Josef Flammer

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi The impact of ocular blood flow in glaucoma
    Josef Flammer
    University Eye Clinic, Basel, Switzerland
    Prog Retin Eye Res 21:359-93. 2002
  2. ncbi Retinal vascular diameter in young subjects with a vasospastic propensity
    Fabrizio Branca
    University Eye Clinic of Basel, Mittlere Strasse 91, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 244:454-9. 2006
  3. ncbi Short-term retinal vessel diameter variability in relation to the history of cold extremities
    Asan Kochkorov
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4026-33. 2006
  4. ncbi Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4034-41. 2006
  5. ncbi Short-term variability of systemic blood pressure and submacular choroidal blood flow in eyes of patients with primary open-angle glaucoma
    Asan Kochkorov
    Ophthalmology Department, University Hospital Basel, Mittlerestr 91, CH 4031, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 248:833-7. 2010
  6. ncbi On pulse-wave propagation in the ocular circulation
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4019-25. 2006
  7. ncbi Relationship between optic nerve head and finger blood flow
    Maneli Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Eur J Ophthalmol 20:136-41. 2010
  8. ncbi Diurnal blood pressure variations are associated with changes in distal-proximal skin temperature gradient
    Kurt Krauchi
    Thermophysiological Chronobiology, Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    Chronobiol Int 29:1273-83. 2012
  9. ncbi Choroidal blood flow response to isometric exercise in glaucoma patients and patients with ocular hypertension
    Natalie Portmann
    Ophthalmology Department, University Hospital Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 52:7068-73. 2011
  10. ncbi Rigidity of retinal vessel in untreated eyes of normal tension primary open-angle glaucoma patients
    Alexander Oettli
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    J Glaucoma 20:303-6. 2011

Collaborators

Detail Information

Publications92

  1. ncbi The impact of ocular blood flow in glaucoma
    Josef Flammer
    University Eye Clinic, Basel, Switzerland
    Prog Retin Eye Res 21:359-93. 2002
    ..This review discusses the potential role of OBF in glaucoma and how a disturbance of OBF could increase the optic nerve's sensitivity to IOP...
  2. ncbi Retinal vascular diameter in young subjects with a vasospastic propensity
    Fabrizio Branca
    University Eye Clinic of Basel, Mittlere Strasse 91, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 244:454-9. 2006
    ..It is probable that the steady-state retinal vessel diameters are no adequate risk indicators for the haemodynamic risk in diseases such as glaucoma...
  3. ncbi Short-term retinal vessel diameter variability in relation to the history of cold extremities
    Asan Kochkorov
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4026-33. 2006
    ..029). CONCLUSIONS: Retinal arterioles in healthy vasospastic women show higher spatial irregularity and an increased vessel diameter variation within the temporal frequency of the heartbeat than do arterioles in nonvasospastic women...
  4. ncbi Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4034-41. 2006
    ..To explore the maximum retinal vasodilation in response to repeated flicker light stimulation in relation to vasospastic propensity in healthy subjects...
  5. ncbi Short-term variability of systemic blood pressure and submacular choroidal blood flow in eyes of patients with primary open-angle glaucoma
    Asan Kochkorov
    Ophthalmology Department, University Hospital Basel, Mittlerestr 91, CH 4031, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 248:833-7. 2010
    ..To analyse short-term variability of systemic blood pressure and choroidal blood flow in glaucoma patients, and compare them with ocular hypertensive patients and controls...
  6. ncbi On pulse-wave propagation in the ocular circulation
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4019-25. 2006
    ....
  7. ncbi Relationship between optic nerve head and finger blood flow
    Maneli Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Eur J Ophthalmol 20:136-41. 2010
    ..To examine the relationship between optic nerve head (ONH) and finger blood flow in subjects with and without a primary vascular dysregulation (PVD)...
  8. ncbi Diurnal blood pressure variations are associated with changes in distal-proximal skin temperature gradient
    Kurt Krauchi
    Thermophysiological Chronobiology, Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    Chronobiol Int 29:1273-83. 2012
    ..This finding might have an impact on individual cardiovascular risk prediction with respect to diurnal, seasonal and weather variations; however, the underlying mechanisms remain to be discovered...
  9. ncbi Choroidal blood flow response to isometric exercise in glaucoma patients and patients with ocular hypertension
    Natalie Portmann
    Ophthalmology Department, University Hospital Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 52:7068-73. 2011
    ..To analyze submacular choroidal blood flow (ChBF) response to isometric exercise in untreated patients with glaucoma and ocular hypertension...
