M Fluck

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi Transcriptional reprogramming during reloading of atrophied rat soleus muscle
    Martin Fluck
    Department of Anatomy, University of Bern, Baltzerstr 2, 3000 Bern 9, Switzerland
    Am J Physiol Regul Integr Comp Physiol 289:R4-14. 2005
  2. ncbi Exercise-modulated mitochondrial phenotype; sensors and gene regulation
    Martin Fluck
    Department of Anatomy, University of Bern, Switzerland
    J Muscle Res Cell Motil 25:235-7. 2004
  3. ncbi [Molecular mechanisms in muscle adaptation]
    M Fluck
    Anatomisches Institut, Universitat Bern, Bern, Schweiz
    Ther Umsch 60:371-81. 2003
  4. ncbi Transient induction of cyclin A in loaded chicken skeletal muscle
    Martin Fluck
    Dept of Anatomy, Univ of Bern, Buhlstrasse 26, 3000 Bern 9, Switzerland
    J Appl Physiol 95:1664-71. 2003
  5. ncbi Molecular basis of skeletal muscle plasticity--from gene to form and function
    M Fluck
    Institute of Anatomy, University of Bern, Buhlstrasse 26, 3000, Bern 9, Switzerland
    Rev Physiol Biochem Pharmacol 146:159-216. 2003
  6. ncbi Tensile stress-dependent collagen XII and fibronectin production by fibroblasts requires separate pathways
    Martin Fluck
    M E Müller Institute for Biomechanics, University of Bern, Bern, Switzerland
    Biochim Biophys Acta 1593:239-48. 2003
  7. ncbi Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers
    Martin Fluck
    M E Müller Institute for Biomechanics, Department of Anatomy, University of Bern, 3000 Bern 9, Switzerland
    Am J Physiol Regul Integr Comp Physiol 284:R792-801. 2003
  8. ncbi Functional, structural and molecular plasticity of mammalian skeletal muscle in response to exercise stimuli
    Martin Fluck
    Unit for Functional Anatomy, Department of Anatomy, University of Berne, Baltzerstrasse 2, Switzerland
    J Exp Biol 209:2239-48. 2006
  9. ncbi Fibre-type specific concentration of focal adhesion kinase at the sarcolemma: influence of fibre innervation and regeneration
    Martin Fluck
    M E Müller Institute for Biomechanics, University of Bern, Bühlestrasse 26, 3000 Bern 9, Switzerland
    J Exp Biol 205:2337-48. 2002
  10. pmc Mechano-regulated tenascin-C orchestrates muscle repair
    Martin Fluck
    Institute of Anatomy and Clinic for Cardiovascular Surgery, University of Bern, CH 3012 Bern, Switzerland
    Proc Natl Acad Sci U S A 105:13662-7. 2008

