Josef Flammer

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Smell perception in normal tension glaucoma patients
    Maneli Mozaffarieh
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Mol Vis 16:506-10. 2010
  2. pmc Comet assay analysis of single-stranded DNA breaks in circulating leukocytes of glaucoma patients
    M Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Mol Vis 14:1584-8. 2008
  3. pmc Ginkgo biloba: an adjuvant therapy for progressive normal and high tension glaucoma
    A K Cybulska-Heinrich
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Mol Vis 18:390-402. 2012
  4. pmc The effect of ranibizumab versus photodynamic therapy on DNA damage in patients with exudative macular degeneration
    M Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Mol Vis 15:1194-9. 2009
  5. pmc Retinitis pigmentosa and ocular blood flow
    Katarzyna Konieczka
    Department of Ophthalmology, University of Basel, Mittlere Strasse 91, Basel, CH 4031, Switzerland
    EPMA J 3:17. 2012
  6. pmc Targeted preventive measures and advanced approaches in personalised treatment of glaucoma neuropathy
    Maneli Mozaffarieh
    Department of Ophthalmology, University of Basel, Mittlere Strasse 91, CH 4031 Basel, Switzerland
    EPMA J 1:229-35. 2010
  7. pmc The eye and the heart
    Josef Flammer
    Department of Ophthalmology, University of Basel, Mittlere Strasse 91, Basel 4031, Switzerland
    Eur Heart J 34:1270-8. 2013
  8. doi request reprint Autoregulation, a balancing act between supply and demand
    Josef Flammer
    University Eye Clinic Basel, Mittlere Str 91, Basel, Switzerland
    Can J Ophthalmol 43:317-21. 2008
  9. pmc Half a pack of cigarettes a day more than doubles DNA breaks in circulating leukocytes
    Maneli Mozaffarieh
    Department of Ophthalmology, University of Basel, Mittlere Strasse 91, CH 4031 Basel, Switzerland
    Tob Induc Dis 8:14. 2010
  10. pmc Thermal discomfort with cold extremities in relation to age, gender, and body mass index in a random sample of a Swiss urban population
    Maneli Mozaffarieh
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Popul Health Metr 8:17. 2010

Collaborators

Detail Information

Publications80

  1. pmc Smell perception in normal tension glaucoma patients
    Maneli Mozaffarieh
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Mol Vis 16:506-10. 2010
    ..The aim of this study was to quantify the ability to identify odors in normal tension glaucoma (NTG) patients and healthy subjects with and without a primary vascular dysregulation (PVD)...
  2. pmc Comet assay analysis of single-stranded DNA breaks in circulating leukocytes of glaucoma patients
    M Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Mol Vis 14:1584-8. 2008
    ..To investigate the amount of single-stranded DNA breaks in circulating leukocytes of primary open-angle glaucoma (POAG) patients...
  3. pmc Ginkgo biloba: an adjuvant therapy for progressive normal and high tension glaucoma
    A K Cybulska-Heinrich
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Mol Vis 18:390-402. 2012
    ..One such risk factor is a primary vascular dysregulation (PVD) occurring in patients with a disturbed autoregulation, another risk factor is oxidative stress...
  4. pmc The effect of ranibizumab versus photodynamic therapy on DNA damage in patients with exudative macular degeneration
    M Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Mol Vis 15:1194-9. 2009
    ..To compare the effect of ranibizumab treatment versus photodynamic therapy (PDT) on single-stranded DNA damage in circulating leukocytes in patients with exudative age-related macular degeneration (AMD)...
  5. pmc Retinitis pigmentosa and ocular blood flow
    Katarzyna Konieczka
    Department of Ophthalmology, University of Basel, Mittlere Strasse 91, Basel, CH 4031, Switzerland
    EPMA J 3:17. 2012
    ..As PVD syndrome is partly treatable, a vascular evaluation of RP patients is meaningful. Based on the outcome, a targeted individualised, preventive or supportive treatment might be introduced in selected RP patients...
