D Duboule

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi The rise and fall of Hox gene clusters
    Denis Duboule
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Development 134:2549-60. 2007
  2. pmc Uncoupling time and space in the collinear regulation of Hox genes
    Patrick Tschopp
    Department of Zoology and Animal Biology, National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Geneva, Switzerland
    PLoS Genet 5:e1000398. 2009
  3. ncbi Vertebrate hox gene regulation: clustering and/or colinearity?
    D Duboule
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211, Geneva 4, Switzerland
    Curr Opin Genet Dev 8:514-8. 1998
  4. ncbi The evolution of 'bricolage'
    D Duboule
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Trends Genet 14:54-9. 1998
  5. pmc Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations
    F Spitz
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland
    Genes Dev 15:2209-14. 2001
  6. ncbi Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex
    F van der Hoeven
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Mech Dev 54:9-21. 1996
  7. ncbi Control of colinearity in AbdB genes of the mouse HoxD complex
    T Kondo
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Mol Cell 1:289-300. 1998
  8. ncbi Genetic analysis of a Hoxd-12 regulatory element reveals global versus local modes of controls in the HoxD complex
    Y Herault
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Geneva, Switzerland
    Development 125:1669-77. 1998
  9. ncbi Hox gene expression in limbs: colinearity by opposite regulatory controls
    Y Herault
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, Geneva 4, 1211, Switzerland
    Dev Biol 208:157-65. 1999
  10. ncbi Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach?
    J Beckers
    Department of Zoology and Animal Biology, Sciences III, University of Geneva, Switzerland
    Dev Dyn 213:1-11. 1998

Collaborators

Detail Information

Publications71

  1. ncbi The rise and fall of Hox gene clusters
    Denis Duboule
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Development 134:2549-60. 2007
    ..By integrating these parameters, general conclusions emerge that can help solve the aforementioned dilemma...
  2. pmc Uncoupling time and space in the collinear regulation of Hox genes
    Patrick Tschopp
    Department of Zoology and Animal Biology, National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Geneva, Switzerland
    PLoS Genet 5:e1000398. 2009
    ..We discuss the potential functions and evolutionary origins of these mechanisms, as well as their relationship with similar processes at work during limb development...
  3. ncbi Vertebrate hox gene regulation: clustering and/or colinearity?
    D Duboule
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211, Geneva 4, Switzerland
    Curr Opin Genet Dev 8:514-8. 1998
    ..Although these results do not address the puzzling issue of colinearity directly, they nevertheless add novel important input to the debate...
  4. ncbi The evolution of 'bricolage'
    D Duboule
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Trends Genet 14:54-9. 1998
    ..In this 'transitionist' scheme, evolution is neither inherently gradualist nor punctuated but, instead, progresses from one extreme to the other, together with the increased complexity of organisms...
  5. pmc Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations
    F Spitz
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland
    Genes Dev 15:2209-14. 2001
    ..Accordingly, deletion of the entire cluster abolished axial expression, whereas recently acquired regulatory controls were preserved...
  6. ncbi Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex
    F van der Hoeven
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Mech Dev 54:9-21. 1996
    ..In this model, a few ancestral Hox genes were involved in the determination of polarity in the digestive tract and were further recruited in more elaborate axial structures...
  7. ncbi Control of colinearity in AbdB genes of the mouse HoxD complex
    T Kondo
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Mol Cell 1:289-300. 1998
    ....
  8. ncbi Genetic analysis of a Hoxd-12 regulatory element reveals global versus local modes of controls in the HoxD complex
    Y Herault
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Geneva, Switzerland
    Development 125:1669-77. 1998
    ..These results support a model whereby global as well as local regulatory influences are necessary to build up the complex expression patterns of Hoxd genes during limb development...
  9. ncbi Hox gene expression in limbs: colinearity by opposite regulatory controls
    Y Herault
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, Geneva 4, 1211, Switzerland
    Dev Biol 208:157-65. 1999
    ..This model provides a conceptual link between the morphology of the future limb and the genetic organization of the Hox gene cluster, a translation of a genomic context into a morphogenetic topology...
  10. ncbi Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach?
    J Beckers
    Department of Zoology and Animal Biology, Sciences III, University of Geneva, Switzerland
    Dev Dyn 213:1-11. 1998
    ..This unexpected observation may show the limitations of the former technology. Alternatively, it could illustrate a redundancy in regulatory circuits and, thus, justify the combination of parallel strategies...
