Research Topics
Genomes and Genes
| Beatrice DesvergneSummaryAffiliation: University of Lausanne Country: Switzerland Publications
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Detail Information
Publications
PPAR-mediated activity of phthalates: A link to the obesity epidemic?Beatrice Desvergne
Centre Intégratif de Génomique, Universite de Lausanne, Switzerland
Mol Cell Endocrinol 304:43-8. 2009..A thorough analysis of its interactions with PPARgamma identified MEHP as a selective PPARgamma modulator, and thus a possible contributor to the obesity epidemic...- PPARdelta/beta: the lobbyist switching macrophage allegiance in favor of metabolismBeatrice Desvergne
Center of Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
Cell Metab 7:467-9. 2008.... 
Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/deltaKarim Nadra
Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
Mol Cell Biol 26:3266-81. 2006..Altogether, this important role of PPARbeta/delta in placenta development and giant cell differentiation should be considered when contemplating the potency of PPARbeta/delta agonist as therapeutic agents of broad application...
The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesisJerome N Feige
Center for Integrative Genomics, University of Lausanne, Genopode, 1015 Lausanne, Switzerland
J Biol Chem 282:19152-66. 2007..These results highlight some key mechanisms in metabolic disruption but are also instrumental in the context of selective PPAR modulation, a promising field for new therapeutic development based on PPAR modulation...- Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteinsNicolas Di-Poï
Center for Integrative Genomics, National Center of Competence in Research Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
J Biol Chem 280:38700-10. 2005..Such insights are crucial for the understanding of the molecular control regulating the balance between proliferation and differentiation in many cell types including keratinocytes... - Genetic- or transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kineticsNguan Soon Tan
Center for Integrative Genomics, National Center of Competence in Research Frontiers in Genetics, University of Lausanne, Lausanne CH 1015, Switzerland
J Biol Chem 280:18163-70. 2005..Also, they provide insight into the so far reported paradoxical effects of the application of exogenous TGF-beta1 at wound sites... - From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functionsJerome N Feige
Center for Integrative Genomics, NCCR Frontiers in Genetics, Le Génopode, University of Lausanne, CH 1015 Lausanne, Switzerland
Prog Lipid Res 45:120-59. 2006..Finally, we discuss how the integration of various intra-cellular signaling pathways allows PPARs to participate to whole-body homeostasis by mediating regulatory crosstalks between organs... - Functions of peroxisome proliferator-activated receptors (PPAR) in skin homeostasisNicolas Di-Poï
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
Lipids 39:1093-9. 2004.... - PPARgamma in placental angiogenesisKarim Nadra
Center for Integrative Genomics, Department of Medical Genetics and Electron Microscopy Platform, University of Lausanne, CH 1015 Lausanne, Switzerland
Endocrinology 151:4969-81. 2010..Together our data demonstrate that PPARγ plays a pivotal role in controlling placental vascular proliferation and contributes to its termination in late pregnancy... - Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle developmentNicolas Di-Poï
Center for Integrative Genomics, Biology Building, University of Lausanne, CH 1015 Lausanne, Switzerland
Mol Cell Biol 25:1696-712. 2005.... - The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanismsJerome N Feige
Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
Environ Health Perspect 118:234-41. 2010..Phthalates can activate the three peroxisome proliferator-activated receptor (PPAR) isotypes on cellular models and induce peroxisome proliferation in rodents... - Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genesNguan Soon Tan
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Biology Building, CH-1015 Lausanne, Switzerland
J Steroid Biochem Mol Biol 93:99-105. 2005..It is also becoming apparent that understanding the regulation of PPAR expression and activity, can itself have a significant influence on how the expression of subgroups of target genes is studied and integrated in current knowledge... - Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gammaSilvia I Anghel
Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Génopode Bldg, CH 1015 Lausanne, Switzerland
J Biol Chem 282:29946-57. 2007..These findings highlight novel roles of PPARgamma in the adipose tissue and underscore the multifaceted action of this receptor in the functional fine tuning of a tissue that is crucial for maintaining the organism in good health... - Combined simulation and mutagenesis analyses reveal the involvement of key residues for peroxisome proliferator-activated receptor alpha helix 12 dynamic behaviorLiliane Michalik
Center for Integrative Genomics and National Research Center Frontiers in Genetics, University of Lausanne, Le Génopode, CH 1015 Lausanne, Switzerland
J Biol Chem 282:9666-77. 2007..Substitution of these residues suppresses PPARalpha constitutive activity, without changing PPARalpha ligand-dependent activation potential... - Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissueKarim Nadra
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
Mol Cell Biol 32:4794-810. 2012..Together, these observations firmly demonstrate a cell autonomous role of lipin 1 in WAT and BAT biology and indicate its potential as a therapeutical target for the treatment of obesity... - PPARs special issue: anchoring the present to explore the futureBeatrice Desvergne
University of Lausanne, Genopode, 1015 Lausanne, Switzerland
Biochim Biophys Acta 1771:913-4. 2007 - Transcriptional regulation of metabolismBeatrice Desvergne
Center for Integrative Genomics, National Centre of Competence in Research Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
Physiol Rev 86:465-514. 2006..Finally, we discuss the molecular mechanisms underlying metabolic regulations, which provide new opportunities for treating complex metabolic disorders... - PixFRET, an ImageJ plug-in for FRET calculation that can accommodate variations in spectral bleed-throughsJerome N Feige
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Switzerland
Microsc Res Tech 68:51-8. 2005..The usefulness of this modeling and of the plug-in are exemplified by the study of FRET in a system where two interacting nuclear receptors labeled with ECFP and EYFP are coexpressed in living cells... - Epineurial adipocytes are dispensable for Schwann cell myelinationKarim Nadra
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
J Neurochem 123:662-7. 2012..Together, our data indicate that while adipocytes, as regulators of lipid and glucose homeostasis, play a role in nerve function, their presence in epineurium is not essential for establishment or maintenance of proper myelin... - Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alphaRaphael Genolet
Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
J Biol Chem 280:24143-52. 2005..Overall, these data indicate a species-specific regulation by PPARalpha of GRHPR, a key gene of the glyoxylate cycle... - Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidationSandrine Gremlich
Center for Integrative Genomics, University of Lausanne, Switzerland
Endocrinology 146:375-82. 2005.... - PPARbeta/delta regulates paneth cell differentiation via controlling the hedgehog signaling pathwayFrédéric Varnat
Center for Integrative Genomics, National Research Centre Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
Gastroenterology 131:538-53. 2006..However, its function in intestinal epithelium homeostasis is understood poorly... - Fluorescence imaging reveals the nuclear behavior of peroxisome proliferator-activated receptor/retinoid X receptor heterodimers in the absence and presence of ligandJerome N Feige
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
J Biol Chem 280:17880-90. 2005.... - Be fit or be sick: peroxisome proliferator-activated receptors are down the roadBeatrice Desvergne
Center for Integrative Genomics, University of Lausanne, Biology Building, CH 1015 Lausanne Dorigny, Switzerland
Mol Endocrinol 18:1321-32. 2004..This review presents a summary of the recent findings on their dual involvement in health and disease... - Endocrine disruptors: from endocrine to metabolic disruptionCristina Casals-Casas
Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Switzerland
Annu Rev Physiol 73:135-62. 2011..Finally, we discuss the difficulties of fairly assessing the risks linked to EDC exposure, including developmental exposure, problems of high- and low-dose exposure, and the complexity of current chemical environments... - A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activityJennifer Rieusset
Institut de Biologie Animale, , CH-1015 Lausanne, Switzerland