  6. pmc Targeted preventive measures and advanced approaches in personalised treatment of glaucoma neuropathy
    Maneli Mozaffarieh
    Department of Ophthalmology, University of Basel, Mittlere Strasse 91, CH 4031 Basel, Switzerland
    EPMA J 1:229-35. 2010
    ..This review describes the individual mechanisms which may be targeted by non-IOP lowering treatment based on our pathogenic scheme...
  7. pmc The eye and the heart
    Josef Flammer
    Department of Ophthalmology, University of Basel, Mittlere Strasse 91, Basel 4031, Switzerland
    Eur Heart J 34:1270-8. 2013
    ..Vascular dysregulation also leads to a barrier dysfunction and thereby to small retinal haemorrhages...
  8. doi request reprint Autoregulation, a balancing act between supply and demand
    Josef Flammer
    University Eye Clinic Basel, Mittlere Str 91, Basel, Switzerland
    Can J Ophthalmol 43:317-21. 2008
    ..This instability, in turn, induces a repeated mild reperfusion injury. The resulting oxidative stress contributes to the pathogenesis of glaucomatous optic neuropathy...
  9. pmc Half a pack of cigarettes a day more than doubles DNA breaks in circulating leukocytes
    Maneli Mozaffarieh
    Department of Ophthalmology, University of Basel, Mittlere Strasse 91, CH 4031 Basel, Switzerland
    Tob Induc Dis 8:14. 2010
    ..Oxidative stress leads to cellular damage including DNA damage, particularly DNA breaks. We conducted this study to test the hypothesis that smokers have increased DNA breaks in their circulating leukocytes...
  10. pmc Thermal discomfort with cold extremities in relation to age, gender, and body mass index in a random sample of a Swiss urban population
    Maneli Mozaffarieh
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Popul Health Metr 8:17. 2010
    ..The aim of this epidemiological study was to investigate the relationship of thermal discomfort with cold extremities (TDCE) to age, gender, and body mass index (BMI) in a Swiss urban population...
  11. ncbi request reprint Vasoactive properties of bimatoprost in isolated porcine ciliary arteries
    Reto Allemann
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Switzerland
    Klin Monbl Augenheilkd 220:161-4. 2003
    ..To investigate the vasoactive effect of bimatoprost (Lumigan), a new topical ocular hypotensive agent, in isolated porcine ciliary arteries...
  12. ncbi request reprint Short-term retinal vessel diameter variability in relation to the history of cold extremities
    Asan Kochkorov
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4026-33. 2006
    ..To test whether the regularity and short-term changes of retinal vessel diameter are related to the history of cold hands and feet and to nailfold circulatory response to cooling...
  13. ncbi request reprint Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4034-41. 2006
    ..To explore the maximum retinal vasodilation in response to repeated flicker light stimulation in relation to vasospastic propensity in healthy subjects...
  14. ncbi request reprint On pulse-wave propagation in the ocular circulation
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:4019-25. 2006
    ....
  15. ncbi request reprint Relationship between optic nerve head and finger blood flow
    Maneli Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Eur J Ophthalmol 20:136-41. 2010
    ..To examine the relationship between optic nerve head (ONH) and finger blood flow in subjects with and without a primary vascular dysregulation (PVD)...
  16. doi request reprint Short-term variability of systemic blood pressure and submacular choroidal blood flow in eyes of patients with primary open-angle glaucoma
    Asan Kochkorov
    Ophthalmology Department, University Hospital Basel, Mittlerestr 91, CH 4031, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 248:833-7. 2010
    ..To analyse short-term variability of systemic blood pressure and choroidal blood flow in glaucoma patients, and compare them with ocular hypertensive patients and controls...
  17. ncbi request reprint Blood flow in glaucoma
    Matthias C Grieshaber
    University Eye Clinic Basel, Switzerland
    Curr Opin Ophthalmol 16:79-83. 2005
    ..This review summarizes the recent publications relevant to blood flow in glaucoma...
