Marc Y Donath

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. doi Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes
    Marc Y Donath
    Division of Endocrinology, Diabetes, and Nutrition, and Center for Integrated Human Physiology, University Hospital of Zurich, Zurich, Switzerland
    Physiology (Bethesda) 24:325-31. 2009
  2. doi Cytokine production by islets in health and diabetes: cellular origin, regulation and function
    Marc Y Donath
    Clinic of Endocrinology and Diabetes, Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Trends Endocrinol Metab 21:261-7. 2010
  3. pmc Type 1, type 1.5, and type 2 diabetes: NOD the diabetes we thought it was
    Marc Y Donath
    Clinic for Endocrinology and Diabetes, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:12217-8. 2006
  4. ncbi Mechanisms of beta-cell death in type 2 diabetes
    Marc Y Donath
    Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Diabetes 54:S108-13. 2005
  5. ncbi Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications
    M Y Donath
    Department of Medicine, University Hospital, 8091, Zurich, Switzerland
    Diabetologia 47:581-9. 2004
  6. ncbi Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes
    Marc Y Donath
    Division of Endocrinology and Diabetes, University Hospital, 8091 Zurich, Switzerland
    J Mol Med (Berl) 81:455-70. 2003
  7. doi Islet inflammation in type 2 diabetes: from metabolic stress to therapy
    Marc Y Donath
    Clinic of Endocrinology and Diabetes, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Diabetes Care 31:S161-4. 2008
  8. pmc Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets
    Kathrin Maedler
    Division of Endocrinology and Diabetes, University Hospital, CH8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 101:8138-43. 2004
  9. doi Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic islets
    Christine Lohmann
    Cardiovascular Research, Institute of Physiology, Zurich University and Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland
    Atherosclerosis 207:360-7. 2009
  10. doi Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I
    Marianne Böni-Schnetzler
    Division of Endocrinology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland marianne
    Endocrinology 150:5218-29. 2009

Detail Information

Publications38

  1. doi Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes
    Marc Y Donath
    Division of Endocrinology, Diabetes, and Nutrition, and Center for Integrated Human Physiology, University Hospital of Zurich, Zurich, Switzerland
    Physiology (Bethesda) 24:325-31. 2009
    ..We propose that this insulitis contributes to the decrease in beta-cell mass and the impaired insulin secretion observed in patients with Type 2 diabetes...
  2. doi Cytokine production by islets in health and diabetes: cellular origin, regulation and function
    Marc Y Donath
    Clinic of Endocrinology and Diabetes, Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Trends Endocrinol Metab 21:261-7. 2010
    ..In this article, we review the islet cellular origin of various cytokines and chemokines and describe their regulation and respective roles in physiology and diabetes...
  3. pmc Type 1, type 1.5, and type 2 diabetes: NOD the diabetes we thought it was
    Marc Y Donath
    Clinic for Endocrinology and Diabetes, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:12217-8. 2006
  4. ncbi Mechanisms of beta-cell death in type 2 diabetes
    Marc Y Donath
    Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Diabetes 54:S108-13. 2005
    ..Thus, the mechanisms regulating beta-cell proliferation, apoptosis, and function are inseparable processes...
  5. ncbi Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications
    M Y Donath
    Department of Medicine, University Hospital, 8091, Zurich, Switzerland
    Diabetologia 47:581-9. 2004
    ..Recognition of decreased functional beta-cell mass and its overlapping multifactorial aetiology in diabetic states, leads us to propose a unifying classification of diabetes...
  6. ncbi Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes
    Marc Y Donath
    Division of Endocrinology and Diabetes, University Hospital, 8091 Zurich, Switzerland
    J Mol Med (Berl) 81:455-70. 2003
    ..Therefore anti-inflammatory therapeutic approaches designed to block beta-cell apoptosis could be a significant new development in type 1 and 2 diabetes...
  7. doi Islet inflammation in type 2 diabetes: from metabolic stress to therapy
    Marc Y Donath
    Clinic of Endocrinology and Diabetes, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Diabetes Care 31:S161-4. 2008
    ..Therefore, modulation of intra-islet inflammatory mediators, in particular interleukin-1 beta, appears as a promising therapeutic approach...
  8. pmc Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets
    Kathrin Maedler
    Division of Endocrinology and Diabetes, University Hospital, CH8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 101:8138-43. 2004
    ..Moreover, siIL-1Ra enhanced glucose-induced beta cell apoptosis. These findings demonstrate expression of IL-1Ra in the human beta cell, providing localized protection against leptin- and glucose-induced islet IL-1beta...
  9. doi Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic islets
    Christine Lohmann
    Cardiovascular Research, Institute of Physiology, Zurich University and Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland
    Atherosclerosis 207:360-7. 2009
    ..Our goal was to characterize systemic inflammation in atherosclerosis with hypercholesterolemia, but without obesity...
  10. doi Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I
    Marianne Böni-Schnetzler
    Division of Endocrinology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland marianne
    Endocrinology 150:5218-29. 2009
    ..We conclude that FFA and TLR stimulation induce proinflammatory factors in islets and that IL-1RI engagement results in signal amplification...
