Dominique J F de Quervain

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. pmc The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: dependence on the basolateral amygdala
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Proc Natl Acad Sci U S A 100:1328-33. 2003
  2. pmc Lack of cortisol response in patients with posttraumatic stress disorder (PTSD) undergoing a diagnostic interview
    Iris Tatjana Kolassa
    Clinical and Neuropsychology, University of Konstanz, Universitatsstr, 10, 78457 Konstanz, Germany
    BMC Psychiatry 7:54. 2007
  3. ncbi Glucocorticoid-related genetic susceptibility for Alzheimer's disease
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Hum Mol Genet 13:47-52. 2004
  4. ncbi Glucocorticoid-induced inhibition of memory retrieval: implications for posttraumatic stress disorder
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
    Ann N Y Acad Sci 1071:216-20. 2006
  5. ncbi The neural basis of altruistic punishment
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
    Science 305:1254-8. 2004
  6. ncbi Preventive effect of beta-adrenoceptor blockade on glucocorticoid-induced memory retrieval deficits
    Dominique J F de Quervain
    Division of Psychiatry Research and the Center for Integrative Human Physiology, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
    Am J Psychiatry 164:967-9. 2007
  7. ncbi A functional genetic variation of the 5-HT2a receptor affects human memory
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Nat Neurosci 6:1141-2. 2003
  8. ncbi A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
    Nat Neurosci 10:1137-9. 2007
  9. ncbi Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Eur J Neurosci 17:1296-302. 2003
  10. pmc Identification of a genetic cluster influencing memory performance and hippocampal activity in humans
    Dominique J F de Quervain
    Division of Psychiatry Research and Center for Integrative Human Physiology, University of Zurich, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:4270-4. 2006

Detail Information

Publications57

  1. pmc The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: dependence on the basolateral amygdala
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Proc Natl Acad Sci U S A 100:1328-33. 2003
    ....
  2. pmc Lack of cortisol response in patients with posttraumatic stress disorder (PTSD) undergoing a diagnostic interview
    Iris Tatjana Kolassa
    Clinical and Neuropsychology, University of Konstanz, Universitatsstr, 10, 78457 Konstanz, Germany
    BMC Psychiatry 7:54. 2007
    ..This study investigated the cortisol response in traumatized refugees with PTSD during a detailed and standardized interview about their personal war and torture experiences...
  3. ncbi Glucocorticoid-related genetic susceptibility for Alzheimer's disease
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Hum Mol Genet 13:47-52. 2004
    ..Our results indicate that a functional variation in the glucocorticoid system increases the risk for AD, which may have important implications for the diagnosis and treatment of this disease...
  4. ncbi Glucocorticoid-induced inhibition of memory retrieval: implications for posttraumatic stress disorder
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
    Ann N Y Acad Sci 1071:216-20. 2006
    ..Future studies with more patients and longer treatment periods are required to evaluate the efficacy of cortisol treatment for PTSD...
  5. ncbi The neural basis of altruistic punishment
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
    Science 305:1254-8. 2004
    ..Our findings support the hypothesis that people derive satisfaction from punishing norm violations and that the activation in the dorsal striatum reflects the anticipated satisfaction from punishing defectors...
  6. ncbi Preventive effect of beta-adrenoceptor blockade on glucocorticoid-induced memory retrieval deficits
    Dominique J F de Quervain
    Division of Psychiatry Research and the Center for Integrative Human Physiology, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
    Am J Psychiatry 164:967-9. 2007
    ..The authors investigated whether the beta-adrenoceptor antagonist propranolol blocks glucocorticoid-induced memory retrieval impairments in human subjects...
  7. ncbi A functional genetic variation of the 5-HT2a receptor affects human memory
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Nat Neurosci 6:1141-2. 2003
    ..Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant...
  8. ncbi A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
    Nat Neurosci 10:1137-9. 2007
    ....
  9. ncbi Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Eur J Neurosci 17:1296-302. 2003
    ....
