Beatrice Desvergne

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. doi request reprint PPAR-mediated activity of phthalates: A link to the obesity epidemic?
    Beatrice Desvergne
    Centre Intégratif de Génomique, Universite de Lausanne, Switzerland
    Mol Cell Endocrinol 304:43-8. 2009
  2. doi request reprint PPARdelta/beta: the lobbyist switching macrophage allegiance in favor of metabolism
    Beatrice Desvergne
    Center of Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    Cell Metab 7:467-9. 2008
  3. pmc Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta
    Karim Nadra
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 26:3266-81. 2006
  4. ncbi request reprint The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis
    Jerome N Feige
    Center for Integrative Genomics, University of Lausanne, Genopode, 1015 Lausanne, Switzerland
    J Biol Chem 282:19152-66. 2007
  5. ncbi request reprint Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins
    Nicolas Di-Poï
    Center for Integrative Genomics, National Center of Competence in Research Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Biol Chem 280:38700-10. 2005
  6. ncbi request reprint Genetic- or transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kinetics
    Nguan Soon Tan
    Center for Integrative Genomics, National Center of Competence in Research Frontiers in Genetics, University of Lausanne, Lausanne CH 1015, Switzerland
    J Biol Chem 280:18163-70. 2005
  7. ncbi request reprint From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
    Jerome N Feige
    Center for Integrative Genomics, NCCR Frontiers in Genetics, Le Génopode, University of Lausanne, CH 1015 Lausanne, Switzerland
    Prog Lipid Res 45:120-59. 2006
  8. ncbi request reprint Functions of peroxisome proliferator-activated receptors (PPAR) in skin homeostasis
    Nicolas Di-Poï
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Lipids 39:1093-9. 2004
  9. doi request reprint PPARgamma in placental angiogenesis
    Karim Nadra
    Center for Integrative Genomics, Department of Medical Genetics and Electron Microscopy Platform, University of Lausanne, CH 1015 Lausanne, Switzerland
    Endocrinology 151:4969-81. 2010
  10. pmc Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development
    Nicolas Di-Poï
    Center for Integrative Genomics, Biology Building, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 25:1696-712. 2005

