Philippe de Moerloose

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Performance of helical computed tomography in unselected outpatients with suspected pulmonary embolism
    A Perrier
    Medical Clinic 1, Department of Internal Medicine, Geneva University Hospital, Rue Micheli du Crest 24, CH 1211 Geneva 14, Switzerland
    Ann Intern Med 135:88-97. 2001
  2. ncbi request reprint Inherited thrombophilia in arterial disease: a selective review
    Philippe de Moerloose
    Hemostasis Unit, Department of Internal Medicine, University Hospital and Faculty of Medicine of Geneva, Geneva, Switzerland
    Semin Hematol 44:106-13. 2007
  3. ncbi request reprint [New oral anticoagulants: from theory to practice]
    P de Moerloose
    Service d angiologie et d hémostase HUG, 1211 Geneve 14
    Rev Med Suisse 9:104-7. 2013
  4. pmc TLR2 ligands induce NF-κB activation from endosomal compartments of human monocytes
    Karim J Brandt
    Division of Angiology and Hemostasis, University Hospital of Geneva and Faculty of Medicine, Geneva, Switzerland
    PLoS ONE 8:e80743. 2013
  5. doi request reprint Congenital fibrinogen disorders: an update
    Philippe de Moerloose
    Division of Angiology and Haemostasis, University Hospital, Geneva, Switzerland
    Semin Thromb Hemost 39:585-95. 2013
  6. doi request reprint Recommendations for assessment, monitoring and follow-up of patients with haemophilia
    P de Moerloose
    University Hospital and Faculty of Medicine, Geneva, Switzerland
    Haemophilia 18:319-25. 2012
  7. ncbi request reprint Two new antithrombotic agents (fondaparinux and ximelagatran) and their implications in anesthesia
    Philippe de Moerloose
    Division of Angiology and Hemostasis, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland
    Can J Anaesth 49:S5-10. 2002
  8. ncbi request reprint [Antiphospholipid syndrome: much new data]
    Philippe de Moerloose
    Unite d hémostase, HUG, Geneve
    Rev Med Suisse 6:298-301. 2010
  9. ncbi request reprint Analytical and clinical performance of a new, automated assay panel for the diagnosis of antiphospholipid syndrome
    P de Moerloose
    Haemostasis Unit, Faculty of Medicine and University Hospital Geneva, Geneva, Switzerland
    J Thromb Haemost 8:1540-6. 2010
  10. ncbi request reprint [Thrombophilias]
    Philippe de Moerloose
    Unité d hémostase Hôpital universitaire de Genève CH 1211 Genève 14
    Rev Prat 53:20-4. 2003

Detail Information

Publications122 found, 100 shown here

  1. ncbi request reprint Performance of helical computed tomography in unselected outpatients with suspected pulmonary embolism
    A Perrier
    Medical Clinic 1, Department of Internal Medicine, Geneva University Hospital, Rue Micheli du Crest 24, CH 1211 Geneva 14, Switzerland
    Ann Intern Med 135:88-97. 2001
    ..Helical computed tomography (CT) is commonly used to diagnose pulmonary embolism, although its operating characteristics have been insufficiently evaluated...
  2. ncbi request reprint Inherited thrombophilia in arterial disease: a selective review
    Philippe de Moerloose
    Hemostasis Unit, Department of Internal Medicine, University Hospital and Faculty of Medicine of Geneva, Geneva, Switzerland
    Semin Hematol 44:106-13. 2007
    ..Therefore thrombophilia tests may be informative in a very restricted population with arterial events. Anticoagulants rather than antiplatelet therapy may be preferable for these patients, although this remains to be proven...
  3. ncbi request reprint [New oral anticoagulants: from theory to practice]
    P de Moerloose
    Service d angiologie et d hémostase HUG, 1211 Geneve 14
    Rev Med Suisse 9:104-7. 2013
    ..However, things are not so simple in the day-to-day practice and this review aims at answering in a brief and simplified manner to some questions...
  4. pmc TLR2 ligands induce NF-κB activation from endosomal compartments of human monocytes
    Karim J Brandt
    Division of Angiology and Hemostasis, University Hospital of Geneva and Faculty of Medicine, Geneva, Switzerland
    PLoS ONE 8:e80743. 2013
    ..These observations further demonstrate the need of endocytosis in the activation and regulation of TLR2-dependent signaling pathways. ..
  5. doi request reprint Congenital fibrinogen disorders: an update
    Philippe de Moerloose
    Division of Angiology and Haemostasis, University Hospital, Geneva, Switzerland
    Semin Thromb Hemost 39:585-95. 2013
    ..Replacement therapy is effective in treating bleeding episodes, but because the pharmacokinetics of fibrinogen after replacement therapy is highly variable among patients, it is important to adjust the treatment individually. ..
  6. doi request reprint Recommendations for assessment, monitoring and follow-up of patients with haemophilia
    P de Moerloose
    University Hospital and Faculty of Medicine, Geneva, Switzerland
    Haemophilia 18:319-25. 2012
    ..Greater standardization should have implications for data collection, improvements in treatment evaluation and optimizing resources...
  7. ncbi request reprint Two new antithrombotic agents (fondaparinux and ximelagatran) and their implications in anesthesia
    Philippe de Moerloose
    Division of Angiology and Hemostasis, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland
    Can J Anaesth 49:S5-10. 2002
    ..To describe two new antithrombotic agents (fondaparinux and ximelagatran), their mechanisms of action, the clinical studies available and some implications (regional anesthesia, monitoring and antidote) in anesthesia...
