Research Topics
| Ingrid FelgerSummaryAffiliation: University of Basel Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host populationSonja Schoepflin
Swiss Tropical Institute, Department of Medical Parasitology and Infection Biology, Socinstr 57, 4002 Basel, Switzerland
Malar J 7:78. 2008..In particular newly acquired haplotypes after radical cure were characterized and compared to haplotypes from persistent infections...- Plasmodium falciparum msp1, msp2 and glurp allele frequency and diversity in sub-Saharan AfricaFelista Mwingira
Dares Salaam University College of Education P O BOX 2329, Dar es Salaam, Tanzania
Malar J 10:79. 2011..This study presents the genetic diversity of P. falciparum msp1, msp2 and glurp markers in selected sub-Saharan Africa countries with varying levels of endemicity namely Malawi, Tanzania, Uganda, Burkina Faso and São Tomé... - Efficacy of sulfadoxine-pyrimethamine in Tanzania after two years as first-line drug for uncomplicated malaria: assessment protocol and implication for treatment policy strategiesKefas Mugittu
Ifakara Health Research and Development Centre, PO Box 53, Ifakara, Tanzania
Malar J 4:55. 2005..This study assessed in vivo SP efficacy after two years of use as an interim first-line drug in Tanzania, and determined the rates of treatment failures obtained after 14 and 28 days of follow-up... - Optimization and validation of multi-coloured capillary electrophoresis for genotyping of Plasmodium falciparum merozoite surface proteins (msp1 and 2)Anne Liljander
Department of Medicine Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
Malar J 8:78. 2009..falciparum msp1 and msp2 has been adapted to the CE technique. The protocol and optimization process as well as the potentials and limitations of the technique in molecular epidemiology studies and anti-malarial drug trials are reported... - Comparison of diagnostic methods for the detection and quantification of the four sympatric Plasmodium species in field samples from Papua New GuineaAnna Rosanas-Urgell
Papua New Guinea Insitute of Medical Research, Madang 511, Papua New Guinea
Malar J 9:361. 2010..Despite great advantages of light microscopy (LM) for malaria diagnosis, its limited sensitivity is a critical shortfall for epidemiological studies. Robust molecular diagnostics tools are thus needed... 
Molecular monitoring in malaria vaccine trialsIngrid Felger
Swiss Tropical Institute, Socinstrasse 57, PO Box 4002, Basel, Switzerland
Trends Parasitol 19:60-3. 2003..In addition, high-throughput methods can be used to apply these techniques routinely in randomized controlled trials, as well as programme-based evaluations of malaria control...- Antigenic cross-reactivity between different alleles of the Plasmodium falciparum merozoite surface protein 2Ingrid Felger
Swiss Tropical Institute, Basel, Switzerland
Parasite Immunol 25:531-43. 2003.... 
Fitness costs of resistance to antimalarial drugsIngrid Felger
Swiss Tropical Institute, Socinstrasse 57, CH 4002 Basel, Switzerland
Trends Parasitol 24:331-3. 2008....- Comparison of PCR-RFLP and Genescan-based genotyping for analyzing infection dynamics of Plasmodium falciparumNicole Falk
Swiss Tropical Institute, Basel, Switzerland
Am J Trop Med Hyg 74:944-50. 2006..This reflects the good performance of GeneScan-based genotyping for studies of parasite infection dynamics... - Monitoring of malaria parasite resistance to chloroquine and sulphadoxine-pyrimethamine in the Solomon Islands by DNA microarray technologyMarie Ballif
Swiss Tropical and Public Health Institute, Department of Medical Parasitology and Biology of Infection, Department of Epidemiology and Public Health, Socinstrasse 57, 4002 Basel, Switzerland
Malar J 9:270. 2010.... - Estimating the numbers of malaria infections in blood samples using high-resolution genotyping dataAmanda Ross
Swiss Tropical and Public Health Institute, Basel, Switzerland
PLoS ONE 7:e42496. 2012..In contrast, the second method by Li et al estimates both the numbers of infections and the true allele frequencies simultaneously and produced accurate estimates of the mean number of infections... - Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New GuineaCristian Koepfli
Swiss Tropical and Public Health Institute, Basel, Switzerland
