P Ferrari

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi Abnormalities in insulin sensitivity, vascular resistance and erythrocyte cation transport are independent genetic traits in familial hypertension
    P Ferrari
    Department of Nephrology and Hypertension, University of Berne, Switzerland
    Blood Press 8:102-9. 1999
  2. ncbi Genetics of the mineralocorticoid system in primary hypertension
    Paolo Ferrari
    Division of Nephrology and Hypertension, Inselspital, University of Berne, Freiburgstrasse 10, 3010 Berne, Switzerland
    Curr Hypertens Rep 4:18-24. 2002
  3. ncbi In vivo 11beta-HSD-2 activity: variability, salt-sensitivity, and effect of licorice
    P Ferrari
    Division of Nephrology and Hypertension, Inselspital, University of Berne, Switzerland
    Hypertension 38:1330-6. 2001
  4. ncbi Modulation of renal calcium handling by 11 beta-hydroxysteroid dehydrogenase type 2
    Paolo Ferrari
    Division of Nephrology and Hypertension, Department of Pediatrics, Inselspital, University of Berne, Switzerland
    J Am Soc Nephrol 13:2540-6. 2002
  5. ncbi Juvenile hypertension, the role of genetically altered steroid metabolism
    P Ferrari
    Division of Nephrology and Hypertension, Inselspital, University of Bern, Switzerland
    Horm Res 55:213-23. 2001
  6. ncbi Additive antiproteinuric effect of combined ACE inhibition and angiotensin II receptor blockade
    Paolo Ferrari
    Division of Nephrology and Hypertension, Inselspital, University of Berne, Freiburgstrasse 10, 3010 Berne, Switzerland
    J Hypertens 20:125-30. 2002
  7. ncbi [Pharmacologic action of diuretics in the kidney]
    P Ferrari
    Abteilung für Nephrologie und Hypertonie, Universitat Bern
    Ther Umsch 57:345-50. 2000
  8. ncbi Role of the 11beta-hydroxysteroid dehydrogenase type 2 in blood pressure regulation
    P Ferrari
    Division of Nephrology and Hypertension, University of Berne, Berne, Switzerland
    Kidney Int 57:1374-81. 2000
  9. ncbi [How relevant is the trough-to peak ratio?]
    P Ferrari
    Abteilung für Nephrologie Hypertonie, Inselspital, Bern
    Schweiz Med Wochenschr 130:329-35. 2000
  10. ncbi The role of the 11beta-hydroxysteroid dehydrogenase type 2 in human hypertension
    P Ferrari
    Division of Nephrology and Hypertension, University of Berne, Switzerland
    J Hypertens 18:241-8. 2000

Collaborators

Detail Information

Publications45

  1. ncbi Abnormalities in insulin sensitivity, vascular resistance and erythrocyte cation transport are independent genetic traits in familial hypertension
    P Ferrari
    Department of Nephrology and Hypertension, University of Berne, Switzerland
    Blood Press 8:102-9. 1999
    ....
  2. ncbi Genetics of the mineralocorticoid system in primary hypertension
    Paolo Ferrari
    Division of Nephrology and Hypertension, Inselspital, University of Berne, Freiburgstrasse 10, 3010 Berne, Switzerland
    Curr Hypertens Rep 4:18-24. 2002
    ..A search for genetic disorders of the mineralocorticoid axis should be an integral part of the diagnostic work-up, particularly in young adults with hypertension...
  3. ncbi In vivo 11beta-HSD-2 activity: variability, salt-sensitivity, and effect of licorice
    P Ferrari
    Division of Nephrology and Hypertension, Inselspital, University of Berne, Switzerland
    Hypertension 38:1330-6. 2001
    ..The (THF+5alpha-THF)/THE ratio better discriminates between salt-sensitive and salt-resistant subjects. Together with BP responses to glycyrrhetinic acid, these findings support a pivotal role of 11beta-HSD-2 in salt sensitivity...
  4. ncbi Modulation of renal calcium handling by 11 beta-hydroxysteroid dehydrogenase type 2
    Paolo Ferrari
    Division of Nephrology and Hypertension, Department of Pediatrics, Inselspital, University of Berne, Switzerland
    J Am Soc Nephrol 13:2540-6. 2002
    ..The likely site of steroid-regulated renal calcium handling appears to be the distal tubule...