  10. ncbi Rigidity of retinal vessel in untreated eyes of normal tension primary open-angle glaucoma patients
    Alexander Oettli
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    J Glaucoma 20:303-6. 2011
    ..To analyze pulse wave propagation in the ocular circulation and vessel stiffness in untreated eyes of normal tension primary open-angle glaucoma (NTG) patients...
  11. ncbi Relationship between retinal glial cell activation in glaucoma and vascular dysregulation
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    J Glaucoma 16:215-9. 2007
    ..To investigate the possible relationship between presumed activated retinal astrocytes and Müller cells (ARAM) and primary vascular dysregulation (PVD) in patients with primary open-angle glaucoma (POAG)...
  12. ncbi Primary cell culture of meningothelial cells--a new model to study the arachnoid in glaucomatous optic neuropathy
    Xiaorong Xin
    Department of Biomedicine, University Eye Clinic, University Hospital Basel, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 248:1273-8. 2010
    ..For this purpose, we developed a culture method for porcine meningothelial cells from the arachnoid layer covering the optic nerve...
  13. ncbi Autoregulation, a balancing act between supply and demand
    Josef Flammer
    University Eye Clinic Basel, Mittlere Str 91, Basel, Switzerland
    Can J Ophthalmol 43:317-21. 2008
    ..This instability, in turn, induces a repeated mild reperfusion injury. The resulting oxidative stress contributes to the pathogenesis of glaucomatous optic neuropathy...
  14. ncbi Cold extremities and difficulties initiating sleep: evidence of co-morbidity from a random sample of a Swiss urban population
    Kurt Krauchi
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Klein Strasse 27, Basel, Switzerland
    J Sleep Res 17:420-6. 2008
    ..Therefore, a thermophysiological approach to DIS may be relevant for its differential diagnosis and its treatment...
  15. ncbi Relationship between ocular pulse amplitude and systemic blood pressure measurements
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland
    Acta Ophthalmol 87:329-34. 2009
    ..This study aimed to determine whether ocular pulse amplitude (OPA) measured with dynamic contour tonometry (DCT) is related to systemic blood pressure (BP) parameters...
  16. ncbi Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure
    Mücahit Satilmis
    University Eye Clinic, Basel, Switzerland
    Am J Ophthalmol 135:664-9. 2003
    ..To evaluate the correlation between progression rate of glaucomatous damage and retrobulbar blood flow in an institutional setting...
  17. ncbi Meningothelial cells react to elevated pressure and oxidative stress
    Xiaorong Xin
    Department of Biomedicine, Ocular Pharmacology and Physiology, University Hospital Basel, Basel, Switzerland
    PLoS ONE 6:e20142. 2011
    ..However, little is known about the influence of pathological conditions on MEC function; e.g., during diseases associated with elevated intracranial pressure, hypoxia or increased oxidative stress...
  18. ncbi Chronobiological characterization of women with primary vasospastic syndrome: body heat loss capacity in relation to sleep initiation and phase of entrainment
    Stephanie Vollenweider
    Psychiatric University Clinics, Thermophysiological Chronobiology, Centre for Chronobiology, Wilhelm Klein Strasse 27, Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 294:R630-8. 2008
    ..2 h; P = 0.01). Similar phase shifts were observed in CBT, DPG, and KSS ratings. In conclusion, WVD exhibit a phase delay of the endogenous circadian system with respect to their habitual sleep-wake cycle, which could be a cause of DIS...
  19. ncbi What is the link between vascular dysregulation and glaucoma?
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Surv Ophthalmol 52:S144-54. 2007
    ..This, in turn, leads to unstable oxygen supply, which seems to be a relevant component in the pathogenesis of glaucomatous optic neuropathy...
  20. ncbi Effect of avosentan (SPP-301) in porcine ciliary arteries
    Katarzyna Konieczka
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Curr Eye Res 36:118-24. 2011
    ..To investigate the effect of avosentan on the endothelin-1 induced contractions in comparison with BQ-123 and BQ-788 (ET(B)-endothelin receptor antagonist) in isolated porcine ciliary arteries with and without endothelium...
