Guy R Cornelis

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Capnocytophaga canimorsus: a human pathogen feeding at the surface of epithelial cells and phagocytes
    Manuela Mally
    Infection Biology, Biozentrum, University of Basel, Klingelbergstrasse, Basel, Switzerland
    PLoS Pathog 4:e1000164. 2008
  2. pmc Oligomeric coiled-coil adhesin YadA is a double-edged sword
    Salome Casutt-Meyer
    Biozentrum der Universitat Basel, Basel, Switzerland
    PLoS ONE 5:e15159. 2010
  3. pmc The N-glycan glycoprotein deglycosylation complex (Gpd) from Capnocytophaga canimorsus deglycosylates human IgG
    Francesco Renzi
    Biozentrum der Universitat Basel, Basel, Switzerland
    PLoS Pathog 7:e1002118. 2011
  4. ncbi request reprint The Yersinia Ysc-Yop virulence apparatus
    Guy R Cornelis
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology ICP and Faculté de Médecine, Universite Catholique de Louvain, Brussels, Belgium
    Int J Med Microbiol 291:455-62. 2002
  5. doi request reprint The type III secretion injectisome, a complex nanomachine for intracellular 'toxin' delivery
    Guy R Cornelis
    Biozentrum der Universitat Basel, CH 4056 Basel, Switzerland
    Biol Chem 391:745-51. 2010
  6. ncbi request reprint The Yersinia Ysc-Yop 'type III' weaponry
    Guy R Cornelis
    Biozentrum der Universitat Basel, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
    Nat Rev Mol Cell Biol 3:742-52. 2002
  7. ncbi request reprint How Yops find their way out of Yersinia
    Guy R Cornelis
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Mol Microbiol 50:1091-4. 2003
  8. pmc Yersinia type III secretion: send in the effectors
    Guy R Cornelis
    Biozentrum der Universitat Basel, Switzerland
    J Cell Biol 158:401-8. 2002
  9. ncbi request reprint The type III secretion injectisome
    Guy R Cornelis
    Biozentrum der Universitat Basel, Klingelbergstrasse 50, CH 4056, Basel, Switzerland
    Nat Rev Microbiol 4:811-25. 2006
  10. ncbi request reprint Length control of extended protein structures in bacteria and bacteriophages
    Guy R Cornelis
    Biozentrum der Universitat Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Curr Opin Microbiol 9:201-6. 2006

Collaborators

Detail Information

Publications57

  1. pmc Capnocytophaga canimorsus: a human pathogen feeding at the surface of epithelial cells and phagocytes
    Manuela Mally
    Infection Biology, Biozentrum, University of Basel, Klingelbergstrasse, Basel, Switzerland
    PLoS Pathog 4:e1000164. 2008
    ....
  2. pmc Oligomeric coiled-coil adhesin YadA is a double-edged sword
    Salome Casutt-Meyer
    Biozentrum der Universitat Basel, Basel, Switzerland
    PLoS ONE 5:e15159. 2010
    ..pestis and clarifies an old enigma. Since YadA imposes the same cost to the food-borne Yersinia but was nevertheless conserved by evolution, this observation also illustrates the duality of some virulence functions...
  3. pmc The N-glycan glycoprotein deglycosylation complex (Gpd) from Capnocytophaga canimorsus deglycosylates human IgG
    Francesco Renzi
    Biozentrum der Universitat Basel, Basel, Switzerland
    PLoS Pathog 7:e1002118. 2011
    ....
  4. ncbi request reprint The Yersinia Ysc-Yop virulence apparatus
    Guy R Cornelis
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology ICP and Faculté de Médecine, Universite Catholique de Louvain, Brussels, Belgium
    Int J Med Microbiol 291:455-62. 2002
    ..YopP downregulates the onset of the inflammatory response by blocking the NF-kappaB and MAPK pathways. Strong arguments indicate that it is a SUMO protease. Finally, YopM has been shown to travel to the nucleus of the target cell...