  8. ncbi request reprint [Antiphospholipid syndrome: much new data]
    Philippe de Moerloose
    Unite d hémostase, HUG, Geneve
    Rev Med Suisse 6:298-301. 2010
    ..Finally this review will propose some algorithms to treat patients with APS...
  9. ncbi request reprint Analytical and clinical performance of a new, automated assay panel for the diagnosis of antiphospholipid syndrome
    P de Moerloose
    Haemostasis Unit, Faculty of Medicine and University Hospital Geneva, Geneva, Switzerland
    J Thromb Haemost 8:1540-6. 2010
    ..Anticardiolipin (aCL) and anti-beta(2)glycoprotein I (abeta(2)GPI) antibodies are part of the criteria for antiphospholipid syndrome (APS). Therefore they are widely measured and about 30 commercial kits are available...
  10. ncbi request reprint [Thrombophilias]
    Philippe de Moerloose
    Unité d hémostase Hôpital universitaire de Genève CH 1211 Genève 14
    Rev Prat 53:20-4. 2003
    ..The present review tries to provide some answers; however the recommendations should be considered as provisional, because new findings and study results will certainly modify them in the near future...
  11. ncbi request reprint Should neurologists measure D-dimer concentrations?
    Philippe de Moerloose
    Division of Angiology and Haemostasis, Department of Medicine, University Hospital, Geneva, Switzerland
    Lancet Neurol 2:77. 2003
  12. ncbi request reprint D-dimer testing and venous thromboembolism: four view points
    P de Moerloose
    Division of Angiology and Haemostasis Unit, University Hospital Geneva and Geneva Faculty of Medicine, Geneva, Switzerland
    J Thromb Haemost 3:380-2. 2005
  13. ncbi request reprint Treatment of congenital fibrinogen disorders
    Philippe de Moerloose
    University Hospital, Division of Angiology and Haemostasis, 1211 Geneva 14, Switzerland
    Expert Opin Biol Ther 8:979-92. 2008
    ..However, apart from the possibility of developing safer fibrinogen concentrates and the availability of prenatal diagnosis, the basic therapeutic approach has changed little...
  14. ncbi request reprint Management of venous thromboembolism
    Philippe de Moerloose
    Service d angiologie et d hémostase, Hopitaux Universitaires de Geneve, 1211 Geneva 14, Switzerland
    Can J Anaesth 53:S80-8. 2006
    ..To describe the drugs used to treat venous thromboembolism (VTE) and to review particular aspects of the management (elastic stockings, thrombolysis, thrombectomy, vena cava filter)...
  15. doi request reprint Preventing and treating bleeding complications: new insights into therapeutic options
    Philippe de Moerloose
    Hôpitaux Universitaires de Genève Unité d Hemostase, Rue Micheli du Crest 24, 1211 Geneve 14, Switzerland
    Thromb Res 122:S1-2. 2008
  16. doi request reprint Congenital fibrinogen disorders
    Philippe de Moerloose
    Division of Angiology and Haemostasis, University Hospital of Geneva, 1211 Geneva 14, Switzerland
    Semin Thromb Hemost 35:356-66. 2009
    ....
  17. ncbi request reprint Severe factor XI deficiency in a Lebanese family: identification of a novel missense mutation (Trp501Cys) in the catalytic domain
    Philippe de Moerloose
    Haemostasis Unit, Geneva University Hospital, Switzerland
    Blood Coagul Fibrinolysis 15:269-72. 2004
    ....
  18. doi request reprint Diagnosis of mild bleeding disorders
    Philippe de Moerloose
    Haemostasis Unit, Department of Internal Medicine, Faculty of Medicine, University Hospital, Geneva, Switzerland
    Swiss Med Wkly 139:327-32. 2009
    ..This review focuses on inherited and not on acquired bleeding disorders...
  19. ncbi request reprint A multicenter evaluation of a new quantitative highly sensitive D-dimer assay for exclusion of venous thromboembolism
    Philippe de Moerloose
    Angiology and Haemostasis Division, University Hospital of Geneva and Faculty of Medicine, Geneva Switzerland
    Thromb Haemost 100:505-12. 2008
    ..Our data indicate that the performances of Innovance D-Dimer, regardless of the analyzer, are similar to the reference methods, and that this assay can be used for the exclusion of venous thromboembolic disease...
  20. ncbi request reprint Antiphospholipid antibodies: do we still need to perform anticardiolipin ELISA assays?
    P de Moerloose
    Division of Angiology and Hemostasis, University Hospital, Geneva, Switzerland
    J Thromb Haemost 2:1071-3. 2004
  21. doi request reprint A survey of adherence to haemophilia therapy in six European countries: results and recommendations
    P de Moerloose
    Haemostasis Unit, University Hospital of Geneva, Geneva, Switzerland
    Haemophilia 14:931-8. 2008
    ..However, it remains important to be aware of the possibility of non-adherence given the serious implications, particularly when considering a differently selected group of patients...
  22. doi request reprint Fibrinogen and the risk of thrombosis
    Philippe de Moerloose
    Division of Angiology and Haemostasis, University Hospital, Geneva, Switzerland
    Semin Thromb Hemost 36:7-17. 2010
    ..This review discusses the various quantitative and qualitative defects of fibrinogen associated with thrombosis, the tests that may predict the thrombotic risk, as well as some preventive or therapeutic approaches...
