Research Topics
| Abdul G DullooSummaryAffiliation: University of Fribourg Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
Body composition phenotypes in pathways to obesity and the metabolic syndromeA G Dulloo
Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
Int J Obes (Lond) 34:S4-17. 2010..These concepts about body composition phenotypes and health risks are reviewed in the light of race/ethnic variability in metabolic susceptibility to obesity and the metabolic syndrome...
A Role for Adipose Tissue De Novo Lipogenesis in Glucose Homeostasis During Catch-up Growth: A Randle Cycle Favoring Fat StorageHelena Marcelino
Corresponding author Abdul G Dulloo
Diabetes 62:362-72. 2013....- How dieting makes some fatter: from a perspective of human body composition autoregulationAbdul G Dulloo
Department of Medicine Physiology, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
Proc Nutr Soc 71:379-89. 2012..A main implication of these findings is that the risk of becoming fatter in response to dieting is greater in lean than in obese individuals... 
Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balanceAbdul G Dulloo
Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
Physiol Behav 83:587-602. 2004..g., cold, infection, nutrient imbalance) when sympathetic activation of thermogenesis has equally important survival value...- Obesity in Parkinson's disease patients on electrotherapy: collateral damage, adiposity rebound or secular trends?Abdul G Dulloo
Department of Medicine Physiology, University of Fribourg, Chemin du Musee 5, 1700 Fribourg, Switzerland
Br J Nutr 93:417-9. 2005 - A role for suppressed skeletal muscle thermogenesis in pathways from weight fluctuations to the insulin resistance syndromeA G Dulloo
Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
Acta Physiol Scand 184:295-307. 2005.... - Regulation of fat storage via suppressed thermogenesis: a thrifty phenotype that predisposes individuals with catch-up growth to insulin resistance and obesityA G Dulloo
Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
Horm Res 65:90-7. 2006.... - The thrifty 'catch-up fat' phenotype: its impact on insulin sensitivity during growth trajectories to obesity and metabolic syndromeA G Dulloo
Division of Physiology, Department of Medicine, University of Fribourg, Switzerland
Int J Obes (Lond) 30:S23-35. 2006.... - Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistanceAbdul G Dulloo
Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
Best Pract Res Clin Endocrinol Metab 22:155-71. 2008..It provides a molecular-physiological framework which integrates emerging insights into mechanisms by which this thrifty 'catch-up fat' phenotype cross-links with insulin and leptin resistance... - A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetesMarina Casimir
Department of Medicine Physiology, University of Fribourg, Switzerland
Nutr Metab (Lond) 8:2. 2011..Such beta-cell hyperresponsiveness to glucose may be a key event in the link between catch-up growth, hyperinsulinemia and risks for later type 2 diabetes... - The search for compounds that stimulate thermogenesis in obesity management: from pharmaceuticals to functional food ingredientsA G Dulloo
Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
Obes Rev 12:866-83. 2011.... - Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicityA G Dulloo
Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
Int J Obes Relat Metab Disord 28:S29-37. 2004.... - The control of partitioning between protein and fat during human starvation: its internal determinants and biological significanceA G Dulloo
Institute of Physiology, University of Fribourg, Switzerland
Br J Nutr 82:339-56. 1999.... - Biomedicine. A sympathetic defense against obesityAbdul G Dulloo
Department of Medicine, Division of Physiology, University of Fribourg, CH-1700 Switzerland
Science 297:780-1. 2002 - Pathways from weight fluctuations to metabolic diseases: focus on maladaptive thermogenesis during catch-up fatA G Dulloo
Department of Medicine Physiology, University of Fribourg, Switzerland
Int J Obes Relat Metab Disord 26:S46-57. 2002.... - An adipose-specific control of thermogenesis in body weight regulationA G Dulloo
Institute of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
Int J Obes Relat Metab Disord 25:S22-9. 2001.... - Uncoupling protein 3 and fatty acid metabolismA G Dulloo
Institute of Physiology, Department of Medicine, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