  5. ncbi Juvenile hypertension, the role of genetically altered steroid metabolism
    P Ferrari
    Division of Nephrology and Hypertension, Inselspital, University of Bern, Switzerland
    Horm Res 55:213-23. 2001
    ..Considering that hypertension in children and adolescents is often 'nonessential', a search for disorders should be integral part of the diagnostic work-up in young patients with hypertension...
  6. ncbi Additive antiproteinuric effect of combined ACE inhibition and angiotensin II receptor blockade
    Paolo Ferrari
    Division of Nephrology and Hypertension, Inselspital, University of Berne, Freiburgstrasse 10, 3010 Berne, Switzerland
    J Hypertens 20:125-30. 2002
    ..Limitation of systemic and glomerular hypertension reduces urinary protein excretion and prevents renal function deterioration...
  7. ncbi [Pharmacologic action of diuretics in the kidney]
    P Ferrari
    Abteilung für Nephrologie und Hypertonie, Universitat Bern
    Ther Umsch 57:345-50. 2000
    ..This information may allow a more appropriate use of diuretics and the design of new substances with diuretic action...
  8. ncbi Role of the 11beta-hydroxysteroid dehydrogenase type 2 in blood pressure regulation
    P Ferrari
    Division of Nephrology and Hypertension, University of Berne, Berne, Switzerland
    Kidney Int 57:1374-81. 2000
    ..These findings indicate that variants of the HSD11B2 gene contribute to the enhanced blood pressure response to salt in humans...
  9. ncbi [How relevant is the trough-to peak ratio?]
    P Ferrari
    Abteilung für Nephrologie Hypertonie, Inselspital, Bern
    Schweiz Med Wochenschr 130:329-35. 2000
    ..It is thus a purely arithmetical index without major clinical relevance. Evaluation of the clinical efficacy of antihypertensive drugs should rather be based on 24-hour measurements, as a more reproducible parameter...
  10. ncbi The role of the 11beta-hydroxysteroid dehydrogenase type 2 in human hypertension
    P Ferrari
    Division of Nephrology and Hypertension, University of Berne, Switzerland
    J Hypertens 18:241-8. 2000
    ..These findings suggest that variants of the HSD11 B2 gene may contribute to the enhanced blood pressure response to salt in some humans...
  11. ncbi Molecular basis of human salt sensitivity: the role of the 11beta-hydroxysteroid dehydrogenase type 2
    E Lovati
    Department of Nephrology and Hypertension, University of Berne, Switzerland
    J Clin Endocrinol Metab 84:3745-9. 1999
    ..The association of a polymorphic microsatellite marker of the gene with a reduced 11betaHSD2 activity suggests that variants of the HSD 11B2 gene contribute to enhanced blood pressure response to salt in humans...
  12. ncbi A mutation in the cofactor-binding domain of 11beta-hydroxysteroid dehydrogenase type 2 associated with mineralocorticoid hypertension
    A Odermatt
    Division of Nephrology and Hypertension, Inselspital, University of Berne, 3010 Berne, Switzerland
    J Clin Endocrinol Metab 86:1247-52. 2001
    ....
  13. ncbi Forms of mineralocorticoid hypertension
    Paolo Ferrari
    Division of Nephrology and Hypertension, Inselspital, University of Berne, 3010 Berne, Switzerland
    Vitam Horm 66:113-56. 2003
    ..The present review addresses the physiology and significance of the key players of the mineralocorticoid axis, placing emphasis on the conditions leading to mineralocorticoid hypertension...
  14. ncbi Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal disease
    E Lovati
    Division of Nephrology and Hypertension, Inselspital, University of Berne, Berne, Switzerland
    Kidney Int 60:46-54. 2001
    ..Genes encoding for angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and aldosterone synthase (CYP11B2) are candidates for abnormal blood pressure regulation...