  18. doi request reprint Diurnal blood pressure variations are associated with changes in distal-proximal skin temperature gradient
    Kurt Krauchi
    Thermophysiological Chronobiology, Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    Chronobiol Int 29:1273-83. 2012
    ..This finding might have an impact on individual cardiovascular risk prediction with respect to diurnal, seasonal and weather variations; however, the underlying mechanisms remain to be discovered...
  19. ncbi request reprint Relationship between retinal glial cell activation in glaucoma and vascular dysregulation
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    J Glaucoma 16:215-9. 2007
    ..To investigate the possible relationship between presumed activated retinal astrocytes and Müller cells (ARAM) and primary vascular dysregulation (PVD) in patients with primary open-angle glaucoma (POAG)...
  20. doi request reprint Choroidal blood flow response to isometric exercise in glaucoma patients and patients with ocular hypertension
    Natalie Portmann
    Ophthalmology Department, University Hospital Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 52:7068-73. 2011
    ..To analyze submacular choroidal blood flow (ChBF) response to isometric exercise in untreated patients with glaucoma and ocular hypertension...
  21. doi request reprint Rigidity of retinal vessel in untreated eyes of normal tension primary open-angle glaucoma patients
    Alexander Oettli
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    J Glaucoma 20:303-6. 2011
    ..To analyze pulse wave propagation in the ocular circulation and vessel stiffness in untreated eyes of normal tension primary open-angle glaucoma (NTG) patients...
  22. ncbi request reprint Choroidal vascular reaction to hand-grip stress in subjects with vasospasm and its relevance in glaucoma
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 44:1573-80. 2003
    ..To assess the impact of vascular dysregulation on choroidal blood flow response to the hand-grip test and the relevance of this response to glaucoma...
  23. ncbi request reprint Primary cell culture of meningothelial cells--a new model to study the arachnoid in glaucomatous optic neuropathy
    Xiaorong Xin
    Department of Biomedicine, University Eye Clinic, University Hospital Basel, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 248:1273-8. 2010
    ..For this purpose, we developed a culture method for porcine meningothelial cells from the arachnoid layer covering the optic nerve...
  24. ncbi request reprint Role of anions in nitric oxide-induced short-circuit current increase in isolated porcine ciliary processes
    Renyi Wu
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 45:3213-22. 2004
    ..To investigate how nitric oxide (NO) modulates short-circuit current (Isc) in isolated porcine ciliary processes...
  25. doi request reprint Association between risk factors and glaucomatous damage in untreated primary open-angle glaucoma
    Konstantin Gugleta
    Ophthalmology Department, University Hospital Basel, University of Basel, Basel, Switzerland
    J Glaucoma 22:501-5. 2013
    ..To analyze an association between the presumed risk factors for glaucoma and the actual extent of glaucomatous damage in untreated primary open-angle glaucoma...
  26. ncbi request reprint Extraocular blood flow and endothelin-1 plasma levels in patients with multiple sclerosis
    Mona Pache
    University Eye Clinic Basel, University Hospital Basel, Basel, Switzerland
    Eur Neurol 49:164-8. 2003
    ..0 +/- 0.4 pg/ml, range 1.1-2.8 vs. 1.5 +/- 0.2 pg/ml, range 0.9-2.0; p < 0.001). Moreover, the patients exhibited significant alterations of extraocular blood flow. The role of ET-1 in the inflammatory process remains to be clarified...
  27. ncbi request reprint Expression and amplification of therapeutic target genes in retinoblastoma
    Doris Bösch
    Universitäts Augenklinik Basel, Mittlere Strasse 91, 4056, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 243:156-62. 2005
    ..We set out to evaluate alterations of the therapeutic target genes KIT (CD 117), EGFR, and HER-2 in human retinoblastoma...