Collaborators

Detail Information

Publications30

  1. ncbi Transcriptional reprogramming during reloading of atrophied rat soleus muscle
    Martin Fluck
    Department of Anatomy, University of Bern, Baltzerstr 2, 3000 Bern 9, Switzerland
    Am J Physiol Regul Integr Comp Physiol 289:R4-14. 2005
    ..The observations demonstrate that early nuclear reprogramming with reloading of atrophic soleus muscle is coordinated and links to the processes involved in mechanical damage and regeneration of muscle fibers...
  2. ncbi Exercise-modulated mitochondrial phenotype; sensors and gene regulation
    Martin Fluck
    Department of Anatomy, University of Bern, Switzerland
    J Muscle Res Cell Motil 25:235-7. 2004
  3. ncbi [Molecular mechanisms in muscle adaptation]
    M Fluck
    Anatomisches Institut, Universitat Bern, Bern, Schweiz
    Ther Umsch 60:371-81. 2003
    ....
  4. ncbi Transient induction of cyclin A in loaded chicken skeletal muscle
    Martin Fluck
    Dept of Anatomy, Univ of Bern, Buhlstrasse 26, 3000 Bern 9, Switzerland
    J Appl Physiol 95:1664-71. 2003
    ....
  5. ncbi Molecular basis of skeletal muscle plasticity--from gene to form and function
    M Fluck
    Institute of Anatomy, University of Bern, Buhlstrasse 26, 3000, Bern 9, Switzerland
    Rev Physiol Biochem Pharmacol 146:159-216. 2003
    ....
  6. ncbi Tensile stress-dependent collagen XII and fibronectin production by fibroblasts requires separate pathways
    Martin Fluck
    M E Müller Institute for Biomechanics, University of Bern, Bern, Switzerland
    Biochim Biophys Acta 1593:239-48. 2003
    ....
  7. ncbi Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers
    Martin Fluck
    M E Müller Institute for Biomechanics, Department of Anatomy, University of Bern, 3000 Bern 9, Switzerland
    Am J Physiol Regul Integr Comp Physiol 284:R792-801. 2003
    ..The observations demonstrate that an unaccustomed increase of rat soleus muscle loading causes modification of the basement membrane of damaged muscle fibers through ectopic endomysial expression of tenascin-C...
  8. ncbi Functional, structural and molecular plasticity of mammalian skeletal muscle in response to exercise stimuli
    Martin Fluck
    Unit for Functional Anatomy, Department of Anatomy, University of Berne, Baltzerstrasse 2, Switzerland
    J Exp Biol 209:2239-48. 2006
    ..The identification of the basic relationships underlying the malleability of muscle tissue is likely to be of relevance for our understanding of compensatory processes in other tissues, species and organisms...
  9. ncbi Fibre-type specific concentration of focal adhesion kinase at the sarcolemma: influence of fibre innervation and regeneration
    Martin Fluck
    M E Müller Institute for Biomechanics, University of Bern, Bühlestrasse 26, 3000 Bern 9, Switzerland
    J Exp Biol 205:2337-48. 2002
    ..Our data suggest that the integrity of sarcolemmal FACs is dependent on the fibre type and that FAC turnover is increased during regeneration of muscle fibres...
  10. pmc Mechano-regulated tenascin-C orchestrates muscle repair
    Martin Fluck
    Institute of Anatomy and Clinic for Cardiovascular Surgery, University of Bern, CH 3012 Bern, Switzerland
    Proc Natl Acad Sci U S A 105:13662-7. 2008
    ..The results presented here show that a TNC-orchestrated molecular pathway integrates muscle repair into the load-dependent control of the striated muscle phenotype...
  11. ncbi Gene expression in skeletal muscle of coronary artery disease patients after concentric and eccentric endurance training
    J Zoll
    Department of Anatomy, University of Bern, Baltzerstrasse 2, 3000 Bern 9, Switzerland
    Eur J Appl Physiol 96:413-22. 2006
    ....
  12. ncbi Regulatory gene expression in skeletal muscle of highly endurance-trained humans
    M Wittwer
    Department of Anatomy, University of Bern, Bern, Switzerland
    Acta Physiol Scand 180:217-27. 2004
    ..Changes in regulatory and structural gene expression provide the molecular basis for the adaptation of human skeletal muscle to endurance exercise...
  13. ncbi Hypoxia-induced gene activity in disused oxidative muscle
    Christoph Däpp
    Department of Anatomy, University of Berne, Switzerland
    Adv Exp Med Biol 588:171-88. 2006
    ..These findings further imply differential mitochondrial turnover and a negative role of HIF-1 alpha for control of fatty acid oxidation in skeletal muscle exposed to one day of severe hypoxia...
  14. ncbi Prolonged unloading of rat soleus muscle causes distinct adaptations of the gene profile
    Matthias Wittwer
    Institute of Anatomy, University of Bern, Bern, Switzerland
    FASEB J 16:884-6. 2002
    ..soleus transcriptome are put into perspective of the physiological adaptations occurring with muscular atrophy...
  15. ncbi Transcriptional adaptations of lipid metabolism in tibialis anterior muscle of endurance-trained athletes
    Beat Schmitt
    Department of Anatomy, University of Bern, 3000 Bern 9, Switzerland
    Physiol Genomics 15:148-57. 2003
    ....
  16. ncbi Endurance training modulates the muscular transcriptome response to acute exercise
    Silvia Schmutz
    Department of Anatomy, University of Bern, Baltzerstrasse 2, 3000, Bern 9, Switzerland
    Pflugers Arch 451:678-87. 2006
    ..Thus, the response is specifically modified with repeated bouts of endurance exercise during which muscle adjustments are established...