  15. ncbi Hypoxia causes down-regulation of 11 beta-hydroxysteroid dehydrogenase type 2 by induction of Egr-1
    Christian D Heiniger
    Division of Nephrology and Hypertension, University of Berne, 3010 Berne, Switzerland
    FASEB J 17:917-9. 2003
    ..Thus, hypoxia decreases 11beta-HSD2 transcription and activity by inducing Egr-1 in vivo and in vitro. This mechanism might account for enhanced renal sodium retention and hypertension associated with hypoxic conditions...
  16. ncbi Angiotensin-converting enzyme inhibition but not angiotensin II receptor blockade regulates matrix metalloproteinase activity in patients with glomerulonephritis
    Nadege Lods
    Division of Nephrology and Hypertension, Inselspital Bern, Bern, Switzerland
    J Am Soc Nephrol 14:2861-72. 2003
    ..Levels of TIMP-1/-2 remained unaffected. In conclusion, ACEI and ARB differentially regulate MMP activity, which may ultimately have consequences in certain types of MMP-dependent glomerulonephritis...
  17. ncbi Glycyrrhetinic acid decreases plasma potassium concentrations in patients with anuria
    Andreas Serra
    University Hospital of Berne, Berne, Switzerland
    J Am Soc Nephrol 13:191-6. 2002
    ..9 +/- 0.7 and 4.5 +/- 0.8 mM/L after 1 and 2 wk on GA, respectively (F = 9.934, P < 0.003). Extrarenal 11beta-HSD activity influences serum potassium concentrations but does not regulate BP independently of renal sodium retention...
  18. ncbi Recipient RAS gene variants and renal allograft function
    Jerome Nicod
    Division of Nephrology and Hypertension, Inselspital, University of Berne, Switzerland
    Transplantation 73:960-5. 2002
    ..A decreased long-term renal allograft function has also been associated with increased activity of RAS, which may be genetically determined...
  19. ncbi Kidney transplantation in rats: an appraisal of surgical techniques and outcome
    Martin Schumacher
    Department of Urology, Inselspital, Berne, Switzerland
    Microsurgery 23:387-94. 2003
    ..Also, end-to-end or end-to-side vascular anastomoses are preferable to the sleeve technique. Other factors do not influence the immediate function of the graft...
  20. ncbi Combination treatment with an ET(A)-receptor blocker and an ACE inhibitor is not superior to the respective monotherapies in attenuating chronic transplant vasculopathy in different aorta allotransplantation rat models
    Stephan R Orth
    Division of Nephrology and Hypertension, University Hospital Berne Inselspital, Berne, Switzerland
    Nephrol Dial Transplant 18:62-9. 2003
    ..Untreated sham-operated and isografted WKY and SHR served as controls. Allotransplanted animals treated with the angiotensin-converting enzyme (ACE) inhibitor trandolapril served as positive treatment controls...
  21. ncbi Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production
    Jerome Nicod
    Division of Nephrology and Hypertension, Inselspital, University of Berne, Berne, Switzerland
    Mol Cell Endocrinol 214:167-74. 2004
    ..We hypothesised that gene variants of CYP11B1 or CYP11B2 may be linked to this abnormal glucocorticoid production...
  22. ncbi A biallelic gene polymorphism of CYP11B2 predicts increased aldosterone to renin ratio in selected hypertensive patients
    Jerome Nicod
    Division of Nephrology and Hypertension, Inselspital, University of Berne, 3010 Berne, Switzerland
    J Clin Endocrinol Metab 88:2495-500. 2003
    ..These findings support the view of a molecular basis regulating aldosterone production...
  23. ncbi Prophylactic hemodialysis after radiocontrast media in patients with renal insufficiency is potentially harmful
    B Vogt
    University Hospital of Berne, Berne, Switzerland
    Am J Med 111:692-8. 2001
    ....
  24. ncbi Heme oxygenase-1 attenuates ischemia/reperfusion-induced apoptosis and improves survival in rat renal allografts
    Markus Wagner
    Department of Visceral and Transplantation Surgery, University of Bern, Bern, Switzerland
    Kidney Int 63:1564-73. 2003
    ..Therefore, we investigated whether the induction of the HSP, heme oxygenase-1 (HO-1), improves outcome following isotransplantation after an extended period of cold storage...