  28. ncbi request reprint Reduction of nitrite production by endothelin-1 in isolated porcine ciliary processes
    Renyi Wu
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Mittlere Strasse 91, PO Box CH 4012 Basel, Switzerland
    Exp Eye Res 77:189-93. 2003
    ..64) or unoprostone (30 microM: 109.3+/-4.8%; P=0.98). These results suggest that endothelin-1, through an ETA receptor activation, can reduce both basal and forskolin-induced nitrite production in isolated porcine ciliary processes...
  29. doi request reprint Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma
    Hanspeter E Killer
    Department of Ophthalmology, Kantonsspital Aarau, CH 5001 Aarau, Switzerland
    Br J Ophthalmol 96:544-8. 2012
    ....
  30. doi request reprint Cold extremities and difficulties initiating sleep: evidence of co-morbidity from a random sample of a Swiss urban population
    Kurt Krauchi
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Klein Strasse 27, Basel, Switzerland
    J Sleep Res 17:420-6. 2008
    ..Therefore, a thermophysiological approach to DIS may be relevant for its differential diagnosis and its treatment...
  31. pmc Meningothelial cells react to elevated pressure and oxidative stress
    Xiaorong Xin
    Department of Biomedicine, Ocular Pharmacology and Physiology, University Hospital Basel, Basel, Switzerland
    PLoS ONE 6:e20142. 2011
    ..However, little is known about the influence of pathological conditions on MEC function; e.g., during diseases associated with elevated intracranial pressure, hypoxia or increased oxidative stress...
  32. ncbi request reprint The pathogenesis of optic disc splinter haemorrhages: a new hypothesis
    Matthias C Grieshaber
    University Eye Clinic, University Hospital of Basel, Basel, Switzerland
    Acta Ophthalmol Scand 84:62-8. 2006
    ..To describe a hypothesized relationship between optic disc haemorrhages (ODHs) and primary vascular dysregulation (PVD)...
  33. doi request reprint Relationship between ocular pulse amplitude and systemic blood pressure measurements
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland
    Acta Ophthalmol 87:329-34. 2009
    ..This study aimed to determine whether ocular pulse amplitude (OPA) measured with dynamic contour tonometry (DCT) is related to systemic blood pressure (BP) parameters...
  34. ncbi request reprint What is the link between vascular dysregulation and glaucoma?
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Surv Ophthalmol 52:S144-54. 2007
    ..This, in turn, leads to unstable oxygen supply, which seems to be a relevant component in the pathogenesis of glaucomatous optic neuropathy...
  35. ncbi request reprint Vascular dysregulation in the choroid of subjects with acral vasospasm
    Pascal W Hasler
    University Eye Clinic Basel, Mittlere Strasse 92, PO Box 4012, Basel, Switzerland
    Arch Ophthalmol 120:302-7. 2002
    ..To assess the relationship between ocular perfusion pressure and blood flow in the choroid in subjects with acral vasospasm...
  36. doi request reprint Refractoriness to the effect of endothelin-1 in porcine ciliary arteries
    Katarzyna Konieczka
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    J Ocul Pharmacol Ther 29:488-92. 2013
    ..However, few details are known about this phenomenon. The aim of our study was to verify the existence of refractoriness in ophthalmic ciliary arteries and, if present, to analyze its time course...
  37. ncbi request reprint Effect of cAMP on porcine ciliary transepithelial short-circuit current, sodium transport, and chloride transport
    Ying Ni
    Laboratory of Ocular Pharmacology and Physiology, University Eye Hospital Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:2065-74. 2006
    ..To investigate the effects of 8-bromo-cAMP (cAMP) on porcine ciliary transepithelial short-circuit current (Isc) and transport of chloride (Cl-) and sodium (Na+)...
  38. doi request reprint New insights in the pathogenesis and treatment of normal tension glaucoma
    Maneli Mozaffarieh
    University of Basel, Department of Ophthalmology, Basel, Switzerland
    Curr Opin Pharmacol 13:43-9. 2013
    ..OBF regulation can be improved by magnesium, calcium channel blockers as well as with carbonic anhydrase inhibitors...
