Josef Flammer

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint The impact of ocular blood flow in glaucoma
    Josef Flammer
    University Eye Clinic, Basel, Switzerland
    Prog Retin Eye Res 21:359-93. 2002
  2. ncbi request reprint Retinal vascular diameter in young subjects with a vasospastic propensity
    Fabrizio Branca
    University Eye Clinic of Basel, Mittlere Strasse 91, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 244:454-9. 2006
  3. ncbi request reprint Short-term retinal vessel diameter variability in relation to the history of cold extremities
    Asan Kochkorov
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4026-33. 2006
  4. ncbi request reprint Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4034-41. 2006
  5. ncbi request reprint Relationship between optic nerve head and finger blood flow
    Maneli Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Eur J Ophthalmol 20:136-41. 2010
  6. ncbi request reprint On pulse-wave propagation in the ocular circulation
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4019-25. 2006
  7. doi request reprint Short-term variability of systemic blood pressure and submacular choroidal blood flow in eyes of patients with primary open-angle glaucoma
    Asan Kochkorov
    Ophthalmology Department, University Hospital Basel, Mittlerestr 91, CH 4031, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 248:833-7. 2010
  8. doi request reprint Diurnal blood pressure variations are associated with changes in distal-proximal skin temperature gradient
    Kurt Krauchi
    Thermophysiological Chronobiology, Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    Chronobiol Int 29:1273-83. 2012
  9. doi request reprint Choroidal blood flow response to isometric exercise in glaucoma patients and patients with ocular hypertension
    Natalie Portmann
    Ophthalmology Department, University Hospital Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 52:7068-73. 2011
  10. doi request reprint Rigidity of retinal vessel in untreated eyes of normal tension primary open-angle glaucoma patients
    Alexander Oettli
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    J Glaucoma 20:303-6. 2011

Collaborators

Detail Information

Publications98

  1. ncbi request reprint The impact of ocular blood flow in glaucoma
    Josef Flammer
    University Eye Clinic, Basel, Switzerland
    Prog Retin Eye Res 21:359-93. 2002
    ..This review discusses the potential role of OBF in glaucoma and how a disturbance of OBF could increase the optic nerve's sensitivity to IOP...
  2. ncbi request reprint Retinal vascular diameter in young subjects with a vasospastic propensity
    Fabrizio Branca
    University Eye Clinic of Basel, Mittlere Strasse 91, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 244:454-9. 2006
    ....
  3. ncbi request reprint Short-term retinal vessel diameter variability in relation to the history of cold extremities
    Asan Kochkorov
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4026-33. 2006
    ..To test whether the regularity and short-term changes of retinal vessel diameter are related to the history of cold hands and feet and to nailfold circulatory response to cooling...
  4. ncbi request reprint Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4034-41. 2006
    ..To explore the maximum retinal vasodilation in response to repeated flicker light stimulation in relation to vasospastic propensity in healthy subjects...
  5. ncbi request reprint Relationship between optic nerve head and finger blood flow
    Maneli Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Eur J Ophthalmol 20:136-41. 2010
    ..To examine the relationship between optic nerve head (ONH) and finger blood flow in subjects with and without a primary vascular dysregulation (PVD)...
  6. ncbi request reprint On pulse-wave propagation in the ocular circulation
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4019-25. 2006
    ....
  7. doi request reprint Short-term variability of systemic blood pressure and submacular choroidal blood flow in eyes of patients with primary open-angle glaucoma
    Asan Kochkorov
    Ophthalmology Department, University Hospital Basel, Mittlerestr 91, CH 4031, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 248:833-7. 2010
    ..To analyse short-term variability of systemic blood pressure and choroidal blood flow in glaucoma patients, and compare them with ocular hypertensive patients and controls...
  8. doi request reprint Diurnal blood pressure variations are associated with changes in distal-proximal skin temperature gradient
    Kurt Krauchi
    Thermophysiological Chronobiology, Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    Chronobiol Int 29:1273-83. 2012
    ..This finding might have an impact on individual cardiovascular risk prediction with respect to diurnal, seasonal and weather variations; however, the underlying mechanisms remain to be discovered...
  9. doi request reprint Choroidal blood flow response to isometric exercise in glaucoma patients and patients with ocular hypertension
    Natalie Portmann
    Ophthalmology Department, University Hospital Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 52:7068-73. 2011
    ..To analyze submacular choroidal blood flow (ChBF) response to isometric exercise in untreated patients with glaucoma and ocular hypertension...
  10. doi request reprint Rigidity of retinal vessel in untreated eyes of normal tension primary open-angle glaucoma patients
    Alexander Oettli
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    J Glaucoma 20:303-6. 2011
    ..To analyze pulse wave propagation in the ocular circulation and vessel stiffness in untreated eyes of normal tension primary open-angle glaucoma (NTG) patients...
