M Curatolo

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi The analgesic effect of oral delta-9-tetrahydrocannabinol (THC), morphine, and a THC-morphine combination in healthy subjects under experimental pain conditions
    Myrtha Naef
    Department of Clinical Research, University of Bern, Murtenstrasse 35, CH 3010 Bern, Switzerland
    Pain 105:79-88. 2003
  2. doi Diagnosis of altered central pain processing
    Michele Curatolo
    University Department of Anaesthesiology and Pain Therapy, University of Bern, Inselspital, Bern, Switzerland
    Spine (Phila Pa 1976) 36:S200-4. 2011
  3. pmc Algometry with a clothes peg compared to an electronic pressure algometer: a randomized cross-sectional study in pain patients
    Niklaus Egloff
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, CH 3010 Bern, Switzerland
    BMC Musculoskelet Disord 12:174. 2011
  4. doi [Pathophysiology of abdominal pain]
    Michele Curatolo
    Universitätsklinik für Anästhesiologie und Schmerztherapie, Inselspital, Bern
    Ther Umsch 68:415-9. 2011
  5. ncbi Evidence, mechanisms, and clinical implications of central hypersensitivity in chronic pain after whiplash injury
    Michele Curatolo
    Department of Anesthesiology, University Hospital of Bern, Switzerland
    Clin J Pain 20:469-76. 2004
  6. pmc The role of tissue damage in whiplash-associated disorders: discussion paper 1
    Michele Curatolo
    University Department of Anesthesiology and Pain Therapy, University of Bern, Bern, Switzerland
    Spine (Phila Pa 1976) 36:S309-15. 2011
  7. ncbi Central hypersensitivity in chronic pain: mechanisms and clinical implications
    Michele Curatolo
    Department of Anesthesiology, Division of Pain Therapy, Inselspital, 3010 Bern, Switzerland
    Phys Med Rehabil Clin N Am 17:287-302. 2006
  8. ncbi Central hypersensitivity in chronic pain after whiplash injury
    M Curatolo
    Department of Anesthesiology, University Hospital of Bern, Inselspital, Switzerland
    Clin J Pain 17:306-15. 2001
  9. ncbi Pharmacologic pain treatment of musculoskeletal disorders: current perspectives and future prospects
    M Curatolo
    Department of Anesthesiology, University Hospital of Bern, Switzerland
    Clin J Pain 17:25-32. 2001
  10. ncbi A direct search procedure to optimize combinations of epidural bupivacaine, fentanyl, and clonidine for postoperative analgesia
    M Curatolo
    Department of Anesthesiology, University of Bern, Inselspital, Switzerland
    Anesthesiology 92:325-37. 2000

Collaborators

Detail Information

Publications48

  1. ncbi The analgesic effect of oral delta-9-tetrahydrocannabinol (THC), morphine, and a THC-morphine combination in healthy subjects under experimental pain conditions
    Myrtha Naef
    Department of Clinical Research, University of Bern, Murtenstrasse 35, CH 3010 Bern, Switzerland
    Pain 105:79-88. 2003
    ..No analgesic effect resulted in the pressure and heat test, neither with THC nor THC-morphine. Psychotropic and somatic side-effects (sleepiness, euphoria, anxiety, confusion, nausea, dizziness, etc.) were common, but usually mild...
  2. doi Diagnosis of altered central pain processing
    Michele Curatolo
    University Department of Anaesthesiology and Pain Therapy, University of Bern, Inselspital, Bern, Switzerland
    Spine (Phila Pa 1976) 36:S200-4. 2011
    ..Nonsystematic review...
  3. pmc Algometry with a clothes peg compared to an electronic pressure algometer: a randomized cross-sectional study in pain patients
    Niklaus Egloff
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, CH 3010 Bern, Switzerland
    BMC Musculoskelet Disord 12:174. 2011
    ..Clinically meaningful" was defined as a medium (r = 0.3-0.5) or high (r > 0.5) correlation coefficient according to Cohen's conventions...
  4. doi [Pathophysiology of abdominal pain]
    Michele Curatolo
    Universitätsklinik für Anästhesiologie und Schmerztherapie, Inselspital, Bern
    Ther Umsch 68:415-9. 2011
    ..A better understanding of the individual pathophysiology may allow in the future the development of individual therapeutic strategies...
  5. ncbi Evidence, mechanisms, and clinical implications of central hypersensitivity in chronic pain after whiplash injury
    Michele Curatolo
    Department of Anesthesiology, University Hospital of Bern, Switzerland
    Clin J Pain 20:469-76. 2004
    ....
