Ingrid Felger

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population
    Sonja Schoepflin
    Swiss Tropical Institute, Department of Medical Parasitology and Infection Biology, Socinstr 57, 4002 Basel, Switzerland
    Malar J 7:78. 2008
  2. pmc Sequence conservation in Plasmodium falciparum alpha-helical coiled coil domains proposed for vaccine development
    Caroline Kulangara
    Swiss Tropical Institute, Basel, Switzerland
    PLoS ONE 4:e5419. 2009
  3. pmc Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea
    Cristian Koepfli
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1424. 2011
  4. pmc A high force of plasmodium vivax blood-stage infection drives the rapid acquisition of immunity in papua new guinean children
    Cristian Koepfli
    Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland Walter and Eliza Hall Institute, Parkville, Victoria, Australia
    PLoS Negl Trop Dis 7:e2403. 2013
  5. pmc Serodiagnosis of Echinococcus spp. infection: explorative selection of diagnostic antigens by peptide microarray
    Claudia List
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 4:e771. 2010
  6. pmc Cell biological characterization of the malaria vaccine candidate trophozoite exported protein 1
    Caroline Kulangara
    Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e46112. 2012
  7. pmc Plasmodium falciparum msp1, msp2 and glurp allele frequency and diversity in sub-Saharan Africa
    Felista Mwingira
    Dares Salaam University College of Education P O BOX 2329, Dar es Salaam, Tanzania
    Malar J 10:79. 2011
  8. pmc Efficacy of sulfadoxine-pyrimethamine in Tanzania after two years as first-line drug for uncomplicated malaria: assessment protocol and implication for treatment policy strategies
    Kefas Mugittu
    Ifakara Health Research and Development Centre, PO Box 53, Ifakara, Tanzania
    Malar J 4:55. 2005
  9. pmc Optimization and validation of multi-coloured capillary electrophoresis for genotyping of Plasmodium falciparum merozoite surface proteins (msp1 and 2)
    Anne Liljander
    Department of Medicine Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Malar J 8:78. 2009
  10. pmc Comparison of diagnostic methods for the detection and quantification of the four sympatric Plasmodium species in field samples from Papua New Guinea
    Anna Rosanas-Urgell
    Papua New Guinea Insitute of Medical Research, Madang 511, Papua New Guinea
    Malar J 9:361. 2010

Collaborators

Detail Information

Publications41

  1. pmc Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population
    Sonja Schoepflin
    Swiss Tropical Institute, Department of Medical Parasitology and Infection Biology, Socinstr 57, 4002 Basel, Switzerland
    Malar J 7:78. 2008
    ..In particular newly acquired haplotypes after radical cure were characterized and compared to haplotypes from persistent infections...
  2. pmc Sequence conservation in Plasmodium falciparum alpha-helical coiled coil domains proposed for vaccine development
    Caroline Kulangara
    Swiss Tropical Institute, Basel, Switzerland
    PLoS ONE 4:e5419. 2009
    ....
  3. pmc Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea
    Cristian Koepfli
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1424. 2011
    ..02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and monitoring the effects of interventions...
  4. pmc A high force of plasmodium vivax blood-stage infection drives the rapid acquisition of immunity in papua new guinean children
    Cristian Koepfli
    Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland Walter and Eliza Hall Institute, Parkville, Victoria, Australia
    PLoS Negl Trop Dis 7:e2403. 2013
    ..vivax ((mol)FOB, i.e. the number of genetically distinct blood-stage infections over time), and compared it to previously reported values for P. falciparum...
  5. pmc Serodiagnosis of Echinococcus spp. infection: explorative selection of diagnostic antigens by peptide microarray
    Claudia List
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 4:e771. 2010
    ....
  6. pmc Cell biological characterization of the malaria vaccine candidate trophozoite exported protein 1
    Caroline Kulangara
    Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e46112. 2012
    ..No classical export motifs such as PEXEL, signal sequence/anchor or transmembrane domain was identified for Tex1...