  23. ncbi request reprint Fluvastatin increases the expression of adhesion molecules, monocyte chemoattractant protein-1 and tissue factor in HUVEC stimulated by patient IgG fractions containing antiphospholipid antibodies
    Sylvie Dunoyer-Geindre
    Unit of Haemostasis, University Hospital of Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland, E mail
    Thromb Haemost 93:339-45. 2005
    ..Our results show that in cultured human EC, statins increase the extent of inflammatory activation induced by APLA. This effect appears to be mediated by an inhibitory effect of statins on one or more geranylgeranylated protein(s)...
  24. ncbi request reprint [Thrombopenias induced by heparin: diagnostic and therapeutic innovations]
    M Righini
    Unite d hémostase, Departement de Medecine Interne, Hopital Universitaire de Geneve, Suisse
    Rev Med Suisse Romande 121:313-8. 2001
    ..In case of suspicion of HIT, treatment by heparin should imperatively be stopped and an alternative anticoagulant treatment should be started before any laboratory confirmation...
  25. ncbi request reprint [Haemostasis. A search for an ideal antithrombotics agent]
    P de Moerloose
    Unite d hémostase, Departement de Medecine Interne, Hopitaux Universitaires de Geneve, 1211 Geneve 14
    Rev Med Suisse 1:35-8. 2005
    ..It was hoped that it could replace vitamin K antagonists but increase of liver enzymes occurring after a few weeks is a major problem. Other new drugs are in advanced stage and will be also described...
  26. ncbi request reprint Variability of anti-beta2 glycoprotein I antibodies measurement by commercial assays
    Guido Reber
    Division of Angiology and Haemostasis, Geneva University Hospital and Faculty of Medicine, Switzerland
    Thromb Haemost 94:665-72. 2005
    ..In conclusion, additional efforts are however necessary, especially concerning the way to assess the cutoff point and the adoption of a reference calibrator, in order to improve standardization of the assays...
  27. pmc Hypodysfibrinogenaemia due to production of mutant fibrinogen alpha-chains lacking fibrinopeptide A and polymerisation knob 'A'
    Silja Vorjohann
    Department of Genetic Medicine and Development, University of Geneva Medical Centre, Geneva, Switzerland
    Thromb Haemost 104:990-7. 2010
    ..Fibrin made from purified patient fibrinogen clotted with thrombin displayed thinner fibers with frequent ends and large pores...
  28. doi request reprint A novel frameshift mutation in FGA (c.1846 del A) leading to congenital afibrinogenemia in a consanguineous Syrian family
    Emmanuel Levrat
    Division of Angiology and Haemostasis, University Hospital, Geneva, Switzerland
    Blood Coagul Fibrinolysis 22:148-50. 2011
    ....
  29. ncbi request reprint Mutations in the fibrinogen gene cluster accounting for congenital afibrinogenemia: an update and report of 10 novel mutations
    Marguerite Neerman-Arbez
    Department of Genetic Medicine and Development, University Medical School, University of Geneva, Geneva, Switzerland
    Hum Mutat 28:540-53. 2007
    ....
  30. doi request reprint Inflammatory and prothrombotic states in obese children of European descent
    Sophie Stoppa-Vaucher
    Pediatric Endocrine and Diabetes Unit, Children s Hospital, University Hospitals and Faculty of Medicine, Geneva, Switzerland
    Obesity (Silver Spring) 20:1662-8. 2012
    ..Further investigation is necessary to determine if these cytokines, together with ETP, can reliably predict the development of diabetes and atherosclerosis...
  31. doi request reprint Toll-like receptor 2 mediates the activation of human monocytes and endothelial cells by antiphospholipid antibodies
    Nathalie Satta
    Division of Angiology and Hemostasis, Faculty of Medicine, University Hospital of Geneva, 4 rue Gabrielle Perret Gentil, Geneva 14, Switzerland
    Blood 117:5523-31. 2011
    ..Our results demonstrate a role for TLR2 and CD14 in human endothelial cell and monocyte activation by aPLAs...
  32. ncbi request reprint Expression and analysis of a split premature termination codon in FGG responsible for congenital afibrinogenemia: escape from RNA surveillance mechanisms in transfected cells
    Marguerite Neerman-Arbez
    Department of Genetic Medicine and Development, University Medical School, Geneva, Switzerland
    Blood 104:3618-23. 2004
    ....
  33. doi request reprint Mutation of the translation initiation codon in FGA causes congenital afibrinogenemia
    Yordanka Tirefort
    Haemostasis Unit, University Hospital of Geneva and University of Geneva Faculty of Medicine, Geneva, Switzerland
    Blood Coagul Fibrinolysis 23:556-8. 2012
    ..385 C>T (CGA>TGA) R129X. The patient suffered from occasional severe arthralgias (shoulder, knee) most likely caused by intra-articular bleeding with subsequent inflammation...
  34. ncbi request reprint The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies
    Nathalie Satta
    Division of Angiology and Hemostasis, University Hospital, Faculty of Medicine, Geneva, Switzerland
    Blood 109:1507-14. 2007
    ..Overexpression of human TLR2 in the TLR2-deficient EFs restituted the response to patient IgG. Our results imply that TLR2 plays a role in mouse fibroblast activation by APLAs...
  35. ncbi request reprint [Evaluating the biological efficacy of clopidogrel: genotype or phenotype?]
    Pierre Fontana
    Service d angiologie et d hémostase, HUG, Geneve
    Rev Med Suisse 6:302-5. 2010
    ..The VASP assay and the 2C19 genotyping are candidates for the identification of patients at risk; this is the focus of the present review...