  11. ncbi request reprint Relationship between retinal glial cell activation in glaucoma and vascular dysregulation
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    J Glaucoma 16:215-9. 2007
    ..To investigate the possible relationship between presumed activated retinal astrocytes and Müller cells (ARAM) and primary vascular dysregulation (PVD) in patients with primary open-angle glaucoma (POAG)...
  12. doi request reprint Association between risk factors and glaucomatous damage in untreated primary open-angle glaucoma
    Konstantin Gugleta
    Ophthalmology Department, University Hospital Basel, University of Basel, Basel, Switzerland
    J Glaucoma 22:501-5. 2013
    ..To analyze an association between the presumed risk factors for glaucoma and the actual extent of glaucomatous damage in untreated primary open-angle glaucoma...
  13. ncbi request reprint Choroidal vascular reaction to hand-grip stress in subjects with vasospasm and its relevance in glaucoma
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 44:1573-80. 2003
    ..To assess the impact of vascular dysregulation on choroidal blood flow response to the hand-grip test and the relevance of this response to glaucoma...
  14. doi request reprint Cold extremities and difficulties initiating sleep: evidence of co-morbidity from a random sample of a Swiss urban population
    Kurt Krauchi
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Klein Strasse 27, Basel, Switzerland
    J Sleep Res 17:420-6. 2008
    ..Therefore, a thermophysiological approach to DIS may be relevant for its differential diagnosis and its treatment...
  15. doi request reprint Autoregulation, a balancing act between supply and demand
    Josef Flammer
    University Eye Clinic Basel, Mittlere Str 91, Basel, Switzerland
    Can J Ophthalmol 43:317-21. 2008
    ..This instability, in turn, induces a repeated mild reperfusion injury. The resulting oxidative stress contributes to the pathogenesis of glaucomatous optic neuropathy...
  16. ncbi request reprint Primary cell culture of meningothelial cells--a new model to study the arachnoid in glaucomatous optic neuropathy
    Xiaorong Xin
    Department of Biomedicine, University Eye Clinic, University Hospital Basel, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 248:1273-8. 2010
    ..For this purpose, we developed a culture method for porcine meningothelial cells from the arachnoid layer covering the optic nerve...
  17. doi request reprint Relationship between ocular pulse amplitude and systemic blood pressure measurements
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland
    Acta Ophthalmol 87:329-34. 2009
    ..This study aimed to determine whether ocular pulse amplitude (OPA) measured with dynamic contour tonometry (DCT) is related to systemic blood pressure (BP) parameters...
  18. ncbi request reprint Role of anions in nitric oxide-induced short-circuit current increase in isolated porcine ciliary processes
    Renyi Wu
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 45:3213-22. 2004
    ..To investigate how nitric oxide (NO) modulates short-circuit current (Isc) in isolated porcine ciliary processes...
  19. ncbi request reprint Expression and amplification of therapeutic target genes in retinoblastoma
    Doris Bösch
    Universitäts Augenklinik Basel, Mittlere Strasse 91, 4056, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 243:156-62. 2005
    ..We set out to evaluate alterations of the therapeutic target genes KIT (CD 117), EGFR, and HER-2 in human retinoblastoma...
  20. doi request reprint New insights in the pathogenesis and treatment of normal tension glaucoma
    Maneli Mozaffarieh
    University of Basel, Department of Ophthalmology, Basel, Switzerland
    Curr Opin Pharmacol 13:43-9. 2013
    ..OBF regulation can be improved by magnesium, calcium channel blockers as well as with carbonic anhydrase inhibitors...
  21. pmc Meningothelial cells react to elevated pressure and oxidative stress
    Xiaorong Xin
    Department of Biomedicine, Ocular Pharmacology and Physiology, University Hospital Basel, Basel, Switzerland
    PLoS ONE 6:e20142. 2011
    ..However, little is known about the influence of pathological conditions on MEC function; e.g., during diseases associated with elevated intracranial pressure, hypoxia or increased oxidative stress...
  22. ncbi request reprint What is the link between vascular dysregulation and glaucoma?
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Surv Ophthalmol 52:S144-54. 2007
    ..This, in turn, leads to unstable oxygen supply, which seems to be a relevant component in the pathogenesis of glaucomatous optic neuropathy...
  23. ncbi request reprint Chronobiological characterization of women with primary vasospastic syndrome: body heat loss capacity in relation to sleep initiation and phase of entrainment
    Stephanie Vollenweider
    Psychiatric University Clinics, Thermophysiological Chronobiology, Centre for Chronobiology, Wilhelm Klein Strasse 27, Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 294:R630-8. 2008
    ..2 h; P = 0.01). Similar phase shifts were observed in CBT, DPG, and KSS ratings. In conclusion, WVD exhibit a phase delay of the endogenous circadian system with respect to their habitual sleep-wake cycle, which could be a cause of DIS...