  17. pmc Focal adhesion kinase is a load-dependent governor of the slow contractile and oxidative muscle phenotype
    Anne Cecile Durieux
    Institute for Anatomy, University of Berne, Berne, Switzerland
    J Physiol 587:3703-17. 2009
    ..These results highlight the analytic power of a systematic somatic transgene approach by mapping a role of FAK in the dominant mechano-regulation of muscular motor performance via control of gene expression...
  18. ncbi Rapid and reciprocal regulation of tenascin-C and tenascin-Y expression by loading of skeletal muscle
    M Fluck
    M E Müller Institute for Biomechanics, Murtenstrasse 35, PO Box 30, CH 3010 Bern
    J Cell Sci 113:3583-91. 2000
    ..The results suggest that mechanical loading directly and reciprocally controls the expression of extracellular matrix proteins of the tenascin family in skeletal muscle...
  19. ncbi Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites
    M Fluck
    Department of Integrative Biology and Pharmacology, University of Texas Medical School, Houston, Texas 77030, USA
    Biochem Biophys Res Commun 270:488-94. 2000
    ..The location of Thr-160 in the 3-D structure of SRF suggests that its phosphorylation by nuclear CaMKII may directly influence DNA binding of SRF and other MADS box factors...
  20. ncbi Transcriptional profiling of tissue plasticity: role of shifts in gene expression and technical limitations
    Martin Fluck
    Dept of Anatomy, Baltzerstrasse 2, 3000 Bern 9, Switzerland
    J Appl Physiol 99:397-413. 2005
    ..This allows for later conversion to diverse tissue-relevant references and should improve the physiological interpretations of phenotypic plasticity...
  21. ncbi Gene expression in working skeletal muscle
    Hans Hoppeler
    Department of Anatomy, University of Bern, Bern, Switzerland
    Adv Exp Med Biol 618:245-54. 2007
    ..It therefore seems feasible to use molecular tools to judge the properties of an exercise stimulus much earlier and at a finer level than is possible with conventional functional or structural techniques...
  22. ncbi Muscle transcriptome adaptations with mild eccentric ergometer exercise
    Stephan Klossner
    Institute of Anatomy, University of Berne, Berne, Switzerland
    Pflugers Arch 455:555-62. 2007
    ..This is the first description of the time course of changes in gene expression as a consequence of a mild eccentric stimulus...
  23. ncbi Normal mammalian skeletal muscle and its phenotypic plasticity
    Hans Hoppeler
    Department of Anatomy, University of Bern, Buhlstrasse 26, CH 3000 Bern 9, Switzerland
    J Exp Biol 205:2143-52. 2002
    ....
  24. ncbi Response of skeletal muscle mitochondria to hypoxia
    Hans Hoppeler
    Anatomisches Institut, Buhlstrasse 26, CH 3000 Bern, Switzerland
    Exp Physiol 88:109-19. 2003
    ..How exactly ROS interfere with HIF-1a as well as MAP kinase and other signalling pathways is debated. The current evidence suggests that mitochondria themselves could be important players in oxygen sensing...
  25. ncbi How do fibroblasts translate mechanical signals into changes in extracellular matrix production?
    Matthias Chiquet
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, P O Box 54, Switzerland
    Matrix Biol 22:73-80. 2003
    ..In the case of the tenascin-C gene, different promoter elements might be involved in induction by cyclic stretch. Thus, different mechanical signals seem to regulate distinct ECM genes in complex ways...
  26. ncbi Expressional reprogramming of survival pathways in rat cardiocytes by neuregulin-1beta
    Marie Noelle Giraud
    Swiss Cardiovascular Center, Bern, Switzerland
    J Appl Physiol 99:313-22. 2005
    ..These MAPK-dependent expressional adjustments point to novel oxidative defense and hypertrophy pathways being involved in the longer lasting protective function of neuregulin in the heart...
  27. ncbi Transcriptional reprogramming and ultrastructure during atrophy and recovery of mouse soleus muscle
    Christoph Däpp
    Institute of Anatomy, University of Bern, Bern, Switzerland
    Physiol Genomics 20:97-107. 2004
    ..These species-specific differences need to be considered when transgenic mice are used for the elucidation of monogenetic factors in mechano-dependent muscle plasticity...
  28. ncbi Exercise training in normobaric hypoxia in endurance runners. III. Muscular adjustments of selected gene transcripts
    Joffrey Zoll
    Department of Anatomy, University of Bern, Buhlstrasse 26, 3000 Bern 9, Switzerland
    J Appl Physiol 100:1258-66. 2006
    ..Expressional adaptations involving redox regulation and glucose uptake are being recognized as a potential molecular pathway, resulting in improved endurance performance in hypoxia-trained subjects...
  29. doi Effect of GH on human skeletal muscle lipid metabolism in GH deficiency
    Roman Trepp
    Division of Endocrinology, Diabetology and Clinical Nutrition, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
    Am J Physiol Endocrinol Metab 294:E1127-34. 2008
    ..The upregulation of IGF-I mRNA suggests a paracrine/autocrine role of IGF-I on skeletal muscle...
  30. ncbi Mechanotransduction in striated muscle via focal adhesion kinase
    A C Durieux
    Institute of Anatomy, University of Berne, Berne, Switzerland
    Biochem Soc Trans 35:1312-3. 2007
    ..Recent advances in somatic gene therapy now allow the exploration of the functional involvement of this enzyme in mechanotransduction in intact muscle...