Abdul G Dulloo

Summary

Affiliation: University of Fribourg
Country: Switzerland

Publications

  1. doi Body composition phenotypes in pathways to obesity and the metabolic syndrome
    A G Dulloo
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Int J Obes (Lond) 34:S4-17. 2010
  2. pmc Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: relevance for muscle-adipose glucose redistribution during catch-up growth
    Serge Summermatter
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Diabetes 58:2228-37. 2009
  3. pmc A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth: a Randle cycle favoring fat storage
    Helena Marcelino
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Diabetes 62:362-72. 2013
  4. pmc Heterogeneity in the energy cost of posture maintenance during standing relative to sitting: phenotyping according to magnitude and time-course
    Jennifer L Miles-Chan
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    PLoS ONE 8:e65827. 2013
  5. doi Body composition, inflammation and thermogenesis in pathways to obesity and the metabolic syndrome: an overview
    A G Dulloo
    Department of Medicine, Division of Physiology, University of Fribourg, Chemin du Musee 5, Fribourg, Switzerland
    Obes Rev 13:1-5. 2012
  6. doi Adaptive thermogenesis in human body weight regulation: more of a concept than a measurable entity?
    A G Dulloo
    Department of Medicine Physiology, University of Fribourg, Chemin du Musee 5, Fribourg, Switzerland
    Obes Rev 13:105-21. 2012
  7. doi How dieting makes some fatter: from a perspective of human body composition autoregulation
    Abdul G Dulloo
    Department of Medicine Physiology, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Proc Nutr Soc 71:379-89. 2012
  8. ncbi Obesity in Parkinson's disease patients on electrotherapy: collateral damage, adiposity rebound or secular trends?
    Abdul G Dulloo
    Department of Medicine Physiology, University of Fribourg, Chemin du Musee 5, 1700 Fribourg, Switzerland
    Br J Nutr 93:417-9. 2005
  9. ncbi A role for suppressed skeletal muscle thermogenesis in pathways from weight fluctuations to the insulin resistance syndrome
    A G Dulloo
    Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    Acta Physiol Scand 184:295-307. 2005
  10. ncbi Regulation of fat storage via suppressed thermogenesis: a thrifty phenotype that predisposes individuals with catch-up growth to insulin resistance and obesity
    A G Dulloo
    Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
    Horm Res 65:90-7. 2006