  10. pmc Identification of a genetic cluster influencing memory performance and hippocampal activity in humans
    Dominique J F de Quervain
    Division of Psychiatry Research and Center for Integrative Human Physiology, University of Zurich, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:4270-4. 2006
    ..The present study indicates that genetic variability in the human homologues of memory-related signaling molecules contributes to interindividual differences in human memory performance and memory-related brain activations...
  11. ncbi Glucocorticoid-induced reduction of traumatic memories: implications for the treatment of PTSD
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032, Zurich, Switzerland
    Prog Brain Res 167:239-47. 2008
    ..Future studies with more patients and longer treatment periods are required to evaluate the efficacy of cortisol treatment for PTSD...
  12. ncbi Glucocorticoids and the regulation of memory in health and disease
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
    Front Neuroendocrinol 30:358-70. 2009
    ..In this context, we review data suggesting that the administration of glucocorticoids might ameliorate chronic anxiety by reducing retrieval of aversive memories and enhancing fear extinction...
  13. doi Glucocorticoids for the treatment of post-traumatic stress disorder and phobias: a novel therapeutic approach
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
    Eur J Pharmacol 583:365-71. 2008
    ..More studies are needed to further evaluate the therapeutic efficacy of glucocorticoids in the treatment of anxiety disorders and to explore the potential of combining glucocorticoid treatment with psychotherapy...
  14. ncbi Low-dose cortisol for symptoms of posttraumatic stress disorder
    Amanda Aerni
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Am J Psychiatry 161:1488-90. 2004
    ....
  15. pmc Glucocorticoids reduce phobic fear in humans
    Leila M Soravia
    Institute of Psychology, Department of Clinical Psychology and Psychotherapy, University of Zurich, Zurichbergstrasse 43, CH 8044 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:5585-90. 2006
    ..Cortisol treatment did not reduce general, phobia-unrelated anxiety. In conclusion, the present findings in two distinct types of phobias indicate that glucocorticoid administration reduces phobic fear...
  16. ncbi Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Neuroreport 16:839-42. 2005
    ..In the group of elderly cognitively healthy participants, the His452Tyr genotype did not affect memory performance. We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory...
  17. doi Glucocorticoid therapy-induced memory deficits: acute versus chronic effects
    Daniel Coluccia
    Department of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    J Neurosci 28:3474-8. 2008
    ..Thus, these findings indicate that memory deficits observed under chronically elevated glucocorticoid levels result, at least in part, from acute and reversible glucocorticoid effects on memory retrieval...
  18. ncbi Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers
    Christian R A Mondadori
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Cereb Cortex 17:1934-47. 2007
    ..We suggest that APOE epsilon4 is associated with good episodic memory and an economic use of memory-related neural resources in young, healthy humans...
  19. ncbi The prion gene is associated with human long-term memory
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Hum Mol Genet 14:2241-6. 2005
    ..These results suggest a role for the prion protein in the formation of long-term memory in humans...
  20. doi Prion protein M129V polymorphism affects retrieval-related brain activity
    Andreas Buchmann
    Division of Psychiatry Research and Hospital for Psychogeriatric Medicine, University of Zurich, Minervastrasse 145, 8032 Zurich, Switzerland
    Neuropsychologia 46:2389-402. 2008
    ..Findings suggest that the prion protein Met129Val polymorphism affects neural plasticity following learning at a time-scale of minutes to hours...
  21. doi Emotion suppression reduces hippocampal activity during successful memory encoding
    Julia Binder
    Division of Biopsychology, University of Zurich, Switzerland
    Neuroimage 63:525-32. 2012
    ....
  22. ncbi Common Kibra alleles are associated with human memory performance
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich 8057, Switzerland
    Science 314:475-8. 2006
    ..Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory...
  23. ncbi Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42
    Alessia Maddalena
    Division of Psychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:1202-6. 2003
    ....