  24. doi request reprint Effect of avosentan (SPP-301) in porcine ciliary arteries
    Katarzyna Konieczka
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Curr Eye Res 36:118-24. 2011
    ..To investigate the effect of avosentan on the endothelin-1 induced contractions in comparison with BQ-123 and BQ-788 (ET(B)-endothelin receptor antagonist) in isolated porcine ciliary arteries with and without endothelium...
  25. doi request reprint Refractoriness to the effect of endothelin-1 in porcine ciliary arteries
    Katarzyna Konieczka
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    J Ocul Pharmacol Ther 29:488-92. 2013
    ..However, few details are known about this phenomenon. The aim of our study was to verify the existence of refractoriness in ophthalmic ciliary arteries and, if present, to analyze its time course...
  26. ncbi request reprint The effect of losartan potassium on choroidal hemodynamics in healthy subjects
    Tatiana Spicher
    University Eye Clinic, Basel, Switzerland
    J Glaucoma 11:177-82. 2002
    ..To investigate the choroidal hemodynamic effects of losartan potassium, a specific angiotensin II subtype AT1 receptor antagonist...
  27. ncbi request reprint The pathogenesis of optic disc splinter haemorrhages: a new hypothesis
    Matthias C Grieshaber
    University Eye Clinic, University Hospital of Basel, Basel, Switzerland
    Acta Ophthalmol Scand 84:62-8. 2006
    ..To describe a hypothesized relationship between optic disc haemorrhages (ODHs) and primary vascular dysregulation (PVD)...
  28. ncbi request reprint Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure
    Mücahit Satilmis
    University Eye Clinic, Basel, Switzerland
    Am J Ophthalmol 135:664-9. 2003
    ..To evaluate the correlation between progression rate of glaucomatous damage and retrobulbar blood flow in an institutional setting...
  29. ncbi request reprint Vascular dysregulation in the choroid of subjects with acral vasospasm
    Pascal W Hasler
    University Eye Clinic Basel, Mittlere Strasse 92, PO Box 4012, Basel, Switzerland
    Arch Ophthalmol 120:302-7. 2002
    ..To assess the relationship between ocular perfusion pressure and blood flow in the choroid in subjects with acral vasospasm...
  30. ncbi request reprint The 'two global flash' mfERG in high and normal tension primary open-angle glaucoma
    Anja M Palmowski-Wolfe
    Department of Ophthalmology, University Eye Hospital, Mittlere Strasse 91, 4012, Basel, Switzerland
    Doc Ophthalmol 114:9-19. 2007
    ..To analyse the sensitivity of the '2 global flash' multifocal electroretinogram (mfERG) to detect glaucomatous dysfunction in normal tension (NTG) and high tension primary open angle glaucoma (POAG) patients...
  31. doi request reprint Heart-rate variability in women during 40-hour prolonged wakefulness
    Doreen Anders
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    Chronobiol Int 27:1609-28. 2010
    ..One implies circadian control and the other homeostatic control, and both are reflected by the LF/HF ratio...
  32. doi request reprint Phase relationship between skin temperature and sleep-wake rhythms in women with vascular dysregulation and controls under real-life conditions
    Britta Gompper
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Wilhelm Klein Strasse 27, Basel, Switzerland
    Chronobiol Int 27:1778-96. 2010
    ..A full factorial design will have to show whether the finding is specific to primary vascular dysregulation, to DIS, or to their interaction...
  33. doi request reprint Meningothelial cells as part of the central nervous system host defence
    Jia Li
    Department of Biomedicine, Ocular Pharmacology and Physiology, University Basel, Basel, Switzerland
    Biol Cell 105:304-15. 2013
    ..In addition, MECs are involved in immunological processes in the brain by secretion of pro-inflammatory cytokines in response to various pathologically relevant stress conditions...
  34. ncbi request reprint Reduced thirst in patients with a vasospastic syndrome
    Barbara Teuchner
    University Eye Clinic, Basel, Switzerland
    Acta Ophthalmol Scand 82:738-40. 2004
    ..To compare thirst, drinking behaviour, and endothelin-1 (ET-1) plasma levels between vasospastic and non-vasospastic subjects...
  35. pmc Inactivation of MARCH5 prevents mitochondrial fragmentation and interferes with cell death in a neuronal cell model
    Lei Fang
    Department of Biomedicine, University Basel, Basel, Switzerland
    PLoS ONE 7:e52637. 2012
    ..To study the impact of the mitochondrial ubiquitin ligase MARCH5 on mitochondrial morphology and induction of apoptosis using an in vitro model of neuronal precursor cells exposed to glaucoma-relevant stress conditions...