  6. pmc The role of tissue damage in whiplash-associated disorders: discussion paper 1
    Michele Curatolo
    University Department of Anesthesiology and Pain Therapy, University of Bern, Bern, Switzerland
    Spine (Phila Pa 1976) 36:S309-15. 2011
    ..Nonsystematic review of cervical spine lesions in whiplash-associated disorders (WAD)...
  7. ncbi Central hypersensitivity in chronic pain: mechanisms and clinical implications
    Michele Curatolo
    Department of Anesthesiology, Division of Pain Therapy, Inselspital, 3010 Bern, Switzerland
    Phys Med Rehabil Clin N Am 17:287-302. 2006
    ..The gap between basic knowledge and clinical benefits remains large and should stimulate further intensive research...
  8. ncbi Central hypersensitivity in chronic pain after whiplash injury
    M Curatolo
    Department of Anesthesiology, University Hospital of Bern, Inselspital, Switzerland
    Clin J Pain 17:306-15. 2001
    ..The hypotheses of this study were: (1) chronic whiplash pain is associated with central hypersensitivity; (2) central hypersensitivity is maintained by nociception arising from the painful or tender muscles in the neck...
  9. ncbi Pharmacologic pain treatment of musculoskeletal disorders: current perspectives and future prospects
    M Curatolo
    Department of Anesthesiology, University Hospital of Bern, Switzerland
    Clin J Pain 17:25-32. 2001
    ..The authors aimed to provide an educational update on the current evidence of the effectiveness of drug therapy in the treatment of musculoskeletal pain and to offer a perspective of possible future developments...
  10. ncbi A direct search procedure to optimize combinations of epidural bupivacaine, fentanyl, and clonidine for postoperative analgesia
    M Curatolo
    Department of Anesthesiology, University of Bern, Inselspital, Switzerland
    Anesthesiology 92:325-37. 2000
    ..The authors applied an optimization model (direct search) to find the optimal combination of bupivacaine dose, fentanyl dose, clonidine dose, and infusion rate for continuous postoperative epidural analgesia...
  11. ncbi Assessment of regional analgesia in clinical practice and research
    Michele Curatolo
    Department of Anaesthesiology, Division of Pain Therapy Inselspital, 3010 Berne, Switzerland
    Br Med Bull 71:61-76. 2004
    ..Test modalities used in clinical practice have limited validity. In recent years almost no research has been performed to develop better test modalities that are suitable for daily practice...
  12. doi Adding regional analgesia to general anaesthesia: increase of risk or improved outcome?
    Michele Curatolo
    Department of Anaesthesiology and Pain Therapy, University Hospital of Bern, Inselspital, Bern, Switzerland
    Eur J Anaesthesiol 27:586-91. 2010
    ..The effect size is mostly small or the number-needed-to-treat is high. However, considering the importance of the outcomes of interest, even minor improvement probably has substantial clinical relevance...
  13. ncbi Block of pinprick and cold sensation poorly correlate with relief of postoperative pain during epidural analgesia
    M Curatolo
    Department of Anesthesiology and Intensive Care, University Hospital of Bern, Switzerland
    Clin J Pain 15:6-12. 1999
    ....
  14. ncbi Lumbar epidural fentanyl: segmental spread and effect on temporal summation and muscle pain
    U Eichenberger
    Department of Anaesthesiology, Division of Pain Therapy, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Br J Anaesth 90:467-73. 2003
    ..We applied a multi-modal sensory test procedure to investigate the effect of epidural fentanyl on segmental spread, temporal summation (as a measure for short-lasting central hyperexcitability) and muscle pain...
  15. ncbi Epidural epinephrine and clonidine: segmental analgesia and effects on different pain modalities
    M Curatolo
    University of Bern, Inselspital, Switzerland
    Anesthesiology 87:785-94. 1997
    ..The segmental distribution of clonidine epidural analgesia and its effects on temporal summation and different types of noxious stimuli are unknown. The aim of this study was to clarify these issues...
  16. ncbi Adding sodium bicarbonate to lidocaine enhances the depth of epidural blockade
    M Curatolo
    Department of Anesthesiology and Intensive Care, University of Bern, Inselspital, Switzerland
    Anesth Analg 86:341-7. 1998
    ..We found that the addition of sodium bicarbonate to the local anesthetic lidocaine enhances analgesia. We observed no effect of adding carbon dioxide to lidocaine...
