Annette Draeger

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi request reprint Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia
    A Draeger
    Institute of Anatomy, Department of Cell Biology, University of Bern, Baltzerstrasse 2, 3012 Bern, Switzerland
    J Pathol 210:94-102. 2006
  2. doi request reprint Plasma membrane repair and cellular damage control: the annexin survival kit
    Annette Draeger
    Department of Cell Biology, Institute of Anatomy, University of Bern Baltzerstr, 2 3012, Bern, Switzerland
    Biochem Pharmacol 81:703-12. 2011
  3. pmc The targeting of plasmalemmal ceramide to mitochondria during apoptosis
    Eduard B Babiychuk
    Institute of Anatomy, University of Bern, Bern, Switzerland
    PLoS ONE 6:e23706. 2011
  4. doi request reprint Ceramide in plasma membrane repair
    Annette Draeger
    Department of Cell Biology, Institute of Anatomy, University of Bern, Baltzerstr 2, 3012, Bern, Switzerland
    Handb Exp Pharmacol 216:341-53. 2013
  5. pmc Statin therapy and the expression of genes that regulate calcium homeostasis and membrane repair in skeletal muscle
    Annette Draeger
    Institute of Anatomy, University of Bern, Baltzerstr 2, 3012 Bern, Switzerland
    Am J Pathol 177:291-9. 2010
  6. ncbi request reprint Membrane segregation and downregulation of raft markers during sarcolemmal differentiation in skeletal muscle cells
    A Draeger
    Department of Cell Biology, Institute of Anatomy, University of Bern, Switzerland
    Dev Biol 262:324-34. 2003
  7. pmc Plasma membrane-associated annexin A6 reduces Ca2+ entry by stabilizing the cortical actin cytoskeleton
    Katia Monastyrskaya
    Department of Cell Biology, Institute of Anatomy, University of Bern, 3000 Bern 9, Switzerland
    J Biol Chem 284:17227-42. 2009
  8. pmc Association between statin-associated myopathy and skeletal muscle damage
    Markus G Mohaupt
    Department of Nephrology and Hypertension, Inselspital, University of Bern, Bern, Switzerland
    CMAJ 181:E11-8. 2009
  9. ncbi request reprint The annexins: spatial and temporal coordination of signaling events during cellular stress
    Katia Monastyrskaya
    Department of Cell Biology, Institute of Anatomy, University of Bern, 3000 Bern 9, Switzerland
    Cell Mol Life Sci 66:2623-42. 2009
  10. doi request reprint Down-regulation of annexin A1 in the urothelium decreases cell survival after bacterial toxin exposure
    Katia Monastyrskaya
    Urology Research Laboratory, Department of Clinical Research, University of Bern, Bern, Switzerland
    J Urol 190:325-33. 2013

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia
    A Draeger
    Institute of Anatomy, Department of Cell Biology, University of Bern, Baltzerstrasse 2, 3012 Bern, Switzerland
    J Pathol 210:94-102. 2006
    ....
  2. doi request reprint Plasma membrane repair and cellular damage control: the annexin survival kit
    Annette Draeger
    Department of Cell Biology, Institute of Anatomy, University of Bern Baltzerstr, 2 3012, Bern, Switzerland
    Biochem Pharmacol 81:703-12. 2011
    ....
  3. pmc The targeting of plasmalemmal ceramide to mitochondria during apoptosis
    Eduard B Babiychuk
    Institute of Anatomy, University of Bern, Bern, Switzerland
    PLoS ONE 6:e23706. 2011
    ..It is conceivable that this "kiss-of-death" increases the permeability of the mitochondrial outer membrane thereby triggering apoptosis...
  4. doi request reprint Ceramide in plasma membrane repair
    Annette Draeger
    Department of Cell Biology, Institute of Anatomy, University of Bern, Baltzerstr 2, 3012, Bern, Switzerland
    Handb Exp Pharmacol 216:341-53. 2013
    ..In this process, ceramide is supported by members of the annexin protein family which act as Ca(2+) sensors and as membrane fusion agents...