  36. ncbi request reprint Postoperative microhyphema as a positive prognostic indicator in canaloplasty
    Matthias C Grieshaber
    Glaucoma Service, Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland
    Acta Ophthalmol 91:151-6. 2013
    ..However, patients with microhyphema had significantly fewer Nd:YAG goniopunctures after surgery than patients without microhyphema (p < 0.001)...
  37. ncbi request reprint Measurement procedures in confocal choroidal laser Doppler flowmetry
    Alain Preitner
    University Eye Clinic, Basel, Switzerland
    Curr Eye Res 28:233-40. 2004
    ..To estimate a practical number of measurements within a series of recordings with a confocal choroidal laser Doppler flowmeter, capable of providing an adequate statistical power for future studies...
  38. ncbi request reprint Extraocular blood flow and endothelin-1 plasma levels in patients with multiple sclerosis
    Mona Pache
    University Eye Clinic Basel, University Hospital Basel, Basel, Switzerland
    Eur Neurol 49:164-8. 2003
    ..0 +/- 0.4 pg/ml, range 1.1-2.8 vs. 1.5 +/- 0.2 pg/ml, range 0.9-2.0; p < 0.001). Moreover, the patients exhibited significant alterations of extraocular blood flow. The role of ET-1 in the inflammatory process remains to be clarified...
  39. ncbi request reprint Transient raise of endothelin-1 plasma level and reduction of ocular blood flow in a patient with optic neuritis
    Timo Haufschild
    University Eye Clinic, Basel, Switzerland
    Ophthalmologica 217:451-3. 2003
    ..To analyze how far an ischemic component might have been involved in optic neuritis...
  40. ncbi request reprint The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    Curr Alzheimer Res 4:47-51. 2007
    ..Since our previous results showed an increase in MT(1) expression in AD retina, the two melatonin receptor subtypes appear to be differentially affected by the course of the neurodegenerative disorder...
  41. doi request reprint Plasma citrate levels as a potential biomarker for glaucoma
    Stephan A Fraenkl
    Department of Ophthalmology, University Hospital Basel, University of Basel, Basel, Switzerland
    J Ocul Pharmacol Ther 27:577-80. 2011
    ..To determine the possibility of plasma citrate as a biomarker in patients with glaucoma...
  42. doi request reprint Is the medication used to achieve the target intraocular pressure in glaucoma therapy of relevance?--an exemplary analysis on the basis of two beta-blockers
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland
    Prog Retin Eye Res 29:79-93. 2010
    ..Future studies on glaucoma treatment should focus on their effect on visual field function, and not just on IOP. This should particularly be considered when comparing drugs from different classes...
  43. doi request reprint Circumferential viscocanalostomy and suture canal distension (canaloplasty) for whites with open-angle glaucoma
    Matthias C Grieshaber
    Department of Ophthalmology, Glaucoma Service, University Hospital of Basel, Basel, Switzerland
    J Glaucoma 20:298-302. 2011
    ..To assess the safety and efficacy of canaloplasty (360-degree viscodilation and tensioning of the Schlemm canal) in Whites with open-angle glaucoma (OAG)...
  44. ncbi request reprint Effect of cAMP on porcine ciliary transepithelial short-circuit current, sodium transport, and chloride transport
    Ying Ni
    Laboratory of Ocular Pharmacology and Physiology, University Eye Hospital Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:2065-74. 2006
    ..To investigate the effects of 8-bromo-cAMP (cAMP) on porcine ciliary transepithelial short-circuit current (Isc) and transport of chloride (Cl-) and sodium (Na+)...
  45. ncbi request reprint Vasoactive responses of U46619, PGF2alpha, latanoprost, and travoprost in isolated porcine ciliary arteries
    Ineta Vysniauskiene
    Laboratory of Pharmacology and Physiology, University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:295-8. 2006
    ..To compare the vasoactive properties of the prostanoids U46619 (thromboxane A2 analogue), prostaglandin F(2alpha) (PGF(2alpha)), latanoprost free acid, and travoprost free acid in isolated porcine ciliary arteries...
  46. ncbi request reprint Therapeutic strategies for normal-tension glaucoma
    Selim Orgul
    University Eye Clinic, Basel, Switzerland
    Ophthalmologica 219:317-23. 2005
    ..Today, calcium channel blockers seem to be the most promising adjunctive treatment to be considered in patients with glaucomatous optic neuropathy without increased intraocular pressure...
  47. pmc Anti-inflammatory response following uptake of apoptotic bodies by meningothelial cells
    Jia Li
    Department of Biomedicine, University Basel, Basel, Switzerland
    J Neuroinflammation 11:35. 2014
    ..As such, they provide important barrier function for the central nervous system (CNS) building the interface between neuronal tissue and the cerebrospinal fluid (CSF), and are also part of the immune response of the CNS...
