G P Dotto

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. pmc Opposing roles for calcineurin and ATF3 in squamous skin cancer
    Xunwei Wu
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Nature 465:368-72. 2010
  2. pmc Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes
    Chiara Lambertini
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    PLoS ONE 5:e10369. 2010
  3. ncbi request reprint Crosstalk of Notch with p53 and p63 in cancer growth control
    G Paolo Dotto
    Department of Biochemistry, University of Lausanne, Epalinges CH 1066, Switzerland
    Nat Rev Cancer 9:587-95. 2009
  4. pmc Notch tumor suppressor function
    G P Dotto
    Department of Biochemistry, Lausanne University, Epalinges, Switzerland
    Oncogene 27:5115-23. 2008
  5. pmc Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
    A Rangarajan
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    EMBO J 20:3427-36. 2001
  6. pmc Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21(WAF1/CIP1) expression in keratinocyte differentiation
    M P Santini
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Proc Natl Acad Sci U S A 98:9575-80. 2001
  7. ncbi request reprint A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation
    S Cabodi
    Cutaneous Biology Research Center Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Cell 6:1121-9. 2000
  8. pmc p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential
    G I Topley
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 96:9089-94. 1999
  9. ncbi request reprint Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron
    F Di Cunto
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 273:29706-11. 1998
  10. ncbi request reprint TGF-beta3, but not TGF-beta1, protects keratinocytes against 12-O-tetradecanoylphorbol-13-acetate-induced cell death in vitro and in vivo
    J Li
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 274:4213-9. 1999

Collaborators

Detail Information

Publications17

  1. pmc Opposing roles for calcineurin and ATF3 in squamous skin cancer
    Xunwei Wu
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Nature 465:368-72. 2010
    ..Thus, intact calcineurin/NFAT signalling is critically required for p53 and senescence-associated mechanisms that protect against skin squamous cancer development...
  2. pmc Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes
    Chiara Lambertini
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    PLoS ONE 5:e10369. 2010
    ..The combined knock-down of Klf4 and Sp3 was necessary for the reverse effect of increasing Notch1 transcription, consistent with the two factors exerting an overlapping repressor function through their binding to the Notch1 promoter...
  3. ncbi request reprint Crosstalk of Notch with p53 and p63 in cancer growth control
    G Paolo Dotto
    Department of Biochemistry, University of Lausanne, Epalinges CH 1066, Switzerland
    Nat Rev Cancer 9:587-95. 2009
    ..Therefore, selective or combined targeting of the two pathways could improve the efficacy and reduce the toxicity of cancer therapies...
  4. pmc Notch tumor suppressor function
    G P Dotto
    Department of Biochemistry, Lausanne University, Epalinges, Switzerland
    Oncogene 27:5115-23. 2008
    ..The possibility that Notch signaling elicits a duality of signals, involved in growth/differentiation control and cell survival will be discussed, in the context of novel approaches for cancer therapy...
  5. pmc Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
    A Rangarajan
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    EMBO J 20:3427-36. 2001
    ..Thus, Notch signaling triggers two distinct pathways leading to keratinocyte growth arrest and differentiation...
  6. pmc Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21(WAF1/CIP1) expression in keratinocyte differentiation
    M P Santini
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Proc Natl Acad Sci U S A 98:9575-80. 2001
    ....
  7. ncbi request reprint A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation
    S Cabodi
    Cutaneous Biology Research Center Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Cell 6:1121-9. 2000
    ..Thus, our findings reveal a direct cross talk between PKC-eta and Fyn, which presides over the decision between keratinocyte (epithelial) cell growth and differentiation...
  8. pmc p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential
    G I Topley
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 96:9089-94. 1999
    ..Thus, these findings have revealed a function of p21 as a suppressor of malignant but not benign skin-tumor formation and a determinant of the growth/differentiation potential of keratinocyte subpopulations...
  9. ncbi request reprint Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron
    F Di Cunto
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 273:29706-11. 1998
    ..In contrast, CRIK exhibits a restricted pattern of expression, suggesting that this kinase may fulfill a more specialized function in specific cell types...
  10. ncbi request reprint TGF-beta3, but not TGF-beta1, protects keratinocytes against 12-O-tetradecanoylphorbol-13-acetate-induced cell death in vitro and in vivo
    J Li
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 274:4213-9. 1999
    ....
  11. ncbi request reprint Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control
    F Di Cunto
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, MA 02129, USA
    Science 280:1069-72. 1998
    ..These findings reveal an inhibitory role of p21 in the late stages of differentiation that does not result from the effects of p21 on the cell cycle...
  12. ncbi request reprint The TGF-beta2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis
    K Foitzik
    Cutaneous Biology Research Center, Massachussetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    Dev Biol 212:278-89. 1999
    ..Thus, the TGF-beta2 isoform plays a specific role, not shared by the other TGF-beta isoforms, as an inducer of hair follicle morphogenesis and is both required and sufficient to promote this process...
  13. ncbi request reprint Control of murine hair follicle regression (catagen) by TGF-beta1 in vivo
    K Foitzik
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA Department of Dermatology, University Hospital Eppendorf, University of Hamburg, D 20246 Hamburg, Germany Departme
    FASEB J 14:752-60. 2000
    ..Thus, TGF-betaRII agonists and antagonists may provide useful therapeutic tools for human hair growth disorders based on premature or retarded catagen development (effluvium, alopecia, hirsutism)...
  14. pmc Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in primary mouse keratinocytes
    B Ortel
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston 02114, USA
    Br J Cancer 77:1744-51. 1998
    ..Overall, the therapeutic implications of these results are that the effectiveness of ALA-dependent PDT depends on the differentiation status of the cell and that this may enable selective targeting of several tissue types...
  15. ncbi request reprint The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation
    J L Brissette
    Cutaneous Biology Research Center, Massachusets General Hospital, Charlestown, USA
    Genes Dev 10:2212-21. 1996
    ..The general implications of these findings for an epithelial self-renewal model will be discussed...
  16. ncbi request reprint fyn tyrosine kinase is involved in keratinocyte differentiation control
    E Calautti
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Genes Dev 9:2279-91. 1995
    ..Thus, at least two tyrosine kinase activities are induced in keratinocyte differentiation, one of which has been identified as fyn and shown to be specifically involved in this process...
  17. pmc Skin-specific expression of a truncated E1a oncoprotein binding to p105-Rb leads to abnormal hair follicle maturation without increased epidermal proliferation
    C Missero
    Department of Pathology, Yale University, New Haven, Connecticut 06510
    J Cell Biol 121:1109-20. 1993
    ....