  36. doi request reprint Identification of a novel F11 missense mutation (Ile463Ser) in a family with congenital factor XI deficiency
    Yordanka Tirefort
    Division of Hematology, University Hospital, Geneva, Switzerland
    Blood Coagul Fibrinolysis 23:251-2. 2012
    ..This novel amino acid substitution in the serine protease catalytic domain appears to be responsible for the low factor XI levels in both individuals...
  37. ncbi request reprint Immunization of LDL receptor-deficient mice with beta2-glycoprotein 1 or human serum albumin induces a more inflammatory phenotype in atherosclerotic plaques
    Sylvie Dunoyer-Geindre
    Service of Angiology and Hemostasis, University Hospital, Switzerland
    Thromb Haemost 97:129-38. 2007
    ..Statin treatment partially prevents these changes...
  38. doi request reprint Induction of TLR2 expression by inflammatory stimuli is required for endothelial cell responses to lipopeptides
    Nathalie Satta
    Division of Angiology and Hemostasis, University Hospital of Geneva, Faculty of Medicine, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Mol Immunol 46:145-57. 2008
    ..The up-regulation of TLR2 may be of relevance for the vascular effects of Gram-positive bacteria...
  39. ncbi request reprint Discrepancy between capillary and venous International Normalised Ratio (INR) in a patient on vitamin-K antagonist: potentially serious clinical consequences
    Sophie Waldvogel Abramowski
    Haemostasis Unit, University Hospital of Geneva, 1211 Geneva 14, Switzerland
    Thromb Haemost 96:688-9. 2006
  40. ncbi request reprint NFkappaB is an essential intermediate in the activation of endothelial cells by anti-beta(2)-glycoprotein 1 antibodies
    Sylvie Dunoyer-Geindre
    Division of Angiology and Haemostasis, University Hospital of Geneva, Geneva, Switzerland
    Thromb Haemost 88:851-7. 2002
    ..Taken together our results imply that NFkappaB is an essential intermediate in the activation of EC by anti-beta(2)GP1 antibodies...
  41. doi request reprint Technical aspects in laboratory testing for antiphospholipid antibodies: is standardization an impossible dream?
    Guido Reber
    Haemostasis Unit, Division of Angiology and Haemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    Semin Thromb Hemost 34:340-6. 2008
    ..Much more effort is needed to reduce the high interlaboratory variability in assay results even if absolute standardization cannot be feasibly achieved...
  42. ncbi request reprint Anti-beta2-glycoprotein I antibodies--when and how should they be measured?
    Guido Reber
    Division of Angiology and Haemostasis, University Hospital, Geneva, Switzerland
    Thromb Res 114:527-31. 2004
    ..We recommend abeta2GPI assays to be included in the panel of antiphospholipid screening tests. However, the standardisation of abeta2GPI assays has to be improved in order to ensure better comparability between the studies...
  43. ncbi request reprint A new rapid point-of-care D-dimer enzyme-linked immunosorbent assay (Stratus CS D-dimer) for the exclusion of venous thromboembolism
    Guido Reber
    Division of Angiology and Haemostasis, Geneva University Hospital, Switzerland
    Blood Coagul Fibrinolysis 15:435-8. 2004
    ..At 400 ng/ml, three results were false-negative, one with both devices and two with the Stratus D-dimer only. Stratus D-dimer appears to be suitable for the exclusion of venous thromboembolism in the emergency room setting...
  44. ncbi request reprint Optimal duration of oral anticoagulant therapy following deep vein thrombosis of lower limbs
    H Bounameaux
    Division of Angiology and Haemostasis, University Hospital of Geneva, Switzerland
    Blood Coagul Fibrinolysis 7:507-14. 1996
    ..g. idiopathic proximal vein thrombosis in a patient with inherited thrombophilia or malignancy)...
  45. doi request reprint Thromboprophylaxis with low-molecular-weight heparin after cesarean delivery
    Marc Blondon
    General Internal Medicine, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Thromb Haemost 103:129-37. 2010
    ..Our decision analysis suggests that the benefits of LMWH after cesarean delivery exceed the risks. This benefit is, however, very low in women with no risk factors...
  46. ncbi request reprint Extensive thromboembolic event as initial presentation of monoclonal gammopathy of undetermined significance
    Marc Righini
    Division of Angiology and Hemostasis, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    Thromb Haemost 96:93-4. 2006
  47. ncbi request reprint Evaluation of advanced D-dimer assay for the exclusion of venous thromboembolism
    Guido Reber
    Division of Angiology and Haemostasis, Geneva University Hospital, Geneva 14, Switzerland
    Thromb Res 107:197-200. 2002
    ..5% (88.9, 98.8) and 47.8% (40.8, 54.9) at a cutt-off value of 1.1 microg/ml. This assay appears promising and should be validated in clinical practise to assess its place in the work-up schemes of thromboembolism...
  48. doi request reprint A novel Asp344Val substitution in the fibrinogen gamma chain (fibrinogen Caen) causes dysfibrinogenemia associated with thrombosis
    Helia Robert-Ebadi
    Division of Angiology and Haemostasis, University Hospital, Geneva, Switzerland
    Blood Coagul Fibrinolysis 19:697-9. 2008
    ....