  7. pmc Plasmodium falciparum msp1, msp2 and glurp allele frequency and diversity in sub-Saharan Africa
    Felista Mwingira
    Dares Salaam University College of Education P O BOX 2329, Dar es Salaam, Tanzania
    Malar J 10:79. 2011
    ..This study presents the genetic diversity of P. falciparum msp1, msp2 and glurp markers in selected sub-Saharan Africa countries with varying levels of endemicity namely Malawi, Tanzania, Uganda, Burkina Faso and São Tomé...
  8. pmc Efficacy of sulfadoxine-pyrimethamine in Tanzania after two years as first-line drug for uncomplicated malaria: assessment protocol and implication for treatment policy strategies
    Kefas Mugittu
    Ifakara Health Research and Development Centre, PO Box 53, Ifakara, Tanzania
    Malar J 4:55. 2005
    ..This study assessed in vivo SP efficacy after two years of use as an interim first-line drug in Tanzania, and determined the rates of treatment failures obtained after 14 and 28 days of follow-up...
  9. pmc Optimization and validation of multi-coloured capillary electrophoresis for genotyping of Plasmodium falciparum merozoite surface proteins (msp1 and 2)
    Anne Liljander
    Department of Medicine Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Malar J 8:78. 2009
    ..falciparum msp1 and msp2 has been adapted to the CE technique. The protocol and optimization process as well as the potentials and limitations of the technique in molecular epidemiology studies and anti-malarial drug trials are reported...
  10. pmc Comparison of diagnostic methods for the detection and quantification of the four sympatric Plasmodium species in field samples from Papua New Guinea
    Anna Rosanas-Urgell
    Papua New Guinea Insitute of Medical Research, Madang 511, Papua New Guinea
    Malar J 9:361. 2010
    ..Despite great advantages of light microscopy (LM) for malaria diagnosis, its limited sensitivity is a critical shortfall for epidemiological studies. Robust molecular diagnostics tools are thus needed...
  11. ncbi request reprint Antigenic cross-reactivity between different alleles of the Plasmodium falciparum merozoite surface protein 2
    Ingrid Felger
    Swiss Tropical Institute, Basel, Switzerland
    Parasite Immunol 25:531-43. 2003
    ....
  12. doi request reprint Fitness costs of resistance to antimalarial drugs
    Ingrid Felger
    Swiss Tropical Institute, Socinstrasse 57, CH 4002 Basel, Switzerland
    Trends Parasitol 24:331-3. 2008
    ....
  13. ncbi request reprint Molecular monitoring in malaria vaccine trials
    Ingrid Felger
    Swiss Tropical Institute, Socinstrasse 57, PO Box 4002, Basel, Switzerland
    Trends Parasitol 19:60-3. 2003
    ..In addition, high-throughput methods can be used to apply these techniques routinely in randomized controlled trials, as well as programme-based evaluations of malaria control...
  14. pmc Comparison of Plasmodium falciparum allelic frequency distribution in different endemic settings by high-resolution genotyping
    Sonja Schoepflin
    Swiss Tropical Institute, Basel, Switzerland
    Malar J 8:250. 2009
    ..These previous reports relied on low resolution genotyping techniques...
  15. doi request reprint Evaluation of Plasmodium vivax genotyping markers for molecular monitoring in clinical trials
    Cristian Koepfli
    Swiss Tropical Institute, Basel, Switzerland
    J Infect Dis 199:1074-80. 2009
    ..The method was tested with samples from an in vivo drug efficacy study...
  16. ncbi request reprint Comparison of PCR-RFLP and Genescan-based genotyping for analyzing infection dynamics of Plasmodium falciparum
    Nicole Falk
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 74:944-50. 2006
    ..This reflects the good performance of GeneScan-based genotyping for studies of parasite infection dynamics...
  17. pmc How much remains undetected? Probability of molecular detection of human Plasmodia in the field
    Cristian Koepfli
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 6:e19010. 2011
    ..falciparum and P. vivax parasite clones in consecutive samples of the same patient and at investigating the impact of sampling strategies on basic epidemiological measures such as multiplicity of infection (MOI)...