Collaborators

Detail Information

Publications40

  1. doi request reprint PPAR-mediated activity of phthalates: A link to the obesity epidemic?
    Beatrice Desvergne
    Centre Intégratif de Génomique, Universite de Lausanne, Switzerland
    Mol Cell Endocrinol 304:43-8. 2009
    ..A thorough analysis of its interactions with PPARgamma identified MEHP as a selective PPARgamma modulator, and thus a possible contributor to the obesity epidemic...
  2. doi request reprint PPARdelta/beta: the lobbyist switching macrophage allegiance in favor of metabolism
    Beatrice Desvergne
    Center of Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    Cell Metab 7:467-9. 2008
    ....
  3. pmc Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta
    Karim Nadra
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 26:3266-81. 2006
    ..Altogether, this important role of PPARbeta/delta in placenta development and giant cell differentiation should be considered when contemplating the potency of PPARbeta/delta agonist as therapeutic agents of broad application...
  4. ncbi request reprint The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis
    Jerome N Feige
    Center for Integrative Genomics, University of Lausanne, Genopode, 1015 Lausanne, Switzerland
    J Biol Chem 282:19152-66. 2007
    ..These results highlight some key mechanisms in metabolic disruption but are also instrumental in the context of selective PPAR modulation, a promising field for new therapeutic development based on PPAR modulation...
  5. ncbi request reprint Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins
    Nicolas Di-Poï
    Center for Integrative Genomics, National Center of Competence in Research Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Biol Chem 280:38700-10. 2005
    ..Such insights are crucial for the understanding of the molecular control regulating the balance between proliferation and differentiation in many cell types including keratinocytes...
  6. ncbi request reprint Genetic- or transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kinetics
    Nguan Soon Tan
    Center for Integrative Genomics, National Center of Competence in Research Frontiers in Genetics, University of Lausanne, Lausanne CH 1015, Switzerland
    J Biol Chem 280:18163-70. 2005
    ..Also, they provide insight into the so far reported paradoxical effects of the application of exogenous TGF-beta1 at wound sites...
  7. ncbi request reprint From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
    Jerome N Feige
    Center for Integrative Genomics, NCCR Frontiers in Genetics, Le Génopode, University of Lausanne, CH 1015 Lausanne, Switzerland
    Prog Lipid Res 45:120-59. 2006
    ..Finally, we discuss how the integration of various intra-cellular signaling pathways allows PPARs to participate to whole-body homeostasis by mediating regulatory crosstalks between organs...
  8. ncbi request reprint Functions of peroxisome proliferator-activated receptors (PPAR) in skin homeostasis
    Nicolas Di-Poï
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Lipids 39:1093-9. 2004
    ....
  9. doi request reprint PPARgamma in placental angiogenesis
    Karim Nadra
    Center for Integrative Genomics, Department of Medical Genetics and Electron Microscopy Platform, University of Lausanne, CH 1015 Lausanne, Switzerland
    Endocrinology 151:4969-81. 2010
    ..Together our data demonstrate that PPARγ plays a pivotal role in controlling placental vascular proliferation and contributes to its termination in late pregnancy...
  10. pmc Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development
    Nicolas Di-Poï
    Center for Integrative Genomics, Biology Building, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 25:1696-712. 2005
    ....
  11. pmc The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms
    Jerome N Feige
    Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    Environ Health Perspect 118:234-41. 2010
    ..Phthalates can activate the three peroxisome proliferator-activated receptor (PPAR) isotypes on cellular models and induce peroxisome proliferation in rodents...
  12. ncbi request reprint Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes
    Nguan Soon Tan
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Biology Building, CH 1015 Lausanne, Switzerland
    J Steroid Biochem Mol Biol 93:99-105. 2005
    ..It is also becoming apparent that understanding the regulation of PPAR expression and activity, can itself have a significant influence on how the expression of subgroups of target genes is studied and integrated in current knowledge...
  13. pmc Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue
    Karim Nadra
    Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
    Mol Cell Biol 32:4794-810. 2012
    ..Together, these observations firmly demonstrate a cell autonomous role of lipin 1 in WAT and BAT biology and indicate its potential as a therapeutical target for the treatment of obesity...
  14. ncbi request reprint Combined simulation and mutagenesis analyses reveal the involvement of key residues for peroxisome proliferator-activated receptor alpha helix 12 dynamic behavior
    Liliane Michalik
    Center for Integrative Genomics and National Research Center Frontiers in Genetics, University of Lausanne, Le Génopode, CH 1015 Lausanne, Switzerland
    J Biol Chem 282:9666-77. 2007
    ..Substitution of these residues suppresses PPARalpha constitutive activity, without changing PPARalpha ligand-dependent activation potential...
  15. ncbi request reprint Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma
    Silvia I Anghel
    Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Génopode Bldg, CH 1015 Lausanne, Switzerland
    J Biol Chem 282:29946-57. 2007
    ..These findings highlight novel roles of PPARgamma in the adipose tissue and underscore the multifaceted action of this receptor in the functional fine tuning of a tissue that is crucial for maintaining the organism in good health...
  16. ncbi request reprint Transcriptional regulation of metabolism
    Beatrice Desvergne
    Center for Integrative Genomics, National Centre of Competence in Research Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    Physiol Rev 86:465-514. 2006
    ..Finally, we discuss the molecular mechanisms underlying metabolic regulations, which provide new opportunities for treating complex metabolic disorders...
  17. ncbi request reprint PPARs special issue: anchoring the present to explore the future
    Beatrice Desvergne
    University of Lausanne, Genopode, 1015 Lausanne, Switzerland
    Biochim Biophys Acta 1771:913-4. 2007
  18. doi request reprint Epineurial adipocytes are dispensable for Schwann cell myelination
    Karim Nadra
    Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
    J Neurochem 123:662-7. 2012
    ..Together, our data indicate that while adipocytes, as regulators of lipid and glucose homeostasis, play a role in nerve function, their presence in epineurium is not essential for establishment or maintenance of proper myelin...
  19. ncbi request reprint PixFRET, an ImageJ plug-in for FRET calculation that can accommodate variations in spectral bleed-throughs
    Jerome N Feige
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Switzerland
    Microsc Res Tech 68:51-8. 2005