Biochem Soc Trans 29:785-91. 2001.... - Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humansA G Dulloo
Department of Physiology, Faculty of Medicine, University of Geneva
Am J Clin Nutr 70:1040-5. 1999..Current interest in the role of functional foods in weight control has focused on plant ingredients capable of interfering with the sympathoadrenal system... - Low-protein overfeeding: a tool to unmask susceptibility to obesity in humansA G Dulloo
Institute of Physiology, University of Fribourg, Rue du Musee 5, Switzerland
Int J Obes Relat Metab Disord 23:1118-21. 1999.... - Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activityA G Dulloo
Institute of Physiology, University of Fribourg, Fribourg, Switzerland
Int J Obes Relat Metab Disord 24:252-8. 2000..International Journal of Obesity (2000) 24, 252-258.. - Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsideredA G Dulloo
Institute of Physiology, Department of Medicine, University of Fribourg, Rue du Musee 5, Fribourg, Switzerland
Br J Nutr 86:123-39. 2001.... - Leptin directly stimulates thermogenesis in skeletal muscleAbdul G Dulloo
Institute of Physiology, Department of Medicine, University of Fribourg, Chemin du Musee 5, CH 1700, Fribourg, Switzerland
FEBS Lett 515:109-13. 2002..These findings indicate that leptin has direct thermogenic effects in skeletal muscle, and that these effects require both the long form of leptin receptors and phosphatidylinositol 3-kinase signalling... - Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: relevance for muscle-adipose glucose redistribution during catch-up growthSerge Summermatter
Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
Diabetes 58:2228-37. 2009..Our objective was to characterize the determinants of enhanced glucose utilization in adipose tissue during catch-up fat... - Redistribution of glucose from skeletal muscle to adipose tissue during catch-up fat: a link between catch-up growth and later metabolic syndromePhilippe Cettour-Rose
Department of Internal Medicine, Faculty of Medicine, University of Geneva, Switzerland
Diabetes 54:751-6. 2005.... - Fructose ingestion acutely elevates blood pressure in healthy young humansClive M Brown
Division of Physiology, Department of Medicine, University of Fribourg, Rue du Musee 5, 1700 Fribourg, Switzerland
Am J Physiol Regul Integr Comp Physiol 294:R730-7. 2008..In particular, fructose ingestion elicits an increase in blood pressure that is probably mediated by an increase in cardiac output without compensatory peripheral vasodilatation... - A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesisDavide Mainieri
Division of Physiology, Department of Medicine, Faculty of Medicine, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
FASEB J 20:1751-3. 2006.... - PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistanceBarbara Becattini
Laboratory of Metabolic Stress Biology, Division of Physiology, Department of Medicine, University of Fribourg, CH 1700 Fribourg, Switzerland
Proc Natl Acad Sci U S A 108:E854-63. 2011..Thus, PI3Kγ is an unexpected but promising drug target for the treatment of obesity and its complications... - The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidationGiovanni Solinas
Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
FEBS Lett 577:539-44. 2004..This substrate cycling linking glucose and lipid metabolism to thermogenesis provides a novel thermogenic mechanism by which leptin protects skeletal muscle from excessive fat storage and lipotoxicity... - A role for suppressed thermogenesis favoring catch-up fat in the pathophysiology of catch-up growthRaffaella Crescenzo
Department of Medicine, Division of Physiology, University of Fribourg, , CH-1700 Fribourg, Switzerland
Diabetes 52:1090-7. 2003.... - Water-induced thermogenesis reconsidered: the effects of osmolality and water temperature on energy expenditure after drinkingClive M Brown
Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, 1700 Fribourg, Switzerland
J Clin Endocrinol Metab 91:3598-602. 2006..However, the concept of a thermogenic effect of water is controversial because other studies have found that water drinking does not increase energy expenditure... - Skeletal muscle heterogeneity in fasting-induced upregulation of genes encoding UCP2, UCP3, PPARgamma and key enzymes of lipid oxidationS Samec
Department of Medicine, University of Fribourg, Rue du Musee 5, 1700 Fribourg, Switzerland
