Research Topics
| M FluckSummaryAffiliation: University of Bern Country: Switzerland Publications
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Detail Information
Publications
Transcriptional reprogramming during reloading of atrophied rat soleus muscleMartin Fluck
Department of Anatomy, University of Bern, Baltzerstr 2, 3000 Bern 9, Switzerland
Am J Physiol Regul Integr Comp Physiol 289:R4-14. 2005..The observations demonstrate that early nuclear reprogramming with reloading of atrophic soleus muscle is coordinated and links to the processes involved in mechanical damage and regeneration of muscle fibers...- Exercise-modulated mitochondrial phenotype; sensors and gene regulationMartin Fluck
Department of Anatomy, University of Bern, Switzerland
J Muscle Res Cell Motil 25:235-7. 2004 - [Molecular mechanisms in muscle adaptation]M Fluck
Anatomisches Institut, Universitat Bern, Bern, Schweiz
Ther Umsch 60:371-81. 2003.... - Transient induction of cyclin A in loaded chicken skeletal muscleMartin Fluck
Dept of Anatomy, Univ of Bern, Buhlstrasse 26, 3000 Bern 9, Switzerland
J Appl Physiol 95:1664-71. 2003.... - Molecular basis of skeletal muscle plasticity--from gene to form and functionM Fluck
Institute of Anatomy, University of Bern, Buhlstrasse 26, 3000, Bern 9, Switzerland
Rev Physiol Biochem Pharmacol 146:159-216. 2003.... - Tensile stress-dependent collagen XII and fibronectin production by fibroblasts requires separate pathwaysMartin Fluck
M E Müller Institute for Biomechanics, University of Bern, Bern, Switzerland
Biochim Biophys Acta 1593:239-48. 2003.... - Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibersMartin Fluck
M E Müller Institute for Biomechanics, Department of Anatomy, University of Bern, 3000 Bern 9, Switzerland
Am J Physiol Regul Integr Comp Physiol 284:R792-801. 2003..The observations demonstrate that an unaccustomed increase of rat soleus muscle loading causes modification of the basement membrane of damaged muscle fibers through ectopic endomysial expression of tenascin-C... - Functional, structural and molecular plasticity of mammalian skeletal muscle in response to exercise stimuliMartin Fluck
Unit for Functional Anatomy, Department of Anatomy, University of Berne, Baltzerstrasse 2, Switzerland
J Exp Biol 209:2239-48. 2006..The identification of the basic relationships underlying the malleability of muscle tissue is likely to be of relevance for our understanding of compensatory processes in other tissues, species and organisms... - Fibre-type specific concentration of focal adhesion kinase at the sarcolemma: influence of fibre innervation and regenerationMartin Fluck
M E Müller Institute for Biomechanics, University of Bern, Bühlestrasse 26, 3000 Bern 9, Switzerland
J Exp Biol 205:2337-48. 2002..Our data suggest that the integrity of sarcolemmal FACs is dependent on the fibre type and that FAC turnover is increased during regeneration of muscle fibres... - Mechano-regulated tenascin-C orchestrates muscle repairMartin Fluck
Institute of Anatomy and Clinic for Cardiovascular Surgery, University of Bern, CH 3012 Bern, Switzerland
Proc Natl Acad Sci U S A 105:13662-7. 2008..The results presented here show that a TNC-orchestrated molecular pathway integrates muscle repair into the load-dependent control of the striated muscle phenotype... - Hypoxia-induced gene activity in disused oxidative muscleChristoph Däpp
Department of Anatomy, University of Berne, Switzerland
Adv Exp Med Biol 588:171-88. 2006..These findings further imply differential mitochondrial turnover and a negative role of HIF-1 alpha for control of fatty acid oxidation in skeletal muscle exposed to one day of severe hypoxia... - Prolonged unloading of rat soleus muscle causes distinct adaptations of the gene profileMatthias Wittwer
Institute of Anatomy, University of Bern, Bern, Switzerland
FASEB J 16:884-6. 2002..soleus transcriptome are put into perspective of the physiological adaptations occurring with muscular atrophy... - Endurance training modulates the muscular transcriptome response to acute exerciseSilvia Schmutz
Department of Anatomy, University of Bern, Baltzerstrasse 2, 3000, Bern 9, Switzerland
Pflugers Arch 451:678-87. 2006..Thus, the response is specifically modified with repeated bouts of endurance exercise during which muscle adjustments are established... - Transcriptional adaptations of lipid metabolism in tibialis anterior muscle of endurance-trained athletesBeat Schmitt
Department of Anatomy, University of Bern, 3000 Bern 9, Switzerland
Physiol Genomics 15:148-57. 2003.... - Focal adhesion kinase is a load-dependent governor of the slow contractile and oxidative muscle phenotypeAnne Cecile Durieux
Institute for Anatomy, University of Berne, Berne, Switzerland
