J A Ehses

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Type 1, type 1.5, and type 2 diabetes: NOD the diabetes we thought it was
    Marc Y Donath
    Clinic for Endocrinology and Diabetes, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:12217-8. 2006
  2. doi request reprint Macrophages, cytokines and beta-cell death in Type 2 diabetes
    Jan A Ehses
    Clinic of Endocrinology and Diabetes, and Centre for Integrated Human Physiology, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    Biochem Soc Trans 36:340-2. 2008
  3. pmc Interleukin-6 regulates pancreatic alpha-cell mass expansion
    Helga Ellingsgaard
    Division of Endocrinology and Diabetes and Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:13163-8. 2008
  4. pmc IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
    J A Ehses
    Division of Endocrinology, Diabetes, and Nutrition and Center for Integrated Human Physiology, University Hospital of Zurich, 8045 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:13998-4003. 2009
  5. doi request reprint Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction
    Jan A Ehses
    Division of Endocrinology, Diabetes and Nutrition, Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Arch Physiol Biochem 115:240-7. 2009
  6. ncbi request reprint Increased number of islet-associated macrophages in type 2 diabetes
    Jan A Ehses
    Division of Endocrinology and Diabetes and Center for Integrated Human Physiology, University Hospital of Zurich, Zurich, Switzerland
    Diabetes 56:2356-70. 2007
  7. doi request reprint Cytokine production by islets in health and diabetes: cellular origin, regulation and function
    Marc Y Donath
    Clinic of Endocrinology and Diabetes, Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Trends Endocrinol Metab 21:261-7. 2010
  8. doi request reprint Islet inflammation in type 2 diabetes: from metabolic stress to therapy
    Marc Y Donath
    Clinic of Endocrinology and Diabetes, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Diabetes Care 31:S161-4. 2008
  9. ncbi request reprint Mechanisms of beta-cell death in type 2 diabetes
    Marc Y Donath
    Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Diabetes 54:S108-13. 2005
  10. doi request reprint Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I
    Marianne Böni-Schnetzler
    Division of Endocrinology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland marianne
    Endocrinology 150:5218-29. 2009