  49. ncbi request reprint HPA-genotyping and antiplatelet antibodies in female blood donors
    Francoise Boehlen
    Hemostasis Unit, Division of Angiology and Hemostasis Department of Medicine, University Hospital, Geneva, Switzerland
    Hematol J 4:441-4. 2003
    ..Although none of the recipients developed passive alloimmune thrombocytopenia, this aspect of blood transfusion safety should be addressed by a large prospective trial...
  50. ncbi request reprint Fibrin D-dimer measurement in suspected pulmonary embolism
    P de Moerloose
    Department of Internal Medicine, University Hospital of Geneva, Switzerland
    Semin Vasc Med 1:175-80. 2001
    ..This article focuses on these questions and also provides some limitations of DD use, such as its poor specificity in hospitalized and elderly patients...
  51. ncbi request reprint Measurement of plasma D-dimer is not useful in the prediction or diagnosis of postoperative deep vein thrombosis in patients undergoing total knee arthroplasty
    H Bounameaux
    Division of Angiology and Hemostasis, University Hospital of Geneva, Switzerland
    Blood Coagul Fibrinolysis 9:749-52. 1998
    ..In conclusion, the results of the present study suggest that plasma measurement of D-dimer concentration is of no value for predicting, diagnosing or ruling out DVT in patients undergoing total knee arthroplasty...
  52. ncbi request reprint Quality control of fibrinogen secretion in the molecular pathogenesis of congenital afibrinogenemia
    Dung Vu
    Department of Genetic Medicine and Development, Swiss Institute of Bioinformatics, University Medical Centre, Geneva, Switzerland
    Hum Mol Genet 14:3271-80. 2005
    ..Our data provide new insight into the mechanisms accounting for the quality control of fibrinogen secretion and confirm that mutant fibrinogen retention is one of the pathological mechanisms responsible for congenital afibrinogenemia...
  53. doi request reprint Acquired factor XIII deficiency: a therapeutic challenge
    Francoise Boehlen
    Division of Angiology and Haemostasis, University Hospitals of Geneva and Faculty of Medicine of Geneva, 1211 Geneva 14, Switzerland
    Thromb Haemost 109:479-87. 2013
    ..After a review of the management of acquired FXIII deficiency patients and based on the management of acquired haemophilia we discuss a possible strategy for such difficult cases...
  54. ncbi request reprint Point of care management of heparin administration after heart surgery: A randomized, controlled trial
    Paolo G Merlani
    Service of Surgical Intensive Care, Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University of Geneva Hospitals and Faculty of Medicine University of Geneva, Geneva, Switzerland
    Intensive Care Med 32:1357-64. 2006
    ..We sought to shorten the time to obtain coagulation results and the desired coagulation state and to reduce blood loss and transfusions using point of care (POC) aPTT determination...
  55. doi request reprint Implementation of an INR self-testing and self-management programme in common ambulatory private practice: our experience with 90 patients
    Stephane Reverdin
    Département des spécialités de médecine, Service de cardiologie, Hopitaux Universitaires de Geneve, Geneve, Switzerland
    Swiss Med Wkly 141:w13199. 2011
    ....
  56. ncbi request reprint Inter-laboratory variability of anti-beta2-glycoprotein I measurement. A collaborative study in the frame of the European Forum on Antiphospholipid Antibodies Standardization Group
    Guido Reber
    Haemostasis Unit, Geneva University Hospital, Switzerland
    Thromb Haemost 88:66-73. 2002
    ..Despite the large variability of anti-beta2-glycoprotein I measurements between centers, the agreement on results with high- and medium-positive samples was good...
  57. ncbi request reprint Clinical usefulness of D-dimer depending on clinical probability and cutoff value in outpatients with suspected pulmonary embolism
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Arch Intern Med 164:2483-7. 2004
    ....
  58. ncbi request reprint Is measurement of D-dimer useful in the diagnosis of cerebral venous thrombosis?
    P H Lalive
    Department of Neurology, University Hospital, Geneva, Switzerland
    Neurology 61:1057-60. 2003
    ..Furthermore, early treatment may be effective. As D-dimer (DD) measurement is a sensitive test for the exclusion of venous thromboembolism, the authors studied whether this test could be useful in the diagnosis of CVT...
  59. ncbi request reprint Cost-effectiveness of noninvasive diagnostic aids in suspected pulmonary embolism
    A Perrier
    Medical Clinic 1, Geneva University Hospital, Switzerland
    Arch Intern Med 157:2309-16. 1997
    ....
  60. ncbi request reprint Receptors involved in cell activation by antiphospholipid antibodies
    Karim J Brandt
    Division of Angiology and Hemostasis, University Hospital of Geneva and Faculty of Medicine, Geneva, Switzerland Electronic address
    Thromb Res 132:408-13. 2013
    ..The relative contribution of these different mechanisms in the pathogenesis of APS is controversial. Here, we review the various in vivo and in vitro models that have been used to investigate the pathogenic mechanisms of aPLA in APS...
  61. doi request reprint Pulmonary embolism and fatal stroke in a patient with severe factor XI deficiency after bariatric surgery
    Francoise Boehlen
    Division of Angiology and Haemostasis bDivision of Visceral Surgery, University Hospitals of Geneva, Geneva, Switzerland
    Blood Coagul Fibrinolysis 24:347-50. 2013
    ..The aim of this report is to alert medical teams to carefully balance the benefit-risk of such an intervention in a patient with a severe FXI deficiency...