  24. ncbi Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Neuron 38:547-54. 2003
    ..Our results establish that antibodies against beta-amyloid plaques can slow cognitive decline in patients with Alzheimer's disease...
  25. doi Glucocorticoids do not reduce subjective fear in healthy subjects exposed to social stress
    Leila M Soravia
    Department of Psychology, Clinical Psychology and Psychobiology, University of Zurich, Zurich, Switzerland
    Biol Psychol 81:184-8. 2009
    ..Whether glucocorticoids reduce subjective fear also in healthy subjects exposed to a socially fearful situation is not known...
  26. ncbi Effects of memory consolidation on human hippocampal activity during retrieval
    Simone Bosshardt
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Cortex 41:486-98. 2005
    ..These fMRI results in the human hippocampal formation may correspond to the neurobiological results in the animal hippocampal formation of a strengthening and growth of synaptic connections within 24 h...
  27. ncbi Association study of cholesterol-related genes in Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurogenetics 8:179-88. 2007
    ..004). We conclude that genetic variants investigated in this study may be associated with a moderate modification of the risk for AD in some samples...
  28. ncbi Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 141:534-6. 2006
    ..These data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic AD and support a role of ABC lipid transporters in the pathogenesis of this disease...
  29. ncbi Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:233-41. 2005
    ....
  30. ncbi Genetic association study on colony-stimulating factor 1 in Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 3:334-7. 2006
    ..The human CSF1 gene maps to chromosome 1p21-p13, a region previously linked to Alzheimer's disease (AD). Thus, CSF1 is a functional and positional candidate gene for AD...
  31. ncbi Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobe
    Katharina Henke
    Division of Psychiatry Research, Psychiatric University Hospital, University of Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
    Neuropsychologia 41:863-76. 2003
    ....
  32. ncbi Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Psychiatr Genet 12:155-60. 2002
    ..In addition, no significant differences were observed after stratification for TIMP 1 genotypes. Our data show that neither genetic variability nor protein levels of TIMP-1 are associated with AD...
  33. ncbi Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    Andreas Papassotiropoulos
    Division of Pychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:29-35. 2003
    ..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain...
  34. ncbi ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Street 1, 8008, Zurich, Switzerland
    Neurobiol Aging 24:421-6. 2003
    ..We conclude that genetic variability of ABCA1 influences the development of AD, possibly by interfering with CNS cholesterol homeostasis...
  35. ncbi Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zurich, Switzerland
    Amyloid 10:1-6. 2003
    ..967 ng/ml, respectively; p < 0.05). These data show that treatment with the m1 agonist talsaclidine reduced A beta peptides, and particularly A beta 42, in AD patients, suggesting it as a potential amyloid lowering therapy of AD...
  36. ncbi Functional neuroimaging predicts individual memory outcome after amygdalohippocampectomy
    Katharina Henke
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neuroreport 14:1197-202. 2003
    ..There was no significant postoperative reallocation of ipsilateral memory functions to the contralateral MTL...
  37. ncbi Biochemical markers of Alzheimer's disease: wish and reality
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurobiol Aging 23:513-4. 2002
  38. ncbi No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Lengstrasse 31, 8029 Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 132:21-3. 2005
    ..Although PLAU may be pathophysiologially related to AD, the contribution of common genetic variants of this gene to the risk for developing AD is likely to be low...
  39. ncbi Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    J Biol Chem 277:33012-7. 2002
    ....
  40. ncbi Implicit associative learning engages the hippocampus and interacts with explicit associative learning
    Nadia Degonda
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neuron 46:505-20. 2005
    ..These findings suggest that implicit semantic associative learning engages the hippocampus and influences explicit memory...
  41. ncbi Clinical observations with AN-1792 using TAPIR analyses
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:273-6. 2005
    ..We briefly summarize here how the proof of concept was established and why it provides the basis for a potential cure for Alzheimer's disease...
  42. ncbi One month of human memory consolidation enhances retrieval-related hippocampal activity
    Simone Bosshardt
    Division of Psychiatry Research, University of Zurich, Switzerland
    Hippocampus 15:1026-40. 2005
    ....