  5. pmc Statin therapy and the expression of genes that regulate calcium homeostasis and membrane repair in skeletal muscle
    Annette Draeger
    Institute of Anatomy, University of Bern, Baltzerstr 2, 3012 Bern, Switzerland
    Am J Pathol 177:291-9. 2010
    ..Hence, even in clinically asymptomatic (non-myopathic) patients, statin therapy leads to an upregulation in the expression of genes that are concerned with skeletal muscle regulation and membrane repair...
  6. ncbi request reprint Membrane segregation and downregulation of raft markers during sarcolemmal differentiation in skeletal muscle cells
    A Draeger
    Department of Cell Biology, Institute of Anatomy, University of Bern, Switzerland
    Dev Biol 262:324-34. 2003
    ....
  7. pmc Plasma membrane-associated annexin A6 reduces Ca2+ entry by stabilizing the cortical actin cytoskeleton
    Katia Monastyrskaya
    Department of Cell Biology, Institute of Anatomy, University of Bern, 3000 Bern 9, Switzerland
    J Biol Chem 284:17227-42. 2009
    ..Taken together, our results implicate annexin A6 in the actin-dependent regulation of Ca(2+) entry, with consequences for the rates of cell proliferation...
  8. pmc Association between statin-associated myopathy and skeletal muscle damage
    Markus G Mohaupt
    Department of Nephrology and Hypertension, Inselspital, University of Bern, Bern, Switzerland
    CMAJ 181:E11-8. 2009
    ..Many patients taking statins often complain of muscle pain and weakness. The extent to which muscle pain reflects muscle injury is unknown...
  9. ncbi request reprint The annexins: spatial and temporal coordination of signaling events during cellular stress
    Katia Monastyrskaya
    Department of Cell Biology, Institute of Anatomy, University of Bern, 3000 Bern 9, Switzerland
    Cell Mol Life Sci 66:2623-42. 2009
    ....
  10. doi request reprint Down-regulation of annexin A1 in the urothelium decreases cell survival after bacterial toxin exposure
    Katia Monastyrskaya
    Urology Research Laboratory, Department of Clinical Research, University of Bern, Bern, Switzerland
    J Urol 190:325-33. 2013
    ..We examined the role of annexins in bladder urothelium. We characterized expression and distribution in normal bladders, biopsies from patients with bladder pain syndrome, cultured human urothelium and urothelial TEU-2 cells...
  11. doi request reprint Fluorescent annexin A1 reveals dynamics of ceramide platforms in living cells
    Eduard B Babiychuk
    Department of Cell Biology, Institute of Anatomy, University of Bern, Bern, Switzerland
    Traffic 9:1757-75. 2008
    ....
  12. doi request reprint miR-199a-5p regulates urothelial permeability and may play a role in bladder pain syndrome
    Katia Monastyrskaya
    Urology Research Laboratory, Department of Clinical Research, University of Bern, Bern, Switzerland
    Am J Pathol 182:431-48. 2013
    ..Up-regulation of miR-199a-5p and concomitant down-regulation of its multiple targets might be detrimental to the establishment of a tight urothelial barrier, leading to chronic pain...
  13. ncbi request reprint Phenotypic conversion leads to structural and functional changes of smooth muscle sarcolemma
    Katharina Matschke
    Department of Cell Biology, Institute of Anatomy, University of Bern, Baltzerstrasse 2, 3012 Bern, Switzerland
    Exp Cell Res 312:3495-503. 2006
    ..The plasma membrane has undergone profound functional changes which are incompatible with cyclic foreshortening, but might be important in the development of vascular disease...
  14. ncbi request reprint Smooth muscle membrane organization in the normal and dysfunctional human urinary bladder: a structural analysis
    Fiona C Burkhard
    Department of Urology, University of Bern, Bern, Switzerland
    Neurourol Urodyn 24:128-35. 2005
    ....
  15. ncbi request reprint Annexins as intracellular calcium sensors
    Katia Monastyrskaya
    Department of Cell Biology, Institute of Anatomy, University of Bern, 3000 Bern 9, Switzerland
    Cell Calcium 41:207-19. 2007
    ..Given the fact that several annexins are present within any one cell, it is likely that they form a sophisticated [Ca(2+)] sensing system, with a regulatory influence on other signaling pathways...