  21. ncbi The 'two global flash' mfERG in high and normal tension primary open-angle glaucoma
    Anja M Palmowski-Wolfe
    Department of Ophthalmology, University Eye Hospital, Mittlere Strasse 91, 4012, Basel, Switzerland
    Doc Ophthalmol 114:9-19. 2007
    ..To analyse the sensitivity of the '2 global flash' multifocal electroretinogram (mfERG) to detect glaucomatous dysfunction in normal tension (NTG) and high tension primary open angle glaucoma (POAG) patients...
  22. ncbi Role of anions in nitric oxide-induced short-circuit current increase in isolated porcine ciliary processes
    Renyi Wu
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 45:3213-22. 2004
    ..CONCLUSIONS: NO activates a guanylate cyclase-cGMP-protein kinase G pathway that appears to stimulate stroma-to-aqueous anionic transport, possibly Cl-, in porcine ciliary epithelium...
  23. ncbi Heart-rate variability in women during 40-hour prolonged wakefulness
    Doreen Anders
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    Chronobiol Int 27:1609-28. 2010
    ..One implies circadian control and the other homeostatic control, and both are reflected by the LF/HF ratio...
  24. ncbi Expression and amplification of therapeutic target genes in retinoblastoma
    Doris Bösch
    Universitäts Augenklinik Basel, Mittlere Strasse 91, 4056, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 243:156-62. 2005
    ..We set out to evaluate alterations of the therapeutic target genes KIT (CD 117), EGFR, and HER-2 in human retinoblastoma...
  25. ncbi Phase relationship between skin temperature and sleep-wake rhythms in women with vascular dysregulation and controls under real-life conditions
    Britta Gompper
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Wilhelm Klein Strasse 27, Basel, Switzerland
    Chronobiol Int 27:1778-96. 2010
    ..A full factorial design will have to show whether the finding is specific to primary vascular dysregulation, to DIS, or to their interaction...
  26. ncbi The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    Curr Alzheimer Res 4:47-51. 2007
    ..Since our previous results showed an increase in MT(1) expression in AD retina, the two melatonin receptor subtypes appear to be differentially affected by the course of the neurodegenerative disorder...
  27. ncbi The pathogenesis of optic disc splinter haemorrhages: a new hypothesis
    Matthias C Grieshaber
    University Eye Clinic, University Hospital of Basel, Basel, Switzerland
    Acta Ophthalmol Scand 84:62-8. 2006
    ..CONCLUSIONS: Optic disc haemorrhages may be due to a disturbed blood-retina barrier rather than to a mechanical rupture of the vessel. This barrier dysfunction may occur in the context of PVD...
  28. ncbi Measurement procedures in confocal choroidal laser Doppler flowmetry
    Alain Preitner
    University Eye Clinic, Basel, Switzerland
    Curr Eye Res 28:233-40. 2004
    ..CONCLUSION: It seems recommendable that experimental measurements with a confocal choroidal laser Doppler flowmeter are preceded by a session of familiarization and that average values of series of at least 6 measurements are used...
  29. ncbi Extraocular blood flow and endothelin-1 plasma levels in patients with multiple sclerosis
    Mona Pache
    University Eye Clinic Basel, University Hospital Basel, Basel, Switzerland
    Eur Neurol 49:164-8. 2003
    ..0 +/- 0.4 pg/ml, range 1.1-2.8 vs. 1.5 +/- 0.2 pg/ml, range 0.9-2.0; p < 0.001). Moreover, the patients exhibited significant alterations of extraocular blood flow. The role of ET-1 in the inflammatory process remains to be clarified...
  30. ncbi Choroidal vascular reaction to hand-grip stress in subjects with vasospasm and its relevance in glaucoma
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 44:1573-80. 2003
    ..Damage by glaucoma in patients with a decrease in choroidal blood flow during a hand-grip test may progress at a relatively lower IOP...
  31. ncbi Transient raise of endothelin-1 plasma level and reduction of ocular blood flow in a patient with optic neuritis
    Timo Haufschild
    University Eye Clinic, Basel, Switzerland
    Ophthalmologica 217:451-3. 2003
    ..CONCLUSIONS: We conclude that there might be an ischemic component in this patient with optic neuritis and hypothesize that this ischemic component is at least in part due to a temporarily increased endothelin-1 level...
  32. ncbi Plasma citrate levels as a potential biomarker for glaucoma
    Stephan A Fraenkl
    Department of Ophthalmology, University Hospital Basel, University of Basel, Basel, Switzerland
    J Ocul Pharmacol Ther 27:577-80. 2011
    ..To determine the possibility of plasma citrate as a biomarker in patients with glaucoma...