  39. ncbi request reprint L-PGDS (betatrace protein) inhibits astrocyte proliferation and mitochondrial ATP production in vitro
    Xiaorong Xin
    University Eye Clinic, Basel, Switzerland
    J Mol Neurosci 39:366-71. 2009
    ..Archives of Ophthalmology, 120, 791-796, 2002), we postulate that a change in the concentration of CSF protein such as L-PGDS could exercise a harmful effect on these structures...
  40. ncbi request reprint Vasoactive responses of U46619, PGF2alpha, latanoprost, and travoprost in isolated porcine ciliary arteries
    Ineta Vysniauskiene
    Laboratory of Pharmacology and Physiology, University Eye Clinic, Basel, Switzerland
    Invest Ophthalmol Vis Sci 47:295-8. 2006
    ..To compare the vasoactive properties of the prostanoids U46619 (thromboxane A2 analogue), prostaglandin F(2alpha) (PGF(2alpha)), latanoprost free acid, and travoprost free acid in isolated porcine ciliary arteries...
  41. doi request reprint Influence of gender and menopausal status on peripheral and choroidal circulation
    Dimitra Kavroulaki
    Department of Ophthalmology, University Hospital Basel, Switzerland
    Acta Ophthalmol 88:850-3. 2010
    ..To evaluate the influence of menopausal status and age on peripheral and ocular circulation assessed by means of continuous laser Doppler flowmetry (LDF)...
  42. ncbi request reprint Adrenomedullin-induced endothelium-dependent relaxation in porcine ciliary arteries
    Eike S Dettmann
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 44:3961-6. 2003
    ..To investigate adrenomedullin-induced relaxation in isolated porcine ciliary arteries...
  43. doi request reprint Effect of avosentan (SPP-301) in porcine ciliary arteries
    Katarzyna Konieczka
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Curr Eye Res 36:118-24. 2011
    ..To investigate the effect of avosentan on the endothelin-1 induced contractions in comparison with BQ-123 and BQ-788 (ET(B)-endothelin receptor antagonist) in isolated porcine ciliary arteries with and without endothelium...
  44. ncbi request reprint Experience with Cosopt, the fixed combination of timolol and dorzolamide, after switch from free combination of timolol and dorzolamide, in Swiss ophthalmologists' offices
    Konstantin Gugleta
    University Eye Clinic, Basel, Switzerland
    Curr Med Res Opin 19:330-5. 2003
    ....
  45. ncbi request reprint Chronobiological characterization of women with primary vasospastic syndrome: body heat loss capacity in relation to sleep initiation and phase of entrainment
    Stephanie Vollenweider
    Psychiatric University Clinics, Thermophysiological Chronobiology, Centre for Chronobiology, Wilhelm Klein Strasse 27, Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 294:R630-8. 2008
    ..2 h; P = 0.01). Similar phase shifts were observed in CBT, DPG, and KSS ratings. In conclusion, WVD exhibit a phase delay of the endogenous circadian system with respect to their habitual sleep-wake cycle, which could be a cause of DIS...
  46. ncbi request reprint The effect of losartan potassium on choroidal hemodynamics in healthy subjects
    Tatiana Spicher
    University Eye Clinic, Basel, Switzerland
    J Glaucoma 11:177-82. 2002
    ..To investigate the choroidal hemodynamic effects of losartan potassium, a specific angiotensin II subtype AT1 receptor antagonist...
  47. doi request reprint Quantification of Contrast Recognizability during Brilliant Blue G- and Indocyanine Green-Assisted Chromovitrectomy
    Paul B Henrich
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Invest Ophthalmol Vis Sci 52:4345-9. 2011
    ..To evaluate the potential of brilliant blue G (BBG) and indocyanine green (ICG) for intraoperative staining of the internal limiting membrane (ILM) with respect to perceivable contrast...