  25. ncbi Impaired protein stability of 11beta-hydroxysteroid dehydrogenase type 2: a novel mechanism of apparent mineralocorticoid excess
    Atanas G Atanasov
    Department of Nephrology and Hypertension, University of Berne, Freiburgstrasse 15, 3010 Berne, Switzerland
    J Am Soc Nephrol 18:1262-70. 2007
    ..Therefore, impaired 11beta-HSD2 protein stability rather than reduced gene expression or loss of catalytic activity seems to be responsible for the development of hypertension in some individuals with AME...
  26. ncbi Fatal cardiac arrhythmia after infusion of dimethyl sulfoxide-cryopreserved hematopoietic stem cells in a patient with severe primary cardiac amyloidosis and end-stage renal failure
    R Zenhausern
    Department of Oncology, University of Berne, Inselspital, Switzerland
    Ann Hematol 79:523-6. 2000
    ....
  27. ncbi Low prevalence of nonconservative mutations of serum and glucocorticoid-regulated kinase (SGK1) gene in hypertensive and renal patients
    Nadja Trochen
    Division of Nephrology and Hypertension, University Hospital, Berne, Switzerland
    Nephrol Dial Transplant 19:2499-504. 2004
    ..Mutations of the SGK1 gene affecting phosphorylation could be responsible for salt-mediated increases in BP and hypertension-related progression to end-stage renal disease (ESRD)...
  28. ncbi CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity
    Santhirasekaran Ganapathipillai
    Division of Nephrology, Zoological Institute, University of Berne, Berne 3010, Switzerland
    J Clin Endocrinol Metab 90:1220-5. 2005
    ..These findings indicate that genotypes at the CYP11B locus are in strong LD and that identified haplotypes predict 11 beta-hydroxylase activity...
  29. ncbi Association of plasminogen activator inhibitor-1 genotype with avascular osteonecrosis in steroid-treated renal allograft recipients
    Paolo Ferrari
    Division of Nephrology and Hypertension, Inselspital, University of Berne, Freiburgstrasse 10, 3010 Berne, Switzerland
    Transplantation 74:1147-52. 2002
    ..We hypothesize that a genetic variant of the plasminogen activator inhibitor-1 (PAI-1) determines the risk of AVN in glucocorticoid-treated patients...
  30. ncbi Hip pain in renal transplant recipients: symptomatic gluteus minimus and gluteus medius tendon abnormality as an alternative MRI diagnosis to avascular necrosis
    Andre W Demant
    Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University of Bern, Freiburg Strasse, 24 Thunstrasses, Bern CH 3010, Switzerland
    AJR Am J Roentgenol 188:515-9. 2007
    ..CONCLUSION: Symptomatic gluteus minimus and medius tendon lesions and abnormalities can occur in renal allograft recipients. The MRI findings of this entity allow an alternative diagnosis in this patient population...
  31. ncbi Long-term calcineurin inhibition and magnesium balance after renal transplantation
    Brunello L Mazzola
    Division of Pediatric Nephrology, University Hospital, 3010 Berne, Switzerland
    Transpl Int 16:76-81. 2003
    ..These observations indicate a modified magnesium steady state in renal transplant recipients treated with cyclosporine...
  32. ncbi Cortisol and the renal handling of electrolytes: role in glucocorticoid-induced hypertension and bone disease
    Paolo Ferrari
    Department of Nephrology, Fremantle Hospital, University of Western Australia, Alma Street, P O Box 480, Fremantle WA, Perth 6160, Australia
    Best Pract Res Clin Endocrinol Metab 17:575-89. 2003
    ..Modulation of renal Na(+) and Ca(2+) excretion with some, but not all, diuretics represents an important specific (for hypertension) or supportive (for bone disease) therapeutic intervention...
  33. ncbi Salt-sensitivity of blood pressure and decreased 11beta-hydroxysteroid dehydrogenase type 2 activity after renal transplantation
    Martin Schumacher
    Division of Nephrology and Hypertension and Institute of Physiology, University of Fribourg, Switzerland
    Transplantation 74:66-72. 2002
    ..There is evidence that BP is salt dependent in renal transplant recipients. We hypothesize that renal transplantation induces salt sensitivity by decreasing 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) activity...