  33. ncbi Effect of cAMP on porcine ciliary transepithelial short-circuit current, sodium transport, and chloride transport
    Ying Ni
    Laboratory of Ocular Pharmacology and Physiology, University Eye Hospital Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:2065-74. 2006
    ..To investigate the effects of 8-bromo-cAMP (cAMP) on porcine ciliary transepithelial short-circuit current (Isc) and transport of chloride (Cl-) and sodium (Na+)...
  34. ncbi Is the medication used to achieve the target intraocular pressure in glaucoma therapy of relevance?--an exemplary analysis on the basis of two beta-blockers
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland
    Prog Retin Eye Res 29:79-93. 2010
    ..Future studies on glaucoma treatment should focus on their effect on visual field function, and not just on IOP. This should particularly be considered when comparing drugs from different classes...
  35. ncbi Therapeutic strategies for normal-tension glaucoma
    Selim Orgul
    University Eye Clinic, Basel, Switzerland
    Ophthalmologica 219:317-23. 2005
    ..Today, calcium channel blockers seem to be the most promising adjunctive treatment to be considered in patients with glaucomatous optic neuropathy without increased intraocular pressure...
  36. ncbi Reduced thirst in patients with a vasospastic syndrome
    Barbara Teuchner
    University Eye Clinic, Basel, Switzerland
    Acta Ophthalmol Scand 82:738-40. 2004
    ..There was also a non-significant trend among vasospastic subjects to smoke less and to have a smaller BMI. CONCLUSION: A reduced desire to drink is found frequently among vasospastic subjects...
  37. ncbi Circumferential viscocanalostomy and suture canal distension (canaloplasty) for whites with open-angle glaucoma
    Matthias C Grieshaber
    Department of Ophthalmology, Glaucoma Service, University Hospital of Basel, Basel, Switzerland
    J Glaucoma 20:298-302. 2011
    ..To assess the safety and efficacy of canaloplasty (360-degree viscodilation and tensioning of the Schlemm canal) in Whites with open-angle glaucoma (OAG)...
  38. ncbi Vasoactive responses of U46619, PGF2alpha, latanoprost, and travoprost in isolated porcine ciliary arteries
    Ineta Vysniauskiene
    Laboratory of Pharmacology and Physiology, University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:295-8. 2006
    ..05-0.001) either by SQ 29548 or AL-8810. CONCLUSIONS: In isolated porcine ciliary arteries, all prostanoids tested induced contractions. Among them, travoprost appeared to be the least potent and U46619 the most efficient...
  39. ncbi Meningothelial cells participate in immunological processes in the cerebrospinal fluid
    Bin Fan
    Department of Biomedicine and Department of Ophthalmology, University Basel, Basel, Switzerland
    J Neuroimmunol 244:45-50. 2012
    ..In addition, phagocytotic clearance by MECs was enhanced suggesting an immunological role for MECs in the CSF compartment and pointing to a possible connection to neurodegenerative processes...
  40. ncbi Congenital iris ectropion and glaucoma associated with intestinal neuronal dysplasia: a manifestation of a neural crest syndrome
    Matthias C Grieshaber
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Arch Ophthalmol 124:1495-7. 2006
  41. ncbi L-PGDS (betatrace protein) inhibits astrocyte proliferation and mitochondrial ATP production in vitro
    Xiaorong Xin
    University Eye Clinic, Basel, Switzerland
    J Mol Neurosci 39:366-71. 2009
    ..Archives of Ophthalmology, 120, 791-796, 2002), we postulate that a change in the concentration of CSF protein such as L-PGDS could exercise a harmful effect on these structures...
  42. ncbi Oxygen and blood flow: players in the pathogenesis of glaucoma
    Maneli Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Mol Vis 14:224-33. 2008
    ..The resulting peroxynitrat (ONOO(-)) diffuses within the axons towards the retina and the lateral geniculate nucleus and induces apoptosis...
  43. ncbi Vascular dysregulation in the choroid of subjects with acral vasospasm
    Pascal W Hasler
    University Eye Clinic Basel, Mittlere Strasse 92, PO Box 4012, Basel, Switzerland
    Arch Ophthalmol 120:302-7. 2002
    ..001 and P =.003, respectively). CONCLUSIONS: Choroidal blood flow seems, to some degree, to be independent of perfusion pressure, but not in subjects with acral vasospasm...