  5. doi request reprint The type III secretion injectisome, a complex nanomachine for intracellular 'toxin' delivery
    Guy R Cornelis
    Biozentrum der Universitat Basel, CH 4056 Basel, Switzerland
    Biol Chem 391:745-51. 2010
    ..The length of the needle is controlled by a protein that it also secreted during assembly and presumably acts as a molecular ruler...
  6. ncbi request reprint The Yersinia Ysc-Yop 'type III' weaponry
    Guy R Cornelis
    Biozentrum der Universitat Basel, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
    Nat Rev Mol Cell Biol 3:742-52. 2002
    ..Type III secretion is key to the pathogenesis of bacteria from the Yersinia genus...
  7. ncbi request reprint How Yops find their way out of Yersinia
    Guy R Cornelis
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Mol Microbiol 50:1091-4. 2003
  8. pmc Yersinia type III secretion: send in the effectors
    Guy R Cornelis
    Biozentrum der Universitat Basel, Switzerland
    J Cell Biol 158:401-8. 2002
    ..Understanding the molecular mechanisms of this system has provided insight into the processes of phagocytosis and inflammation...
  9. ncbi request reprint The type III secretion injectisome
    Guy R Cornelis
    Biozentrum der Universitat Basel, Klingelbergstrasse 50, CH 4056, Basel, Switzerland
    Nat Rev Microbiol 4:811-25. 2006
    ..However, despite the ongoing concerted efforts of molecular and structural biologists, the role of many of the constituent components of this nanomachine remain unknown...
  10. ncbi request reprint Length control of extended protein structures in bacteria and bacteriophages
    Guy R Cornelis
    Biozentrum der Universitat Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Curr Opin Microbiol 9:201-6. 2006
    ..The bacterial flagellum is evolutionarily related to the injectisome. The length of the hook is also controlled by a secreted protein. This protein acts as a substrate specificity switch and, possibly, also as a ruler...
  11. doi request reprint Assembly of the Yersinia injectisome: the missing pieces
    Andreas Diepold
    Biozentrum der Universitat Basel, Basel, Switzerland
    Mol Microbiol 85:878-92. 2012
    ..In contrast, YscP(1-137) -PhoA accumulated in the periplasm in the absence of YscF, suggesting that YscF is not required for the function of the export apparatus, but that its polymerization opens the secretin YscC...
  12. ncbi request reprint Bacterial injectisomes: needle length does matter
    Luis Jaime Mota
    Biozentrum, Universitat Basel, 4056 Basel, Switzerland
    Science 307:1278. 2005
    ..The needle may be required for triggering type III secretion, and its length may have evolved to match specific structures at the bacterial and host cell surfaces...
  13. doi request reprint Prevalence of Capnocytophaga canimorsus in dogs and occurrence of potential virulence factors
    Manuela Mally
    Infection Biology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, Basel, Switzerland
    Microbes Infect 11:509-14. 2009
    ..The comparative analysis of 69 16S rDNA sequences revealed the existence of C. canimorsus strains that could be misdiagnosed...
  14. ncbi request reprint Characterization of a Type III secretion substrate specificity switch (T3S4) domain in YscP from Yersinia enterocolitica
    Céline Agrain
    Biozentrum der Universitat Basel, Basel, Switzerland
    Mol Microbiol 56:54-67. 2005
    ....
  15. pmc The discovery of SycO highlights a new function for type III secretion effector chaperones
    Michel Letzelter
    Biozentrum der Universitat Basel, Basel, Switzerland
    EMBO J 25:3223-33. 2006
    ..We propose that covering an MLD might be an essential function of T3S effector chaperones...
  16. doi request reprint The genome and surface proteome of Capnocytophaga canimorsus reveal a key role of glycan foraging systems in host glycoproteins deglycosylation
    Pablo Manfredi
    Biozentrum der Universitat Basel, Basel, Switzerland Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Mol Microbiol 81:1050-60. 2011
    ..It was essential for growth on cells and contributed to survival in mice. It thus represents a fitness factor during infection...