PLoS Negl Trop Dis 5:e1424. 2011..02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and monitoring the effects of interventions... - Comparison of Plasmodium falciparum allelic frequency distribution in different endemic settings by high-resolution genotypingSonja Schoepflin
Swiss Tropical Institute, Basel, Switzerland
Malar J 8:250. 2009..These previous reports relied on low resolution genotyping techniques... - Detectability of Plasmodium falciparum clonesMichael T Bretscher
Swiss TPH, Basel, Switzerland
Malar J 9:234. 2010..Detectability can be estimated by typing repeated samples from the same host but it has been unclear what should be the time interval between the samples and how the data should be analysed... - How much remains undetected? Probability of molecular detection of human Plasmodia in the fieldCristian Koepfli
Swiss Tropical and Public Health Institute, Basel, Switzerland
PLoS ONE 6:e19010. 2011..falciparum and P. vivax parasite clones in consecutive samples of the same patient and at investigating the impact of sampling strategies on basic epidemiological measures such as multiplicity of infection (MOI)... - Evaluation of Plasmodium vivax genotyping markers for molecular monitoring in clinical trialsCristian Koepfli
Swiss Tropical Institute, Basel, Switzerland
J Infect Dis 199:1074-80. 2009..The method was tested with samples from an in vivo drug efficacy study... - Effect of the malaria vaccine Combination B on merozoite surface antigen 2 diversityChristian Flück
Swiss Tropical Institute, Socinstrasse 57, Postfach, CH 4002 Basel, Switzerland
Infect Genet Evol 7:44-51. 2007.... - Treatment with coartem (artemether-lumefantrine) in Papua New GuineaSonja Schoepflin
Swiss Tropical Institute, Basel, Switzerland
Am J Trop Med Hyg 82:529-34. 2010..In contrast to the situation in classic drug trials with ideal treatment conditions, our field survey highlights potential problems with unsupervised usage of Coartem in routine clinical practice and under program conditions... - The distribution of Plasmodium falciparum infection durationsMichael T Bretscher
Swiss TPH, Basel, Switzerland
Epidemics 3:109-18. 2011..Conversely, the statistical properties of the distribution of infection durations, and how these are affected by exposure, should contain information on within-host dynamics... - Strain-specific humoral response to a polymorphic malaria vaccineChristian Flück
Swiss Tropical Institute, Socinstrasse 57, Basel
Infect Immun 72:6300-5. 2004..These findings support the inclusion of both family-specific domains (3D7 and FC27) in an improved vaccine formulation... - Quantifying the evolution and impact of antimalarial drug resistance: drug use, spread of resistance, and drug failure over a 12-year period in Papua New GuineaChristian Nsanzabana
Swiss Tropical Institute, Basel, and 2Institut de biologie, Universite de Neuchatel, Neuchatel, Switzerland
J Infect Dis 201:435-43. 2010..Our estimates of mutation and haplotype frequencies provide estimates of selection coefficients acting in this environment, which are key parameters for understanding the dynamics of resistance... - An immigration-death model to estimate the duration of malaria infection when detectability of the parasite is imperfectWilson Sama
Swiss Tropical Institute, Postfach, CH 4002 Basel, Switzerland
Stat Med 24:3269-88. 2005..This model provides a basis for analyses of how these quantities vary with the age, and hence the immune status of the host... - Evaluation of two long synthetic merozoite surface protein 2 peptides as malaria vaccine candidatesChristian Flueck
Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, CH 4002 Basel, Switzerland
Vaccine 27:2653-61. 2009..Immunization of mice with these antigens yielded high titre antibody responses and monoclonal antibodies recognized parasite-derived MSP2. Our results justify taking these candidate poly-peptides into further vaccine development... - Sequence conservation in Plasmodium falciparum alpha-helical coiled coil domains proposed for vaccine developmentCaroline Kulangara
Swiss Tropical Institute, Basel, Switzerland
PLoS ONE 4:e5419. 2009.... - Identification and differentiation of Leishmania species in clinical samples by PCR amplification of the miniexon sequence and subsequent restriction fragment length polymorphism analysisJutta Marfurt
Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
J Clin Microbiol 41:3147-53. 2003..The miniexon PCR-RFLP assay will facilitate such determination and might improve diagnosis and treatment of leishmaniasis... - The dynamics of natural Plasmodium falciparum infectionsIngrid Felger
Swiss Tropical and Public Health Institute, Basel, Switzerland
PLoS ONE 7:e45542. 2012..Consequently, information on effects of host immune status or age on infection dynamics is fragmentary... - Rapid microarray-based method for monitoring of all currently known single-nucleotide polymorphisms associated with parasite resistance to antimalaria drugsAndreas Crameri
Swiss Tropical Institute, Socinstrasse 57, CH 4002, Basel, Switzerland
J Clin Microbiol 45:3685-91. 2007..Due to the simplicity of the approach, newly identified SNPs can be incorporated rapidly. Such a monitoring system also makes it possible to identify the reemergence of drug-susceptible parasites once a drug has been withdrawn... - A point mutation in codon 76 of pfcrt of P. falciparum is positively selected for by Chloroquine treatment in TanzaniaAchim G Schneider
Swiss Tropical Institute, Socinstrasse 57, Postfach, CH 4002 Basel, Switzerland
Infect Genet Evol 1:183-9. 2002..No selective elimination of the pfmdr1(86) wild-type allele was observed... - Genotyping of Plasmodium falciparum. PCR-RFLP analysisIngrid Felger
Swiss Tropical Institute, Basel, Switzerland
Methods Mol Med 72:117-29. 2002 - Cell biological characterization of the malaria vaccine candidate trophozoite exported protein 1Caroline Kulangara
Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
PLoS ONE 7:e46112. 2012..No classical export motifs such as PEXEL, signal sequence/anchor or transmembrane domain was identified for Tex1... - Diagnostic genotyping of Old and New World Leishmania species by PCR-RFLPJutta Marfurt
Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
Diagn Microbiol Infect Dis 46:115-24. 2003..Restriction fragment length polymorphism (RFLP) generated species-specific patterns of bands visualized in agarose gels, which allowed to differentiate each species unequivocally... - Serodiagnosis of Echinococcus spp. infection: explorative selection of diagnostic antigens by peptide microarrayClaudia List
Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
PLoS Negl Trop Dis 4:e771. 2010.... - Molecular approaches to diversity of populations of apicomplexan parasitesHans Peter Beck
Swiss Tropical Institute, Socinstrasse 57, CH 4002 Basel, Switzerland
Int J Parasitol 39:175-89. 2009..This fosters mutual learning and has the potential for cross-fertilisation of ideas and technical approaches... - Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazoleJoachim Muller
Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
J Antimicrob Chemother 62:72-82. 2008..The characterization of differential gene expression in Giardia lamblia WB C6 strain C4 resistant to metronidazole and nitazoxanide using microarray technology and quantitative real-time PCR... - Safety and immunogenicity of a three-component blood-stage malaria vaccine (MSP1, MSP2, RESA) against Plasmodium falciparum in Papua New Guinean childrenBlaise Genton
PNG Institute of Medical Research, Maprik, Papua, New Guinea
Vaccine 22:30-41. 2003..Vaccine immunogenicity was neither impaired by circulating parasites nor increased after pre-treatment with SP and pre-treatment is not advisable in future trials of malaria vaccines, at least for those including blood-stage antigens... - Molecular parasitology of malaria in Papua New GuineaAlfred Cortes
Papua New Guinea Institute of Medical Research, Madang, 511 Madang Province, Papua New Guinea
Trends Parasitol 19:246-9. 2003..In addition, research has been conducted on human host factors and, more recently, the molecular analysis of drug resistance and the underlying molecular mechanisms of host-parasite interactions have been investigated... - A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New GuineaBlaise Genton
Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
J Infect Dis 185:820-7. 2002..The vaccine-induced selection pressure exerted on the parasites and its consequences for morbidity strongly argue for developing vaccines comprising conserved antigens and/or multiple components covering all important allelic types...