  17. ncbi Single-injection thoracic paravertebral block for postoperative pain treatment after thoracoscopic surgery
    A Vogt
    Department of Anaesthesiology, Division of Thoracic Surgery, University Hospital of Bern, Inselspital, 3010 Bern, Switzerland
    Br J Anaesth 95:816-21. 2005
    ..We tested the hypothesis that a single-injection thoracic paravertebral block, performed preoperatively, reduces pain scores after thoracoscopic surgery...
  18. doi Comparison of randomized treatments for late whiplash
    U Pato
    Departments of Neurology, Inselspital, Bern University Hospital, and University of Bern, Berne, Switzerland
    Neurology 74:1223-30. 2010
    ..To compare 4 different treatment strategies in patients with late whiplash syndrome...
  19. ncbi Modulation of remifentanil-induced analgesia, hyperalgesia, and tolerance by small-dose ketamine in humans
    Martin Luginbuhl
    Department of Anesthesiology, University Hospital of Bern, Switzerland
    Anesth Analg 96:726-32, table of contents. 2003
    ..Remifentanil at a 2 ng/mL target concentration induced a slight respiratory depression that was antagonized by ketamine. We conclude that ketamine effects on opioid analgesia are pain-modality specific...
  20. ncbi Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia
    Borut Banic
    Division of Pain Therapy, Department of Anesthesiology, University Hospital of Bern, Inselspital, 3010 Bern, Switzerland
    Pain 107:7-15. 2004
    ..This can cause exaggerated pain following low intensity nociceptive or innocuous peripheral stimulation. Spinal hypersensitivity may explain, at least in part, pain in the absence of detectable tissue damage...
  21. doi What does local tenderness say about the origin of pain? An investigation of cervical zygapophysial joint pain
    Andreas Siegenthaler
    University Department of Anesthesiology and Pain Therapy, University Hospital of Bern, Inselspital, Bern, Switzerland
    Anesth Analg 110:923-7. 2010
    ..We tested the hypothesis that assessing mechanical pain sensitivity distinguishes damaged from healthy cervical zygapophysial (facet) joints...
  22. doi The nociceptive withdrawal reflex: normative values of thresholds and reflex receptive fields
    Alban Y Neziri
    University Department of Anesthesiology and Pain Therapy, University Hospital of Bern, Inselspital, Bern, Switzerland
    Eur J Pain 14:134-41. 2010
    ..The parameters investigated explore different aspects of sensitization processes that are largely independent of demographic characteristics, cognitive and affective factors...
  23. ncbi Safety of mixture of morphine with ketamine for postoperative patient-controlled analgesia: an audit with 1026 patients
    G Sveticic
    Department of Anesthesiology, Division of Pain Therapy, University of Bern, Inselspital, Switzerland
    Acta Anaesthesiol Scand 49:870-5. 2005
    ..However, data on this drug combination have been collected on small sample sizes. In order to evaluate the safety of the combination morphine- ketamine, we conducted a prospective study on a large patient population...
  24. ncbi Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury
    Renate Herren-Gerber
    Department of Anesthesiology, Division of Pain Therapy, University Hospital of Bern, Inselspital, 3010 Bern, Switzerland
    Pain Med 5:366-76. 2004
    ..It is unclear whether central hypersensitivity is modulated by peripheral nociceptive input. We hypothesized that changes in nociceptive input would correlate with changes in magnitude of central hypersensitivity...
  25. doi New method for quantification and statistical analysis of nociceptive reflex receptive fields in humans
    Alban Y Neziri
    University Dept of Anaesthesiology and Pain Therapy, University Hospital of Berne, Inselspital, Switzerland
    J Neurosci Methods 178:24-30. 2009
    ..It may be utilized as a new diagnostic tool for central hypersensitivity and quantification of therapeutic interventions...
  26. ncbi Is epinephrine unfairly neglected for postoperative epidural mixtures?
    Michele Curatolo
    Anesth Analg 94:1381-3. 2002
  27. ncbi Ultrasound-guided blocks of the ilioinguinal and iliohypogastric nerve: accuracy of a selective new technique confirmed by anatomical dissection
    U Eichenberger
    Department of Anaesthesia and General Intensive Care B, Medical University of Vienna, A 1090 Vienna, Austria
    Br J Anaesth 97:238-43. 2006
    ..This study describes a new ultrasound-guided approach to these nerves and determines its accuracy using anatomical dissection control...