  62. ncbi request reprint Presence of autoantibodies to apolipoprotein A-1 in patients with acute coronary syndrome further links autoimmunity to cardiovascular disease
    Nicolas Vuilleumier
    Division of Immunology and Allergy and Department of Internal Medicine, Geneva University Hospital, 24 Micheli du Crest, 1211 Geneva 14, Switzerland
    J Autoimmun 23:353-60. 2004
    ..76, P=0.0066) and anti-Apo A-1 IgG titre in ACS patients. The presence of anti-Apo A-1 autoantibodies in patients with ACS highlights an additional link between autoimmunity, inflammation and atherosclerosis...
  63. ncbi request reprint [Introduction of acenocoumarol using an algorithm for prescription]
    Grigorios Notaridis
    Unite d hémostase, Service d angiologie et d hémostase, Departement de Medecine, HUG, 1211 Geneve 14
    Rev Med Suisse 6:292, 294-7. 2010
    ..The goal of these algorithms, combined with frequent monitoring of INR, is to limit the bleeding risk during the introduction of anticoagulant therapy...
  64. doi request reprint Platelet reactivity is a stable and global phenomenon in aspirin-treated cardiovascular patients
    Anne Zufferey
    Division of Angiology and Haemostasis, Geneva University Hospital and Faculty of Medicine, Switzerland
    Thromb Haemost 106:466-74. 2011
    ..This index is not dependent on clinical or biological variables, suggesting that genetic factors regulate platelet reactivity in these patients...
  65. ncbi request reprint [What is the role for the non-specialist physician in the care of patients with hemophilia?]
    Francoise Boehlen
    Unité d hémostase HUG, 1211 Geneve 14
    Rev Med Suisse 4:328-32, 334-5. 2008
    ..Therefore physicians should know how to recognize this coagulation disorder and how to manage these patients. It is still important that treating physicians and PAH remain in contact with treatment centres...
  66. ncbi request reprint [Von Willebrand disease: a common and unrecognized bleeding disorder]
    F Boehlen
    Unite d hémostase, HUG, Geneve
    Rev Med Suisse 3:346-50. 2007
    ..It is then important to confirm the diagnosis in a specialized laboratory because an adequate treatment can be prescribed to avoid hemorrhagic complications, in particular at the time of surgical procedures...
  67. ncbi request reprint [Update on new antithrombotic treatments]
    F Boehlen
    Unité D Hémostase Service, d angiologie et d hémostase, Département de médicine interne, HUG, Geneve
    Rev Med Suisse 6:109-12. 2010
    ..Studies have shown an increased bleeding risk for some of them as well as unexpected side effects. In the next future, these new molecules could allow a more individualised prescription of antithrombotic agents...
  68. ncbi request reprint Performances of a new, automated latex assay for the exclusion of venous thromboembolism
    G Reber
    Division of Angiology and Haemostasis, Geneva University Hospital, Switzerland
    Blood Coagul Fibrinolysis 12:217-20. 2001
    ..6-99.4). This new assay is fast and fully automated, and its performance is suitable to exclude venous thromboembolism. Management studies should be performed to assess its utility...
  69. ncbi request reprint [Diagnosis of deep venous thrombosis of the lower limbs: performance of diagnostic tests]
    T Merminod
    Division d angiologie et d hémostase, Hopital Universitaire de Geneve, Rue Micheli du Crest 24, CH 1211 Geneve 14, Suisse
    Ann Cardiol Angeiol (Paris) 51:135-8. 2002
    ..Scintigraphy, scanner and RMI must still be validated. Phlebography remains the gold standard in case of negative compressive venous ultrasonography and a high clinical probability...
  70. ncbi request reprint Pelvic haemophilic pseudotumour: management of a patient with high level of inhibitors
    A Keller
    Department of Radiology, Univesity Hospitals Geneva, Switzerland
    Skeletal Radiol 31:550-3. 2002
    ..The different therapeutic options (conservative management by replacement therapy, surgical approach, radiotherapy, percutaneous evacuation with secondary refilled cavity and transcatheter arterial embolization) are reviewed...
  71. ncbi request reprint Performances of the fibrin monomer test for the exclusion of pulmonary embolism in symptomatic outpatients
    G Reber
    Division of Angiology and haemostasis and Medical Clinic 1, Geneva University Hospital, Switzerland
    Thromb Haemost 81:221-3. 1999
    ..In conclusion, this is the first study suggesting the interest of this Fibrin Monomer test to rule out PE; these results, however, need to be confirmed by other studies...
  72. ncbi request reprint [Changes in D-dimer levels during pregnancy and the postpartum period: results of two studies]
    F Boehlen
    Unite d hémostase, Service d angiologie et hémostase
    Rev Med Suisse 1:296-8. 2005
    ..This increase of DD values until 4 to 6 weeks after delivery correlates with the length of antithrombotic prophylaxis recommended for women at high risk of VTE...
  73. ncbi request reprint Prevalence of factor V Leiden and prothrombin G20210A mutations in unselected patients with venous thromboembolism
    P de Moerloose
    Division of Angiology and Haemostasis, Unit, University Hospital of Geneva, Switzerland
    Br J Haematol 110:125-9. 2000
    ..No statistically significant differences were observed between patients and controls for the prothrombin G20210A mutation...
  74. ncbi request reprint Inability of serial fibrin monomer measurements to predict or exclude deep venous thrombosis in asymptomatic patients undergoing total knee arthroplasty
    G Reber
    Division of Angiology and Haemostasis, Geneva University Hospital, Switzerland
    Blood Coagul Fibrinolysis 11:305-8. 2000
    ..Therefore, despite differences between patients with or without DVT, serial FM determinations are of no value for predicting or ruling out DVT in individual patients undergoing total knee arthroplasty...