Pflugers Arch 445:80-6. 2002.... - Hemodynamic consequences of chronic parasympathetic blockade with a peripheral muscarinic antagonistAntoine Ayer
Department of Medicine Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
Am J Physiol Heart Circ Physiol 293:H1265-72. 2007..The data suggest that chronic peripheral muscarinic blockade leads to modest, but sustained, increases in BP, HR, and BPV, which are known risk factors for cardiovascular morbidity... - Skeletal muscle mitochondrial oxidative capacity and uncoupling protein 3 are differently influenced by semistarvation and refeedingR Crescenzo
Department of Medicine, Division of Physiology, University of Fribourg, Chemin du Musee 5, Switzerland
FEBS Lett 544:138-42. 2003.... - Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseasesJ P Montani
Department of Medicine Division of Physiology, University of Fribourg, Switzerland
Int J Obes Relat Metab Disord 28:S58-65. 2004..Taken together, ectopic fat storage in key target-organs of cardiovascular control may impair their functions, contributing to the increased prevalence of cardiovascular diseases in obese subjects... - Sugary drinks in the pathogenesis of obesity and cardiovascular diseasesC M Brown
Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
Int J Obes (Lond) 32:S28-34. 2008..This review focuses on the potential role of sugar drinks, particularly the fructose component, in the pathogenesis of obesity and cardiovascular diseases... - Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the 'repeated overshoot' theoryJ P Montani
Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
Int J Obes (Lond) 30:S58-66. 2006..Overshoot of those risks factors, when repeated over time, will stress the cardiovascular system and probably contribute to the overall cardiovascular morbidity of weight cycling... - Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinaseS Summermatter
Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
FASEB J 22:774-85. 2008.... - Ectopic fat stores: housekeepers that can overspill into weapons of lean body mass destructionA G Dulloo
Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
Int J Obes Relat Metab Disord 28:S1-2. 2004 - Cardiovascular responses to water drinking: does osmolality play a role?Clive M Brown
Dept of Medicine, Div of Physiology, Univ of Fribourg, Rue du Musee 5, 1700 Fribourg, Switzerland
Am J Physiol Regul Integr Comp Physiol 289:R1687-92. 2005..That these effects were absent after drinking physiological saline indicate that the cardiovascular responses to water drinking are influenced by its hypoosmotic properties... - beta-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesisD Mainieri
Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
Int J Obes (Lond) 31:378-81. 2007..Whether approaches that target both SCD1 and molecular effectors of thermogenesis under beta-adrenergic control might be more effective than targeting SCD1 alone are potential avenues for future research in obesity management... - Corticotropin-releasing hormone directly stimulates thermogenesis in skeletal muscle possibly through substrate cycling between de novo lipogenesis and lipid oxidationG Solinas
Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
Endocrinology 147:31-8. 2006.... - Telmisartan prevents the glitazone-induced weight gain without interfering with its insulin-sensitizing propertiesAnne Zanchi
Division of Nephrology and Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
Am J Physiol Endocrinol Metab 293:E91-5. 2007..This study demonstrates that telmisartan attenuates the glitazone-induced increase in fat mass without interfering with its insulin-sensitizing properties... - Skeletal muscle mitochondrial efficiency and uncoupling protein 3 in overeating rats with increased thermogenesisSusanna Iossa
Department of General and Environmental Physiology, University of Naples Federico II, Via Mezzocannone 8, I 80134, Naples, Italy
Pflugers Arch 445:431-6. 2002..Both mitochondrial populations in skeletal muscle cells from rats with increased thermogenesis display an increased fatty acid-induced uncoupling and UCP3 content, which could contribute to avoiding obesity... - Altered skeletal muscle subsarcolemmal mitochondrial compartment during catch-up fat after caloric restrictionRaffaella Crescenzo
Department of Biological Sciences, Section of Physiology, University of Naples, Naples, Italy
Diabetes 55:2286-93. 2006....