  16. ncbi request reprint P2X7 receptors mediate resistance to toxin-induced cell lysis
    Roman Schoenauer
    Institute of Anatomy, University of Bern, Bern, Switzerland
    Biochim Biophys Acta 1843:915-22. 2014
    ..It pre-empts plasmalemmal damage and promotes cellular survival. This mechanism is of considerable importance for cells of the immune system which carry the P2X7R and which are specifically exposed to toxin attacks. ..
  17. pmc MicroRNAs may mediate the down-regulation of neurokinin-1 receptor in chronic bladder pain syndrome
    Veronica Sanchez Freire
    Department of Cell Biology, Institute of Anatomy, University of Bern, 3000 Bern 9, Switzerland
    Am J Pathol 176:288-303. 2010
    ..Our findings further the knowledge of the molecular mechanisms of BPS, and have relevance for other clinical conditions involving the NK1 receptor...
  18. pmc Domain architecture of the smooth-muscle plasma membrane: regulation by annexins
    Annette Draeger
    Department of Cell Biology, Institute of Anatomy, University of Bern, Bern 9, CH 3000, Switzerland
    Biochem J 387:309-14. 2005
    ....
  19. pmc Tailored protection against plasmalemmal injury by annexins with different Ca2+ sensitivities
    Sarah Potez
    Department of Cell Biology, Institute of Anatomy, University of Bern, 3012 Bern, Switzerland
    J Biol Chem 286:17982-91. 2011
    ....
  20. ncbi request reprint Modulating signaling events in smooth muscle: cleavage of annexin 2 abolishes its binding to lipid rafts
    Eduard B Babiychuk
    Department of Cell Biology, Institute of Anatomy, University of Bern, Switzerland
    FASEB J 16:1177-84. 2002
    ..Proteolysis abolishes annexin binding to the plasma membrane and might result in rearrangement of membrane constituents followed by the interruption of segregation-dependent signaling events...
  21. ncbi request reprint Annexins sense changes in intracellular pH during hypoxia
    Katia Monastyrskaya
    Department of Cell Biology, Institute of Anatomy, University of Bern, 3000 Bern 9, Switzerland
    Biochem J 409:65-75. 2008
    ..The pH-induced membrane binding of annexins A6 and A2-S100A10 might have consequences for their functions as membrane organizers and channel modulators...
  22. pmc Biochemical characterization of detergent-resistant membranes: a systematic approach
    Eduard B Babiychuk
    Department of Cell Biology, Institute of Anatomy, University of Bern, Bern 9, CH 3000, Switzerland
    Biochem J 397:407-16. 2006
    ..Our findings demonstrate a need for critical re-evaluation of the accumulated detergent-extraction data...
  23. pmc Microvesicle shedding and lysosomal repair fulfill divergent cellular needs during the repair of streptolysin O-induced plasmalemmal damage
    Alexander P Atanassoff
    Department of Cell Biology, Institute of Anatomy, University of Bern, Bern, Switzerland
    PLoS ONE 9:e89743. 2014
    ..Our study provides new insights into the functioning of non-immune cellular defenses against bacterial pathogens. ..
  24. ncbi request reprint Membrane cholesterol regulates smooth muscle phasic contraction
    E B Babiychuk
    Department of Cell Biology, Institute of Anatomy, University of Bern, Bern 9, CH, 3000, Switzerland
    J Membr Biol 198:95-101. 2004
    ..These findings are important in understanding the complex signalling pathways in smooth muscle and conditions such as premature labor and hypertension...
  25. pmc Blebbing confers resistance against cell lysis
    E B Babiychuk
    Department of Cell Biology, Institute of Anatomy, University of Bern, Bern 3012, Switzerland
    Cell Death Differ 18:80-9. 2011
    ..By targeting annexin A1/blebbing, new therapeutic approaches could be developed to avert the necrotic loss of cells in a variety of human pathologies...
  26. doi request reprint Intracellular Ca(2+) operates a switch between repair and lysis of streptolysin O-perforated cells
    E B Babiychuk
    Department of Cell Biology, Institute of Anatomy, University of Bern, Bern, Switzerland
    Cell Death Differ 16:1126-34. 2009
    ..These findings show that the extent of [Ca(2+)](i) elevation determines the fate of targeted cells and establishes how different Ca(2+)-dependent mechanisms facilitate either cell survival or death...
