Section of Clinical Immunology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 31:2302-12. 2001
    ..Taken collectively the effect of SEB to overcome EAE resistance points to a transient IL-6 independent but TNFR1 dependent proinflamatory pathway in EAE pathogenesis and suggests a crucial function for IL-6 in disease perpetuation...
  4. ncbi request reprint Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis
    U C Sahrbacher
    Departement of Internal Medicine, University Hospital Zurich, Switzerland
    Eur J Immunol 28:1332-8. 1998
    ..In conclusion, these results do not support the hypothesis that NO is crucial for the development of EAE...
  5. ncbi request reprint Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice
    U Malipiero
    Department of Neurosurgery, University Hospital Zurich, Switzerland
    Eur J Immunol 27:3151-60. 1997
    ..Unlike oligodendrocytes, astrocytes were killed by FasL in vitro. It remains to be established whether this latter finding explains the different disease course of lpr and gld mice compared to wild-type and perforin knockout mice...
  6. ncbi request reprint Differential effects of TNF and LTalpha in the host defense against M. bovis BCG
    M Bopst
    Institute of Toxicology, Swiss Federal Institute of Technology, Schwerzenbach, Switzerland
    Eur J Immunol 31:1935-43. 2001
    ..These results demonstrate that TNF as well as LTalpha are involved in murine host defense against BCG and that absence of TNF / LTalpha protects BCG-infected mice from LPS mediated shock...
  7. pmc Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice
    R Bachmann
    Institute of Neurology, University of Vienna, Schwarzspanierstrasse 17, 1090 Wien, Austria
    Am J Pathol 154:1417-22. 1999
    ..Our study thus identified the TNF receptor 1 signaling pathway as one mechanism responsible for the removal of T lymphocytes from inflammatory demyelinating lesions of the central nervous system...
  8. ncbi request reprint Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1
    H P Eugster
    Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Eur J Immunol 29:626-32. 1999
    ..Taken together these findings define TNFR1 as crucial mediator in MOG-induced EAE and suggest a protective role for TNFR2 signaling in the clinical course of EAE...
  9. ncbi request reprint Reduced antilisterial activity of TNF-deficient bone marrow-derived macrophages is due to impaired superoxide production
    M Muller
    Novartis Pharma Research Basel, Switzerland
    Eur J Immunol 29:3089-97. 1999
    ..monocytogenes...
  10. ncbi request reprint Down-regulation of occludin expression in astrocytes by tumour necrosis factor (TNF) is mediated via TNF type-1 receptor and nuclear factor-kappaB activation
    M Wachtel
    Institute of Biochemistry, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Neurochem 78:155-62. 2001
    ..These findings demonstrate that TNF selectively down-regulates occludin in astrocytes, but not in cells forming established tight junctions, through TNFR1 and suggest that NF-kappaB is involved as a negative regulator...
  11. pmc Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis
    K Frei
    Department of Neurosurgery, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Exp Med 185:2177-82. 1997
    ..These results indicate that TNF-alpha and LT-alpha are not essential for the development of EAE...