Collaborators

Detail Information

Publications51

  1. doi Body composition phenotypes in pathways to obesity and the metabolic syndrome
    A G Dulloo
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Int J Obes (Lond) 34:S4-17. 2010
    ..These concepts about body composition phenotypes and health risks are reviewed in the light of race/ethnic variability in metabolic susceptibility to obesity and the metabolic syndrome...
  2. pmc Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: relevance for muscle-adipose glucose redistribution during catch-up growth
    Serge Summermatter
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Diabetes 58:2228-37. 2009
    ..Our objective was to characterize the determinants of enhanced glucose utilization in adipose tissue during catch-up fat...
  3. pmc A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth: a Randle cycle favoring fat storage
    Helena Marcelino
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Diabetes 62:362-72. 2013
    ....
  4. pmc Heterogeneity in the energy cost of posture maintenance during standing relative to sitting: phenotyping according to magnitude and time-course
    Jennifer L Miles-Chan
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    PLoS ONE 8:e65827. 2013
    ....
  5. doi Body composition, inflammation and thermogenesis in pathways to obesity and the metabolic syndrome: an overview
    A G Dulloo
    Department of Medicine, Division of Physiology, University of Fribourg, Chemin du Musee 5, Fribourg, Switzerland
    Obes Rev 13:1-5. 2012
    ....
  6. doi Adaptive thermogenesis in human body weight regulation: more of a concept than a measurable entity?
    A G Dulloo
    Department of Medicine Physiology, University of Fribourg, Chemin du Musee 5, Fribourg, Switzerland
    Obes Rev 13:105-21. 2012
    ....
  7. doi How dieting makes some fatter: from a perspective of human body composition autoregulation
    Abdul G Dulloo
    Department of Medicine Physiology, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Proc Nutr Soc 71:379-89. 2012
    ..A main implication of these findings is that the risk of becoming fatter in response to dieting is greater in lean than in obese individuals...
  8. ncbi Obesity in Parkinson's disease patients on electrotherapy: collateral damage, adiposity rebound or secular trends?
    Abdul G Dulloo
    Department of Medicine Physiology, University of Fribourg, Chemin du Musee 5, 1700 Fribourg, Switzerland
    Br J Nutr 93:417-9. 2005
  9. ncbi A role for suppressed skeletal muscle thermogenesis in pathways from weight fluctuations to the insulin resistance syndrome
    A G Dulloo
    Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    Acta Physiol Scand 184:295-307. 2005
    ....
  10. ncbi Regulation of fat storage via suppressed thermogenesis: a thrifty phenotype that predisposes individuals with catch-up growth to insulin resistance and obesity
    A G Dulloo
    Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
    Horm Res 65:90-7. 2006
    ....
  11. ncbi An adipose-specific control of thermogenesis in body weight regulation
    A G Dulloo
    Institute of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    Int J Obes Relat Metab Disord 25:S22-9. 2001
    ....
  12. ncbi The thrifty 'catch-up fat' phenotype: its impact on insulin sensitivity during growth trajectories to obesity and metabolic syndrome
    A G Dulloo
    Division of Physiology, Department of Medicine, University of Fribourg, Switzerland
    Int J Obes (Lond) 30:S23-35. 2006
    ....
  13. doi Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance
    Abdul G Dulloo
    Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Best Pract Res Clin Endocrinol Metab 22:155-71. 2008
    ..It provides a molecular-physiological framework which integrates emerging insights into mechanisms by which this thrifty 'catch-up fat' phenotype cross-links with insulin and leptin resistance...
  14. pmc A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes
    Marina Casimir
    Department of Medicine Physiology, University of Fribourg, Switzerland
    Nutr Metab (Lond) 8:2. 2011
    ..Such beta-cell hyperresponsiveness to glucose may be a key event in the link between catch-up growth, hyperinsulinemia and risks for later type 2 diabetes...
  15. doi The search for compounds that stimulate thermogenesis in obesity management: from pharmaceuticals to functional food ingredients
    A G Dulloo
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Obes Rev 12:866-83. 2011
    ....
  16. ncbi Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance
    Abdul G Dulloo
    Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Physiol Behav 83:587-602. 2004
    ..g., cold, infection, nutrient imbalance) when sympathetic activation of thermogenesis has equally important survival value...
  17. ncbi Pathways from weight fluctuations to metabolic diseases: focus on maladaptive thermogenesis during catch-up fat
    A G Dulloo
    Department of Medicine Physiology, University of Fribourg, Switzerland
    Int J Obes Relat Metab Disord 26:S46-57. 2002
    ....
  18. ncbi Biomedicine. A sympathetic defense against obesity
    Abdul G Dulloo
