Research Topics
Genomes and GenesSpecies | David ConenSummaryAffiliation: University Hospital Country: Switzerland Publications
| Collaborators
|
Detail Information
Publications
Noninvasive 24-h ambulatory blood pressure and cardiovascular disease: a systematic review and meta-analysisDavid Conen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Hypertens 26:1290-9. 2008..We systematically assessed the evidence regarding the association between noninvasive 24-h systolic blood pressure and incident cardiovascular events...- Genetic and phenotypic determinants of blood pressure and other cardiovascular risk factors (GAPP)David Conen
Department of Medicine, University Hospital, Basel, Switzerland
Swiss Med Wkly 143:w13728. 2013..The pathogenesis of elevated blood pressure and other cardiovascular risk factors in the population and their progression over time is still incompletely understood, especially in young and healthy adults... - Premature atrial contractions in the general population: frequency and risk factorsDavid Conen
Department of Medicine, University Hospital, Petersgraben 4, 4031 Basel, Switzerland
Circulation 126:2302-8. 2012..Premature atrial contractions (PACs) are independent predictors of atrial fibrillation, stroke, and death. However, little is known about PAC frequency in the general population and its association with other cardiovascular risk factors... 
Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort studyD Conen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Intern Med 263:376-85. 2008..The aim of this study was to assess the relationship between a set of well-characterized genetic variants of the renin-angiotensin system and the endothelial nitric oxide synthase (NOS3) gene and the incidence of type 2 diabetes...
Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort studyDavid Conen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
J Hypertens 26:1780-6. 2008..The aim of the present study was to assess the relationship of six previously characterized gene variants in the renin-angiotensin system and the NOS3 gene with blood pressure progression and incident hypertension...- Twenty-four hour ambulatory blood pressure for the management of antihypertensive treatment: a randomized controlled trialD Conen
Department of Cardiology, University Hospital, Basel, Switzerland
J Hum Hypertens 23:122-9. 2009.... - Alcohol consumption and risk of incident atrial fibrillation in womenDavid Conen
Center for Arrhythmia Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
JAMA 300:2489-96. 2008..However, these studies were not powered to investigate the association of alcohol consumption and atrial fibrillation among women... - Socioeconomic status, blood pressure progression, and incident hypertension in a prospective cohort of female health professionalsDavid Conen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Eur Heart J 30:1378-84. 2009..The aim of this study was to examine the association between socioeconomic status, blood pressure (BP) progression, and incident hypertension... - Influence of systolic and diastolic blood pressure on the risk of incident atrial fibrillation in womenDavid Conen
Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Circulation 119:2146-52. 2009..The influence of systolic and diastolic blood pressure (BP) on incident atrial fibrillation (AF) is not well studied among initially healthy, middle-aged women... - Epidemiology of atrial fibrillationD Conen
Department of Medicine, Cardiology Division, University Hospital, Basel, Switzerland
Swiss Med Wkly 139:346-52. 2009..Knowledge of these interrelationships may eventually help to develop new treatment strategies and decrease the burden of atrial fibrillation in the general population... - Influence of blood pressure and blood pressure change on the risk of congestive heart failure in the elderlyDavid Conen
Department of Medicine, University Hospital, Basel, Switzerland
Swiss Med Wkly 140:202-8. 2010..We therefore assessed the association of BP change over time with subsequent risk of CHF... - Clinical significance of high-sensitivity C-reactive protein in cardiovascular diseaseDavid Conen
Harvard Medical School, Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston MA 02215, USA
Biomark Med 1:229-41. 2007..However, this controversy does not diminish the clinical utility of hsCRP as a biomarker of risk that, if appropriately used in clinical practice, can substantially improve clinical care... - A multimarker approach to assess the influence of inflammation on the incidence of atrial fibrillation in womenDavid Conen
Center for Arrhythmia Prevention Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Eur Heart J 31:1730-6. 2010..To assess the joint influence of inflammatory biomarkers on the risk of incident atrial fibrillation (AF) in women... - Caffeine consumption and incident atrial fibrillation in womenDavid Conen
Center for Arrhythmia Prevention, Department of Medicine, Brigham and Womenrsquos Hospital, Harvard Medical School, Boston, MA, USA
Am J Clin Nutr 92:509-14. 2010..It is somewhat controversial whether caffeine consumption is associated with an increased risk of developing atrial fibrillation (AF)... - Birth weight is a significant risk factor for incident atrial fibrillationDavid Conen
Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Circulation 122:764-70. 2010..Few if any studies have assessed the relationship between birth weight and incident atrial fibrillation (AF)... - Risk of death and cardiovascular events in initially healthy women with new-onset atrial fibrillationDavid Conen
Department of Medicine, University Hospital, Petersgraben 4, 4031 Basel, Switzerland
JAMA 305:2080-7. 2011..The risks associated with new-onset atrial fibrillation (AF) among middle-aged women and populations with a low comorbidity burden are poorly defined... - Natriuretic peptide precursor a gene polymorphisms and risk of blood pressure progression and incident hypertensionDavid Conen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Hypertension 50:1114-9. 2007..031), respectively. If corroborated by other large-scale, prospective studies, our findings indicate that the natriuretic peptide precursor A gene plays a significant role in blood pressure regulation and development of hypertension... - C-reactive protein and B-type natriuretic peptides in never-treated white coat hypertensivesDavid Conen