  75. ncbi request reprint [Should we treat all diabetic patients with aspirin in primary prevention?]
    A Righetti
    Service d endocrinologie, diabétologie et nutrition, Hopitaux Universitaires de Geneve, 1211 Geneve 14
    Rev Med Suisse 1:1500-4. 2005
    ..The guidelines from different speciality societies, notably the American Diabetes Association, are positive. However, the results of these studies are not conclusive. Cautions recommendations are proposed...
  76. ncbi request reprint Is laboratory monitoring of low-molecular-weight heparin therapy necessary? No
    H Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland
    J Thromb Haemost 2:551-4. 2004
  77. ncbi request reprint [Inherited thrombophilia and arterial diseases]
    H Robert-Ebadi
    Unite d hémostase, Service d angiologie et d hémostase, HUG, Geneve
    Rev Med Suisse 3:331-2, 334-5. 2007
    ..Anticoagulation rather than antiplatelet therapy may be preferable for these patients...
  78. ncbi request reprint Using clinical evaluation and lung scan to rule out suspected pulmonary embolism: Is it a valid option in patients with normal results of lower-limb venous compression ultrasonography?
    A Perrier
    Medical Clinic 1, Geneva University Hospital, Switzerland
    Arch Intern Med 160:512-6. 2000
    ..In patients with a low clinical probability of pulmonary embolism (PE) and a nondiagnostic lung scan, the prevalence of PE is theoretically very low. We assessed the safety and usefulness of this association for ruling out PE...
  79. ncbi request reprint Non-invasive diagnosis of venous thromboembolism in outpatients
    A Perrier
    Medical Clinic 1, Geneva University Hospital, Switzerland
    Lancet 353:190-5. 1999
    ....
  80. ncbi request reprint Superficial vein thrombosis of lower limbs: influence of factor V Leiden, factor II G20210A and overweight
    P de Moerloose
    Division d angiologie et d hémostase, Hôpital Universitaire Genève, Switzerland
    Thromb Haemost 80:239-41. 1998
    ..62, 95% CI 1.25-18.0) and with a BMI > or =28 kg/m2 (OR 3.74, 95% CI 1.05-15.1). In conclusion, both FV Leiden and overweight seem to predispose to SVT, a finding that should be confirmed in larger studies...
  81. ncbi request reprint Thrombomodulin levels during normal pregnancy, at delivery and in the postpartum: comparison with tissue-type plasminogen activator and plasminogen activator inhibitor-1
    P de Moerloose
    Unite d hémostase, Hopital Cantonal Universitaire, Geneve, Switzerland
    Thromb Haemost 79:554-6. 1998
    ..Our data suggest that it would be more appropriate to take into account TM baseline values in a given woman to examine her TM increase during pregnancy...
  82. ncbi request reprint D-dimer levels during delivery and the postpartum
    M Epiney
    Department of Obstetrics and Gynecology, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland
    J Thromb Haemost 3:268-71. 2005
    ..Only a few studies have reported measurements of DD levels in the postpartum...
  83. ncbi request reprint Fibrinogen geneva II: a new congenitally abnormal fibrinogen alpha chain (Gly17Asp) with a review of similar mutations resulting in abnormal knob A
    Alessandro Casini
    aDivision of Angiology and Haemostasis, University Hospitals and Faculty of Medicine, Geneva, Switzerland bDepartment of Biology and Haematology, CHU Dijon, Dijon, France cDivision of Internal Medicine, University Hospitals and Faculty of Medicine dDepartment of Genetic Medicine and Development, University of Geneva, Faculty of Medicine, Geneva, Switzerland
    Blood Coagul Fibrinolysis 25:280-2. 2014
    ....
  84. ncbi request reprint Prolonged treatment of massive postpartum haemorrhage with recombinant factor VIIa: case report and review of the literature
    Francoise Boehlen
    Haemostasis Unit, Division of Angiology and Haemostasis, Department of Medicine, University Hospitals, 1211 Geneva 4, Switzerland
    BJOG 111:284-7. 2004
  85. ncbi request reprint Agreement of a new whole-blood PT/INR test using capillary samples with plasma INR determinations
    Francoise Boehlen
    Haemostasis Unit, Department of Medicine, University Hospital, 1211 Geneva 14, Switzerland
    Thromb Res 115:131-4. 2005
    ....
  86. ncbi request reprint [A reference to know: the 2008 Chest Supplement on antithrombotic agents]
    Philippe de Moerloose
    Unite d hémostase, Departement de Medecine Interne, Faculté de médecine de Genève HUG, 1211 Geneve 14
    Rev Med Suisse 5:110-3. 2009
    ..We review some recommendations about the appropriate use of anticoagulants to prevent and treat venous thromboembolic diseases as well as the use of antiplatelet agents in case of arterial diseases...
  87. ncbi request reprint Evaluation of unfractionated heparin and recombinant hirudin on survival in a sustained ovine endotoxin shock model
    Eduardo R C Schiffer
    Division of Anesthesiological Investigations, University Medical Center, Geneva, Switzerland
    Crit Care Med 30:2689-99. 2002
    ..To compare and evaluate the potential benefit of two different anticoagulation regimens during endotoxemia in an ovine model...
  88. ncbi request reprint Aspirin inhibits endothelial cell activation induced by antiphospholipid antibodies
    S Dunoyer-Geindre
    Division of Angiology and Hemostasis, University Hospital, Geneva, Switzerland
    J Thromb Haemost 2:1176-81. 2004
    ..Currently, treatment of patients with the antiphospholipid syndrome includes aspirin, particularly for women with recurrent fetal loss...