  44. ncbi Inactivation of MARCH5 prevents mitochondrial fragmentation and interferes with cell death in a neuronal cell model
    Lei Fang
    Department of Biomedicine, University Basel, Basel, Switzerland
    PLoS ONE 7:e52637. 2012
    ..To study the impact of the mitochondrial ubiquitin ligase MARCH5 on mitochondrial morphology and induction of apoptosis using an in vitro model of neuronal precursor cells exposed to glaucoma-relevant stress conditions...
  45. ncbi Thermal discomfort with cold extremities in relation to age, gender, and body mass index in a random sample of a Swiss urban population
    Maneli Mozaffarieh
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Popul Health Metr 8:17. 2010
    ..The aim of this epidemiological study was to investigate the relationship of thermal discomfort with cold extremities (TDCE) to age, gender, and body mass index (BMI) in a Swiss urban population...
  46. ncbi Does the blood-brain barrier play a role in Glaucoma?
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Surv Ophthalmol 52:S115-21. 2007
    ....
  47. ncbi Is there more to glaucoma treatment than lowering IOP?
    Maneli Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Surv Ophthalmol 52:S174-9. 2007
    ..This can be achieved by gingko; dark chocolate; polyphenolic flavonoids occurring in tea, coffee, or red wine; anthocyanosides found in bilberries; as well as by ubiquinone and melatonin...
  48. ncbi Effect of hospitalization on intraocular pressure in patients with high tension and normal tension glaucoma
    Timo Haufschild
    University Eye Clinic Basel, Basel, Switzerland
    Am J Ophthalmol 142:179-81. 2006
    ..Although this decrease was more pronounced among the treated patients, it was also present in nontreated patients. Consequently, other factors than improved compliance during hospitalization must play a role in this phenomenon...
  49. ncbi Experience with Cosopt, the fixed combination of timolol and dorzolamide, after switch from free combination of timolol and dorzolamide, in Swiss ophthalmologists' offices
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Curr Med Res Opin 19:330-5. 2003
    ....
  50. ncbi Vasospastic persons exhibit differential expression of ABC-transport proteins
    Kerstin Wunderlich
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Mol Vis 9:756-61. 2003
    ..To quantify the gene expression levels of the ABC-proteins MDR1 (P-glycoprotein) and MRP (multidrug resistance-associated protein) isoforms in isolated mononuclear cells of vasospastic persons with increased Endothelin-1 plasma levels...
  51. ncbi Adrenomedullin-induced endothelium-dependent relaxation in porcine ciliary arteries
    Eike S Dettmann
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 44:3961-6. 2003
    ..Endothelium-dependent relaxation was blocked by some potassium channel inhibitors, suggesting the possible release of an endothelium-derived hyperpolarizing factor (EDHF)...
  52. ncbi Immunohistochemical localization of angiotensin-converting enzyme, angiotensin II and AT1 receptor in human ocular tissues
    Egemen Savaskan
    Psychiatric University Clinic, University of Basel, Basel, Switzerland
    Ophthalmic Res 36:312-20. 2004
    ..The manifold localization sites of the observed antigens point to rather generalized functions of the RAS in human ocular tissues, such as regulatory effects on neuronal cells, vessels and vitreous humor homeostasis...
  53. ncbi Effect of central corneal thickness on dynamic contour tonometry and Goldmann applanation tonometry in primary open-angle glaucoma
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Mittlere Strasse 91, PO Box, CH 4031 Basel, Switzerland
    Arch Ophthalmol 125:740-4. 2007
    ..To compare the dependence of dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) on central corneal thickness (CCT) in primary open-angle glaucoma...
  54. ncbi Idiopathic isolated abscess in an extraocular muscle in a child
    Timo Haufschild
    Arch Ophthalmol 122:1233-4. 2004
  55. ncbi Half a pack of cigarettes a day more than doubles DNA breaks in circulating leukocytes
    Maneli Mozaffarieh
    Department of Ophthalmology, University of Basel, Mittlere Strasse 91, CH 4031 Basel, Switzerland
    Tob Induc Dis 8:14. 2010
    ..Oxidative stress leads to cellular damage including DNA damage, particularly DNA breaks. We conducted this study to test the hypothesis that smokers have increased DNA breaks in their circulating leukocytes...
