Research Topics
Genomes and Genes
| Dominique J F de QuervainSummaryAffiliation: University of Zurich Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: dependence on the basolateral amygdalaBenno Roozendaal
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Proc Natl Acad Sci U S A 100:1328-33. 2003....- Lack of cortisol response in patients with posttraumatic stress disorder (PTSD) undergoing a diagnostic interviewIris Tatjana Kolassa
Clinical and Neuropsychology, University of Konstanz, Universitatsstr, 10, 78457 Konstanz, Germany
BMC Psychiatry 7:54. 2007..This study investigated the cortisol response in traumatized refugees with PTSD during a detailed and standardized interview about their personal war and torture experiences... 
Glucocorticoid-related genetic susceptibility for Alzheimer's diseaseDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Hum Mol Genet 13:47-52. 2004..Our results indicate that a functional variation in the glucocorticoid system increases the risk for AD, which may have important implications for the diagnosis and treatment of this disease...- Identification of a genetic cluster influencing memory performance and hippocampal activity in humansDominique J F de Quervain
Division of Psychiatry Research and Center for Integrative Human Physiology, University of Zurich, CH 8057 Zurich, Switzerland
Proc Natl Acad Sci U S A 103:4270-4. 2006..The present study indicates that genetic variability in the human homologues of memory-related signaling molecules contributes to interindividual differences in human memory performance and memory-related brain activations... - Glucocorticoid-induced inhibition of memory retrieval: implications for posttraumatic stress disorderDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
Ann N Y Acad Sci 1071:216-20. 2006..Future studies with more patients and longer treatment periods are required to evaluate the efficacy of cortisol treatment for PTSD... - The neural basis of altruistic punishmentDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
Science 305:1254-8. 2004..Our findings support the hypothesis that people derive satisfaction from punishing norm violations and that the activation in the dorsal striatum reflects the anticipated satisfaction from punishing defectors... - Preventive effect of beta-adrenoceptor blockade on glucocorticoid-induced memory retrieval deficitsDominique J F de Quervain
Division of Psychiatry Research and the Center for Integrative Human Physiology, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
Am J Psychiatry 164:967-9. 2007..The authors investigated whether the beta-adrenoceptor antagonist propranolol blocks glucocorticoid-induced memory retrieval impairments in human subjects... - A functional genetic variation of the 5-HT2a receptor affects human memoryDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
Nat Neurosci 6:1141-2. 2003..Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant... - A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and AfricansDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
Nat Neurosci 10:1137-9. 2007.... - Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobeDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
Eur J Neurosci 17:1296-302. 2003.... 
Glucocorticoids and the regulation of memory in health and diseaseDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
Front Neuroendocrinol 30:358-70. 2009..In this context, we review data suggesting that the administration of glucocorticoids might ameliorate chronic anxiety by reducing retrieval of aversive memories and enhancing fear extinction...- Glucocorticoid-induced reduction of traumatic memories: implications for the treatment of PTSDDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032, Zurich, Switzerland
Prog Brain Res 167:239-47. 2008..Future studies with more patients and longer treatment periods are required to evaluate the efficacy of cortisol treatment for PTSD... - Glucocorticoids for the treatment of post-traumatic stress disorder and phobias: a novel therapeutic approachDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
Eur J Pharmacol 583:365-71. 2008..More studies are needed to further evaluate the therapeutic efficacy of glucocorticoids in the treatment of anxiety disorders and to explore the potential of combining glucocorticoid treatment with psychotherapy... - Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memoryAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
Neuroreport 16:839-42. 2005..In the group of elderly cognitively healthy participants, the His452Tyr genotype did not affect memory performance. We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory... - Glucocorticoid therapy-induced memory deficits: acute versus chronic effectsDaniel Coluccia
Department of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
J Neurosci 28:3474-8. 2008..Thus, these findings indicate that memory deficits observed under chronically elevated glucocorticoid levels result, at least in part, from acute and reversible glucocorticoid effects on memory retrieval... - The prion gene is associated with human long-term memoryAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
Hum Mol Genet 14:2241-6. 2005..These results suggest a role for the prion protein in the formation of long-term memory in humans... - Better memory and neural efficiency in young apolipoprotein E epsilon4 carriersChristian R A Mondadori
Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
Cereb Cortex 17:1934-47. 2007..We suggest that APOE epsilon4 is associated with good episodic memory and an economic use of memory-related neural resources in young, healthy humans... - Prion protein M129V polymorphism affects retrieval-related brain activityAndreas Buchmann
Division of Psychiatry Research and Hospital for Psychogeriatric Medicine, University of Zurich, Minervastrasse 145, 8032 Zurich, Switzerland