  43. ncbi A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Clin Psychiatry 66:940-7. 2005
    ..Polygenic diseases are related to the complex interplay of genetic variations. We evaluated whether clusters of cholesterol- and lipid-related genetic variations are associated with Alzheimer's disease...
  44. ncbi Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Nat Med 8:1270-5. 2002
    ..Whether vaccination to produce antibodies against beta-amyloid will halt the cognitive decline in AD will depend upon clinical assessments over time...
  45. doi Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice
    Barbara Biscaro
    Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    J Neurosci 29:14108-19. 2009
    ....
  46. ncbi Sexual dimorphism in the parietal substrate associated with visuospatial cognition independent of general intelligence
    Jürgen Hänggi
    Division of Neuropsychology, Institute of Psychology, University of Zurich, Binzmuehlestrasse 14 PO Box 25, 8050 Zurich, Switzerland
    J Cogn Neurosci 22:139-55. 2010
    ....
  47. doi Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy
    Roger M Nitsch
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurotherapeutics 5:415-20. 2008
    ....
  48. ncbi Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer's disease determined by protein biochip technology
    Alessia S Maddalena
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:231-5. 2004
    ..Quantitation revealed that CSF levels of Abeta1-38 were significantly decreased in AD as compared to CTR subjects. The CSF profile of Abeta peptides may be used for diagnostic and therapeutic purposes in clinical studies...
  49. pmc Urinary alpha1-antichymotrypsin: a biomarker of prion infection
    Gino Miele
    Department of Pathology, Universitatsspital Zurich, Institute of Neuropathology, Zurich, Switzerland
    PLoS ONE 3:e3870. 2008
    ....
  50. ncbi Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteers
    Valerie Treyer
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    Eur J Nucl Med Mol Imaging 35:766-70. 2008
    ..In this study, we assessed the whole-body biodistribution and radiation dosimetry of the new glutamatergic ligand (11)C-ABP688. This ligand binds specifically to the metabotropic glutamatergic receptor of subtype 5 (mGluR5)...
  51. ncbi Stress doses of hydrocortisone reduce chronic stress symptoms and improve health-related quality of life in high-risk patients after cardiac surgery: a randomized study
    Florian Weis
    Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    J Thorac Cardiovasc Surg 131:277-82. 2006
    ....
  52. ncbi Can posttraumatic stress disorder be prevented with glucocorticoids?
    Gustav Schelling
    Ludwig Maximilians University, Klinikum Grosshadern, Department of Anaesthesiology, 81377 Muenchen, Germany
    Ann N Y Acad Sci 1032:158-66. 2004
    ..Therefore, stress doses of hydrocortisone could be useful for prophylaxis and treatment of PTSD...
  53. ncbi Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance
    Matthew J Huentelman
    Neurogenomics Division, The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, AZ 85004, USA
    Hum Mol Genet 16:1469-77. 2007
    ..Our validated genomic and functional biological findings described herein suggest a role for CAMTA1 in human episodic memory...
  54. ncbi A systemically administered beta-adrenoceptor antagonist blocks corticosterone-induced impairment of contextual memory retrieval in rats
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Neurobiol Learn Mem 81:150-4. 2004
    ..These findings provide evidence for the view that glucocorticoids interact with noradrenergic mechanisms in influencing memory retrieval...
  55. ncbi Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized study
    Gustav Schelling
    Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 55:627-33. 2004
    ....
  56. ncbi Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    J Neurosci 24:8161-9. 2004
    ....
  57. ncbi Encoding difficulty promotes postlearning changes in sleep spindle activity during napping
    Christina Schmidt
    Centre for Chronobiology, Psychiatric University Clinics, CH 4025 Basel, Switzerland
    J Neurosci 26:8976-82. 2006
    ..Furthermore, we demonstrate here that the nature of the learning material is a determinant factor for sleep-related alterations after declarative learning...