    Department of Medicine, Division of Physiology, University of Fribourg, CH 1700 Switzerland
    Science 297:780-1. 2002
  19. ncbi Leptin directly stimulates thermogenesis in skeletal muscle
    Abdul G Dulloo
    Institute of Physiology, Department of Medicine, University of Fribourg, Chemin du Musee 5, CH 1700, Fribourg, Switzerland
    FEBS Lett 515:109-13. 2002
    ..These findings indicate that leptin has direct thermogenic effects in skeletal muscle, and that these effects require both the long form of leptin receptors and phosphatidylinositol 3-kinase signalling...
  20. ncbi Uncoupling protein 3 and fatty acid metabolism
    A G Dulloo
    Institute of Physiology, Department of Medicine, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Biochem Soc Trans 29:785-91. 2001
    ....
  21. ncbi Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered
    A G Dulloo
    Institute of Physiology, Department of Medicine, University of Fribourg, Rue du Musee 5, Fribourg, Switzerland
    Br J Nutr 86:123-39. 2001
    ....
  22. ncbi Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity
    A G Dulloo
    Institute of Physiology, University of Fribourg, Fribourg, Switzerland
    Int J Obes Relat Metab Disord 24:252-8. 2000
    ..International Journal of Obesity (2000) 24, 252-258..
  23. ncbi Low-protein overfeeding: a tool to unmask susceptibility to obesity in humans
    A G Dulloo
    Institute of Physiology, University of Fribourg, Rue du Musee 5, Switzerland
    Int J Obes Relat Metab Disord 23:1118-21. 1999
    ....
  24. ncbi Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity
    A G Dulloo
    Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
    Int J Obes Relat Metab Disord 28:S29-37. 2004
    ....
  25. ncbi The control of partitioning between protein and fat during human starvation: its internal determinants and biological significance
    A G Dulloo
    Institute of Physiology, University of Fribourg, Switzerland
    Br J Nutr 82:339-56. 1999
    ....
  26. ncbi Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans
    A G Dulloo
    Department of Physiology, Faculty of Medicine, University of Geneva
    Am J Clin Nutr 70:1040-5. 1999
    ..Current interest in the role of functional foods in weight control has focused on plant ingredients capable of interfering with the sympathoadrenal system...
  27. ncbi Redistribution of glucose from skeletal muscle to adipose tissue during catch-up fat: a link between catch-up growth and later metabolic syndrome
    Philippe Cettour-Rose
    Department of Internal Medicine, Faculty of Medicine, University of Geneva, Switzerland
    Diabetes 54:751-6. 2005
    ....
  28. ncbi Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA
    Gayathri Yepuri
    Division of Physiology, Department of Medicine, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Br J Nutr 105:1750-63. 2011
    ..In particular, diets enriched in essential fatty acids (LA and/or ALA) markedly improve insulin sensitivity and composition of weight regained, independently of the n-6:n-3 fatty acid ratio. ..
  29. ncbi A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis
    Davide Mainieri
    Division of Physiology, Department of Medicine, Faculty of Medicine, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    FASEB J 20:1751-3. 2006
    ....
  30. ncbi A role for suppressed thermogenesis favoring catch-up fat in the pathophysiology of catch-up growth
    Raffaella Crescenzo
    Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Diabetes 52:1090-7. 2003
    ....
  31. pmc PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance
    Barbara Becattini
    Laboratory of Metabolic Stress Biology, Division of Physiology, Department of Medicine, University of Fribourg, CH 1700 Fribourg, Switzerland
    Proc Natl Acad Sci U S A 108:E854-63. 2011
    ..Thus, PI3Kγ is an unexpected but promising drug target for the treatment of obesity and its complications...
  32. doi Fructose ingestion acutely elevates blood pressure in healthy young humans
    Clive M Brown
    Division of Physiology, Department of Medicine, University of Fribourg, Rue du Musee 5, 1700 Fribourg, Switzerland
    Am J Physiol Regul Integr Comp Physiol 294:R730-7. 2008
    ..In particular, fructose ingestion elicits an increase in blood pressure that is probably mediated by an increase in cardiac output without compensatory peripheral vasodilatation...
  33. ncbi The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation
    Giovanni Solinas
    Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
    FEBS Lett 577:539-44. 2004
    ..This substrate cycling linking glucose and lipid metabolism to thermogenesis provides a novel thermogenic mechanism by which leptin protects skeletal muscle from excessive fat storage and lipotoxicity...
  34. ncbi Skeletal muscle heterogeneity in fasting-induced upregulation of genes encoding UCP2, UCP3, PPARgamma and key enzymes of lipid oxidation
    S Samec
    Department of Medicine, University of Fribourg, Rue du Musee 5, 1700 Fribourg, Switzerland
    Pflugers Arch 445:80-6. 2002
    ....
  35. ncbi Water-induced thermogenesis reconsidered: the effects of osmolality and water temperature on energy expenditure after drinking
    Clive M Brown
    Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, 1700 Fribourg, Switzerland
    J Clin Endocrinol Metab 91:3598-602. 2006
    ..However, the concept of a thermogenic effect of water is controversial because other studies have found that water drinking does not increase energy expenditure...
  36. ncbi Skeletal muscle mitochondrial oxidative capacity and uncoupling protein 3 are differently influenced by semistarvation and refeeding
    R Crescenzo
    Department of Medicine, Division of Physiology, University of Fribourg, Chemin du Musee 5, Switzerland
    FEBS Lett 544:138-42. 2003
    ....
  37. ncbi Hemodynamic consequences of chronic parasympathetic blockade with a peripheral muscarinic antagonist
    Antoine Ayer
    Department of Medicine Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Am J Physiol Heart Circ Physiol 293:H1265-72. 2007
    ..The data suggest that chronic peripheral muscarinic blockade leads to modest, but sustained, increases in BP, HR, and BPV, which are known risk factors for cardiovascular morbidity...
  38. ncbi Sugary drinks in the pathogenesis of obesity and cardiovascular diseases
    C M Brown
    Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    Int J Obes (Lond) 32:S28-34. 2008
    ..This review focuses on the potential role of sugar drinks, particularly the fructose component, in the pathogenesis of obesity and cardiovascular diseases...
  39. ncbi Ectopic fat stores: housekeepers that can overspill into weapons of lean body mass destruction
    A G Dulloo
    Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
    Int J Obes Relat Metab Disord 28:S1-2. 2004
  40. ncbi Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the 'repeated overshoot' theory
    J P Montani
    Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    Int J Obes (Lond) 30:S58-66. 2006
    ..Overshoot of those risks factors, when repeated over time, will stress the cardiovascular system and probably contribute to the overall cardiovascular morbidity of weight cycling...
  41. ncbi Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase
    S Summermatter
    Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    FASEB J 22:774-85. 2008
    ....
  42. ncbi Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases
    J P Montani
    Department of Medicine Division of Physiology, University of Fribourg, Switzerland
    Int J Obes Relat Metab Disord 28:S58-65. 2004
    ..Taken together, ectopic fat storage in key target-organs of cardiovascular control may impair their functions, contributing to the increased prevalence of cardiovascular diseases in obese subjects...
  43. ncbi Cardiovascular responses to water drinking: does osmolality play a role?
    Clive M Brown
    Dept of Medicine, Div of Physiology, Univ of Fribourg, Rue du Musee 5, 1700 Fribourg, Switzerland
    Am J Physiol Regul Integr Comp Physiol 289:R1687-92. 2005
    ..That these effects were absent after drinking physiological saline indicate that the cardiovascular responses to water drinking are influenced by its hypoosmotic properties...
  44. doi Translational issues in targeting brown adipose tissue thermogenesis for human obesity management
    Abdul G Dulloo
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Ann N Y Acad Sci 1302:1-10. 2013
    ....
  45. ncbi beta-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis
    D Mainieri
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Int J Obes (Lond) 31:378-81. 2007
    ..Whether approaches that target both SCD1 and molecular effectors of thermogenesis under beta-adrenergic control might be more effective than targeting SCD1 alone are potential avenues for future research in obesity management...
  46. ncbi Corticotropin-releasing hormone directly stimulates thermogenesis in skeletal muscle possibly through substrate cycling between de novo lipogenesis and lipid oxidation
    G Solinas
    Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    Endocrinology 147:31-8. 2006
    ....
  47. ncbi Telmisartan prevents the glitazone-induced weight gain without interfering with its insulin-sensitizing properties
    Anne Zanchi
    Division of Nephrology and Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Am J Physiol Endocrinol Metab 293:E91-5. 2007
    ..This study demonstrates that telmisartan attenuates the glitazone-induced increase in fat mass without interfering with its insulin-sensitizing properties...
  48. ncbi Altered skeletal muscle subsarcolemmal mitochondrial compartment during catch-up fat after caloric restriction
    Raffaella Crescenzo
    Department of Biological Sciences, Section of Physiology, University of Naples, Naples, Italy
    Diabetes 55:2286-93. 2006
    ....
  49. ncbi Skeletal muscle mitochondrial efficiency and uncoupling protein 3 in overeating rats with increased thermogenesis
    Susanna Iossa
    Department of General and Environmental Physiology, University of Naples Federico II, Via Mezzocannone 8, I 80134, Naples, Italy
    Pflugers Arch 445:431-6. 2002
    ..Both mitochondrial populations in skeletal muscle cells from rats with increased thermogenesis display an increased fatty acid-induced uncoupling and UCP3 content, which could contribute to avoiding obesity...