  48. ncbi request reprint Effect of hospitalization on intraocular pressure in patients with high tension and normal tension glaucoma
    Timo Haufschild
    University Eye Clinic Basel, Basel, Switzerland
    Am J Ophthalmol 142:179-81. 2006
    ..To determine the effect of hospitalization on intraocular pressure (IOP) in glaucoma patients...
  49. doi request reprint Meningothelial cells participate in immunological processes in the cerebrospinal fluid
    Bin Fan
    Department of Biomedicine and Department of Ophthalmology, University Basel, Basel, Switzerland
    J Neuroimmunol 244:45-50. 2012
    ..In addition, phagocytotic clearance by MECs was enhanced suggesting an immunological role for MECs in the CSF compartment and pointing to a possible connection to neurodegenerative processes...
  50. ncbi request reprint L-PGDS (betatrace protein) inhibits astrocyte proliferation and mitochondrial ATP production in vitro
    Xiaorong Xin
    University Eye Clinic, Basel, Switzerland
    J Mol Neurosci 39:366-71. 2009
    ..Archives of Ophthalmology, 120, 791-796, 2002), we postulate that a change in the concentration of CSF protein such as L-PGDS could exercise a harmful effect on these structures...
  51. pmc Oxygen and blood flow: players in the pathogenesis of glaucoma
    Maneli Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Mol Vis 14:224-33. 2008
    ..The exact mechanisms leading to the corresponding changes in the TM are not yet known. We know, however, that all risk factors for arteriosclerosis are also risk factors for an increase in IOP...
  52. ncbi request reprint Congenital iris ectropion and glaucoma associated with intestinal neuronal dysplasia: a manifestation of a neural crest syndrome
    Matthias C Grieshaber
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Arch Ophthalmol 124:1495-7. 2006
  53. pmc Septin expression in proliferative retinal membranes
    Xiaorong Xin
    Department of Ophthalmic Pathology, University of Basel, Basel, Switzerland
    J Histochem Cytochem 55:1089-94. 2007
    ..SEPT5 was seen in 54% of all cases; strong immunostaining was found in only one case of PVR membranes. Our finding suggests a role for members of the septin family in the development of proliferative retinal membranes...
  54. ncbi request reprint Effect of melatonin on vascular responses of porcine ciliary arteries
    Mona Pache
    Basel University Eye Clinic, Basel, Switzerland
    Curr Eye Res 24:313-7. 2002
    ..To investigate the effect of melatonin on isolated porcine ciliary arteries...
  55. ncbi request reprint Thermoregulatory effects of melatonin in relation to sleepiness
    Kurt Krauchi
    Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    Chronobiol Int 23:475-84. 2006
    ..Besides the role of melatonin as "nature's soporific", it can also serve as nature's nocturnal vascular modulator...
  56. ncbi request reprint Is there more to glaucoma treatment than lowering IOP?
    Maneli Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Surv Ophthalmol 52:S174-9. 2007
    ..This can be achieved by gingko; dark chocolate; polyphenolic flavonoids occurring in tea, coffee, or red wine; anthocyanosides found in bilberries; as well as by ubiquinone and melatonin...
  57. ncbi request reprint Experience with Cosopt, the fixed combination of timolol and dorzolamide, after switch from free combination of timolol and dorzolamide, in Swiss ophthalmologists' offices
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Curr Med Res Opin 19:330-5. 2003
    ....
  58. ncbi request reprint Vasospastic persons exhibit differential expression of ABC-transport proteins
    Kerstin Wunderlich
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Mol Vis 9:756-61. 2003
    ..To quantify the gene expression levels of the ABC-proteins MDR1 (P-glycoprotein) and MRP (multidrug resistance-associated protein) isoforms in isolated mononuclear cells of vasospastic persons with increased Endothelin-1 plasma levels...
  59. ncbi request reprint Immunohistochemical localization of angiotensin-converting enzyme, angiotensin II and AT1 receptor in human ocular tissues
    Egemen Savaskan
    Psychiatric University Clinic, University of Basel, Basel, Switzerland
    Ophthalmic Res 36:312-20. 2004
    ..The manifold localization sites of the observed antigens point to rather generalized functions of the RAS in human ocular tissues, such as regulatory effects on neuronal cells, vessels and vitreous humor homeostasis...
  60. ncbi request reprint Adrenomedullin-induced endothelium-dependent relaxation in porcine ciliary arteries
    Eike S Dettmann
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 44:3961-6. 2003
    ..To investigate adrenomedullin-induced relaxation in isolated porcine ciliary arteries...