  11. pmc Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation
    Marianne Böni-Schnetzler
    Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    J Clin Endocrinol Metab 93:4065-74. 2008
    ..Elevated glucose levels impair islet function and survival, and it has been proposed that intraislet expression of IL-1beta contributes to glucotoxicity...
  12. pmc The Fas pathway is involved in pancreatic beta cell secretory function
    Desiree M Schumann
    Clinic of Endocrinology and Diabetes, and Department of Pathology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:2861-6. 2007
    ..This led to increased PDX-1 and insulin production independent of changes in cell turnover. The results support a previously undescribed role for the Fas pathway in regulating insulin production and release...
  13. pmc Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice
    Stephan Wueest
    Division of Pediatric Endocrinology and Diabetology, University Children s Hospital, Steinwiesstrasse 75, Zurich, Switzerland
    J Clin Invest 120:191-202. 2010
    ....
  14. doi Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells
    Sabine Rütti
    Division of Endocrinology and Diabetes, University Hospital of Zurich, Zurich 8091, Switzerland
    Endocrinology 150:4521-30. 2009
    ..Our data show that both LDL and HDL affect function or survival of beta-cells and raise the question whether dyslipidemia contributes to beta-cell failure and hence the manifestation and progression of type 2 diabetes mellitus...
  15. doi Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction
    Jan A Ehses
    Division of Endocrinology, Diabetes and Nutrition, Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Arch Physiol Biochem 115:240-7. 2009
    ..Here, we summarize the current evidence that islet inflammation is a feature of type 2 diabetes, and discuss its role with respect to alpha and beta cell compensation and eventual beta cell failure...
  16. ncbi Sulfonylurea induced beta-cell apoptosis in cultured human islets
    Kathrin Maedler
    Division of Endocrinology and Diabetes, University Hospital, CH 8091 Zurich, Switzerland
    J Clin Endocrinol Metab 90:501-6. 2005
    ....
  17. pmc Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
    Kathrin Maedler
    Division of Endocrinology and Diabetes, University Hospital, Zurich, Switzerland
    J Clin Invest 110:851-60. 2002
    ..These findings implicate an inflammatory process in the pathogenesis of glucotoxicity in type 2 diabetes and identify the IL-1beta/NF-kappaB pathway as a target to preserve beta cell mass and function in this condition...
  18. ncbi Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassiu
    Kathrin Maedler
    Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Diabetes 53:1706-13. 2004
    ..Thus, in human islets, glucose- and IL-1beta-induced beta-cell secretory dysfunction and apoptosis are Ca(2+) influx and ERK dependent and can be prevented by the beta-cell selective potassium channel opener NN414...
  19. ncbi Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function
    Kathrin Maedler
    Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Diabetes 52:726-33. 2003
    ..The deleterious effect of palmitic acid is mediated via formation of ceramide and activation of the apoptotic mitochondrial pathway, whereas Bcl-2 may contribute to the protective effect of monounsaturated fatty acids...
  20. doi Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity
    Marc Y Donath
    Endocrinology, Diabetes, and Metabolism and Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland
    Cell Metab 17:860-72. 2013
    ..In this article, we describe the physiology and pathology of the immune system during obesity and diabetes with a focus on islet inflammation, the IL-1β pathway, and clinical translation...
  21. doi Macrophages, cytokines and beta-cell death in Type 2 diabetes
    Jan A Ehses
    Clinic of Endocrinology and Diabetes, and Centre for Integrated Human Physiology, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    Biochem Soc Trans 36:340-2. 2008
    ..It follows that modulation of intra-islet inflammatory mediators, particularly interleukin-1beta, may prevent islet inflammation in Type 2 diabetes and therefore presents itself as a promising therapeutic approach...
  22. pmc Identification of a SIRT1 mutation in a family with type 1 diabetes
    Anna Biason-Lauber
    Department of Medicine, University of Fribourg, CH 1700 Fribourg, Switzerland
    Cell Metab 17:448-55. 2013
    ..These observations identify a role for SIRT1 in human autoimmunity and unveil a monogenic form of type 1 diabetes...
  23. doi The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus
    Marc Y Donath
    Clinic for Endocrinology and Diabetes, University Hospital Zurich and Center for Integrated Human Physiology, University of Zurich, Switzerland
    Nat Clin Pract Endocrinol Metab 4:240-1. 2008
  24. pmc Interleukin-6 regulates pancreatic alpha-cell mass expansion
    Helga Ellingsgaard
    Division of Endocrinology and Diabetes and Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:13163-8. 2008
    ....
  25. ncbi Cytokines and beta-cell biology: from concept to clinical translation
    Marc Y Donath
    The Clinic for Endocrinology and Diabetes, University Hospital Zurich, Zurich, Switzerland
    Endocr Rev 29:334-50. 2008
    ..The aim of this chapter is to present an overview of early and recent key observations from our own groups as well as other laboratories that serve to illuminate the road from concept to clinical translation...