  48. ncbi request reprint Measurement procedures in confocal choroidal laser Doppler flowmetry
    Alain Preitner
    University Eye Clinic, Basel, Switzerland
    Curr Eye Res 28:233-40. 2004
    ..To estimate a practical number of measurements within a series of recordings with a confocal choroidal laser Doppler flowmeter, capable of providing an adequate statistical power for future studies...
  49. ncbi request reprint Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure
    Mücahit Satilmis
    University Eye Clinic, Basel, Switzerland
    Am J Ophthalmol 135:664-9. 2003
    ..To evaluate the correlation between progression rate of glaucomatous damage and retrobulbar blood flow in an institutional setting...
  50. doi request reprint Phase relationship between skin temperature and sleep-wake rhythms in women with vascular dysregulation and controls under real-life conditions
    Britta Gompper
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Wilhelm Klein Strasse 27, Basel, Switzerland
    Chronobiol Int 27:1778-96. 2010
    ..A full factorial design will have to show whether the finding is specific to primary vascular dysregulation, to DIS, or to their interaction...
  51. doi request reprint Heart-rate variability in women during 40-hour prolonged wakefulness
    Doreen Anders
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    Chronobiol Int 27:1609-28. 2010
    ..One implies circadian control and the other homeostatic control, and both are reflected by the LF/HF ratio...
  52. ncbi request reprint The 'two global flash' mfERG in high and normal tension primary open-angle glaucoma
    Anja M Palmowski-Wolfe
    Department of Ophthalmology, University Eye Hospital, Mittlere Strasse 91, 4012, Basel, Switzerland
    Doc Ophthalmol 114:9-19. 2007
    ..To analyse the sensitivity of the '2 global flash' multifocal electroretinogram (mfERG) to detect glaucomatous dysfunction in normal tension (NTG) and high tension primary open angle glaucoma (POAG) patients...
  53. ncbi request reprint Anatomical and functional outcome in brilliant blue G assisted chromovitrectomy
    Paul B Henrich
    Department of Ophthalmology, University Hospital Basel, Switzerland
    Acta Ophthalmol 88:588-93. 2010
    ..To evaluate the potential of brilliant blue G (BBG) for intraoperative staining of the inner limiting membrane (ILM) with respect to staining properties and surgical outcome...
  54. ncbi request reprint Postoperative microhyphema as a positive prognostic indicator in canaloplasty
    Matthias C Grieshaber
    Glaucoma Service, Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland
    Acta Ophthalmol 91:151-6. 2013
    ..However, patients with microhyphema had significantly fewer Nd:YAG goniopunctures after surgery than patients without microhyphema (p < 0.001)...
  55. ncbi request reprint Effect of melatonin on vascular responses of porcine ciliary arteries
    Mona Pache
    Basel University Eye Clinic, Basel, Switzerland
    Curr Eye Res 24:313-7. 2002
    ..To investigate the effect of melatonin on isolated porcine ciliary arteries...
  56. doi request reprint Meningothelial cells as part of the central nervous system host defence
    Jia Li
    Department of Biomedicine, Ocular Pharmacology and Physiology, University Basel, Basel, Switzerland
    Biol Cell 105:304-15. 2013
    ..In addition, MECs are involved in immunological processes in the brain by secretion of pro-inflammatory cytokines in response to various pathologically relevant stress conditions...
  57. pmc Inactivation of MARCH5 prevents mitochondrial fragmentation and interferes with cell death in a neuronal cell model
    Lei Fang
    Department of Biomedicine, University Basel, Basel, Switzerland
    PLoS ONE 7:e52637. 2012
    ..To study the impact of the mitochondrial ubiquitin ligase MARCH5 on mitochondrial morphology and induction of apoptosis using an in vitro model of neuronal precursor cells exposed to glaucoma-relevant stress conditions...
  58. doi request reprint Meningothelial cells participate in immunological processes in the cerebrospinal fluid
    Bin Fan
    Department of Biomedicine and Department of Ophthalmology, University Basel, Basel, Switzerland
    J Neuroimmunol 244:45-50. 2012
    ..In addition, phagocytotic clearance by MECs was enhanced suggesting an immunological role for MECs in the CSF compartment and pointing to a possible connection to neurodegenerative processes...