  17. pmc Identification of substrates and chaperone from the Yersinia enterocolitica 1B Ysa type III secretion system
    Boris Foultier
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology, Faculte de Medecine, Universite Catholique de Louvain, B1200 Brussels, Belgium
    Infect Immun 71:242-53. 2003
    ..However, they could not form detectable pores in eukaryotic target cells and could not substitute for YopB and YopD for translocation of Yop effectors...
  18. ncbi request reprint Escape from immune surveillance by Capnocytophaga canimorsus
    Hwain Shin
    Biozentrum, University of Basel, Basel, Switzerland
    J Infect Dis 195:375-86. 2007
    ..These results highlight passive and active mechanisms of immune evasion by C. canimorsus, which may explain its capacity to escape from the host immune system...
  19. ncbi request reprint Function and molecular architecture of the Yersinia injectisome tip complex
    Petr Broz
    Biozentrum der Universitat Basel, Basel, Switzerland
    Mol Microbiol 65:1311-20. 2007
    ..Hence, the base of the tip complex appears to be critical for the functional insertion of YopB into the host cell membrane...
  20. ncbi request reprint YopH prevents monocyte chemoattractant protein 1 expression in macrophages and T-cell proliferation through inactivation of the phosphatidylinositol 3-kinase pathway
    Nathalie Sauvonnet
    Microbial Pathogenesis Unit, Christian de Duve, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Mol Microbiol 45:805-15. 2002
    ..Consistent with the observation that YopH inactivated the Akt pathway, YopH inhibited PI 3-kinase-dependent secretion of interleukin 2 and proliferation. These data reveal a new effect of YopH in Yersinia pathogenesis...
  21. ncbi request reprint Type III secretion: the bacteria-eukaryotic cell express
    Luis Jaime Mota
    Biozentrum der Universitat Basel, Biozentrum, Klingelbergstrasse, 50 70 CH4051 Basel, Switzerland
    FEMS Microbiol Lett 252:1-10. 2005
    ..Here, we review these different aspects focusing in open questions that promise exciting findings in the near future...
  22. pmc YscU recognizes translocators as export substrates of the Yersinia injectisome
    Isabel Sorg
    Infection Biology, Biozentrum der Universitat Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    EMBO J 26:3015-24. 2007
    ..Increasing YscP export resulted in needles with normal size, depending on the length of the ruler. Hence, the effect of the yscU(N263A) mutation on needle length was the consequence of a reduced YscP export...
  23. pmc Resistance of Capnocytophaga canimorsus to killing by human complement and polymorphonuclear leukocytes
    Hwain Shin
    Infection Biology, Biozentrum, University of Basel, Basel, Switzerland
    Infect Immun 77:2262-71. 2009
    ..In conclusion, a polysaccharide structure, likely an LPS, protects C. canimorsus from deposition of the complement MAC and from efficient phagocytosis by PMNs...
  24. ncbi request reprint DNA sequence and analysis of the pYVa127/90 virulence plasmid of Yersinia enterocolitica strain A127/90
    Boris Foultier
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Res Microbiol 154:553-7. 2003
    ..These observations suggest that both pYV plasmids are from a common ancestor but may have evolved independently following the conquest of two distant ecological niches...
  25. ncbi request reprint Secretion of YscP from Yersinia enterocolitica is essential to control the length of the injectisome needle but not to change the type III secretion substrate specificity
    Céline Agrain
    Biozentrum der Universitat Basel, Basel, Switzerland
    Mol Microbiol 57:1415-27. 2005
    ..YscP deprived of both signals could not control length, even when overproduced. We conclude from this that YscP needs to be secreted to exert its length control function but not its substrate-specificity switch function...
  26. pmc Translocators YopB and YopD from Yersinia enterocolitica form a multimeric integral membrane complex in eukaryotic cell membranes
    Caroline Montagner
    Biozentrum der Universitat Basel, Basel, Switzerland
    J Bacteriol 193:6923-8. 2011
    ..This heteropolymeric YopBD complex could be copurified after solubilization in 0.5% dodecyl maltoside but not visualized in the electron microscope. We speculate that this complex may not be stable and rigid but only transient...