Neuropsychologia 46:2389-402. 2008..Findings suggest that the prion protein Met129Val polymorphism affects neural plasticity following learning at a time-scale of minutes to hours... - Emotion suppression reduces hippocampal activity during successful memory encodingJulia Binder
Division of Biopsychology, University of Zurich, Switzerland
Neuroimage 63:525-32. 2012.... - Common Kibra alleles are associated with human memory performanceAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Zurich 8057, Switzerland
Science 314:475-8. 2006..Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory... - Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42Alessia Maddalena
Division of Psychiatry Research, University of Zurich, Switzerland
Arch Neurol 60:1202-6. 2003..CONCLUSION: The diagnostic usefulness of the CSF ratio of phospho-tau to Abeta42 is superior to either measure alone and can be recommended as an aid to evaluating individuals suspected of having dementia... - Glucocorticoids do not reduce subjective fear in healthy subjects exposed to social stressLeila M Soravia
Department of Psychology, Clinical Psychology and Psychobiology, University of Zurich, Zurich, Switzerland
Biol Psychol 81:184-8. 2009..Whether glucocorticoids reduce subjective fear also in healthy subjects exposed to a socially fearful situation is not known... - Antibodies against beta-amyloid slow cognitive decline in Alzheimer's diseaseChristoph Hock
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
Neuron 38:547-54. 2003..Our results establish that antibodies against beta-amyloid plaques can slow cognitive decline in patients with Alzheimer's disease... - Effects of memory consolidation on human hippocampal activity during retrievalSimone Bosshardt
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Cortex 41:486-98. 2005..These fMRI results in the human hippocampal formation may correspond to the neurobiological results in the animal hippocampal formation of a strengthening and growth of synaptic connections within 24 h... - Glucocorticoids reduce phobic fear in humansLeila M Soravia
Institute of Psychology, Department of Clinical Psychology and Psychotherapy, , , , Switzerland
Proc Natl Acad Sci U S A 103:5585-90. 2006..Cortisol treatment did not reduce general, phobia-unrelated anxiety. In conclusion, the present findings in two distinct types of phobias indicate that glucocorticoid administration reduces phobic fear... - Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, Switzerland
Am J Med Genet B Neuropsychiatr Genet 141:534-6. 2006..These data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic AD and support a role of ABC lipid transporters in the pathogenesis of this disease... - Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's diseaseAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 2:233-41. 2005.... - Association study of cholesterol-related genes in Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
Neurogenetics 8:179-88. 2007..004). We conclude that genetic variants investigated in this study may be associated with a moderate modification of the risk for AD in some samples... - Genetic association study on colony-stimulating factor 1 in Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 3:334-7. 2006..The human CSF1 gene maps to chromosome 1p21-p13, a region previously linked to Alzheimer's disease (AD). Thus, CSF1 is a functional and positional candidate gene for AD... - Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobeKatharina Henke
Division of Psychiatry Research, Psychiatric University Hospital, University of Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
Neuropsychologia 41:863-76. 2003.... - One month of human memory consolidation enhances retrieval-related hippocampal activitySimone Bosshardt
Division of Psychiatry Research, University of Zurich, Switzerland
Hippocampus 15:1026-40. 2005.... - Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, Switzerland
Psychiatr Genet 12:155-60. 2002..In addition, no significant differences were observed after stratification for TIMP 1 genotypes. Our data show that neither genetic variability nor protein levels of TIMP-1 are associated with AD... - Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphismAndreas Papassotiropoulos
Division of Pychiatry Research, University of Zurich, Switzerland
Arch Neurol 60:29-35. 2003..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain... - ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, August Forel Street 1, 8008, Zurich, Switzerland
Neurobiol Aging 24:421-6. 2003..We conclude that genetic variability of ABCA1 influences the development of AD, possibly by interfering with CNS cholesterol homeostasis... - Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's diseaseChristoph Hock
Division of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zurich, Switzerland
Amyloid 10:1-6. 2003..967 ng/ml, respectively; p < 0.05). These data show that treatment with the m1 agonist talsaclidine reduced A beta peptides, and particularly A beta 42, in AD patients, suggesting it as a potential amyloid lowering therapy of AD... - Functional neuroimaging predicts individual memory outcome after amygdalohippocampectomyKatharina Henke
Division of Psychiatry Research, University of Zurich, Switzerland
Neuroreport 14:1197-202. 2003..There was no significant postoperative reallocation of ipsilateral memory functions to the contralateral MTL... - Biochemical markers of Alzheimer's disease: wish and realityAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Switzerland
Neurobiol Aging 23:513-4. 2002 - Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutationM Hasan Mohajeri
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
J Biol Chem 277:33012-7. 2002.... - Clinical observations with AN-1792 using TAPIR analysesChristoph Hock