  28. doi Blockade of the sinuvertebral nerve for the diagnosis of lumbar diskogenic pain: an exploratory study
    Juerg Schliessbach
    Department of Anesthesiology and Pain Therapy, Inselspital Bern, Bern, Switzerland
    Anesth Analg 111:204-6. 2010
    ..The sensitivity was 73.3% (95% CI: 50.9%-95.7%). The target specificity was 40% (15.2%-64.8%). The results indicate that SVNB cannot yet replace diskography but encourage future studies to improve its target specificity...
  29. doi Detrusor activity is impaired during thoracic epidural analgesia after open renal surgery
    Patrick Y Wuethrich
    Department of Anesthesiology and Pain Therapy, University Hospital Bern, Berne, Switzerland
    Anesthesiology 112:1345-9. 2010
    ..Because selected segmental blockade can be achieved with epidural analgesia, we hypothesized that lower urinary tract function remains unchanged during TEA within segments T4-T11 after open renal surgery...
  30. doi The role of central hypersensitivity in the determination of intradiscal mechanical hyperalgesia in discogenic pain
    Juerg Schliessbach
    University Department of Anaesthesiology and Pain Therapy, Inselspital, 3010 Bern, Switzerland
    Pain Med 11:701-8. 2010
    ..The secondary aim was to test the hypothesis that peripheral noxious stimulation dynamically modulates central hypersensitivity...
  31. doi The effect of brief electrical and manual acupuncture stimulation on mechanical experimental pain
    Juerg Schliessbach
    University Department of Anesthesiology and Pain Therapy, Inselspital Bern, Switzerland
    Pain Med 12:268-75. 2011
    ..This blinded, placebo-controlled cross-over study investigates effects of brief manual and electrical acupuncture stimulation on pressure pain detection thresholds (PPDT) compared with nonpenetrating sham acupuncture (NPSA)...
  32. doi Minimal local anesthetic volume for peripheral nerve block: a new ultrasound-guided, nerve dimension-based method
    Urs Eichenberger
    Department of Anesthesiology and Pain Therapy, Bern University Hospital and University of Bern, Switzerland
    Reg Anesth Pain Med 34:242-6. 2009
    ..In this study, we estimated the 50% effective dose (ED50) and 95% effective dose (ED95) volume of 1% mepivacaine relative to the cross-sectional area of the nerve for an adequate sensory block...
  33. ncbi Combinations of bupivacaine, fentanyl, and clonidine for lumbar epidural postoperative analgesia: a novel optimization procedure
    Gorazd Sveticic
    Division of Pain Therapy, Department of Anesthesiology, Inselspital, Bern, Switzerland
    Anesthesiology 101:1381-93. 2004
    ..The authors developed and applied a method to optimize the combination of bupivacaine, fentanyl, and clonidine for continuous postoperative lumbar epidural analgesia...
  34. ncbi Sonographic visualization and ultrasound-guided block of the third occipital nerve: prospective for a new method to diagnose C2-C3 zygapophysial joint pain
    Urs Eichenberger
    Department of Anesthesiology, Division of Pain Therapy, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Anesthesiology 104:303-8. 2006
    ..Diagnostic blocks of nerves supplying the joints are performed using fluoroscopy. The authors' hypothesis was that the third occipital nerve can be visualized and blocked with use of an ultrasound-guided technique...
  35. doi Chronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholds
    Urs Eichenberger
    Department of Anesthesiology, Division of Pain Therapy, University Hospital of Bern, Inselspital, 3010 Bern, Switzerland
    Anesth Analg 106:1265-73, table of contents. 2008
    ..Our secondary aim was to improve our understanding of the mechanisms of action of the investigated drugs using quantitative sensory testing...
  36. ncbi Combinations of morphine with ketamine for patient-controlled analgesia: a new optimization method
    Gorazd Sveticic
    Department of Anesthesiology, Inselspital, 3010 Bern, Switzerland
    Anesthesiology 98:1195-205. 2003
    ..The authors developed and applied a new model to optimize the combination of morphine, ketamine, and a lockout interval for PCA after lumbar spine and hip surgery...
  37. ncbi [Ultrasound in anesthesiology--ultrasound in interventional pain therapy]
    Urs Eichenberger
    Klinik und Poliklinik für Anästhesiologie des Inselspitals Bern, Switzerland
    Anasthesiol Intensivmed Notfallmed Schmerzther 41:760-6. 2006
    ..The increasing published data available and the personal experience of the authors suggest a potential usefulness in interventional pain therapy, but also limitations...
  38. doi Is the combination of morphine with ketamine better than morphine alone for postoperative intravenous patient-controlled analgesia?