    ..The usefulness of this modeling and of the plug-in are exemplified by the study of FRET in a system where two interacting nuclear receptors labeled with ECFP and EYFP are coexpressed in living cells...
  20. ncbi request reprint Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha
    Raphael Genolet
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Biol Chem 280:24143-52. 2005
    ..Overall, these data indicate a species-specific regulation by PPARalpha of GRHPR, a key gene of the glyoxylate cycle...
  21. ncbi request reprint Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation
    Sandrine Gremlich
    Center for Integrative Genomics, University of Lausanne, Switzerland
    Endocrinology 146:375-82. 2005
    ....
  22. ncbi request reprint PPARbeta/delta regulates paneth cell differentiation via controlling the hedgehog signaling pathway
    Frédéric Varnat
    Center for Integrative Genomics, National Research Centre Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    Gastroenterology 131:538-53. 2006
    ..However, its function in intestinal epithelium homeostasis is understood poorly...
  23. ncbi request reprint Fluorescence imaging reveals the nuclear behavior of peroxisome proliferator-activated receptor/retinoid X receptor heterodimers in the absence and presence of ligand
    Jerome N Feige
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Biol Chem 280:17880-90. 2005
    ....
  24. ncbi request reprint Be fit or be sick: peroxisome proliferator-activated receptors are down the road
    Beatrice Desvergne
    Center for Integrative Genomics, University of Lausanne, Biology Building, CH 1015 Lausanne Dorigny, Switzerland
    Mol Endocrinol 18:1321-32. 2004
    ..This review presents a summary of the recent findings on their dual involvement in health and disease...
  25. doi request reprint Endocrine disruptors: from endocrine to metabolic disruption
    Cristina Casals-Casas
    Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Switzerland
    Annu Rev Physiol 73:135-62. 2011
    ..Finally, we discuss the difficulties of fairly assessing the risks linked to EDC exposure, including developmental exposure, problems of high- and low-dose exposure, and the complexity of current chemical environments...
  26. ncbi request reprint A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity
    Jennifer Rieusset
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    Mol Endocrinol 16:2628-44. 2002
    ..Because it yields both antiobesity and antidiabetic effects, SR-202 may be a lead for new compounds to be used in the treatment of obesity and type 2 diabetes...
  27. pmc NCoR1 is a conserved physiological modulator of muscle mass and oxidative function
    Hiroyasu Yamamoto
    Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Cell 147:827-39. 2011
    ..Collectively, our data suggest that NCoR1 plays an adaptive role in muscle physiology and that interference with NCoR1 action could be used to improve muscle function...
  28. pmc Morbillivirus glycoprotein expression induces ER stress, alters Ca2+ homeostasis and results in the release of vasostatin
    Jean Marc Brunner
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS ONE 7:e32803. 2012
    ....
  29. ncbi request reprint RXR: from partnership to leadership in metabolic regulations
    Beatrice Desvergne
    Center for Integrative Genomics, Building Génopode, University of Lausanne, CH 1015 Lausanne, Switzerland
    Vitam Horm 75:1-32. 2007
    ..Indeed, while the nature of the endogenous ligand for RXR is still in question, as we will discuss herein, a better understanding of RXR activities is necessary to envisage the potential therapeutic applications of synthetic RXR ligands...
  30. pmc Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression
    Nguan Soon Tan
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, 1015 Lausanne, Switzerland
    EMBO J 23:4211-21. 2004
    ....
  31. ncbi request reprint Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action
    Jennifer Rieusset
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Endocrinol 18:2363-77. 2004
    ....
  32. ncbi request reprint PPAR expression and function during vertebrate development
    Liliane Michalik
    Institut de Biologie Animale, Universite de Lausanne, Switzerland
    Int J Dev Biol 46:105-14. 2002
    ..Particular attention is given to studies undertaken by us and others on the implication of PPARalpha and beta in rodent epidermal differentiation...
  33. ncbi request reprint Peroxisome proliferator-activated receptor beta/delta as a therapeutic target for metabolic diseases
    Elodie Bedu
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Expert Opin Ther Targets 9:861-73. 2005
    ..Thus, it appears that further exploration of PPARbeta/delta functions is necessary to better define its potential as a therapeutic target...
  34. ncbi request reprint Peroxisome proliferator-activated receptor-beta as a target for wound healing drugs
    Nguan Soon Tan
    Center for Integrative Genomics, NNCR Frontiers in Genetics, University of Lausanne, Switzerland
    Expert Opin Ther Targets 8:39-48. 2004
    ..These novel insights into the orchestrating roles of PPARbeta during wound healing may be helpful in the development of drugs for acute and chronic wound disorders...
  35. ncbi request reprint Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway
    Nicolas Di-Poï
    Institut de Biologie Animale, Universite de Lausanne, CH 1015, Lausanne, Switzerland
    Mol Cell 10:721-33. 2002
    ..Together, these results provide a molecular mechanism by which PPARbeta protects keratinocytes against apoptosis and may contribute to the process of skin wound closure...
  36. pmc In vivo activation of PPAR target genes by RXR homodimers
    Annemieke IJpenberg
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    EMBO J 23:2083-91. 2004
    ..These observations have important pharmacological implications for the development of new rexinoid-based treatments...
  37. ncbi request reprint The anti-apoptotic role of PPARbeta contributes to efficient skin wound healing
    Nicolas Di-Poï
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Steroid Biochem Mol Biol 85:257-65. 2003
    ..Finally, comparison of PPARbeta and Akt1 knock-out mice reveals many similarities, and suggests that the ability of PPARbeta to modulate the Akt1 pathway has significant impact during skin wound healing...
  38. ncbi request reprint Peroxisome proliferator-activated receptors beta/delta: emerging roles for a previously neglected third family member
    Liliane Michalik
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Curr Opin Lipidol 14:129-35. 2003
    ..In this review, we focus on emerging knowledge about peroxisome proliferator-activated receptor beta activation and roles...
  39. ncbi request reprint Kinase signaling cascades that modulate peroxisome proliferator-activated receptors
    Laurent Gelman
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Switzerland
    Curr Opin Cell Biol 17:216-22. 2005
    ..The study of this dual regulation mode, which allows PPARs to integrate signals conveyed by lipophilic ligands with those coming from the plasma membrane, may ultimately offer new therapeutic strategies...
  40. ncbi request reprint Peroxisome-proliferator-activated receptors and cancers: complex stories
    Liliane Michalik
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Nat Rev Cancer 4:61-70. 2004