  59. ncbi request reprint Effect of central corneal thickness on dynamic contour tonometry and Goldmann applanation tonometry in primary open-angle glaucoma
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Mittlere Strasse 91, PO Box, CH 4031 Basel, Switzerland
    Arch Ophthalmol 125:740-4. 2007
    ..To compare the dependence of dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) on central corneal thickness (CCT) in primary open-angle glaucoma...
  60. ncbi request reprint Absence of vasoactive properties of travoprost in isolated porcine ciliary arteries
    Reto Allemann
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Switzerland
    Klin Monbl Augenheilkd 220:152-5. 2003
    ..The present study evaluates the vasoactive effect of the ocular hypotensive agent travoprost (Travatan) on isolated pig ciliary arteries...
  61. ncbi request reprint Retinal vascular diameter in young subjects with a vasospastic propensity
    Fabrizio Branca
    University Eye Clinic of Basel, Mittlere Strasse 91, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 244:454-9. 2006
    ....
  62. ncbi request reprint Is open-angle glaucoma caused by impaired cerebrospinal fluid circulation: around the optic nerve?
    Hanspeter E Killer
    University of Basel, Eye Institute, Switzerland
    Clin Experiment Ophthalmol 36:308-11. 2008
    ....
  63. ncbi request reprint Reduced thirst in patients with a vasospastic syndrome
    Barbara Teuchner
    University Eye Clinic, Basel, Switzerland
    Acta Ophthalmol Scand 82:738-40. 2004
    ..To compare thirst, drinking behaviour, and endothelin-1 (ET-1) plasma levels between vasospastic and non-vasospastic subjects...
  64. ncbi request reprint Transient raise of endothelin-1 plasma level and reduction of ocular blood flow in a patient with optic neuritis
    Timo Haufschild
    University Eye Clinic, Basel, Switzerland
    Ophthalmologica 217:451-3. 2003
    ..To analyze how far an ischemic component might have been involved in optic neuritis...
  65. ncbi request reprint The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    Curr Alzheimer Res 4:47-51. 2007
    ..Since our previous results showed an increase in MT(1) expression in AD retina, the two melatonin receptor subtypes appear to be differentially affected by the course of the neurodegenerative disorder...
  66. doi request reprint Plasma citrate levels as a potential biomarker for glaucoma
    Stephan A Fraenkl
    Department of Ophthalmology, University Hospital Basel, University of Basel, Basel, Switzerland
    J Ocul Pharmacol Ther 27:577-80. 2011
    ..To determine the possibility of plasma citrate as a biomarker in patients with glaucoma...
  67. ncbi request reprint Therapeutic strategies for normal-tension glaucoma
    Selim Orgul
    University Eye Clinic, Basel, Switzerland
    Ophthalmologica 219:317-23. 2005
    ..Today, calcium channel blockers seem to be the most promising adjunctive treatment to be considered in patients with glaucomatous optic neuropathy without increased intraocular pressure...
  68. pmc Oxygen and blood flow: players in the pathogenesis of glaucoma
    Maneli Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Mol Vis 14:224-33. 2008
    ..The exact mechanisms leading to the corresponding changes in the TM are not yet known. We know, however, that all risk factors for arteriosclerosis are also risk factors for an increase in IOP...
  69. doi request reprint Is the medication used to achieve the target intraocular pressure in glaucoma therapy of relevance?--an exemplary analysis on the basis of two beta-blockers
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland
    Prog Retin Eye Res 29:79-93. 2010
    ..Future studies on glaucoma treatment should focus on their effect on visual field function, and not just on IOP. This should particularly be considered when comparing drugs from different classes...
