Serge L Ferrari

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. pmc Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL
    Dominique D Pierroz
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospital and Faculty of Medicine, 1211 Geneva 14, Switzerland
    J Biol Chem 285:28164-73. 2010
  2. doi request reprint Inhibition of T cell-dependent and RANKL-dependent osteoclastogenic processes associated with high levels of bone mass in interleukin-15 receptor-deficient mice
    Souad Djaafar
    World Health Organization Collaborating Center for Osteoporosis Prevention, Geneva University Medical School, and Geneva University Hospital, Geneva, Switzerland
    Arthritis Rheum 62:3300-10. 2010
  3. ncbi request reprint Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass
    Serge L Ferrari
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva, Switzerland
    Curr Opin Lipidol 16:207-14. 2005
  4. pmc Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice
    Dominique D Pierroz
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, WHO Center for Osteoporosis Prevention, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Bone Miner Res 24:775-84. 2009
  5. doi request reprint Deletion of β-adrenergic receptor 1, 2, or both leads to different bone phenotypes and response to mechanical stimulation
    Dominique D Pierroz
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Bone Miner Res 27:1252-62. 2012
  6. pmc Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, World Health Organization Collaborating Center for Osteoporosis Prevention, Geneva University Hospital and Faculty of Medicine, Geneva 14, Switzerland
    Proc Natl Acad Sci U S A 109:15048-53. 2012
  7. ncbi request reprint Childhood fractures are associated with decreased bone mass gain during puberty: an early marker of persistent bone fragility?
    Serge L Ferrari
    Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva, Switzerland
    J Bone Miner Res 21:501-7. 2006
  8. pmc Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites
    Serge L Ferrari
    Division of Bone Diseases, University Hospital of Geneva, Geneva 1211, Switzerland
    Am J Hum Genet 74:866-75. 2004
  9. doi request reprint Effects of long-term supplementation with omega-3 fatty acids on longitudinal changes in bone mass and microstructure in mice
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, WHO Collaborating Center for Osteoporosis Prevention, Geneva University Hospital, 1211 Geneva 14, Switzerland
    J Nutr Biochem 22:665-72. 2011
  10. ncbi request reprint Osteoporosis: a complex disorder of aging with multiple genetic and environmental determinants
    Serge L Ferrari
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva, Switzerland
    World Rev Nutr Diet 95:35-51. 2005