Mol Endocrinol 16:2628-44. 2002..Because it yields both antiobesity and antidiabetic effects, SR-202 may be a lead for new compounds to be used in the treatment of obesity and type 2 diabetes... - NCoR1 is a conserved physiological modulator of muscle mass and oxidative functionHiroyasu Yamamoto
Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
Cell 147:827-39. 2011..Collectively, our data suggest that NCoR1 plays an adaptive role in muscle physiology and that interference with NCoR1 action could be used to improve muscle function... - Morbillivirus glycoprotein expression induces ER stress, alters Ca2+ homeostasis and results in the release of vasostatinJean Marc Brunner
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
PLoS ONE 7:e32803. 2012.... - RXR: from partnership to leadership in metabolic regulationsBeatrice Desvergne
Center for Integrative Genomics, Building Génopode, University of Lausanne, CH 1015 Lausanne, Switzerland
Vitam Horm 75:1-32. 2007..Indeed, while the nature of the endogenous ligand for RXR is still in question, as we will discuss herein, a better understanding of RXR activities is necessary to envisage the potential therapeutic applications of synthetic RXR ligands... - Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expressionNguan Soon Tan
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, 1015 Lausanne, Switzerland
EMBO J 23:4211-21. 2004.... - Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone actionJennifer Rieusset
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
Mol Endocrinol 18:2363-77. 2004.... - Peroxisome proliferator-activated receptor-beta as a target for wound healing drugsNguan Soon Tan
Center for Integrative Genomics, NNCR Frontiers in Genetics, University of Lausanne, Switzerland
Expert Opin Ther Targets 8:39-48. 2004..These novel insights into the orchestrating roles of PPARbeta during wound healing may be helpful in the development of drugs for acute and chronic wound disorders... - Peroxisome proliferator-activated receptor beta/delta as a therapeutic target for metabolic diseasesElodie Bedu
Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland
Expert Opin Ther Targets 9:861-73. 2005..Thus, it appears that further exploration of PPARbeta/delta functions is necessary to better define its potential as a therapeutic target... - PPAR expression and function during vertebrate developmentLiliane Michalik
Institut de Biologie Animale, , Switzerland
Int J Dev Biol 46:105-14. 2002..Particular attention is given to studies undertaken by us and others on the implication of PPARalpha and beta in rodent epidermal differentiation... - Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathwayNicolas Di-Poï
Institut de Biologie Animale, Universite de Lausanne, CH 1015, Lausanne, Switzerland
Mol Cell 10:721-33. 2002..Together, these results provide a molecular mechanism by which PPARbeta protects keratinocytes against apoptosis and may contribute to the process of skin wound closure... - The anti-apoptotic role of PPARbeta contributes to efficient skin wound healingNicolas Di-Poï
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
J Steroid Biochem Mol Biol 85:257-65. 2003..Finally, comparison of PPARbeta and Akt1 knock-out mice reveals many similarities, and suggests that the ability of PPARbeta to modulate the Akt1 pathway has significant impact during skin wound healing... - In vivo activation of PPAR target genes by RXR homodimersAnnemieke IJpenberg
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
EMBO J 23:2083-91. 2004..These observations have important pharmacological implications for the development of new rexinoid-based treatments... - Peroxisome proliferator-activated receptors beta/delta: emerging roles for a previously neglected third family memberLiliane Michalik
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH-1015 Lausanne, Switzerland
Curr Opin Lipidol 14:129-35. 2003.... - Peroxisome-proliferator-activated receptors and cancers: complex storiesLiliane Michalik
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH-1015 Lausanne, Switzerland
Nat Rev Cancer 4:61-70. 2004 - Kinase signaling cascades that modulate peroxisome proliferator-activated receptorsLaurent Gelman
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Switzerland
Curr Opin Cell Biol 17:216-22. 2005..The study of this dual regulation mode, which allows PPARs to integrate signals conveyed by lipophilic ligands with those coming from the plasma membrane, may ultimately offer new therapeutic strategies...