  26. ncbi Increased number of islet-associated macrophages in type 2 diabetes
    Jan A Ehses
    Division of Endocrinology and Diabetes and Center for Integrated Human Physiology, University Hospital of Zurich, Zurich, Switzerland
    Diabetes 56:2356-70. 2007
    ..Therefore, islet-derived inflammatory factors are regulated by a type 2 diabetic milieu and may contribute to the macrophage infiltration of pancreatic islets that we observe in type 2 diabetes...
  27. ncbi Interleukin-6 contributes to early fasting-induced free fatty acid mobilization in mice
    Stephan Wueest
    Department of Pediatric Endocrinology and Diabetology and Children s Research Center, University Children s Hospital, Zurich, Switzerland
    Am J Physiol Regul Integr Comp Physiol 306:R861-7. 2014
    ..Consistently, phosphorylation of HSL was significantly reduced in adipose tissue of IL-6-depleted mice. Hence, our findings suggest a novel role for IL-6 in energy supply during early fasting. ..
  28. pmc Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes
    Claudia Cavelti-Weder
    Department of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland
    Diabetes Care 35:1654-62. 2012
    ..Gevokizumab is a novel, human-engineered monoclonal anti-IL-1β antibody. We evaluated the safety and biological activity of gevokizumab in patients with type 2 diabetes...
  29. ncbi High glucose alters cardiomyocyte contacts and inhibits myofibrillar formation
    Daniela Dyntar
    Division of Endocrinology and Diabetes, University Hospital of Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    J Clin Endocrinol Metab 91:1961-7. 2006
    ..Previously we have shown that glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in cultivated cardiomyocytes...
  30. pmc FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication
    Kathrin Maedler
    Divisions of Endocrinology and Diabetes and Clinical Immunology, University Hospital, Zurich CH 8091, Switzerland
    Proc Natl Acad Sci U S A 99:8236-41. 2002
    ..The present data provide evidence for expression of FLIP in the human beta cell and suggest a novel approach to prevent and treat diabetes by switching Fas signaling from apoptosis to proliferation...
  31. ncbi Islets secretory capacity determines glucose homoeostasis in the face of insulin resistance
    Peter Wiesli
    Department of Internal Medicine, University Hospital of Zurich, Switzerland
    Swiss Med Wkly 134:559-64. 2004
    ..We therefore defined insulin secretion and sensitivity in patients with impaired glucose homoeostasis of varying aetiology and duration...
  32. ncbi Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control
    Nurit Kaiser
    Endocrinology and Metabolism Service, Department of Medicine, Hadassah Hebrew University Medical Center, P O Box 12000, Jerusalem 91120, Israel
    Diabetes 54:138-45. 2005
    ..The rapid recovery of the pancreas by phlorizin-induced normoglycemia implies a causal relationship between hyperglycemia and islet dysfunction. Similar mechanisms could be operative during the evolution of type 2 diabetes in humans...
  33. ncbi Psammomys obesus, a model for environment-gene interactions in type 2 diabetes
    Nurit Kaiser
    Endocrinology and Metabolism Service, Department of Internal Medicine, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Diabetes 54:S137-44. 2005
    ..The major culprit is the inappropriate insulin production with depletion of insulin stores as a consequence. Similar mechanisms could operate during the evolution of type 2 diabetes in humans...
  34. doi Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases
    Kathrin Maedler
    Larry L Hillblom Islet Research Center, University of California, Los Angeles, California, USA
    FASEB J 22:1905-13. 2008
    ..Therefore, JNK inhibition may protect beta-cells from the deleterious effects of high glucose and leptin in diabetes...
  35. ncbi Interleukin-1-receptor antagonist in type 2 diabetes mellitus
    Claus M Larsen
    Steno Diabetes Center, Gentofte, Denmark
    N Engl J Med 356:1517-26. 2007
    ....
  36. ncbi Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells
    Pascale Ribaux
    Department of Genetic Medicine and Development, University Medical Center, 1211, Geneva 4, Switzerland
    Endocrinology 148:5582-90. 2007
    ..It is concluded that ECM induces expression of cytokines including CXCL1 with amplification by IL-1 acting via a positive autocrine feedback loop...
  37. ncbi Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1
    Kathrin Maedler
    Larry L Hillblom Islet Research Center, University of California, Los Angeles, USA
    Diabetes 55:2455-62. 2006
    ..These data provide a possible explanation for the increased incidence of type 2 diabetes at an older age and support the use of islets from older rats as a more appropriate model to study glucose-induced beta-cell apoptosis...
  38. ncbi Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets
    Kathrin Maedler
    Larry L Hillblom Islet Research Center, University of California, Los Angeles, CA, USA
    Diabetes 55:2713-22. 2006
    ..These findings indicate that low IL-1beta levels positively influence beta-cell function and turnover through the Fas-FLIP pathway and that IL-1Ra production prevents harmful effects of high IL-1beta concentrations...