Michelangelo Foti

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. pmc The neck of caveolae is a distinct plasma membrane subdomain that concentrates insulin receptors in 3T3-L1 adipocytes
    Michelangelo Foti
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, CH 1211 Geneva, Switzerland
    Proc Natl Acad Sci U S A 104:1242-7. 2007
  2. ncbi request reprint Role of two dileucine-like motifs in insulin receptor anchoring to microvilli
    Sue Shackleton
    Department of Morphology, Faculty of Medicine, University of Geneva, Switzerland
    J Biol Chem 277:43631-7. 2002
  3. doi request reprint Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN
    Manlio Vinciguerra
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland
    J Hepatol 50:1132-41. 2009
  4. doi request reprint Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes
    Manlio Vinciguerra
    Department of Cellular Physiology and Metabolism, Geneva Medical Faculty, Switzerland
    Hepatology 49:1176-84. 2009
  5. ncbi request reprint Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism
    Christopher R Cederroth
    Department of Genetic Medicine and Development, National Centre of Competence in Research Frontiers in Genetics, University of Geneva, 1211 Geneva 4, Switzerland
    Diabetes 57:1176-85. 2008
  6. ncbi request reprint Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation
    Sarah Mouche
    Department of Cellular Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Biochim Biophys Acta 1773:1015-27. 2007
  7. doi request reprint CD4 dimerization requires two cysteines in the cytoplasmic domain of the molecule and occurs in microdomains distinct from lipid rafts
    Margot Fournier
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Mol Immunol 47:2594-603. 2010
  8. pmc Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats
    Nicolas Deblon
    Division of Endocrinology, Diabetology and Nutrition, Department of Internal Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    PLoS ONE 6:e25565. 2011
  9. pmc CC chemokine receptor 5 (CCR5) desensitization: cycling receptors accumulate in the trans-Golgi network
    Jean Michel Escola
    Department of Structural Biology and Bioinformatics, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland
    J Biol Chem 285:41772-80. 2010
  10. pmc The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, World Health Organization Collaborating Center for Osteoporosis Prevention, 1211 Geneva 14, Switzerland
    J Biol Chem 284:35939-50. 2009