  61. pmc Thermal discomfort with cold extremities in relation to age, gender, and body mass index in a random sample of a Swiss urban population
    Maneli Mozaffarieh
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Popul Health Metr 8:17. 2010
    ..The aim of this epidemiological study was to investigate the relationship of thermal discomfort with cold extremities (TDCE) to age, gender, and body mass index (BMI) in a Swiss urban population...
  62. ncbi request reprint Does the blood-brain barrier play a role in Glaucoma?
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Surv Ophthalmol 52:S115-21. 2007
    ....
  63. ncbi request reprint Anatomical and functional outcome in brilliant blue G assisted chromovitrectomy
    Paul B Henrich
    Department of Ophthalmology, University Hospital Basel, Switzerland
    Acta Ophthalmol 88:588-93. 2010
    ..To evaluate the potential of brilliant blue G (BBG) for intraoperative staining of the inner limiting membrane (ILM) with respect to staining properties and surgical outcome...
  64. ncbi request reprint Effect of central corneal thickness on dynamic contour tonometry and Goldmann applanation tonometry in primary open-angle glaucoma
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Mittlere Strasse 91, PO Box, CH 4031 Basel, Switzerland
    Arch Ophthalmol 125:740-4. 2007
    ..To compare the dependence of dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) on central corneal thickness (CCT) in primary open-angle glaucoma...
  65. ncbi request reprint Idiopathic isolated abscess in an extraocular muscle in a child
    Timo Haufschild
    Arch Ophthalmol 122:1233-4. 2004
  66. pmc Half a pack of cigarettes a day more than doubles DNA breaks in circulating leukocytes
    Maneli Mozaffarieh
    Department of Ophthalmology, University of Basel, Mittlere Strasse 91, CH 4031 Basel, Switzerland
    Tob Induc Dis 8:14. 2010
    ..Oxidative stress leads to cellular damage including DNA damage, particularly DNA breaks. We conducted this study to test the hypothesis that smokers have increased DNA breaks in their circulating leukocytes...
  67. doi request reprint Human cytokines activate JAK-STAT signaling pathway in porcine ocular tissue
    Elizaveta Fasler-Kan
    Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland Institute of Chemistry and Bioanalytics, University of Applied Sciences Northwestern Switzerland, Muttenz, Switzerland
    Xenotransplantation 20:469-80. 2013
    ..The aim of this study was to investigate the response of various porcine ocular cells in vitro to human cytokines in regard to the activation of JAK-STAT signaling pathways...
  68. ncbi request reprint Colour vision deficiencies in Alzheimer's disease
    Mona Pache
    University Eye Clinic, Mittlere Strasse 91, CH 4012 Basel, Switzerland
    Age Ageing 32:422-6. 2003
    ..In this study, colour vision of Alzheimer's disease patients was tested using the Ishihara test and the PV-16 choice test. The latter test, primarily designed for children, was chosen in order to avoid problems due to cognitive decline...
  69. ncbi request reprint What is the present pathogenetic concept of glaucomatous optic neuropathy?
    Josef Flammer
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Surv Ophthalmol 52:S162-73. 2007
    ..The involvement of primary vascular dysregulation in the pathogenesis of glaucomatous optic neuropathy may explain why women, as well as Japanese, suffer more often from normal-tension glaucoma...
  70. ncbi request reprint Activated STAT 3 in choroidal neovascular membranes of patients with age-related macular degeneration
    Elizaveta Fasler-Kan
    Department of Research, University of Basel, Basel, Switzerland
    Ophthalmologica 219:214-21. 2005
    ..Abnormal activity of certain STAT family members, particularly STAT 3 and STAT 5, is associated with a wide variety of human malignancies and other diseases. Here were studied STAT activation in CNVM of patients with AMD...
  71. ncbi request reprint Reliability of confocal choroidal laser Doppler flowmetry
    Konstantin Gugleta
    University Eye Clinic Basel, Mittlere Strasse 91, PO Box CH 4012, Basel, Switzerland
    Invest Ophthalmol Vis Sci 43:723-8. 2002
    ..To assess the variability in choroidal laser Doppler flowmetry (LDF)...
  72. ncbi request reprint Increased plasma levels of 20S proteasome alpha-subunit in glaucoma patients: an observational pilot study
    Kerstin Wunderlich
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Mol Vis 8:431-5. 2002
    ..Here we investigated whether altered gene expression of the alpha-subunit of 20S proteasomes in leukocytes of glaucoma patients at the level of mRNA, shown by us earlier, is reflected by the level of protein synthesis...