J Physiol 587:3703-17. 2009..These results highlight the analytic power of a systematic somatic transgene approach by mapping a role of FAK in the dominant mechano-regulation of muscular motor performance via control of gene expression... - Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sitesM Fluck
Department of Integrative Biology and Pharmacology, University of Texas Medical School, Houston, Texas 77030, USA
Biochem Biophys Res Commun 270:488-94. 2000..The location of Thr-160 in the 3-D structure of SRF suggests that its phosphorylation by nuclear CaMKII may directly influence DNA binding of SRF and other MADS box factors... - Rapid and reciprocal regulation of tenascin-C and tenascin-Y expression by loading of skeletal muscleM Fluck
M E Müller Institute for Biomechanics, Murtenstrasse 35, PO Box 30, CH 3010 Bern
J Cell Sci 113:3583-91. 2000..The results suggest that mechanical loading directly and reciprocally controls the expression of extracellular matrix proteins of the tenascin family in skeletal muscle... - Gene expression in working skeletal muscleHans Hoppeler
Department of Anatomy, University of Bern, Bern, Switzerland
Adv Exp Med Biol 618:245-54. 2007..It therefore seems feasible to use molecular tools to judge the properties of an exercise stimulus much earlier and at a finer level than is possible with conventional functional or structural techniques... - Muscle transcriptome adaptations with mild eccentric ergometer exerciseStephan Klossner
Institute of Anatomy, University of Berne, Berne, Switzerland
Pflugers Arch 455:555-62. 2007..This is the first description of the time course of changes in gene expression as a consequence of a mild eccentric stimulus... - Normal mammalian skeletal muscle and its phenotypic plasticityHans Hoppeler
Department of Anatomy, University of Bern, Buhlstrasse 26, CH 3000 Bern 9, Switzerland
J Exp Biol 205:2143-52. 2002.... - Response of skeletal muscle mitochondria to hypoxiaHans Hoppeler
Anatomisches Institut, Buhlstrasse 26, CH 3000 Bern, Switzerland
Exp Physiol 88:109-19. 2003..How exactly ROS interfere with HIF-1a as well as MAP kinase and other signalling pathways is debated. The current evidence suggests that mitochondria themselves could be important players in oxygen sensing... - How do fibroblasts translate mechanical signals into changes in extracellular matrix production?Matthias Chiquet
ITI Research Institute for Dental and Skeletal Biology, University of Bern, P O Box 54, Switzerland
Matrix Biol 22:73-80. 2003..In the case of the tenascin-C gene, different promoter elements might be involved in induction by cyclic stretch. Thus, different mechanical signals seem to regulate distinct ECM genes in complex ways... - Expressional reprogramming of survival pathways in rat cardiocytes by neuregulin-1betaMarie Noelle Giraud
Swiss Cardiovascular Center, Bern, Switzerland
J Appl Physiol 99:313-22. 2005..These MAPK-dependent expressional adjustments point to novel oxidative defense and hypertrophy pathways being involved in the longer lasting protective function of neuregulin in the heart... - Transcriptional profiling of tissue plasticity: role of shifts in gene expression and technical limitationsMartin Fluck
Dept of Anatomy, Baltzerstrasse 2, 3000 Bern 9, Switzerland
J Appl Physiol 99:397-413. 2005..This allows for later conversion to diverse tissue-relevant references and should improve the physiological interpretations of phenotypic plasticity... - Transcriptional reprogramming and ultrastructure during atrophy and recovery of mouse soleus muscleChristoph Däpp
Institute of Anatomy, University of Bern, Bern, Switzerland
Physiol Genomics 20:97-107. 2004..These species-specific differences need to be considered when transgenic mice are used for the elucidation of monogenetic factors in mechano-dependent muscle plasticity... - Exercise training in normobaric hypoxia in endurance runners. III. Muscular adjustments of selected gene transcriptsJoffrey Zoll
Department of Anatomy, University of Bern, , 3000 Bern 9, Switzerland
J Appl Physiol 100:1258-66. 2006..Expressional adaptations involving redox regulation and glucose uptake are being recognized as a potential molecular pathway, resulting in improved endurance performance in hypoxia-trained subjects... - Effect of GH on human skeletal muscle lipid metabolism in GH deficiencyRoman Trepp
Division of Endocrinology, Diabetology and Clinical Nutrition, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
Am J Physiol Endocrinol Metab 294:E1127-34. 2008..The upregulation of IGF-I mRNA suggests a paracrine/autocrine role of IGF-I on skeletal muscle... - Mechanotransduction in striated muscle via focal adhesion kinaseA C Durieux
Institute of Anatomy, University of Berne, Berne, Switzerland
Biochem Soc Trans 35:1312-3. 2007..Recent advances in somatic gene therapy now allow the exploration of the functional involvement of this enzyme in mechanotransduction in intact muscle...