  89. ncbi request reprint Localization of beta2-glycoprotein 1 in late endosomes of human endothelial cells
    S Dunoyer-Geindre
    Division of Angiology and Haemostasis, University Hospital of Geneva, Switzerland
    Thromb Haemost 85:903-7. 2001
    ..The accumulation of anti-beta2GP1 antibodies in late endosomes of endothelial cells and the resulting modification of intracellular protein trafficking may contribute to the pathogenic effects of these antibodies...
  90. ncbi request reprint [Oral anticoagulation and pharmacogenetics: importance in the clinical setting]
    Patrick R Benusiglio
    Service de médecine interne générale, HUG, 1211 Geneve 14
    Rev Med Suisse 3:2030, 2033-4, 2036. 2007
    ..CYP2C9 and VKORC1 account for up to half the variability in vitamin K antagonists requirements and incorporating genotying data for these two genes into dosing algorithms could lead to a safer anticoagulation therapy...
  91. ncbi request reprint Purpura fulminans in a child as a complication of chickenpox infection
    Alexandre Campanelli
    Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland
    Dermatology 208:262-4. 2004
    ..As in our patient, an acquired protein S deficiency is probably responsible for most cases of purpura fulminans occurring after varicella, but the concomitant presence of antiphospholipid antibodies may also play a role...
  92. ncbi request reprint Deep venous thrombosis and thrombophilia: indications for testing and clinical implications
    P de Moerloose
    Division of Angiology and Haemostasis, University Hospital Geneva, Geneva, Switzerland
    Semin Vasc Med 1:89-96. 2001
    ..This article provides answers to some of these issues. These answers should, however, be considered as tentative and provisional because new findings and study results will certainly modify them in the near future...
  93. ncbi request reprint Haemostatic properties of human pulmonary and cerebral microvascular endothelial cells
    G E Grau
    Department of Anaesthesiology, University Hospital, Geneva, Switzerland
    Thromb Haemost 77:585-90. 1997
    ..It is concluded that MVEC display different haemostatic features depending on the tissue they come from and that lung MVEC from ARDS patients present a procoagulant profile when compared with those from controls...
  94. ncbi request reprint Biological effects of aspirin and clopidogrel in a randomized cross-over study in 96 healthy volunteers
    P Fontana
    Department of Internal Medicine, Faculty of Medicine, Division of Angiology and Hemostasis, University Hospitals of Geneva, Geneva, Switzerland
    J Thromb Haemost 4:813-9. 2006
    ..Some data suggest that biological 'resistance' to aspirin or clopidogrel may influence clinical outcome...
  95. ncbi request reprint Anticoagulation by ancrod for carbon dioxide removal by extracorporeal membrane lung in the dog
    M E Sinclair
    Department of Surgery, Geneva University Hospital, Switzerland
    J Thorac Cardiovasc Surg 97:275-81. 1989
    ..We conclude that, despite the drop in coagulation factors and in alpha 2-antiplasmin activity during bypass, ancrod can be considered as a valuable alternative anticoagulant for extracorporeal carbon dioxide removal...
  96. ncbi request reprint Assessing aspirin responsiveness using the Verify Now Aspirin assay
    P Fontana
    Division of Angiology and Hemostasis, Department of Internal Medicine, Faculty of Medicine and University Hospitals of Geneva, Geneva, Switzerland
    Thromb Res 121:581-2. 2008
  97. ncbi request reprint Point of care and central laboratory determinations of the aPTT are not interchangeable in surgical intensive care patients
    M Ferring
    Divisions of Surgical Intensive Care, Department of Anesthesiology, Pharmacology and Surgical Intensive Care and the Hemostasis unit, Division of Angiology and Hemostasis, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland
    Can J Anaesth 48:1155-60. 2001
    ..The best test to monitor heparin treatment in this setting was anti-factor Xa activity...
  98. doi request reprint D-Dimer for venous thromboembolism diagnosis: 20 years later
    M Righini
    Division of Angiology and Hemostasis, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Thromb Haemost 6:1059-71. 2008
    ....
  99. ncbi request reprint Activation of multiple cryptic donor splice sites by the common congenital afibrinogenemia mutation, FGA IVS4 + 1 G-->T
    C Attanasio
    Division of Medical Genetics, University Medical School and University Hospital, Geneva, Switzerland
    Blood 97:1879-81. 2001
    ..Our results confirm the utility of transfecting COS-7 cells to study mRNA splice-site mutations and demonstrate that the common FGA IVS4 variant is a null mutation leading to afibrinogenemia...
  100. ncbi request reprint Not all statins interfere with clopidogrel during antiplatelet therapy
    F Mach
    University Hospital, Geneva, Switzerland
    Eur J Clin Invest 35:476-81. 2005
    ..The objective of the present study was to define which statin might interfere with the antiaggregation property of clopidogrel...
  101. ncbi request reprint [Menorrhagia and hemostatic abnormalities: diagnosis and treatment]
    S Gueddi
    Service d angiologie et d hémostase Unité d hémostase, Hopitaux Universitaires de Geneve, 1211 Geneve 14
    Rev Med Suisse 1:279-82. 2005
    ..We present here the results of our small series. Identification of coagulation disorders may allow specific treatments. These improve the quality of life and prevent unnecessary radical measures such as notably, hysterectomies...