D A Dobbelaere

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi Theileria-induced leukocyte transformation
    Dirk A E Dobbelaere
    Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, Langgassstrasse 122, CH 3012 Bern, Switzerland
    Curr Opin Microbiol 6:377-82. 2003
  2. ncbi The strategies of the Theileria parasite: a new twist in host-pathogen interactions
    Dirk A E Dobbelaere
    Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, Langgassstrasse 122, CH 3012 Bern, Switzerland
    Curr Opin Immunol 16:524-30. 2004
  3. ncbi Transformation of leukocytes by Theileria parva and T. annulata
    D Dobbelaere
    Department of Molecular Pathology, University of Berne, Switzerland
    Annu Rev Microbiol 53:1-42. 1999
  4. ncbi Theileria parva: taking control of host cell proliferation and survival mechanisms
    D A Dobbelaere
    Institute of Animal Pathology, Molecular Pathology, Berne, Switzerland
    Cell Microbiol 2:91-9. 2000
  5. ncbi The Akt/PKB pathway is constitutively activated in Theileria-transformed leucocytes, but does not directly control constitutive NF-kappaB activation
    V T Heussler
    Molecular Pathology, Institute of Animal Pathology, University of Berne, CH-3012 Berne, Switzerland
    Cell Microbiol 3:537-50. 2001
  6. ncbi Characterisation of NF-kappa B complexes in Theileria parva-transformedT cells
    J Machado
    Laboratory of Molecular Pathology, Institute of Animal Pathology, University of Berne, Langgass strasse 122, 3012, Berne, Switzerland
    Microbes Infect 2:1311-20. 2000
  7. ncbi Cloning, sequencing and expression of the bovine CD3 epsilon and TCR-zeta chains, two invariant components of the T-cell receptor complex
    G Hagens
    Institute of Animal Pathology, University of Berne, Switzerland
    Gene 169:165-71. 1996
  8. ncbi Hijacking of host cell IKK signalosomes by the transforming parasite Theileria
    Volker T Heussler
    Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, CH 3012 Bern, Switzerland
    Science 298:1033-6. 2002
  9. ncbi Cloning of a full-length cDNA encoding bovine interleukin 4 by the polymerase chain reaction
    V T Heussler
    Department of Parasitology, University of Berne, Switzerland
    Gene 114:273-8. 1992
  10. ncbi Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha
    Sven Rottenberg
    Institute of Animal Pathology, Molecular Pathology, University of Berne, Langgassstrasse 122, CH 3012 Berne, Switzerland
    Gene 299:293-300. 2002

Collaborators

Detail Information

Publications10

  1. ncbi Theileria-induced leukocyte transformation
    Dirk A E Dobbelaere
    Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, Langgassstrasse 122, CH 3012 Bern, Switzerland
    Curr Opin Microbiol 6:377-82. 2003
    ..The PtdIns-3K/Akt/PKB pathway is also constitutively activated in a parasite-dependent manner, but contrary to IKK, activation is probably not triggered by direct association with the parasite...
  2. ncbi The strategies of the Theileria parasite: a new twist in host-pathogen interactions
    Dirk A E Dobbelaere
    Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, Langgassstrasse 122, CH 3012 Bern, Switzerland
    Curr Opin Immunol 16:524-30. 2004
    ....
  3. ncbi Transformation of leukocytes by Theileria parva and T. annulata
    D Dobbelaere
    Department of Molecular Pathology, University of Berne, Switzerland
    Annu Rev Microbiol 53:1-42. 1999
    ..This, in turn, leads to the activation of transcription factors, including nuclear factor-kappa B, which appear to be essential for the survival of Theileria-transformed T cells...
  4. ncbi Theileria parva: taking control of host cell proliferation and survival mechanisms
    D A Dobbelaere
    Institute of Animal Pathology, Molecular Pathology, Berne, Switzerland
    Cell Microbiol 2:91-9. 2000
    ..Inhibitor studies also suggest an important role for the lipid kinase, PI-3K, in the continuous proliferation of T. parva-transformed lymphocytes...
  5. ncbi The Akt/PKB pathway is constitutively activated in Theileria-transformed leucocytes, but does not directly control constitutive NF-kappaB activation
    V T Heussler
    Molecular Pathology, Institute of Animal Pathology, University of Berne, CH-3012 Berne, Switzerland
    Cell Microbiol 3:537-50. 2001
    ..We also demonstrate that Akt/PKB contributes, at least in part, to the proliferation of Theileria-transformed T cells...
  6. ncbi Characterisation of NF-kappa B complexes in Theileria parva-transformedT cells
    J Machado
    Laboratory of Molecular Pathology, Institute of Animal Pathology, University of Berne, Langgass strasse 122, 3012, Berne, Switzerland
    Microbes Infect 2:1311-20. 2000
    ..Additionally, several agents known to inhibit a wide range of NF-kappa B activation pathways had no inhibitory effect on the activation of NF-kappa B DNA binding in TpM(803) T cells...
  7. ncbi Cloning, sequencing and expression of the bovine CD3 epsilon and TCR-zeta chains, two invariant components of the T-cell receptor complex
    G Hagens
    Institute of Animal Pathology, University of Berne, Switzerland
    Gene 169:165-71. 1996
    ..coli, and were used in Western blot analysis to further characterise TCR zeta-chain expression in T-cells. The regents provide valuable tools for the study of signal transduction pathways in normal and transformed bovine T-cells...
  8. ncbi Hijacking of host cell IKK signalosomes by the transforming parasite Theileria
    Volker T Heussler
    Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, CH 3012 Bern, Switzerland
    Science 298:1033-6. 2002
    ..Our findings provide insights into IKK activation and how pathogens subvert host-cell signaling pathways...
  9. ncbi Cloning of a full-length cDNA encoding bovine interleukin 4 by the polymerase chain reaction
    V T Heussler
    Department of Parasitology, University of Berne, Switzerland
    Gene 114:273-8. 1992
    ..This homology is not evenly distributed, however, with the nt sequences 5' and 3' of the coding region showing a much greater homology between all three species than the coding sequence...
  10. ncbi Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha
    Sven Rottenberg
    Institute of Animal Pathology, Molecular Pathology, University of Berne, Langgassstrasse 122, CH 3012 Berne, Switzerland
    Gene 299:293-300. 2002
    ..Finally, a yeast two-hybrid analysis showed that bovine NEMO molecules, in addition to the binding to IKKalpha and IKKbeta, also strongly interact with each other...