  27. pmc Genetic tools for studying Capnocytophaga canimorsus
    Manuela Mally
    Infection Biology, Biozentrum, University of Basel, Basel, Switzerland
    Appl Environ Microbiol 74:6369-77. 2008
    ..Finally, a method that allows site-directed mutagenesis is described. All these genetic tools pave the way, not only for molecular studies of the pathogenesis of C. canimorsus, but also for studies of other oral Capnocytophaga species...
  28. doi request reprint Structure of the dodecameric Yersinia enterocolitica secretin YscC and its trypsin-resistant core
    Julia Kowal
    Center for Cellular Imaging and Nanoanalytics C CINA, Biozentrum, University Basel, Mattenstrasse 26, 4058 Basel, Switzerland
    Structure 21:2152-61. 2013
    ..These petals harbor the binding site of YscD, a component of the inner membrane ring. A change in their orientation adapts the length of the YscC secretin and facilitates its interaction with YscD. ..
  29. pmc Role of Yops and adhesins in resistance of Yersinia enterocolitica to phagocytosis
    Nadine Grosdent
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Infect Immun 70:4165-76. 2002
    ..These results show that YopH, YopT, YopO, and, in some instances, YopE act synergistically to increase the resistance of Y. enterocolitica to phagocytosis by macrophages and PMNs...
  30. pmc The lipopolysaccharide from Capnocytophaga canimorsus reveals an unexpected role of the core-oligosaccharide in MD-2 binding
    Simon Ittig
    Biozentrum der Universitat Basel, Switzerland
    PLoS Pathog 8:e1002667. 2012
    ....
  31. ncbi request reprint Genetic analysis of the formation of the Ysc-Yop translocation pore in macrophages by Yersinia enterocolitica: role of LcrV, YscF and YopN
    Marie Noëlle Marenne
    Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite de Louvain, B 1200, Brussels, Belgium
    Microb Pathog 35:243-58. 2003
    ..This observation suggests that many translocation pores are not filled in the absence of YopN and thus that YopN might form a link between the needle and the pore, guiding the effectors...
  32. ncbi request reprint Type III secretion: a secretory pathway serving both motility and virulence (review)
    Laure Journet
    Biozentrum der Universitat Basel, Switzerland
    Mol Membr Biol 22:41-50. 2005
    ..Both appear to be assembled in the same fashion. They recognize their substrate by a loose N-terminal peptide signal and the help of individual chaperones of a new type...
  33. doi request reprint The helical content of the YscP molecular ruler determines the length of the Yersinia injectisome
    Stefanie Wagner
    Biozentrum der Universitat Basel, Basel, Switzerland
    Mol Microbiol 71:692-701. 2009
    ..These data support the ruler model and show that the functional ruler has a helical structure...
  34. doi request reprint Capnocytophaga canimorsus resists phagocytosis by macrophages and blocks the ability of macrophages to kill other bacteria
    Salome Meyer
    Infection Biology, Biozentrum Basel, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Immunobiology 213:805-14. 2008
    ..These results provide an example of how C. canimorsus neutralizes the innate immune system...
  35. ncbi request reprint The needle length of bacterial injectisomes is determined by a molecular ruler
    Laure Journet
    Biozentrum, Universitat Basel, 4056 Basel, Switzerland
    Science 302:1757-60. 2003
    ..Here, we provide evidence that the length of this needle is determined by the size of a protein, YscP, acting as a molecular ruler...
  36. ncbi request reprint Identification of a nuclear targeting signal in YopM from Yersinia spp
    Rachid Benabdillah
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, B1200 Brussels, Belgium
    Microb Pathog 36:247-61. 2004
    ..Critical residues for nuclear targeting were identified by site-directed mutagenesis in YopMC-ter. In addition, we show that YopMC-ter NLS is crucial for the nuclear targeting of an EGFP-YopM fusion protein...