  11. ncbi Transgenic analysis of a potential Hoxd-11 limb regulatory element present in tetrapods and fish
    J Beckers
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, Geneva 4, 1211, Switzerland
    Dev Biol 180:543-53. 1996
    ..These results are discussed in light of both the control of Hoxd gene expression during limb development and the use of a comparative interspecies approach to understand the regulation of genes involved in vertebrate development...
  12. ncbi The mouse Hoxd13(spdh) mutation, a polyalanine expansion similar to human type II synpolydactyly (SPD), disrupts the function but not the expression of other Hoxd genes
    S Bruneau
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Dev Biol 237:345-53. 2001
    ..Developmental studies indicate that the morphological effect is mostly due to a severe retardation in the growth and ossification of the bony elements, in agreement with a general impairment in the function of posterior Hoxd genes...
  13. ncbi Breaking colinearity in the mouse HoxD complex
    T Kondo
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Cell 97:407-17. 1999
    ..These data suggest that a regulatory element located upstream of the complex is necessary for setting up the early pattern of Hox gene colinear activation...
  14. ncbi Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock
    J Zakany
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Cell 106:207-17. 2001
    ..These results suggest a molecular link between Hox gene activation and the segmentation clock. Such a linkage would efficiently keep in phase the production of novel segments with their morphological specification...
  15. ncbi In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries
    M Gerard
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Genes Dev 10:2326-34. 1996
    ..These results illustrate the sharing, in cis, of a single regulatory element in order to establish the expression boundaries of two neighboring Hoxd genes...
  16. pmc Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum
    J Zakany
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    EMBO J 16:4393-402. 1997
    ..A slight time delay in expression (transcriptional heterochrony) cannot be compensated for at a later developmental stage, eventually leading to morphological alterations...
  17. ncbi Hox gene expression in teleost fins and the origin of vertebrate digits
    P Sordino
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Nature 375:678-81. 1995
    ..The results suggest a scheme for the fin-limb transition in which the distal autopods (digits) are neomorphic structures produced by unequal proliferation of the posterior part of an ancestral appendix...
  18. ncbi Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing
    M Kmita
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Geneva, Switzerland
    Nat Genet 26:451-4. 2000
    ..This polar silencer appears to limit the number of genes that respond to one type of regulation and thus indicates how separate regulatory domains may be implemented within intricate gene clusters...
  19. ncbi Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes
    Y Herault
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Development 124:3493-500. 1997
    ....
  20. pmc Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex
    M Kmita
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland
    Genes Dev 14:198-211. 2000
    ..These results are discussed in the context of existing models, which account for colinear activation of vertebrate Hox genes...
  21. ncbi Hox genes in digit development and evolution
    J Zakany
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, CH 1211 Geneva 4, Switzerland
    Cell Tissue Res 296:19-25. 1999
    ..Molecular analysis of the underlying regulatory processes promises further exciting insights into the genetic control of development, pathology and the course of evolution...
  22. pmc Regulation of number and size of digits by posterior Hox genes: a dose-dependent mechanism with potential evolutionary implications
    J Zakany
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Proc Natl Acad Sci U S A 94:13695-700. 1997
    ..Thus, transition through a polydactylous limb before reaching and stabilizing the pentadactyl pattern may have relied, at least in part, on asynchronous and independent changes in the regulation of HoxA and HoxD gene complexes...
  23. ncbi Interspecies exchange of a Hoxd enhancer in vivo induces premature transcription and anterior shift of the sacrum
    M Gerard
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Dev Biol 190:32-40. 1997
    ....
  24. ncbi Synpolydactyly in mice with a targeted deficiency in the HoxD complex
    J Zakany
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Nature 384:69-71. 1996
    ..8), may involve the loss of function of several Hoxd genes. These results indicate the existence of a functional hierarchy among these genes and provide us with an animal model to study human digit malformations...
  25. pmc Function of the Evx-2 gene in the morphogenesis of vertebrate limbs
    Y Herault
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    EMBO J 15:6727-38. 1996
    ..These results show that, in limbs, Evx-2 functions like a Hoxd gene. A potential evolutionary scenario is discussed, in which Evx-2 was recruited by the HoxD complex in conjunction with the emergence of digits in an ancestral tetrapod...
  26. ncbi Function of posterior HoxD genes in the morphogenesis of the anal sphincter
    T Kondo
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Development 122:2651-9. 1996
    ..Similarly, Hoxd-12 and Hoxd-13 functionally overlap during digit development. The function of these genes in the morphogenesis of the digestive system as well as their functional evolution are discussed...