    Gorazd Sveticic
    Department of Anesthesiology, Inselspital, Bern, Switzerland
    Anesth Analg 106:287-93, table of contents. 2008
    ..In this study, we compared the combination of morphine and ketamine with morphine alone for postoperative PCA in large patient groups. We used a morphine-ketamine combination identified by an optimization procedure in our previous study...
  39. ncbi Neuroplasticity--an important factor in acute and chronic pain
    Steen Petersen-Felix
    Anästhesie Frauenklinik, Institut für Anästhesiologie, Inselspital, Bern, Switzerland
    Swiss Med Wkly 132:273-8. 2002
    ..The present review examines the current knowledge on mechanism, clinical significance and prevention of neuroplastic changes...
  40. doi Psychologic factors are related to some sensory pain thresholds but not nociceptive flexion reflex threshold in chronic whiplash
    Michele Sterling
    Centre for National Research on Disability and Rehabilitation Medicine, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia
    Clin J Pain 24:124-30. 2008
    ..However, relationships between these substrates are not clear. This study tested the hypothesis that psychologic distress and catastrophization are correlated with sensory hypersensitivity and NFR responses in chronic whiplash...
  41. ncbi Human experimental pain models in drug development: translational pain research
    Lars Arendt-Nielsen
    Addresses Aalborg University, Department of Health Sciences and Technology, Laboratory for Experimental Pain Research, Fredrik Bajers Vej 7, D3, DK 9220 Aalborg, Denmark
    Curr Opin Investig Drugs 8:41-53. 2007
    ..Proof-of-concept studies provide cheap, fast and reliable information on dose-efficacy relationships and how pain sensed in the skin, muscles and viscera are inhibited...
  42. ncbi Drug combinations in pain treatment: a review of the published evidence and a method for finding the optimal combination
    Michele Curatolo
    Department of Anaesthesiology, Division of Pain Therapy, University Hospital of Bern, Inselspital, 3010 Bern, Switzerland
    Best Pract Res Clin Anaesthesiol 16:507-19. 2002
    ..Because of the enormous number of possible combinations, randomized controlled trials may fail to test the optimal combination. A stepwise optimization model that has been applied in clinical investigations is presented...
  43. doi Ilioinguinal and iliohypogastric nerves cannot be selectively blocked by using ultrasound guidance: a volunteer study
    M Schmutz
    University Department of Anaesthesiology and Pain Therapy, University Hospital of Bern and University of Bern, CH 3010 Bern, Switzerland
    Br J Anaesth 111:264-70. 2013
    ..The present study tested the hypothesis that our method, previously developed in cadavers, blocks the nerves separately and selectively in human volunteers...
  44. ncbi Obturator nerve block: a technique based on anatomical findings and MRI analysis
    Stephan Locher
    Department of Anesthesiology, Division of Pain Therapy, University Hospital of Bern, Inselspital, Switzerland
    Pain Med 9:1012-15. 2008
    ..The aim of this study was to define an injection technique based on an anatomical investigation and a magnetic resonance (MRI) analysis...
  45. ncbi Pain treatment with a COX-2 inhibitor after coronary artery bypass operation: a randomized trial
    Franz F Immer
    Department of Cardiovascular Surgery, Division of Pain Therapy, University Hospital, Berne, Switzerland
    Ann Thorac Surg 75:490-5. 2003
    ..Adequate analgesic medication is mandatory after cardiac operations. Cyclooxygenase-2 inhibitors represent a new therapeutic option, acting primarily on the response to inflammation...
  46. ncbi The well-being model: a new drug interaction model for positive and negative effects
    Eleonora Zanderigo
    Automatic Control Laboratory, Swiss Federal Institute of Technology, University Hospital, Bern, Switzerland
    Anesthesiology 104:742-53. 2006
    ..Therefore, when addressing the question of optimal drug combinations, side effects must be taken into account...
  47. doi Radiological anatomy of the obturator nerve and its articular branches: basis to develop a method of radiofrequency denervation for hip joint pain
    Stephan Locher
    Department of Anesthesiology, Division of Pain Therapy, University Hospital of Bern, Bern, Switzerland
    Pain Med 9:291-8. 2008
    ..Based on an anatomical and radiological study, we sought to define a potentially more effective radiofrequency method...
  48. ncbi Re: Niemisto L, Kalso E, Malmivaara A, et al. Radiofrequency denervation for neck and back pain: a systematic review within the framework of the Cochrane Collaboration Back Review Group. Spine 2003;28:1877-88
    Michele Curatolo
    Spine (Phila Pa 1976) 30:263-4; author reply 264-5. 2005