Collaborators

Detail Information

Publications29

  1. pmc The neck of caveolae is a distinct plasma membrane subdomain that concentrates insulin receptors in 3T3-L1 adipocytes
    Michelangelo Foti
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, CH 1211 Geneva, Switzerland
    Proc Natl Acad Sci U S A 104:1242-7. 2007
    ....
  2. ncbi request reprint Role of two dileucine-like motifs in insulin receptor anchoring to microvilli
    Sue Shackleton
    Department of Morphology, Faculty of Medicine, University of Geneva, Switzerland
    J Biol Chem 277:43631-7. 2002
    ....
  3. doi request reprint Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN
    Manlio Vinciguerra
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland
    J Hepatol 50:1132-41. 2009
    ..In this study, we investigated whether unsaturated fatty acids promote hepatoma progression by downregulating PTEN expression...
  4. doi request reprint Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes
    Manlio Vinciguerra
    Department of Cellular Physiology and Metabolism, Geneva Medical Faculty, Switzerland
    Hepatology 49:1176-84. 2009
    ..Consistent with these data, microRNA-21 expression was increased in the livers of rats fed high-fat diets and in human liver biopsies of obese patients having diminished PTEN expression and steatosis...
  5. ncbi request reprint Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism
    Christopher R Cederroth
    Department of Genetic Medicine and Development, National Centre of Competence in Research Frontiers in Genetics, University of Geneva, 1211 Geneva 4, Switzerland
    Diabetes 57:1176-85. 2008
    ..Here, we investigate the mechanisms mediating the action of dietary phytoestrogens on lipid and glucose metabolism in rodents...
  6. ncbi request reprint Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation
    Sarah Mouche
    Department of Cellular Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Biochim Biophys Acta 1773:1015-27. 2007
    ..In conclusion, we reveal that decreased NOX4 mRNA content is a hallmark of adipocyte differentiation and that NOX4 expression measured in whole adipose tissue is not an unequivocal indicator of intact or impaired insulin action...
  7. doi request reprint CD4 dimerization requires two cysteines in the cytoplasmic domain of the molecule and occurs in microdomains distinct from lipid rafts
    Margot Fournier
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Mol Immunol 47:2594-603. 2010
    ....
  8. pmc Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats
    Nicolas Deblon
    Division of Endocrinology, Diabetology and Nutrition, Department of Internal Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    PLoS ONE 6:e25565. 2011
    ..Altogether, these results suggest that oxytocin administration could represent a promising therapeutic approach for the treatment of human obesity and type 2 diabetes...
  9. pmc CC chemokine receptor 5 (CCR5) desensitization: cycling receptors accumulate in the trans-Golgi network
    Jean Michel Escola
    Department of Structural Biology and Bioinformatics, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland
    J Biol Chem 285:41772-80. 2010
    ....
  10. pmc The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, World Health Organization Collaborating Center for Osteoporosis Prevention, 1211 Geneva 14, Switzerland
    J Biol Chem 284:35939-50. 2009
    ..Taken together, these results indicate that the matricellular periostin protein is required for Sost inhibition and thereby plays an important role in the determination of bone mass and microstructural in response to loading...
  11. doi request reprint The Lou/C rat: a model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue
    Christelle Veyrat-Durebex
    Department of Internal Medicine, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    Am J Physiol Endocrinol Metab 296:E1120-32. 2009
    ..Independently from its reduced caloric intake, it also exhibits a preferential channeling of nutrients toward utilization rather than storage...
  12. ncbi request reprint Microarray analyses and molecular profiling of steatosis induction in immortalized human hepatocytes
    Andrea De Gottardi
    Division of Gastroenterology and Hepatology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Lab Invest 87:792-806. 2007
    ....
  13. doi request reprint NADPH oxidase 1 deficiency alters caveolin phosphorylation and angiotensin II-receptor localization in vascular smooth muscle
    Olivier Basset
    Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    Antioxid Redox Signal 11:2371-84. 2009
    ..The lack cell-surface AT1R expression in smooth muscle could be involved in the decreased blood pressure in NOX1-deficient mice...
  14. ncbi request reprint PTEN in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and cancer
    Marion Peyrou
    Department of Cellular Physiology and Metabolism, Geneva Medical Faculty, Geneva, Switzerland
    Dig Dis 28:236-46. 2010
    ....
  15. pmc Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters
    Paula Nunes
    Department of Cellular Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Autophagy 9:550-67. 2013
    ..The data document a general and hitherto overlooked mechanism, where autophagy and microtubule remodeling play prominent roles in the osmoprotective response...
  16. pmc p56Lck anchors CD4 to distinct microdomains on microvilli
    Michelangelo Foti
    Department of Morphology, Faculty of Medicine, 1211 Geneva 4, Switzerland
    Proc Natl Acad Sci U S A 99:2008-13. 2002
    ..This localization, which prevents CD4 internalization, might facilitate CD4-mediated adhesion processes and could correspond to the signaling site of the receptor...
  17. ncbi request reprint Insulin-induced vascular endothelial growth factor expression is mediated by the NADPH oxidase NOX3
    Stephanie Carnesecchi
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Exp Cell Res 312:3413-24. 2006
    ..In conclusion, our results demonstrate that NOX3, a ROS generating NADPH oxidase, plays an integral role in insulin-induced p42/44 MAPK signal transmission and VEGF-A production...
  18. doi request reprint PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism
    Marion Peyrou
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Hepatol 59:420-6. 2013
    ..We showed that HCV induces steatosis via the downregulation of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN). We here investigated how PTEN may affect HCV production...
  19. pmc PPARs in Liver Diseases and Cancer: Epigenetic Regulation by MicroRNAs
    Marion Peyrou
    Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universiatire CMU, 1206 Geneva, Switzerland
    PPAR Res 2012:757803. 2012
    ..Recent works highlighting the regulation of PPARs by microRNAs in both physiological and pathological situations with a focus on the liver are also discussed...
  20. doi request reprint Prevention of diabetes in db/db mice by dietary soy is independent of isoflavone levels
    Celine Zimmermann
    Department of Genetic Medicine and Development, University of Geneva Medical School, Switzerland
    Endocrinology 153:5200-11. 2012
    ..Overall, these findings suggest that consumption of soy is beneficial for improving glucose homeostasis and delaying the progression of diabetes in the db/db mice but act independently of isoflavone concentration...
  21. ncbi request reprint Insulin and IGF-1 receptor trafficking and signalling
    Michelangelo Foti
    Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Novartis Found Symp 262:125-41; discussion 141-7, 265-8. 2004
    ....
  22. ncbi request reprint PTEN and SHIP2 phosphoinositide phosphatases as negative regulators of insulin signalling
    Manlio Vinciguerra
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Arch Physiol Biochem 112:89-104. 2006
    ..Current knowledge on the role of PTEN and SHIP2 in insulin resistance, type II diabetes and related disorders will also be discussed...
  23. pmc A phytoestrogen-rich diet increases energy expenditure and decreases adiposity in mice
    Christopher R Cederroth
    Department of Genetic Medicine and Development and National Center for Competence in Research Frontiers in Genetics, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Environ Health Perspect 115:1467-73. 2007
    ..Phytoestrogens are plant-derived compounds with estrogenic activities; they can bind to both estrogen receptors alpha and beta and mimic the action of estrogens on target organs...
  24. doi request reprint Dexamethasone-containing PLGA superparamagnetic microparticles as carriers for the local treatment of arthritis
    Nicoleta Butoescu
    School of Pharmaceutical Sciences, University of Geneva, Switzerland
    Biomaterials 30:1772-80. 2009
    ..This type of carrier could represent a suitable magnetically retainable intra-articular drug delivery system for treating joint diseases such as arthritis or osteoarthritis...
  25. doi request reprint Development of human nervous tissue upon differentiation of embryonic stem cells in three-dimensional culture
    Olivier Preynat-Seauve
    Department of Pathology and Immunology, University of Geneva, Geneva Hospital, Switzerland
    Stem Cells 27:509-20. 2009
    ....
  26. ncbi request reprint Proteomics analysis of insulin secretory granules
    Yannick Brunner
    Biomedical Proteomics Research Group, University Medical Center, 1211 Geneva 4, Switzerland
    Mol Cell Proteomics 6:1007-17. 2007
    ..The elucidation of their role will further help in the understanding of the mechanisms governing impaired insulin secretion during diabetes...
  27. pmc Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1
    Sascha Nydegger
    Graduate Program in Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA
    J Cell Biol 173:795-807. 2006
    ....
  28. ncbi request reprint Membrane stress is coupled to a rapid translational control of gene expression in chlorpromazine-treated cells
    Loic De Filippi
    Département de Microbiologie et Médecine Moléculaire, Centre Medical Universitaire, Universite de Geneve, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Curr Genet 52:171-85. 2007
    ....
  29. ncbi request reprint HIV-1 egress is gated through late endosomal membranes
    Sascha Nydegger
    Department of Microbiology and Molecular Genetics, College of Medicine and CALS, 318 Stafford Hall, University of Vermont, Burlington, VT 05405, USA
    Traffic 4:902-10. 2003
    ..Together with those observations, our study suggests that HIV-1 morphogenesis is thoroughly rooted in the endosomal system...