  56. ncbi Anatomical and functional outcome in brilliant blue G assisted chromovitrectomy
    Paul B Henrich
    Department of Ophthalmology, University Hospital Basel, Switzerland
    Acta Ophthalmol 88:588-93. 2010
    ..To evaluate the potential of brilliant blue G (BBG) for intraoperative staining of the inner limiting membrane (ILM) with respect to staining properties and surgical outcome...
  57. ncbi Postoperative microhyphema as a positive prognostic indicator in canaloplasty
    Matthias C Grieshaber
    Glaucoma Service, Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland
    Acta Ophthalmol 91:151-6. 2013
    ....
  58. ncbi Colour vision deficiencies in Alzheimer's disease
    Mona Pache
    University Eye Clinic, Mittlere Strasse 91, CH-4012 Basel, Switzerland
    Age Ageing 32:422-6. 2003
    ..0008) than the controls. No relation between test performance and severity of Alzheimer's disease was found. CONCLUSIONS: Alzheimer's disease patients have an unspecific colour vision deficiency independent of the severity of the disease...
  59. ncbi What is the present pathogenetic concept of glaucomatous optic neuropathy?
    Josef Flammer
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Surv Ophthalmol 52:S162-73. 2007
    ..The involvement of primary vascular dysregulation in the pathogenesis of glaucomatous optic neuropathy may explain why women, as well as Japanese, suffer more often from normal-tension glaucoma...
  60. ncbi Septin expression in proliferative retinal membranes
    Xiaorong Xin
    Department of Ophthalmic Pathology, University of Basel, Basel, Switzerland
    J Histochem Cytochem 55:1089-94. 2007
    ..SEPT5 was seen in 54% of all cases; strong immunostaining was found in only one case of PVR membranes. Our finding suggests a role for members of the septin family in the development of proliferative retinal membranes...
  61. ncbi Thermoregulatory effects of melatonin in relation to sleepiness
    Kurt Krauchi
    Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    Chronobiol Int 23:475-84. 2006
    ..Besides the role of melatonin as "nature's soporific", it can also serve as nature's nocturnal vascular modulator...
  62. ncbi Activated STAT 3 in choroidal neovascular membranes of patients with age-related macular degeneration
    Elizaveta Fasler-Kan
    Department of Research, University of Basel, Basel, Switzerland
    Ophthalmologica 219:214-21. 2005
    ..In addition, no immunoreactivity for both STAT 1 and STAT 5 was detected in all CNVM and in all control samples. CONCLUSION: In CNVM, activation of STAT 3 appears in RPE cells simultaneously with the formation of scars...
  63. ncbi Reliability of confocal choroidal laser Doppler flowmetry
    Konstantin Gugleta
    University Eye Clinic Basel, Mittlere Strasse 91, PO Box CH-4012, Basel, Switzerland
    Invest Ophthalmol Vis Sci 43:723-8. 2002
    ..Partializing out the influence of yield markedly improves the reproducibility of choroidal LDF...
  64. ncbi Retinal vasospasm during an attack of migraine
    Hanspeter E Killer
    Augenklinik Kantonsspital Aarau and dagger University Eye Clinic, Basel, Switzerland
    Retina 23:253-4. 2003
  65. ncbi Unilateral fungal and mycobacterial keratitis after simultaneous laser in situ keratomileusis
    Mona Pache
    University Eye Clinic, P.O. Box, CH-4012 Basel, Switzerland
    Cornea 22:72-5. 2003
    ..CONCLUSION: Fungi and M. chelonae are rare and insidious causes of infectious keratitis after LASIK. Our case emphasizes the possible difficulties in diagnosing and treating a combined or subsequent infection with both species...
  66. ncbi 30 Hz-flicker mfERG in primary open-angle glaucoma patients : 30 Hz-flicker-mfERG in POAG
    Margarita G Todorova
    Department of Ophthamlology, University Eye Hospital Basel, Mittlere Strasse 91, CH-4012, Basel, Switzerland
    Doc Ophthalmol 113:11-20. 2006
    ..05-ANOVA). There was no significant correlation between mfERG values and the MD (Spearman-test, Bonferroni). CONCLUSION: Thus, the 30 Hz-flicker mfERG does not seem to be sensitive enough to separate glaucoma patients from normal...
  67. ncbi Increased plasma levels of 20S proteasome alpha-subunit in glaucoma patients: an observational pilot study
    Kerstin Wunderlich
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Mol Vis 8:431-5. 2002
    ..CONCLUSIONS: During the pathological process of glaucoma, proteasome protein levels increase. This indicates that proteasome protein levels may be a diagnostic or eventually a prognostic marker for glaucomatous damage...