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 2:273-6. 2005..We briefly summarize here how the proof of concept was established and why it provides the basis for a potential cure for Alzheimer's disease... - No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traitsAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Lengstrasse 31, 8029 Zurich, Switzerland
Am J Med Genet B Neuropsychiatr Genet 132:21-3. 2005..Although PLAU may be pathophysiologially related to AD, the contribution of common genetic variants of this gene to the risk for developing AD is likely to be low... - Implicit associative learning engages the hippocampus and interacts with explicit associative learningNadia Degonda
Division of Psychiatry Research, University of Zurich, Switzerland
Neuron 46:505-20. 2005..These findings suggest that implicit semantic associative learning engages the hippocampus and influences explicit memory... - A cluster of cholesterol-related genes confers susceptibility for Alzheimer's diseaseAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
J Clin Psychiatry 66:940-7. 2005..Polygenic diseases are related to the complex interplay of genetic variations. We evaluated whether clusters of cholesterol- and lipid-related genetic variations are associated with Alzheimer's disease... - Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer diseaseChristoph Hock
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Nat Med 8:1270-5. 2002..Whether vaccination to produce antibodies against beta-amyloid will halt the cognitive decline in AD will depend upon clinical assessments over time... - Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 miceBarbara Biscaro
Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
J Neurosci 29:14108-19. 2009.... - Sexual dimorphism in the parietal substrate associated with visuospatial cognition independent of general intelligenceJürgen Hänggi
Division of Neuropsychology, Institute of Psychology, University of Zurich, Binzmuehlestrasse 14 PO Box 25, 8050 Zurich, Switzerland
J Cogn Neurosci 22:139-55. 2010.... - Low-dose cortisol for symptoms of posttraumatic stress disorderAmanda Aerni
Division of Psychiatry Research, University of Zurich, Lenggstr. 31, 8029 Zurich, Switzerland
Am J Psychiatry 161:1488-90. 2004..CONCLUSIONS: The results of this pilot study indicate that low-dose cortisol treatment reduces the cardinal symptoms of PTSD... - Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapyRoger M Nitsch
Division of Psychiatry Research, University of Zurich, Switzerland
Neurotherapeutics 5:415-20. 2008.... - Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer's disease determined by protein biochip technologyAlessia S Maddalena
Division of Psychiatry Research, , , Switzerland
Neurodegener Dis 1:231-5. 2004..Quantitation revealed that CSF levels of Abeta1-38 were significantly decreased in AD as compared to CTR subjects. The CSF profile of Abeta peptides may be used for diagnostic and therapeutic purposes in clinical studies... - Urinary alpha1-antichymotrypsin: a biomarker of prion infectionGino Miele
Department of Pathology, Universitatsspital Zurich, Institute of Neuropathology, Zurich, Switzerland
PLoS ONE 3:e3870. 2008.... - Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteersValerie Treyer
PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
Eur J Nucl Med Mol Imaging 35:766-70. 2008..In this study, we assessed the whole-body biodistribution and radiation dosimetry of the new glutamatergic ligand (11)C-ABP688. This ligand binds specifically to the metabotropic glutamatergic receptor of subtype 5 (mGluR5)... - Stress doses of hydrocortisone reduce chronic stress symptoms and improve health-related quality of life in high-risk patients after cardiac surgery: a randomized studyFlorian Weis
Department of Anesthesiology, Ludwig-Maximilians-University, Munich, Germany
J Thorac Cardiovasc Surg 131:277-82. 2006.... - Can posttraumatic stress disorder be prevented with glucocorticoids?Gustav Schelling
Ludwig Maximilians University, Klinikum Grosshadern, Department of Anaesthesiology, 81377 Muenchen, Germany
Ann N Y Acad Sci 1032:158-66. 2004..Therefore, stress doses of hydrocortisone could be useful for prophylaxis and treatment of PTSD... - Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performanceMatthew J Huentelman
Neurogenomics Division, The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, AZ 85004, USA
Hum Mol Genet 16:1469-77. 2007..Our validated genomic and functional biological findings described herein suggest a role for CAMTA1 in human episodic memory... - A systemically administered beta-adrenoceptor antagonist blocks corticosterone-induced impairment of contextual memory retrieval in ratsBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Neurobiol Learn Mem 81:150-4. 2004..These findings provide evidence for the view that glucocorticoids interact with noradrenergic mechanisms in influencing memory retrieval... - Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized studyGustav Schelling
Department of Anesthesiology, Ludwig-Maximilians-University, Munich, Germany
Biol Psychiatry 55:627-33. 2004..CONCLUSIONS: Stress doses of hydrocortisone in patients undergoing CS are associated with a lower intensity of chronic stress and PTSD symptoms at 6 months after CS... - Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdalaBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
J Neurosci 24:8161-9. 2004.... - Encoding difficulty promotes postlearning changes in sleep spindle activity during nappingChristina Schmidt
Centre for Chronobiology, Psychiatric University Clinics, CH-4025 Basel, Switzerland
J Neurosci 26:8976-82. 2006..Furthermore, we demonstrate here that the nature of the learning material is a determinant factor for sleep-related alterations after declarative learning...