  18. pmc Treatment with coartem (artemether-lumefantrine) in Papua New Guinea
    Sonja Schoepflin
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 82:529-34. 2010
    ..In contrast to the situation in classic drug trials with ideal treatment conditions, our field survey highlights potential problems with unsupervised usage of Coartem in routine clinical practice and under program conditions...
  19. pmc Detectability of Plasmodium falciparum clones
    Michael T Bretscher
    Swiss TPH, Basel, Switzerland
    Malar J 9:234. 2010
    ..Detectability can be estimated by typing repeated samples from the same host but it has been unclear what should be the time interval between the samples and how the data should be analysed...
  20. pmc Monitoring of malaria parasite resistance to chloroquine and sulphadoxine-pyrimethamine in the Solomon Islands by DNA microarray technology
    Marie Ballif
    Swiss Tropical and Public Health Institute, Department of Medical Parasitology and Biology of Infection, Department of Epidemiology and Public Health, Socinstrasse 57, 4002 Basel, Switzerland
    Malar J 9:270. 2010
    ....
  21. pmc Strain-specific humoral response to a polymorphic malaria vaccine
    Christian Flück
    Swiss Tropical Institute, Socinstrasse 57, Basel
    Infect Immun 72:6300-5. 2004
    ..These findings support the inclusion of both family-specific domains (3D7 and FC27) in an improved vaccine formulation...
  22. pmc Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data
    Amanda Ross
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e42496. 2012
    ..In contrast, the second method by Li et al estimates both the numbers of infections and the true allele frequencies simultaneously and produced accurate estimates of the mean number of infections...
  23. ncbi request reprint Effect of the malaria vaccine Combination B on merozoite surface antigen 2 diversity
    Christian Flück
    Swiss Tropical Institute, Socinstrasse 57, Postfach, CH 4002 Basel, Switzerland
    Infect Genet Evol 7:44-51. 2007
    ....
  24. doi request reprint The distribution of Plasmodium falciparum infection durations
    Michael T Bretscher
    Swiss TPH, Basel, Switzerland
    Epidemics 3:109-18. 2011
    ..Conversely, the statistical properties of the distribution of infection durations, and how these are affected by exposure, should contain information on within-host dynamics...
  25. pmc The dynamics of natural Plasmodium falciparum infections
    Ingrid Felger
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e45542. 2012
    ..Consequently, information on effects of host immune status or age on infection dynamics is fragmentary...
  26. doi request reprint Quantifying the evolution and impact of antimalarial drug resistance: drug use, spread of resistance, and drug failure over a 12-year period in Papua New Guinea
    Christian Nsanzabana
    Swiss Tropical Institute, Basel, and 2Institut de biologie, Universite de Neuchatel, Neuchatel, Switzerland
    J Infect Dis 201:435-43. 2010
    ..Our estimates of mutation and haplotype frequencies provide estimates of selection coefficients acting in this environment, which are key parameters for understanding the dynamics of resistance...
  27. ncbi request reprint An immigration-death model to estimate the duration of malaria infection when detectability of the parasite is imperfect
    Wilson Sama
    Swiss Tropical Institute, Postfach, CH 4002 Basel, Switzerland
    Stat Med 24:3269-88. 2005
    ..This model provides a basis for analyses of how these quantities vary with the age, and hence the immune status of the host...
  28. doi request reprint Evaluation of two long synthetic merozoite surface protein 2 peptides as malaria vaccine candidates
    Christian Flueck
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, CH 4002 Basel, Switzerland
    Vaccine 27:2653-61. 2009
    ..Immunization of mice with these antigens yielded high titre antibody responses and monoclonal antibodies recognized parasite-derived MSP2. Our results justify taking these candidate poly-peptides into further vaccine development...
  29. pmc Strategies for detection of Plasmodium species gametocytes
    Rahel Wampfler
    Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland
    PLoS ONE 8:e76316. 2013
    ....