  27. ncbi Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls
    F van der Hoeven
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Cell 85:1025-35. 1996
    ..These results suggest that high order regulation controls the activation of Hox genes and highlight three important constraints responsible for the conservation of Hox gene clustering...
  28. ncbi Engineering chromosomes in mice through targeted meiotic recombination (TAMERE)
    Y Herault
    Department of Zoology and Animal Biology, University of Geneva, Science III, Switzerland
    Nat Genet 20:381-4. 1998
    ..The high frequency of such targeted exchanges in vivo makes TAMERE a powerful genetic tool applicable to research areas in which complex genomic modifications are required...
  29. ncbi Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs
    Marie Kmita
    Department of Zoology and Animal Biology, NCCR Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Nature 420:145-50. 2002
    ....
  30. ncbi Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity
    Basile Tarchini
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Nature 443:985-8. 2006
    ..This in turn further contributed to stabilize the architecture and operational mode of this genetic system...
  31. ncbi Organizing axes in time and space; 25 years of colinear tinkering
    Marie Kmita
    Department of Zoology and Animal Biology and National Center of Competence in Research Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Science 301:331-3. 2003
    ....
  32. ncbi Control of Hoxd genes' collinearity during early limb development
    Basile Tarchini
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Dev Cell 10:93-103. 2006
    ....
  33. ncbi A dual role for Hox genes in limb anterior-posterior asymmetry
    Jozsef Zakany
    Department of Zoology and Animal Biology and National Program Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Science 304:1669-72. 2004
    ..This signal is subsequently translated into digit morphological asymmetry by promoting the late expression of Hoxd genes, two collinear processes relying on opposite genomic topographies, upstream and downstream Shh signaling...
  34. ncbi Tinkering with constraints in the evolution of the vertebrate limb anterior-posterior polarity
    Denis Duboule
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Novartis Found Symp 284:130-7; discussion 138-41, 158-63. 2007
    ..This major regulatory constraint imposed a polarity to our limbs as the most parsimonious solution to grow appendages...
  35. ncbi [A STRING lifts the veil on the mechanisms controlling Hox genes expression]
    Francois Spitz
    National Research Centre Frontiers in Genetics, Département de Zoologie et de Biologie animale, Universite de Geneve, Sciences III, quai Ernest Genève, Suisse
    Med Sci (Paris) 22:14-6. 2006
  36. doi Changes in Hox genes' structure and function during the evolution of the squamate body plan
    Nicolas Di-Poï
    National Research Center Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland
    Nature 464:99-103. 2010
    ....
  37. ncbi The role of Hox genes during vertebrate limb development
    Jozsef Zakany
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Curr Opin Genet Dev 17:359-66. 2007
    ..brought into focus by gene expression analyses in mice (P Dolle, JC Izpisua-Belmonte, H Falkenstein, A Renucci, D Duboule, Nature 1989, 342:767-772), at a time when limb growth and patterning were thought to depend upon two distinct ..
  38. ncbi Transgenic analysis of Hoxd gene regulation during digit development
    Federico Gonzalez
    National Center for Competence in Research Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Dev Biol 306:847-59. 2007
    ..Based on DNA sequence conservation and transgenic assays, we discuss the functions of these regulatory regions as well as a potential evolutionary scheme accounting for their emergence along with the evolution of tetrapod limbs...
  39. ncbi Interactions between HOXD and Gli3 genes control the limb apical ectodermal ridge via Fgf10
    Jozsef Zakany
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Dev Biol 306:883-93. 2007
    ..The nature of these potential interactions is discussed in the context of proximal-distal growth and patterning...
  40. pmc Distinct roles and regulations for HoxD genes in metanephric kidney development
    Nicolas Di-Poï
    Department of Zoology and Animal Biology, University of Geneva, Geneva, Swizerland
    PLoS Genet 3:e232. 2007
    ..These insights further our knowledge of the genetic control of kidney morphogenesis and may contribute to understanding certain congenital kidney malformations, including polycystic kidney disease and renal hypoplasia...
  41. pmc Conserved elements within open reading frames of mammalian Hox genes
    Joost M Woltering
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Switzerland
    J Biol 8:17. 2009
    ..These findings support an emerging view that gene regulatory and coding sequences are likely to be more intermingled than once believed...