  37. pmc Length control of the injectisome needle requires only one molecule of Yop secretion protein P (YscP)
    Stefanie Wagner
    Biozentrum der Universitat Basel, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 107:13860-5. 2010
    ..The experimental data are compatible with the single ruler model and not with the scenarios involving more than one ruler per needle...
  38. ncbi request reprint The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles
    Catherine A Mueller
    Biozentrum der Universitat Basel, Klingelbergstrasse 50 70, CH 4056, Basel, Switzerland
    Science 310:674-6. 2005
    ..This unique localization of LcrV may explain its crucial role in the translocation process and its efficacy as the main protective antigen against plague...
  39. pmc The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways
    Jacob G Malone
    Biozentrum of the University of Basel, Basel, Switzerland
    PLoS Pathog 8:e1002760. 2012
    ..aeruginosa during chronic lung infections. These experiments uncover an important new principle of in vivo persistence, and identify the c-di-GMP network as a valid target for novel anti-infectives directed against chronic infections...
  40. ncbi request reprint The bacterial injection kit: type III secretion systems
    Luís J Mota
    Biozentrum der Universitat Basel, Switzerland
    Ann Med 37:234-49. 2005
    ....
  41. ncbi request reprint The multitalented type III chaperones: all you can do with 15 kDa
    Mario F Feldman
    Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056, Basel, Switzerland
    FEMS Microbiol Lett 219:151-8. 2003
    ..Here, we review this enigmatic family of proteins, and discuss the experimental data supporting the roles proposed for type III chaperones...
  42. ncbi request reprint SycE allows secretion of YopE-DHFR hybrids by the Yersinia enterocolitica type III Ysc system
    Mario F Feldman
    Division of Molecular Microbiology, University of Basel, Switzerland
    Mol Microbiol 46:1183-97. 2002
    ..In addition, they show that the secretion apparatus can reject folded proteins if they are not deeply engaged into the injectisome...
  43. ncbi request reprint Characterization of the ysa pathogenicity locus in the chromosome of Yersinia enterocolitica and phylogeny analysis of type III secretion systems
    Boris Foultier
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, Belgium
    J Mol Evol 55:37-51. 2002
    ..All the TTSSs fall into five different clusters. The phylogenetic tree of these TTSSs is completely different from the evolutionary tree based on 16S RNA, indicating that TTSSs have been distributed by horizontal transfer...
  44. doi request reprint The assembly of the export apparatus (YscR,S,T,U,V) of the Yersinia type III secretion apparatus occurs independently of other structural components and involves the formation of an YscV oligomer
    Andreas Diepold
    Biozentrum, Universitat Basel, Basel, Switzerland
    Mol Microbiol 82:502-14. 2011
    ....
  45. ncbi request reprint Type III secretion translocation pores of Yersinia enterocolitica trigger maturation and release of pro-inflammatory IL-1beta
    Hwain Shin
    Biozentrum, University of Basel, Basel, Switzerland
    Cell Microbiol 9:2893-902. 2007
    ..These data show that T3S translocation is intrinsically a pro-inflammatory phenomenon. However, in the case of Yersinia, this effect is neutralized by the action of effectors...
  46. pmc Effect of low- and high-virulence Yersinia enterocolitica strains on the inflammatory response of human umbilical vein endothelial cells
    Geertrui Denecker
    Christian de Duve Institute of Cellular and Molecular Pathology and Faculté de Médecine, Universite Catholique de Louvain, Brussels, Belgium
    Infect Immun 70:3510-20. 2002
    ..In addition, we found that high-virulence strains inject more YopP into the cytosol of eukaryotic target cells than do low-virulence strains...
  47. pmc Deciphering the assembly of the Yersinia type III secretion injectisome
    Andreas Diepold
    Infection Biology, Biozentrum der Universitat Basel, Basel, Switzerland
    EMBO J 29:1928-40. 2010
    ..These results show that assembly is initiated by the formation of the OM ring and progresses inwards to the IM ring and, finally, to a large cytosolic complex...