  68. ncbi Sequence analysis and high-throughput immunohistochemical profiling of KIT (CD 117) expression in uveal melanoma using tissue microarrays
    Mona Pache
    University Eye Clinic of Basel, Basel, Switzerland
    Virchows Arch 443:741-4. 2003
    ..In conclusion, human posterior uveal melanoma frequently expresses CD117 at high levels. Although KIT mutations could not be found, it appears justified to investigate the utility of imatinib mesylate in the treatment of these patients...
  69. ncbi Effect of melatonin on vascular responses of porcine ciliary arteries
    Mona Pache
    Basel University Eye Clinic, Basel, Switzerland
    Curr Eye Res 24:313-7. 2002
    ..The role of melatonin in human ocular circulation remains to be established...
  70. ncbi Smell perception in normal tension glaucoma patients
    Maneli Mozaffarieh
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Mol Vis 16:506-10. 2010
    ..The aim of this study was to quantify the ability to identify odors in normal tension glaucoma (NTG) patients and healthy subjects with and without a primary vascular dysregulation (PVD)...
  71. ncbi The effect of ranibizumab versus photodynamic therapy on DNA damage in patients with exudative macular degeneration
    M Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Mol Vis 15:1194-9. 2009
    ..To compare the effect of ranibizumab treatment versus photodynamic therapy (PDT) on single-stranded DNA damage in circulating leukocytes in patients with exudative age-related macular degeneration (AMD)...
  72. ncbi The effect of losartan potassium on choroidal hemodynamics in healthy subjects
    Tatiana Spicher
    University Eye Clinic, Basel, Switzerland
    J Glaucoma 11:177-82. 2002
    ..CONCLUSION: A single oral 50-mg dose of the angiotensin II AT1 receptor antagonist losartan potassium given does not disturb the homeostasis of ocular perfusion pressure or choroidal blood flow in young healthy subjects...
  73. ncbi Elevated plasma endothelin-1 levels and vascular dysregulation in patients with rheumatoid arthritis
    Mona Pache
    University Eye Clinic, Basel, Switzerland
    Med Sci Monit 8:CR616-9. 2002
    ....
  74. ncbi Human connective tissue growth factor mRNA expression of epiretinal and subretinal fibrovascular membranes: a report of three cases
    Peter Meyer
    University Eye Clinic, Department of Ophthamopathology, Basel, Switzerland
    Ophthalmologica 216:284-91. 2002
    ....
  75. ncbi The beta-blocker carteolol inhibits contractions induced by KCl in pig ciliary arteries: an effect modulated by extracellular Ca++
    Giovanni Brogiolo
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic, Basel, Switzerland
    Klin Monbl Augenheilkd 219:268-72. 2002
    ..To assess if the vasorelaxing properties of the ocular hypotensive beta-blocker carteolol could share some pharmacological features of calcium-channel antagonists in isolated porcine ciliary arteries...
  76. ncbi Forskolin upregulation of NOS I protein expression in porcine ciliary processes: a new aspect of aqueous humor regulation
    Rong Liu
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic, Basel, Switzerland
    Klin Monatsbl Augenheilkd 219:281-3. 2002
    ..These results suggest that selective inhibition of NOS I could be tried for reducing aqueous humor production. The clinical relevance requires further investigations...
  77. ncbi Vasoactive properties of bimatoprost in isolated porcine ciliary arteries
    Reto Allemann
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Switzerland
    Klin Monatsbl Augenheilkd 220:161-4. 2003
    ..The question whether Lumigan has an influence on ocular blood flow needs to be further investigated...
  78. ncbi Circulatory response to blood gas perturbations in vasospasm
    Konstantin Gugleta
    Ophthalmology Department of the University Eye Clinic Basel, Mittlerestrasse 12, 4012 Basel, Switzerland
    Invest Ophthalmol Vis Sci 46:3288-94. 2005
    ..The women with vasospasm demonstrated an inverse response pattern of choroidal and optic nerve head circulation to blood gas perturbation compared with the women without vasospasm and compared with the men...
  79. ncbi Is open-angle glaucoma caused by impaired cerebrospinal fluid circulation: around the optic nerve?