  27. doi request reprint Annexin A1 is a biomarker of T-tubular repair in skeletal muscle of nonmyopathic patients undergoing statin therapy
    Tilman Voigt
    Institute of Anatomy, Inselspital, University of Bern, Bern, Switzerland
    FASEB J 27:2156-64. 2013
    ..Ca(2+)-dependent membrane repair proteins such as dysferlin and annexin A1 are deployed at T-tubular sites. The up-regulation of annexin A1 gene expression and protein points to this protein as a biomarker for T-tubular repair...
  28. ncbi request reprint The NK1 receptor localizes to the plasma membrane microdomains, and its activation is dependent on lipid raft integrity
    Katia Monastyrskaya
    Department of Cell Biology, Institute of Anatomy, University of Bern, Switzerland
    J Biol Chem 280:7135-46. 2005
    ..Our results demonstrate that reorganization of the plasma membrane has an effect on the activation of the raft-associated NK1R and the down-stream events such as recruitment of protein kinases...
  29. ncbi request reprint Stress fibres-a Ca2+ -independent store for annexins?
    E B Babiychuk
    Department of Cell Biology, Institute of Anatomy, University of Bern, Buhlstrasse 26, 3012, Bern, Switzerland
    Biochim Biophys Acta 1600:154-61. 2002
    ..This type of Ca(2+)-dependent annexin mobility is observed only in cells of mesenchymal phenotype, which have a well-developed stress-fibre system; not in epithelial cells...
  30. ncbi request reprint The expression levels of three raft-associated molecules in cultivated vascular cells are dependent on culture conditions
    K Monastyrskaya
    Department of Cell Biology, Institute of Anatomy, University of Bern, Bühlstr 26, 3012 Bern, Switzerland
    Cell Mol Life Sci 60:2702-9. 2003
    ..Our data point to a shift of raft components in monolayer cultures and demonstrate potential advantages of the spheroid coculture system for investigation of raft-mediated signalling events in endothelial cells...
  31. ncbi request reprint Regulation of ecto-5'-nucleotidase activity via Ca2+-dependent, annexin 2-mediated membrane rearrangement?
    E B Babiychuk
    Department of Cell Biology, Institute of Anatomy, University of Bern, Switzerland
    Biochem Soc Trans 34:374-6. 2006
    ..Our results point to a regulation of ecto-5'-nucleotidase activity by Ca(2+)-dependent, annexin-mediated stabilization of membrane rafts...
  32. ncbi request reprint MMP-19: cellular localization of a novel metalloproteinase within normal breast tissue and mammary gland tumours
    V Djonov
    Institute of Anatomy, University of Bern, Switzerland
    J Pathol 195:147-55. 2001
    ....
  33. ncbi request reprint Increased cholesterol decreases uterine activity: functional effects of cholesterol alteration in pregnant rat myometrium
    R D Smith
    Dept of Physiology, The University of Liverpool, Crown St, Liverpool, L69 3BX, UK
    Am J Physiol Cell Physiol 288:C982-8. 2005
    ..It may be one of the mechanisms operating to maintain uterine quiescence throughout gestation and may also contribute to difficulties in labor suffered by obese women...
  34. pmc Diacylglycerol kinase theta is translocated and phosphoinositide 3-kinase-dependently activated by noradrenaline but not angiotensin II in intact small arteries
    A J Walker
    Department of Medicine, University of Manchester, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Biochem J 353:129-137. 2001
    ..The rapid and agonist-specific activation of DGKtheta suggests that this pathway may have a physiological role in vascular smooth-muscle responses...
  35. ncbi request reprint [Calcium-dependent association of membrane rafts]
    E B Babiĭchuk
    Petro Bogach Institute of Physiology, Taras Schevchenko Kyiv National University, Kyiv, Ukraine
    Ukr Biokhim Zh 74:37-41. 2002
    ..Occurring in the presence of physiologically relevant calcium concentrations these interactions may play a role in regulation of smooth muscle contraction...