Fraser D, Podvinec M, Kaufmann M, Meyer U. Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR). J Biol Chem. 2002;277:34717-26 pubmed
..This is the first report describing direct transcriptional activation of ALAS1 by drugs via drug-responsive enhancer sequences. ..