  30. ncbi request reprint A point mutation in codon 76 of pfcrt of P. falciparum is positively selected for by Chloroquine treatment in Tanzania
    Achim G Schneider
    Swiss Tropical Institute, Socinstrasse 57, Postfach, CH 4002 Basel, Switzerland
    Infect Genet Evol 1:183-9. 2002
    ..No selective elimination of the pfmdr1(86) wild-type allele was observed...
  31. pmc Identification and differentiation of Leishmania species in clinical samples by PCR amplification of the miniexon sequence and subsequent restriction fragment length polymorphism analysis
    Jutta Marfurt
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    J Clin Microbiol 41:3147-53. 2003
    ..The miniexon PCR-RFLP assay will facilitate such determination and might improve diagnosis and treatment of leishmaniasis...
  32. pmc Rapid microarray-based method for monitoring of all currently known single-nucleotide polymorphisms associated with parasite resistance to antimalaria drugs
    Andreas Crameri
    Swiss Tropical Institute, Socinstrasse 57, CH 4002, Basel, Switzerland
    J Clin Microbiol 45:3685-91. 2007
    ..Due to the simplicity of the approach, newly identified SNPs can be incorporated rapidly. Such a monitoring system also makes it possible to identify the reemergence of drug-susceptible parasites once a drug has been withdrawn...
  33. ncbi request reprint Genotyping of Plasmodium falciparum. PCR-RFLP analysis
    Ingrid Felger
    Swiss Tropical Institute, Basel, Switzerland
    Methods Mol Med 72:117-29. 2002
  34. ncbi request reprint Diagnostic genotyping of Old and New World Leishmania species by PCR-RFLP
    Jutta Marfurt
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Diagn Microbiol Infect Dis 46:115-24. 2003
    ..Restriction fragment length polymorphism (RFLP) generated species-specific patterns of bands visualized in agarose gels, which allowed to differentiate each species unequivocally...
  35. doi request reprint Molecular approaches to diversity of populations of apicomplexan parasites
    Hans Peter Beck
    Swiss Tropical Institute, Socinstrasse 57, CH 4002 Basel, Switzerland
    Int J Parasitol 39:175-89. 2009
    ..This fosters mutual learning and has the potential for cross-fertilisation of ideas and technical approaches...
  36. pmc Prevalence of drug resistance mutations and HIV type 1 subtypes in an HIV type 1-infected cohort in rural Tanzania
    Pax Masimba
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    AIDS Res Hum Retroviruses 29:1229-36. 2013
    ..Statistically, frequencies of major mutations did not change significantly over the studied 5-year interval. These mutations could reflect primary resistances and may indicate a possible risk for treatment failure...
  37. ncbi request reprint Safety and immunogenicity of a three-component blood-stage malaria vaccine (MSP1, MSP2, RESA) against Plasmodium falciparum in Papua New Guinean children
    Blaise Genton
    PNG Institute of Medical Research, Maprik, Papua, New Guinea
    Vaccine 22:30-41. 2003
    ..Vaccine immunogenicity was neither impaired by circulating parasites nor increased after pre-treatment with SP and pre-treatment is not advisable in future trials of malaria vaccines, at least for those including blood-stage antigens...
  38. ncbi request reprint A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea
    Blaise Genton
    Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    J Infect Dis 185:820-7. 2002
    ..The vaccine-induced selection pressure exerted on the parasites and its consequences for morbidity strongly argue for developing vaccines comprising conserved antigens and/or multiple components covering all important allelic types...
  39. ncbi request reprint Molecular parasitology of malaria in Papua New Guinea
    Alfred Cortes
    Papua New Guinea Institute of Medical Research, Madang, 511 Madang Province, Papua New Guinea
    Trends Parasitol 19:246-9. 2003
    ..In addition, research has been conducted on human host factors and, more recently, the molecular analysis of drug resistance and the underlying molecular mechanisms of host-parasite interactions have been investigated...
  40. ncbi request reprint Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 62:72-82. 2008
    ..The characterization of differential gene expression in Giardia lamblia WB C6 strain C4 resistant to metronidazole and nitazoxanide using microarray technology and quantitative real-time PCR...