Collaborators

Detail Information

Publications23

  1. pmc Type 1, type 1.5, and type 2 diabetes: NOD the diabetes we thought it was
    Marc Y Donath
    Clinic for Endocrinology and Diabetes, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:12217-8. 2006
  2. doi request reprint Macrophages, cytokines and beta-cell death in Type 2 diabetes
    Jan A Ehses
    Clinic of Endocrinology and Diabetes, and Centre for Integrated Human Physiology, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    Biochem Soc Trans 36:340-2. 2008
    ..It follows that modulation of intra-islet inflammatory mediators, particularly interleukin-1beta, may prevent islet inflammation in Type 2 diabetes and therefore presents itself as a promising therapeutic approach...
  3. pmc Interleukin-6 regulates pancreatic alpha-cell mass expansion
    Helga Ellingsgaard
    Division of Endocrinology and Diabetes and Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:13163-8. 2008
    ....
  4. pmc IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
    J A Ehses
    Division of Endocrinology, Diabetes, and Nutrition and Center for Integrated Human Physiology, University Hospital of Zurich, 8045 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:13998-4003. 2009
    ..Rather than being directly cytotoxic, IL-1beta may drive tissue inflammation that impacts on both beta cell functional mass and insulin sensitivity in type 2 diabetes...
  5. doi request reprint Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction
    Jan A Ehses
    Division of Endocrinology, Diabetes and Nutrition, Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Arch Physiol Biochem 115:240-7. 2009
    ..Here, we summarize the current evidence that islet inflammation is a feature of type 2 diabetes, and discuss its role with respect to alpha and beta cell compensation and eventual beta cell failure...
  6. ncbi request reprint Increased number of islet-associated macrophages in type 2 diabetes
    Jan A Ehses
    Division of Endocrinology and Diabetes and Center for Integrated Human Physiology, University Hospital of Zurich, Zurich, Switzerland
    Diabetes 56:2356-70. 2007
    ..Therefore, islet-derived inflammatory factors are regulated by a type 2 diabetic milieu and may contribute to the macrophage infiltration of pancreatic islets that we observe in type 2 diabetes...
  7. doi request reprint Cytokine production by islets in health and diabetes: cellular origin, regulation and function
    Marc Y Donath
    Clinic of Endocrinology and Diabetes, Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Trends Endocrinol Metab 21:261-7. 2010
    ..In this article, we review the islet cellular origin of various cytokines and chemokines and describe their regulation and respective roles in physiology and diabetes...
  8. doi request reprint Islet inflammation in type 2 diabetes: from metabolic stress to therapy
    Marc Y Donath
    Clinic of Endocrinology and Diabetes, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Diabetes Care 31:S161-4. 2008
    ..Therefore, modulation of intra-islet inflammatory mediators, in particular interleukin-1 beta, appears as a promising therapeutic approach...
  9. ncbi request reprint Mechanisms of beta-cell death in type 2 diabetes
    Marc Y Donath
    Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Diabetes 54:S108-13. 2005
    ..Thus, the mechanisms regulating beta-cell proliferation, apoptosis, and function are inseparable processes...
  10. doi request reprint Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I
    Marianne Böni-Schnetzler
    Division of Endocrinology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland marianne
    Endocrinology 150:5218-29. 2009
    ..We conclude that FFA and TLR stimulation induce proinflammatory factors in islets and that IL-1RI engagement results in signal amplification...
  11. doi request reprint Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes
    Marc Y Donath
    Division of Endocrinology, Diabetes, and Nutrition, and Center for Integrated Human Physiology, University Hospital of Zurich, Zurich, Switzerland
    Physiology (Bethesda) 24:325-31. 2009
    ..We propose that this insulitis contributes to the decrease in beta-cell mass and the impaired insulin secretion observed in patients with Type 2 diabetes...
  12. pmc Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation
    Marianne Böni-Schnetzler
    Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    J Clin Endocrinol Metab 93:4065-74. 2008
    ..Elevated glucose levels impair islet function and survival, and it has been proposed that intraislet expression of IL-1beta contributes to glucotoxicity...
  13. doi request reprint Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells
    Sabine Rütti
    Division of Endocrinology and Diabetes, University Hospital of Zurich, Zurich 8091, Switzerland
    Endocrinology 150:4521-30. 2009
    ..Our data show that both LDL and HDL affect function or survival of beta-cells and raise the question whether dyslipidemia contributes to beta-cell failure and hence the manifestation and progression of type 2 diabetes mellitus...
  14. doi request reprint Insulitis in type 2 diabetes
    M Boni-Schnetzler
    Clinic of Endocrinology and Diabetes and Centre for Integrated Human Physiology, University Hospital of Zurich, Zurich, Switzerland
    Diabetes Obes Metab 10:201-4. 2008
    ..It follows that modulation of intra-islet inflammatory mediators, in particular IL-1 beta, may prevent insulitis in type 2 diabetes and therefore presents itself as a possible causal therapy with disease-modifying potential...
  15. ncbi request reprint TNF-alpha -308G>A polymorphism modulates cytokine serum concentrations and macrovascular complications in diabetic patients on aspirin
    P A Krayenbuehl
    Department of Internal Medicine, Medical Policlinic, University Hospital of Zurich, Zurich, Switzerland
    Exp Clin Endocrinol Diabetes 115:322-6. 2007
    ..Previous studies in non-diabetic subjects showed no association between TNF-alpha -308G>A polymorphism and coronary artery disease...
  16. ncbi request reprint Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells
    Pascale Ribaux
    Department of Genetic Medicine and Development, University Medical Center, 1211, Geneva 4, Switzerland
    Endocrinology 148:5582-90. 2007
    ..It is concluded that ECM induces expression of cytokines including CXCL1 with amplification by IL-1 acting via a positive autocrine feedback loop...
  17. ncbi request reprint Interleukin-1-receptor antagonist in type 2 diabetes mellitus
    Claus M Larsen
    Steno Diabetes Center, Gentofte, Denmark
    N Engl J Med 356:1517-26. 2007
    ....
  18. pmc Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets
    Kathrin Maedler
    Division of Endocrinology and Diabetes, University Hospital, CH8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 101:8138-43. 2004
    ..Moreover, siIL-1Ra enhanced glucose-induced beta cell apoptosis. These findings demonstrate expression of IL-1Ra in the human beta cell, providing localized protection against leptin- and glucose-induced islet IL-1beta...
  19. ncbi request reprint Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
    J Andrew Pospisilik
    Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada
    Diabetes 52:741-50. 2003
    ..These novel findings provide evidence to support the potential utility of DP IV inhibitors in the treatment of type 1 and possibly late-stage type 2 diabetes...
  20. ncbi request reprint A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells
    Francis C Lynn
    Department of Physiology, University of British Columbia, Vancouver Canada, V6T 1Z3
    FASEB J 17:91-3. 2003
    ....
  21. ncbi request reprint Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase
    Jan A Ehses
    Department of Physiology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Endocrinology 144:4433-45. 2003
    ....
  22. ncbi request reprint Dipeptidyl peptidase IV inhibition in animal models of diabetes
    J Andrew Pospisilik
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Adv Exp Med Biol 524:281-91. 2003
  23. ncbi request reprint Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway
    Jan A Ehses
    Department of Physiology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 277:37088-97. 2002
    ..These results establish the importance of GIP in the cellular regulation of the ERK1/2 module and identify a role for cAMP in coupling its G protein-coupled receptors to ERK1/2 activity in pancreatic beta-cells...