  73. ncbi request reprint Retinal vasospasm during an attack of migraine
    Hanspeter E Killer
    Augenklinik Kantonsspital Aarau and dagger University Eye Clinic, Basel, Switzerland
    Retina 23:253-4. 2003
  74. ncbi request reprint 30 Hz-flicker mfERG in primary open-angle glaucoma patients : 30 Hz-flicker-mfERG in POAG
    Margarita G Todorova
    Department of Ophthamlology, University Eye Hospital Basel, Mittlere Strasse 91, CH 4012, Basel, Switzerland
    Doc Ophthalmol 113:11-20. 2006
    ..This study was performed in an attempt to gain more information on whether the 30 Hz-flicker mfERG indeed provides a sensitive measure of dysfunction in patients with primary open-angle glaucoma (POAG) as has been suggested previously...
  75. ncbi request reprint Sequence analysis and high-throughput immunohistochemical profiling of KIT (CD 117) expression in uveal melanoma using tissue microarrays
    Mona Pache
    University Eye Clinic of Basel, Basel, Switzerland
    Virchows Arch 443:741-4. 2003
    ..In conclusion, human posterior uveal melanoma frequently expresses CD117 at high levels. Although KIT mutations could not be found, it appears justified to investigate the utility of imatinib mesylate in the treatment of these patients...
  76. ncbi request reprint Unilateral fungal and mycobacterial keratitis after simultaneous laser in situ keratomileusis
    Mona Pache
    University Eye Clinic, P O Box, CH 4012 Basel, Switzerland
    Cornea 22:72-5. 2003
    ..To report a case of unilateral fungal and mycobacterial keratitis after simultaneous laser in situ keratomileusis (LASIK)...
  77. pmc Smell perception in normal tension glaucoma patients
    Maneli Mozaffarieh
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Mol Vis 16:506-10. 2010
    ..The aim of this study was to quantify the ability to identify odors in normal tension glaucoma (NTG) patients and healthy subjects with and without a primary vascular dysregulation (PVD)...
  78. pmc The effect of ranibizumab versus photodynamic therapy on DNA damage in patients with exudative macular degeneration
    M Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Mol Vis 15:1194-9. 2009
    ..To compare the effect of ranibizumab treatment versus photodynamic therapy (PDT) on single-stranded DNA damage in circulating leukocytes in patients with exudative age-related macular degeneration (AMD)...
  79. ncbi request reprint The beta-blocker carteolol inhibits contractions induced by KCl in pig ciliary arteries: an effect modulated by extracellular Ca++
    Giovanni Brogiolo
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic, Basel, Switzerland
    Klin Monbl Augenheilkd 219:268-72. 2002
    ..To assess if the vasorelaxing properties of the ocular hypotensive beta-blocker carteolol could share some pharmacological features of calcium-channel antagonists in isolated porcine ciliary arteries...
  80. ncbi request reprint Forskolin upregulation of NOS I protein expression in porcine ciliary processes: a new aspect of aqueous humor regulation
    Rong Liu
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic, Basel, Switzerland
    Klin Monbl Augenheilkd 219:281-3. 2002
    ..To determine whether nitric oxide synthase (NOS) protein expression can be modulated by forskolin in porcine ciliary processes...
  81. ncbi request reprint Human connective tissue growth factor mRNA expression of epiretinal and subretinal fibrovascular membranes: a report of three cases
    Peter Meyer
    University Eye Clinic, Department of Ophthamopathology, Basel, Switzerland
    Ophthalmologica 216:284-91. 2002
    ....
  82. ncbi request reprint Elevated plasma endothelin-1 levels and vascular dysregulation in patients with rheumatoid arthritis
    Mona Pache
    University Eye Clinic, Basel, Switzerland
    Med Sci Monit 8:CR616-9. 2002
    ..Since systemically increased levels of ET-1 are known to occur in tandem with primary or secondary vascular dysregulation, we also measured peripheral blood flow by means of nailfold capillaroscopy combined with a cold provocation test...
  83. ncbi request reprint Vasoactive properties of bimatoprost in isolated porcine ciliary arteries
    Reto Allemann
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Switzerland
    Klin Monbl Augenheilkd 220:161-4. 2003
    ..To investigate the vasoactive effect of bimatoprost (Lumigan), a new topical ocular hypotensive agent, in isolated porcine ciliary arteries...
  84. ncbi request reprint Is open-angle glaucoma caused by impaired cerebrospinal fluid circulation: around the optic nerve?
    Hanspeter E Killer
    University of Basel, Eye Institute, Switzerland
    Clin Experiment Ophthalmol 36:308-11. 2008
    ....
  85. ncbi request reprint The effects of antiglaucoma and systemic medications on ocular blood flow
    Vital P Costa
    Glaucoma Service, University of Campinas, Rua Bauru, 40, São Paulo 01248 010, Brazil
    Prog Retin Eye Res 22:769-805. 2003
    ..Longitudinal, prospective, randomized trials are needed to investigate the effects of vasoactive substances with no hypotensive effect on the progression of glaucoma...