  48. pmc Complete genome sequence of the dog commensal and human pathogen Capnocytophaga canimorsus strain 5
    Pablo Manfredi
    Biozentrum, University of Basel, Klingelbergstrasse 50, CH 4056, Basel, Switzerland
    J Bacteriol 193:5558-9. 2011
    ..C. canimorsus has the unusual ability to feed on host cells, including phagocytes. This capacity depends on surface-exposed glycan-foraging systems. Here we present the first complete genome sequence of a C. canimorsus strain (Cc5)...
  49. ncbi request reprint Type III secretion: more systems than you think
    Paul Troisfontaines
    Biozentrum der Universitat Basel, CH 4056 Basel, Switzerland
    Physiology (Bethesda) 20:326-39. 2005
    ..There are probably a few hundred effectors interfering with control and signaling in eukaryotic cells and offering a wealth of new tools to cell biologists...
  50. ncbi request reprint Regulation of mRNA expression in macrophages after Yersinia enterocolitica infection. Role of different Yop effectors
    Nathalie Sauvonnet
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, B 1200 Brussels, Belgium
    J Biol Chem 277:25133-42. 2002
    ..In conclusion, these results provide new insight into the mechanisms of Yersinia pathogenicity by identifying the changes in host genes expression after infection and highlight the concerted actions of the different Yop effectors...
  51. pmc In situ structural analysis of the Yersinia enterocolitica injectisome
    Mikhail Kudryashev
    Center for Cellular Imaging and Nanoanalytics C CINA, Biozentrum, University of Basel, Basel, Switzerland
    elife 2:e00792. 2013
    ..We suggest that elasticity is critical for some two-membrane spanning protein complexes to cope with variations in the intermembrane distance. DOI:http://dx.doi.org/10.7554/eLife.00792.001. ..
  52. ncbi request reprint Structure of the Yersinia enterocolitica type III secretion translocator chaperone SycD
    Carina R Büttner
    Division of Structural Biology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
    J Mol Biol 375:997-1012. 2008
    ..Expression of this stable SycD monomer in Yersinia does not rescue the phenotype of a sycD null mutant, suggesting a physiological relevance of the dimerization interface...
  53. pmc Up-regulation of the Yersinia enterocolitica yop regulon by deletion of the flagellum master operon flhDC
    Sophie Bleves
    Christian de Duve Institute of Cellular Pathology, Faculte de Medecine, Universite de Louvain, B 1200 Brussels, Belgium
    J Bacteriol 184:3214-23. 2002
    ..In agreement with this notion, increased expression of flhDC in wild-type bacteria resulted in the oversecretion of flagellins at room temperature and in decreased Yop secretion at 37 degrees C...
  54. ncbi request reprint Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranes
    Julien Goure
    Biochimie et Biophysique des Systèmes Intégrés, CEA Grenoble, UMR5092 CNRS, Grenoble, France
    J Infect Dis 192:218-25. 2005
    ..The hemolysis assay could be adapted for high-throughput screening of anti-infectious compounds that specifically target the type III translocon...
  55. ncbi request reprint Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta
    Peter Schotte
    Unit of Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology VIB, Ghent Unniversity, Ghent, Belgium
    J Biol Chem 279:25134-42. 2004
    ..These results highlight a previously unknown function of Rho GTPases in the activation of caspase-1 and give new insight on the role of YopE in immune-escape mechanisms of Yersinia...
  56. pmc Role of the pilot protein YscW in the biogenesis of the YscC secretin in Yersinia enterocolitica
    Peter Burghout
    Department of Molecular Microbiology and Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands
    J Bacteriol 186:5366-75. 2004
    ..Hence, YscW interacts with the unassembled YscC protein and facilitates efficient oligomerization, likely at the outer membrane...
  57. pmc Crystal structure of Yersinia enterocolitica type III secretion chaperone SycT
    Carina R Büttner
    Division of Structural Biology, German Research Centre for Biotechnology, D 38124, Braunschweig, Germany
    Protein Sci 14:1993-2002. 2005
    ..The structural similarity of SycT to other chaperones and the spatial conservation of effector-binding sites support the idea that TTS effector chaperones form a single functional and structural group...