Sonja A Dames

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability
    Sonja A Dames
    Department of Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    J Biol Chem 280:20558-64. 2005
  2. ncbi NMR assignment of the Cyclin T-binding domain of human Hexim1
    Sonja A Dames
    Department of Structural Biology, Biozentrum, University of Basel, Klingelbergstr 70, Basel, 4056, Switzerland
    J Biomol NMR 36:39. 2006
  3. pmc Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb
    Sonja A Dames
    Department of Structural Biology, Biozentrum Basel, University of Basel, 4003 Basel, Switzerland
    Proc Natl Acad Sci U S A 104:14312-7. 2007
  4. doi A fast and simple method to prepare the FKBP-rapamycin binding domain of human target of rapamycin for NMR binding assays
    Sonja A Dames
    Biozentrum Basel, Department of Structural Biology, University of Basel, Klingelbergstr 70, 4056 Basel, Switzerland
    Protein Expr Purif 59:31-7. 2008
  5. ncbi Insights into the low adhesive capacity of human T-cadherin from the NMR structure of Its N-terminal extracellular domain
    Sonja A Dames
    Department of Structural Biology, University of Basel, Klingelbergstr 70, 4056 Basel, Switzerland
    J Biol Chem 283:23485-95. 2008
  6. pmc Structural basis for the association of the redox-sensitive target of rapamycin FATC domain with membrane-mimetic micelles
    Sonja A Dames
    Department of Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    J Biol Chem 285:7766-75. 2010
  7. pmc Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response
    Sonja A Dames
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:5271-6. 2002
  8. ncbi 1H, 13C, and 15N chemical shift assignments for the N-terminal extracellular domain of T-cadherin
    Eunjung Bang
    J Biomol NMR 38:179. 2007

Detail Information

Publications8

  1. ncbi The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability
    Sonja A Dames
    Department of Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    J Biol Chem 280:20558-64. 2005
    ..Because the amount of TOR mRNA is not changed, the redox state of the FATC disulfide bond is probably influencing the degradation of TOR...
  2. ncbi NMR assignment of the Cyclin T-binding domain of human Hexim1
    Sonja A Dames
    Department of Structural Biology, Biozentrum, University of Basel, Klingelbergstr 70, Basel, 4056, Switzerland
    J Biomol NMR 36:39. 2006
  3. pmc Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb
    Sonja A Dames
    Department of Structural Biology, Biozentrum Basel, University of Basel, 4003 Basel, Switzerland
    Proc Natl Acad Sci U S A 104:14312-7. 2007
    ..Thus, our studies provide structural insights how Hexim1 recognizes the Cyclin T1 subunit of P-TEFb, which is a key step toward the regulation of transcription elongation...
  4. doi A fast and simple method to prepare the FKBP-rapamycin binding domain of human target of rapamycin for NMR binding assays
    Sonja A Dames
    Biozentrum Basel, Department of Structural Biology, University of Basel, Klingelbergstr 70, 4056 Basel, Switzerland
    Protein Expr Purif 59:31-7. 2008
    ..The procedure is very simple and can easily be scaled up to prepare large amounts of functional protein for high-throughput cancer drug screening assays by NMR and other techniques...
  5. ncbi Insights into the low adhesive capacity of human T-cadherin from the NMR structure of Its N-terminal extracellular domain
    Sonja A Dames
    Department of Structural Biology, University of Basel, Klingelbergstr 70, 4056 Basel, Switzerland
    J Biol Chem 283:23485-95. 2008
    ..The apparent low adhesiveness of T-cadherin suggests that it is likely to be involved in reversible and dynamic cellular adhesion-deadhesion processes, which are consistent with its role in cell growth and migration...
  6. pmc Structural basis for the association of the redox-sensitive target of rapamycin FATC domain with membrane-mimetic micelles
    Sonja A Dames
    Department of Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    J Biol Chem 285:7766-75. 2010
    ....
  7. pmc Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response
    Sonja A Dames
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:5271-6. 2002
    ..The structure of this complex provides new insights into the mechanism through which Hif-1 alpha recruits CBP/p300 in response to hypoxia...
  8. ncbi 1H, 13C, and 15N chemical shift assignments for the N-terminal extracellular domain of T-cadherin
    Eunjung Bang
    J Biomol NMR 38:179. 2007