  42. pmc Atypical relaxation of structural constraints in Hox gene clusters of the green anole lizard
    Nicolas Di-Poï
    National Research Center Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, 1211 Geneva 4, Switzerland
    Genome Res 19:602-10. 2009
    ..Finally, sequence alignments highlight some divergent evolution in highly conserved DNA regions between vertebrate Hox clusters, which may coincide with the emergence of mammalian-specific features...
  43. doi Epigenetic temporal control of mouse Hox genes in vivo
    Natalia Soshnikova
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Science 324:1320-3. 2009
    ..These results suggest that chromatin modifications are important parameters in the temporal regulation of this gene family...
  44. ncbi Epigenetic regulation of vertebrate Hox genes: a dynamic equilibrium
    Natalia Soshnikova
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Geneva, Switzerland
    Epigenetics 4:537-40. 2009
    ..In vertebrates, dynamic changes in chromatin modifications are also observed during the sequential activation of Hox genes in the embryo, suggesting that progressive epigenetic modifications could regulate collinear gene activation...
  45. doi The origin of digits: expression patterns versus regulatory mechanisms
    Joost M Woltering
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Dev Cell 18:526-32. 2010
    ..In this context, we discuss the adaptive relevance of evolving stepwise, distinct developmental regulatory mechanisms to build an arm, i.e., a composite structure with functional coherence...
  46. ncbi Colinearity loops out
    Denis Duboule
    Department of Zoology and Animal Biology and National Program Frontiers in Genetics, University of Geneva, CH 1211 Geneva, Switzerland
    Dev Cell 6:738-40. 2004
    ..They show that, while chromatin remodeling confers transcriptional competence to the gene cluster, subsequent sequential extrusion of genes from their chromosome territory may determine their coordinated expression in time...
  47. ncbi Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes
    Francois Spitz
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Nat Genet 37:889-93. 2005
    ..This approach can be used to study the relationship between genome architecture and gene expression, such as the effects of genome rearrangements in human diseases or during evolution...
  48. ncbi Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia
    John Cobb
    National Research Center NCCR Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Development 132:3055-67. 2005
    ..e. the digits and the penis/clitoris...
  49. ncbi Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function
    Marie Kmita
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Nature 435:1113-6. 2005
    ..Accordingly, these mutant limbs may be reminiscent of an ancestral trunk extension, related to that proposed for arthropods...
  50. ncbi An enhancer-titration effect induces digit-specific regulatory alleles of the HoxD cluster
    Ignacio Monge
    Department of Zoology and Animal Biology and NCCR Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 11, Switzerland
    Dev Biol 256:212-20. 2003
    ....
  51. ncbi Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells
    Marie Kmita
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, Switzerland
    Development 129:5521-8. 2002
    ..These results suggest that insulation of this important gene cluster relies, at least in part, upon a sequence-specific mechanism that displays some redundancy...
  52. ncbi A global control region defines a chromosomal regulatory landscape containing the HoxD cluster
    Francois Spitz
    Department of Zoology and Animal Biology, NCCR Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Cell 113:405-17. 2003
    ..These domains were interrupted in the Ulnaless mutation, a balanced inversion that modified the topography of the locus. We discuss the heuristic value of these results in term of locus specific versus gene-specific regulation...
  53. ncbi A t(2;8) balanced translocation with breakpoints near the human HOXD complex causes mesomelic dysplasia and vertebral defects
    Francois Spitz
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Genomics 79:493-8. 2002
    ..However, gain- and loss-of-function of Hoxd genes in mice can induce mesomelic dysplasia-like phenotypes, suggesting that misexpression of HOXD genes may indeed be at the origin of this hereditary phenotype...
  54. ncbi Hox gene function in vertebrate gut morphogenesis: the case of the caecum
    Giovanna Zacchetti
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Development 134:3967-73. 2007
    ..These results illuminate components of the genetic cascade necessary for the emergence of this gut segment, crucial for many vertebrates...
  55. pmc Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness
    Thomas Montavon
    National Research Centre Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Federale, CH 1015 Lausanne, Switzerland
    Genes Dev 22:346-59. 2008
    ..We also show that the same model applies to the collinear regulation of Hox genes during the emergence of external genitalia, though with some differences likely illustrating the distinct functionalities of these structures in adults...