  70. ncbi request reprint Effect of palmitoleic acid on bradykinin-induced endothelium-dependent relaxation in isolated pig ciliary artery
    Thomas Morf
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Basel
    Klin Monbl Augenheilkd 219:284-8. 2002
    ..The present study investigates whether the gap junction uncoupling agent palmitoleic acid (PA) affects bradykinin-induced endothelium-dependent relaxation in isolated pig ciliary artery...
  71. ncbi request reprint Inhibition by brimonidine of forskolin-induced nitrite production in isolated pig ciliary processes
    Rong Liu
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Switzerland
    Invest Ophthalmol Vis Sci 43:2727-31. 2002
    ..To investigate by which mechanism the ocular hypotensive drug brimonidine (selective alpha(2)-adrenoreceptor agonist) inhibits the production of nitrite induced by forskolin in isolated porcine ciliary processes...
  72. doi request reprint Circumferential viscocanalostomy and suture canal distension (canaloplasty) for whites with open-angle glaucoma
    Matthias C Grieshaber
    Department of Ophthalmology, Glaucoma Service, University Hospital of Basel, Basel, Switzerland
    J Glaucoma 20:298-302. 2011
    ..To assess the safety and efficacy of canaloplasty (360-degree viscodilation and tensioning of the Schlemm canal) in Whites with open-angle glaucoma (OAG)...
  73. ncbi request reprint Congenital iris ectropion and glaucoma associated with intestinal neuronal dysplasia: a manifestation of a neural crest syndrome
    Matthias C Grieshaber
    Department of Ophthalmology, University of Basel, Basel, Switzerland
    Arch Ophthalmol 124:1495-7. 2006
  74. ncbi request reprint Effect of hospitalization on intraocular pressure in patients with high tension and normal tension glaucoma
    Timo Haufschild
    University Eye Clinic Basel, Basel, Switzerland
    Am J Ophthalmol 142:179-81. 2006
    ..To determine the effect of hospitalization on intraocular pressure (IOP) in glaucoma patients...
  75. ncbi request reprint Forskolin upregulation of NOS I protein expression in porcine ciliary processes: a new aspect of aqueous humor regulation
    Rong Liu
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic, Basel, Switzerland
    Klin Monbl Augenheilkd 219:281-3. 2002
    ..To determine whether nitric oxide synthase (NOS) protein expression can be modulated by forskolin in porcine ciliary processes...
  76. ncbi request reprint A novel perspective on natural therapeutic approaches in glaucoma therapy
    Maneli Mozaffarieh
    University Eye Clinic Basel, Mittlere Strasse 91, PO Box, CH 4031 Basel, Switzerland
    Expert Opin Emerg Drugs 12:195-8. 2007
    ..Future intensive studies on the effect of these compounds may open up a new therapeutic era in glaucoma...
  77. ncbi request reprint Transepithelial short circuit currents in human and porcine isolated ciliary bodies: effect of acetazolamide and epinephrine
    Renyi Wu
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Switzerland
    Klin Monbl Augenheilkd 220:156-60. 2003
    ..To investigate in human and porcine isolated ciliary bodies the effect of acetazolamide and epinephrine on ciliary transepithelial ionic currents (a parameter linked to aqueous humor production)...
  78. ncbi request reprint Is there more to glaucoma treatment than lowering IOP?
    Maneli Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Surv Ophthalmol 52:S174-9. 2007
    ..This can be achieved by gingko; dark chocolate; polyphenolic flavonoids occurring in tea, coffee, or red wine; anthocyanosides found in bilberries; as well as by ubiquinone and melatonin...
  79. ncbi request reprint Immunohistochemical localization of angiotensin-converting enzyme, angiotensin II and AT1 receptor in human ocular tissues
    Egemen Savaskan
    Psychiatric University Clinic, University of Basel, Basel, Switzerland
    Ophthalmic Res 36:312-20. 2004
    ..The manifold localization sites of the observed antigens point to rather generalized functions of the RAS in human ocular tissues, such as regulatory effects on neuronal cells, vessels and vitreous humor homeostasis...