Detail Information

Publications24

  1. pmc Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL
    Dominique D Pierroz
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospital and Faculty of Medicine, 1211 Geneva 14, Switzerland
    J Biol Chem 285:28164-73. 2010
    ....
  2. doi request reprint Inhibition of T cell-dependent and RANKL-dependent osteoclastogenic processes associated with high levels of bone mass in interleukin-15 receptor-deficient mice
    Souad Djaafar
    World Health Organization Collaborating Center for Osteoporosis Prevention, Geneva University Medical School, and Geneva University Hospital, Geneva, Switzerland
    Arthritis Rheum 62:3300-10. 2010
    ..The purpose of this study was to characterize the effects of interleukin-15 (IL-15), a master T cell growth factor whose role in bone remodeling remains unknown...
  3. ncbi request reprint Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass
    Serge L Ferrari
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva, Switzerland
    Curr Opin Lipidol 16:207-14. 2005
    ..This review summarizes recent findings concerning the genomic variations of the lipoprotein receptor-related protein 5 (LPR5) in relation to bone biology...
  4. pmc Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice
    Dominique D Pierroz
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, WHO Center for Osteoporosis Prevention, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Bone Miner Res 24:775-84. 2009
    ..As such, beta-arrestins should be considered an important mechanism for the control of bone remodeling in response to PTH and estrogen deprivation...
  5. doi request reprint Deletion of β-adrenergic receptor 1, 2, or both leads to different bone phenotypes and response to mechanical stimulation
    Dominique D Pierroz
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Bone Miner Res 27:1252-62. 2012
    ....
  6. pmc Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, World Health Organization Collaborating Center for Osteoporosis Prevention, Geneva University Hospital and Faculty of Medicine, Geneva 14, Switzerland
    Proc Natl Acad Sci U S A 109:15048-53. 2012
    ..These data elucidate the complex role of periostin on bone anabolism, through the regulation of Sost, Wnt-β-catenin signaling, and osteoblast differentiation...
  7. ncbi request reprint Childhood fractures are associated with decreased bone mass gain during puberty: an early marker of persistent bone fragility?
    Serge L Ferrari
    Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva, Switzerland
    J Bone Miner Res 21:501-7. 2006
    ..Among those, BMC gain at multiple sites and vertebral bone size at pubertal maturity were significantly decreased. Hence, childhood fractures may be markers of low peak bone mass acquisition and persistent skeletal fragility...
  8. pmc Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites
    Serge L Ferrari
    Division of Bone Diseases, University Hospital of Geneva, Geneva 1211, Switzerland
    Am J Hum Genet 74:866-75. 2004
    ..Together, these results suggest that LRP5 variants significantly contribute to LS-bone-mass and size determination in men by influencing vertebral bone growth during childhood...
  9. doi request reprint Effects of long-term supplementation with omega-3 fatty acids on longitudinal changes in bone mass and microstructure in mice
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, WHO Collaborating Center for Osteoporosis Prevention, Geneva University Hospital, 1211 Geneva 14, Switzerland
    J Nutr Biochem 22:665-72. 2011
    ..These data suggest that long-term intake of omega-3 FA, particularly EPA, may modestly improve the structural and mechanical properties of cortical bone by an increase in leptin and IGF-1 levels, without affecting trabecular bone loss...
  10. ncbi request reprint Osteoporosis: a complex disorder of aging with multiple genetic and environmental determinants
    Serge L Ferrari
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva, Switzerland
    World Rev Nutr Diet 95:35-51. 2005
  11. ncbi request reprint Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men
    Serge L Ferrari
    Service of Bone Diseases, Geneva University Hospital, 24 Rue Micheli du Crest, Geneva 1211, Switzerland
    J Clin Endocrinol Metab 90:1519-24. 2005
    ..These data suggest that FGF-23 may be implicated in the physiological regulation of Pi homeostasis in response to dietary phosphate changes, independent of PTH...
  12. doi request reprint Effects of an interleukin-15 antagonist on systemic and skeletal alterations in mice with DSS-induced colitis
    Bénédicte Brounais-Le Royer
    Service of Bone Diseases, Department of Medical Specialties, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    Am J Pathol 182:2155-67. 2013
    ..These results delineate the role of IL-15 on the systemic and skeletal manifestations of chronic colitis and provide a proof-of-concept for future therapeutic developments...
  13. ncbi request reprint Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized mice
    Dominique D Pierroz
    Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital, HUGs, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Bone 39:260-7. 2006
    ..In turn, PRO exerted synergistic effects with intermittent PTH on bone mass and cancellous bone architecture. As such, combined therapy of beta-blockers and PTH may be of interest in the treatment of postmenopausal osteoporosis...
  14. pmc The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, World Health Organization Collaborating Center for Osteoporosis Prevention, 1211 Geneva 14, Switzerland
    J Biol Chem 284:35939-50. 2009
    ..Taken together, these results indicate that the matricellular periostin protein is required for Sost inhibition and thereby plays an important role in the determination of bone mass and microstructural in response to loading...
  15. doi request reprint Beta-arrestin-biased parathyroid hormone ligands: a new approach to the development of agents that stimulate bone formation
    Serge L Ferrari
    Service of Bone Diseases, World Health Organization Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva, Switzerland
    Sci Transl Med 1:1ps1. 2009
    ..This targeted approach may pave the way for future pharmacological developments in the treatment of osteoporosis...
  16. ncbi request reprint Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis Study
    Serge L Ferrari
    Division of Bone Diseases and WHO Collaborating Center for Osteoporosis, Departments of Geriatrics and Internal Medicine, Geneva University Hospital, Geneva, Switzerland
    J Bone Miner Res 19:552-9. 2004
    ..Hence, association of IL-6 polymorphisms with BMD may be limited to discrete population subgroups...
  17. pmc Beta-arrestin2 regulates parathyroid hormone effects on a p38 MAPK and NFkappaB gene expression network in osteoblasts
    Estelle N Bianchi
    Department of Rehabilitation and Geriatrics, WHO Center for Osteoporosis Prevention, Geneva University Hospitals and University of Geneva, Faculty of Medicine, Switzerland
    Bone 45:716-25. 2009
    ..PTH, and delineates new molecular mechanisms to explain the anabolic and catabolic effects of PTH on bone...
  18. ncbi request reprint Gene variants for osteoporosis and their pleiotropic effects in aging
    Serge L Ferrari
    Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Switzerland
    Mol Aspects Med 26:145-67. 2005
    ....
  19. ncbi request reprint Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation
    Alexandre Rey
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital, 1211 Geneva 14, Switzerland
    J Biol Chem 281:38181-8. 2006
    ....
  20. doi request reprint Caloric restriction decreases cortical bone mass but spares trabecular bone in the mouse skeleton: implications for the regulation of bone mass by body weight
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Bone Miner Res 23:870-8. 2008
    ..We examined bone metabolism in calorically restricted mice to determine how alterations in soft tissue mass affect bone mass, density, and strength...
  21. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    ..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population...
  22. pmc Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men
    Douglas P Kiel
    Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02131, USA
    Bone 40:587-96. 2007
    ..These observations suggest that Wnt-LRP5 may play a role in the adaptation of bone to mechanical load in humans, and may explain some gender-related differences in bone mass...
  23. pmc beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 20:635-43. 2005
    ..These data indicate that arrestin-mediated regulation of intracellular signaling contributes to the differential effects of PTH at endosteal and periosteal bone surfaces...
  24. ncbi request reprint Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization
    Alessandro Bisello
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 18:1486-98. 2004
    ....