  56. pmc HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside
    Basile Tarchini
    National Research Centre Frontiers in Genetics and Department of Zoology and Animal Biology, University of Geneva, 1211 Geneva 4, Switzerland
    Genes Dev 19:2862-76. 2005
    ..These results highlight the importance of a systematic approach when studying such clustered gene families, and give insights into the function and regulation of Hox and Evx2 genes during early spinal cord development...
  57. ncbi A nested deletion approach to generate Cre deleter mice with progressive Hox profiles
    Yann Herault
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Int J Dev Biol 46:185-91. 2002
    ..We used the R26R (R26R) reporter mouse line to functionally assess the distribution and efficiency of the CRE enzyme and discuss the usefulness of these various lines as deleter strains...
  58. ncbi Functional equivalence and rescue among group 11 Hox gene products in vertebral patterning
    J Zakany
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Dev Biol 176:325-8. 1996
    ..The phenotypic rescue of these genotypes shows that the Hoxa-11 and Hoxd-11 products are functionally equivalent and that extra doses of Hoxd-11 can rescue Hoxa-11 loss of function...
  59. doi Additive and global functions of HoxA cluster genes in mesoderm derivatives
    Nicolas Di-Poï
    National Research Center Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland
    Dev Biol 341:488-98. 2010
    ..Finally, the combined deletions of Hoxa and Hoxd genes reveal abnormalities in axial elongation as well as skin morphogenesis that are likely the results of defects in epithelial-mesenchymal interactions...
  60. pmc A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development
    John Cobb
    Department of Zoology and Animal Biology and National Research Center Frontiers in Genetics, Sciences III, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Proc Natl Acad Sci U S A 103:4511-5. 2006
    ..Furthermore, using this mouse model, we establish the cellular etiology of these defects and show that Shox2 acts upstream the Runx2 gene, a key regulator of chondrogenesis...
  61. doi Epigenetic regulation of Hox gene activation: the waltz of methyls
    Natalia Soshnikova
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland
    Bioessays 30:199-202. 2008
    ..Though the overall importance of these enzymes for proper embryogenesis was demonstrated, their precise role in Hox gene epigenetic regulation during development still remains to be firmly established...
  62. ncbi The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
    Nicolas Preitner
    Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 4, Geneva, Switzerland
    Cell 110:251-60. 2002
    ..While REV-ERBalpha influences the period length and affects the phase-shifting properties of the clock, it is not required for circadian rhythm generation...
  63. pmc Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd
    Céline Morey
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh University, Crewe Road, Edinburgh EH4 2XU, UK
    J Cell Sci 121:571-7. 2008
    ..This shows that reorganisation of chromosome territories and chromatin decondensation can be uncoupled from transcription itself and suggests that they can therefore operate upstream of gene expression...
  64. ncbi Developmental biology: reproduction in clusters
    Francois Spitz
    Nature 434:715-6. 2005
  65. ncbi Tracing microRNA patterns in mice
    John Cobb
    Nat Genet 36:1033-4. 2004
  66. doi Global control regions and regulatory landscapes in vertebrate development and evolution
    Francois Spitz
    Developmental Biology Unit, EMBL, 69117 Heidelberg, Germany
    Adv Genet 61:175-205. 2008
    ..In some cases, these processes led to the formation of groups of adjacent genes that appear to be controlled by both global and shared mechanisms...
  67. ncbi Making progress with limb models
    Denis Duboule
    Nature 418:492-3. 2002
  68. ncbi Head-tail patterning of the vertebrate embryo: one, two or many unresolved problems?
    Claudio D Stern
    European Union Network of Excellence Cells into Organs, University College London, UK
    Int J Dev Biol 50:3-15. 2006
    ..In this paper, we outline some of the major outstanding problems and controversies and try to identify some reasons why it has been so difficult to resolve this important issue...
  69. ncbi Differentiation and gene regulation
    Frank G Grosveld
    Curr Opin Genet Dev 17:369-72. 2007
  70. pmc Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression
    Aimee Zuniga
    Developmental Genetics, Department of Clinical Biological Sciences, University of Basel Medical School, CH 4056 Basel, Switzerland
    Genes Dev 18:1553-64. 2004
    ..Our studies reveal the large genomic landscape harboring this GCR, which is required for tissue-specific coexpression of two structurally and functionally unrelated genes...
  71. doi Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3
    Marc Friedli
    Department of Genetic Medicine and Development, University of Geneva Medical School and University Hospitals of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Mamm Genome 19:272-8. 2008
    ..Interestingly, the Dac2j mutation occurs within a highly conserved element that may represent a regulatory sequence for a neighboring gene...