  86. ncbi request reprint Blood flow in glaucoma
    Matthias C Grieshaber
    University Eye Clinic Basel, Switzerland
    Curr Opin Ophthalmol 16:79-83. 2005
    ..This review summarizes the recent publications relevant to blood flow in glaucoma...
  87. ncbi request reprint Circulatory response to blood gas perturbations in vasospasm
    Konstantin Gugleta
    Ophthalmology Department of the University Eye Clinic Basel, Mittlerestrasse 12, 4012 Basel, Switzerland
    Invest Ophthalmol Vis Sci 46:3288-94. 2005
    ..To investigate the response of the optic nerve head and the choroidal circulation to blood gas perturbations in otherwise healthy subjects with a history of cold hands...
  88. ncbi request reprint Fundamental sciences in glaucoma. Introduction
    Matthias C Grieshaber
    Surv Ophthalmol 52:S99-S100. 2007
  89. ncbi request reprint Effect of Xalatan(R) and Cosopt(R) on the vascular tone of quiescent isolated pig ciliary arteries
    Mustafa El Sherbini
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Switzerland
    Klin Monbl Augenheilkd 219:273-6. 2002
    ..To investigate whether dilutions of the commercially available Xalatan(R) or Cosopt(R) induce vasoconstrictions in isolated quiescent porcine ciliary arteries...
  90. ncbi request reprint What are the biomarkers for glaucoma?
    Olga Golubnitschaja
    Department of Radiology, University of Bonn, Germany
    Surv Ophthalmol 52:S155-61. 2007
    ..New technologies such as disease proteomics and transcriptomics open new perspectives for the development of rapid molecular diagnostics and follow-up in glaucoma...
  91. ncbi request reprint Effect of palmitoleic acid on bradykinin-induced endothelium-dependent relaxation in isolated pig ciliary artery
    Thomas Morf
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Basel
    Klin Monbl Augenheilkd 219:284-8. 2002
    ..The present study investigates whether the gap junction uncoupling agent palmitoleic acid (PA) affects bradykinin-induced endothelium-dependent relaxation in isolated pig ciliary artery...
  92. ncbi request reprint [Reproducibility of measurements with the retinal vessel analyzer under optimal conditions]
    Mona Pache
    Universitäts Augenklinik Basel, Germany
    Klin Monbl Augenheilkd 219:523-7. 2002
    ..corrected] To evaluate the reproducibility of measurements with the Retinal Vessel Analyzer (RVA) in healthy subjects and to describe which measuring conditions should be guaranteed to obtain optimal results...
  93. ncbi request reprint A novel perspective on natural therapeutic approaches in glaucoma therapy
    Maneli Mozaffarieh
    University Eye Clinic Basel, Mittlere Strasse 91, PO Box, CH 4031 Basel, Switzerland
    Expert Opin Emerg Drugs 12:195-8. 2007
    ..Future intensive studies on the effect of these compounds may open up a new therapeutic era in glaucoma...
  94. ncbi request reprint A sick eye in a sick body? Systemic findings in patients with primary open-angle glaucoma
    Mona Pache
    University Eye Clinic Freiburg, Germany
    Surv Ophthalmol 51:179-212. 2006
    ..Furthermore, the diagnosis of glaucoma can affect the patient's quality of life. By highlighting the systemic alterations found in POAG, this review attempts to bring glaucoma into a broader medical context...
  95. ncbi request reprint Absence of vasoactive properties of travoprost in isolated porcine ciliary arteries
    Reto Allemann
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Switzerland
    Klin Monbl Augenheilkd 220:152-5. 2003
    ..The present study evaluates the vasoactive effect of the ocular hypotensive agent travoprost (Travatan) on isolated pig ciliary arteries...
  96. ncbi request reprint Increased expression of matrix metalloproteinases in mononuclear blood cells of normal-tension glaucoma patients
    Olga Golubnitschaja
    Department of Radiology, University of Bonn, Germany
    J Glaucoma 13:66-72. 2004
    ..In this study we investigated MMP gene expression in circulating leukocytes isolated from normal tension glaucoma (NTG) patients in comparison to healthy controls...
  97. ncbi request reprint Pro: non-penetrating glaucoma surgery--a fair chance
    Tarek Shaarawy
    Graefes Arch Clin Exp Ophthalmol 241:699-702. 2003
  98. pmc Sildenafil induces retinal vasodilatation in healthy subjects
    Mona Pache
    University Eye Clinic Basel, Switzerland
    Br J Ophthalmol 86:156-8. 2002
    ..However, its effect on human retinal arteries and veins has not yet been investigated. The effect of a single dose administration of sildenafil on the retinal vessel diameters of healthy subjects was evaluated...