    Hanspeter E Killer
    University of Basel, Eye Institute, Switzerland
    Clin Experiment Ophthalmol 36:308-11. 2008
    ....
  80. ncbi The effects of antiglaucoma and systemic medications on ocular blood flow
    Vital P Costa
    Glaucoma Service, University of Campinas, Rua Bauru, 40, São Paulo 01248 010, Brazil
    Prog Retin Eye Res 22:769-805. 2003
    ..Longitudinal, prospective, randomized trials are needed to investigate the effects of vasoactive substances with no hypotensive effect on the progression of glaucoma...
  81. ncbi Blood flow in glaucoma
    Matthias C Grieshaber
    University Eye Clinic Basel, Switzerland
    Curr Opin Ophthalmol 16:79-83. 2005
    ..Therapeutically, therefore, both an intraocular pressure reduction and an improvement of the ocular blood flow might be considered...
  82. ncbi Effect of Xalatan(R) and Cosopt(R) on the vascular tone of quiescent isolated pig ciliary arteries
    Mustafa El Sherbini
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Switzerland
    Klin Monatsbl Augenheilkd 219:273-6. 2002
    ..At low dilutions, responses to KCl were inhibited, possibly in relation to an unclear effect of the excipients of Xalatan(R) and Cosopt(R)...
  83. ncbi A novel perspective on natural therapeutic approaches in glaucoma therapy
    Maneli Mozaffarieh
    University Eye Clinic Basel, Mittlere Strasse 91, PO Box, CH 4031 Basel, Switzerland
    Expert Opin Emerg Drugs 12:195-8. 2007
    ..Future intensive studies on the effect of these compounds may open up a new therapeutic era in glaucoma...
  84. ncbi Absence of vasoactive properties of travoprost in isolated porcine ciliary arteries
    Reto Allemann
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Switzerland
    Klin Monatsbl Augenheilkd 220:152-5. 2003
    ....
  85. ncbi Sildenafil induces retinal vasodilatation in healthy subjects
    Mona Pache
    University Eye Clinic Basel, Switzerland
    Br J Ophthalmol 86:156-8. 2002
    ..CONCLUSION: Sildenafil causes a significant dilatation of retinal arteries and veins in healthy subjects. A possible role for PDE5 in the regulation of retinal blood flow is implicated...
  86. ncbi Effect of palmitoleic acid on bradykinin-induced endothelium-dependent relaxation in isolated pig ciliary artery
    Thomas Morf
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Basel
    Klin Monatsbl Augenheilkd 219:284-8. 2002
    ..Further investigations are needed to understand the physiology of the endothelium-dependent ocular blood flow modulation that is considered to be dysregulated in some glaucoma patients...
  87. ncbi What are the biomarkers for glaucoma?
    Olga Golubnitschaja
    Department of Radiology, University of Bonn, Germany
    Surv Ophthalmol 52:S155-61. 2007
    ..New technologies such as disease proteomics and transcriptomics open new perspectives for the development of rapid molecular diagnostics and follow-up in glaucoma...
  88. ncbi Increased expression of matrix metalloproteinases in mononuclear blood cells of normal-tension glaucoma patients
    Olga Golubnitschaja
    Department of Radiology, University of Bonn, Germany
    J Glaucoma 13:66-72. 2004
    ....
  89. ncbi [Reproducibility of measurements with the retinal vessel analyzer under optimal conditions]
    Mona Pache
    , Germany
    Klin Monatsbl Augenheilkd 219:523-7. 2002
    ..97. Long-term variability was 1.5 %, with a kappa of 0.98. CONCLUSION: Due to the high reproducibility of its measurements, the RVA appears to be a useful device for both analysis and follow-up of retinal vessel diameters...
  90. ncbi Fundamental sciences in glaucoma. Introduction
    Matthias C Grieshaber
    Surv Ophthalmol 52:S99-S100. 2007
  91. ncbi Pro: non-penetrating glaucoma surgery--a fair chance
    Tarek Shaarawy
    Graefes Arch Clin Exp Ophthalmol 241:699-702. 2003
  92. ncbi A sick eye in a sick body? Systemic findings in patients with primary open-angle glaucoma
    Mona Pache
    University Eye Clinic Freiburg, Germany
    Surv Ophthalmol 51:179-212. 2006
    ..Furthermore, the diagnosis of glaucoma can affect the patient's quality of life. By highlighting the systemic alterations found in POAG, this review attempts to bring glaucoma into a broader medical context...