  34. ncbi Active renin versus plasma renin activity to define aldosterone-to-renin ratio for primary aldosteronism
    Paolo Ferrari
    Department of Nephrology, Fremantle Hospital, University of Western Australia, Fremantle, Australia
    J Hypertens 22:377-81. 2004
    ..Plasma renin activity (PRA) is usually measured to define ARR although, increasingly, renin concentration alone is often measured in clinical routine...
  35. ncbi Reasons for not intensifying antihypertensive treatment (RIAT): a primary care antihypertensive intervention study
    Paolo Ferrari
    Department of Nephrology, Fremantle Hospital, Perth, Australia
    J Hypertens 22:1221-9. 2004
    ....
  36. ncbi Endothelin 1 type a receptor antagonism prevents vascular dysfunction and hypertension induced by 11beta-hydroxysteroid dehydrogenase inhibition: role of nitric oxide
    Paolo Ferrari
    Circulation 105:e126; author reply e126. 2002
  37. ncbi Prescribing angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in chronic kidney disease
    Paolo Ferrari
    Department of Nephrology, Fremantle Hospital, Perth, Western Australia, Australia
    Nephrology (Carlton) 12:81-9. 2007
    ..Finally, it is important to emphasize that progressive lowering of blood pressure to 120 mmHg is associated with improved renal outcome and that this effect is independent of baseline renal function...
  38. ncbi Pharmacokinetic-pharmacodynamic modelling of magnesium plasma concentration and blood pressure in preeclamptic women
    Jianfeng Lu
    Department of Biopharmaceutical Sciences, University of California San Francisco, 94143, USA
    Clin Pharmacokinet 41:1105-13. 2002
    ..To describe the relationship between plasma magnesium (Mg(2+)) concentration and blood pressure response in pregnant women with preeclampsia...
  39. ncbi Apparent mineralocorticoid excess: report of six new cases and extensive personal experience
    Gilles Morineau
    Assistance Publique Hopitaux de Paris, Biochemistry Laboratory, Hopital St Antoine, Paris
    J Am Soc Nephrol 17:3176-84. 2006
    ....
  40. ncbi Swiss Hypertension and Risk Factor Program (SHARP): cardiovascular risk factors management in patients with type 2 diabetes in Switzerland
    Antoinette Pechere-Bertschi
    Division of Endocrinology and Medical Policlinic, University Hospital, Geneva, Switzerland
    Blood Press 14:337-44. 2005
    ..In this country with easy access to medical care, high medical density and few financial constraints, appropriate detection and treatment for cardiovascular risk factors remain highly problematic...
  41. ncbi Activity of 11beta-hydroxysteroid dehydrogenase type 2 in normotensive blacks and whites
    R Ravi Shankar
    Indiana University School of Medicine Indianapolis, Indiana, USA
    Ethn Dis 15:407-10. 2005
    ..We tested the hypothesis that less activity of the enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) is present in Blacks than in Whites...
  42. ncbi Effects of smoking on renal function in patients with type 1 and type 2 diabetes mellitus
    Stephan R Orth
    Klinik und Poliklinik für Innere Medizin II Nephrologie, University of Regensburg, Regensburg, Germany
    Nephrol Dial Transplant 20:2414-9. 2005
    ..Whether and to what extent smoking affects the kidneys in diabetic patients with normal renal function and variable degrees of proteinuria has not been fully studied...
  43. ncbi Salt-sensitive blood pressure--an intermediate phenotype predisposing to diabetic nephropathy?
    Krzysztof Strojek
    Department of Internal Diseases, Diabetology and Nephrology, Silesian Medical Academy, 3 go Maja 13 15, Zabrze 41 800, Poland
    Nephrol Dial Transplant 20:2113-9. 2005
    ..Family studies point to important genetic determinants of diabetic nephropathy (DN). Blood pressure (BP) is higher in offspring of patients with type 2 diabetes and DN, but the pathomechanisms involved have not been elucidated...
  44. ncbi The distinction between Liddle syndrome and apparent mineralocorticoid excess
    Mario G Bianchetti
    Pediatr Nephrol 18:607-8; author reply 609. 2003
  45. ncbi The challenge of renal cystic disease and its association with hypertension, age and abnormal potassium handling
    Paolo Ferrari
    J Hypertens 25:1347-9. 2007