Medical Outpatient Clinic, University Hospital Basel, Basel, Switzerland
Hypertens Res 29:411-5. 2006..36). The plasma concentrations of CRP and BNP did not differ between patients with white coat hypertension and those with sustained hypertension... - Effect of valsartan compared with valsartan/hydrochlorothiazide on plasma levels of cellular adhesion molecules: the Val-MARC trialD Conen
Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Heart 94:e13. 2008.... - Risk of cardiovascular events among women with high normal blood pressure or blood pressure progression: prospective cohort studyDavid Conen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, USA
BMJ 335:432. 2007..To compare cardiovascular risk among women with high normal blood pressure (130-9/85-9 mm Hg) against those with normal blood pressure (120-9/75-84 mm Hg) and those with baseline hypertension... - Interstitial lung disease in an intravenous drug userD Conen
Department of Internal Medicine, University Hospital, Basel, Switzerland
Respiration 70:101-3. 2003 - Substantial intraindividual variability of BNP concentrations in patients with hypertensionD Conen
Department of Cardiology, University Hospital, Basel, Switzerland
J Hum Hypertens 20:387-91. 2006..Care should be taken in the interpretation of single BNP values below the currently accepted thresholds for heart failure... - Montelukast and Churg-Strauss syndromeDavid Conen
Department of Internal Medicine, University Hospital Basel, Switzerland
Swiss Med Wkly 134:377-80. 2004..This case is noteworthy because the time course of events strongly suggests a direct aetiological role for montelukast in the development of CSS. The pathophysiological mechanism of the association remains unknown... - [Sudden onset of left-sided epigastric pain]D Conen
Departement Innere Medizin, Kantonsspital Basel
Praxis (Bern 1994) 92:294-6. 2003 - Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing countryD Conen
Division of Hypertension and Vascular Medicine, CHUV, Lausanne, Switzerland
BMC Public Health 4:9. 2004.... - C-reactive protein and echocardiography have little impact on risk stratification in never-treated hypertensive patientsD Conen
Department of Cardiology, University Hospital Basel, Basel, Switzerland
J Hum Hypertens 20:587-92. 2006..An hsCRP cutoff level of 3 mg/l may be more suitable for risk stratification. Finally, our data suggest that depending on the population studied, there is minimal impact of echocardiography on risk stratification... - The long- and short-term impact of elevated body mass index on the risk of new atrial fibrillation the WHS (women's health study)Usha B Tedrow
Center for Arrhythmia Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 55:2319-27. 2010..The purpose of this study was to characterize the relationship between changes in body mass index (BMI) and incident atrial fibrillation (AF) in a large cohort of women... - Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health StudyDavid Conen
Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
J Hypertens 27:476-83. 2009..The aim of the present study was to assess the association of 77 previously characterized gene variants in 52 candidate genes from various biological pathways with blood pressure (BP) progression and incident hypertension... - Socioeconomic status and incident type 2 diabetes mellitus: data from the Women's Health StudyTimothy C Lee
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 6:e27670. 2011..We prospectively examined whether socioeconomic status (SES) predicts incident type II diabetes (diabetes), a cardiovascular risk equivalent and burgeoning public health epidemic among women... - Physical activity and the risk of incident atrial fibrillation in womenBrendan M Everett
Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
Circ Cardiovasc Qual Outcomes 4:321-7. 2011..We hypothesized that regular PA, possibly acting through reductions in blood pressure and body mass index (BMI), would reduce the risk of incident atrial fibrillation (AF) in women... - Smoking, smoking cessation, [corrected] and risk for symptomatic peripheral artery disease in women: a cohort studyDavid Conen
University Hospital, Basel, Switzerland
Ann Intern Med 154:719-26. 2011..Smoking has a well-documented detrimental effect on risk for myocardial infarction and stroke, but less information is available regarding peripheral artery disease (PAD), particularly among women... - Blood pressure and risk of developing type 2 diabetes mellitus: the Women's Health StudyDavid Conen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
Eur Heart J 28:2937-43. 2007..To examine the relationship of blood pressure (BP) and BP progression with the subsequent development of type 2 diabetes... - Risk for incident atrial fibrillation in patients who receive antihypertensive drugs: a nested case-control studyBeat A Schaer
University Hospital, Basel, Switzerland
Ann Intern Med 152:78-84. 2010..Different antihypertensive drug classes may alter risk for atrial fibrillation. Some studies suggest that drugs that interfere with the renin-angiotensin system may be favorable because of their effect on atrial remodeling... - Metabolic syndrome, inflammation, and risk of symptomatic peripheral artery disease in women: a prospective studyDavid Conen
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Circulation 120:1041-7. 2009..We therefore evaluated the relationship between MetS, inflammation, and incident PAD... - Lipoprotein subclass abnormalities and incident hypertension in initially healthy womenNina P Paynter
Divisions of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Clin Chem 57:1178-87. 2011..Whether lipoprotein particle size or subclass concentrations play a role in the development of hypertension is unknown... - Type 2 diabetes mellitus and risk of incident atrial fibrillation in womenTobias Schoen
Department of Medicine, University Hospital, Basel, Switzerland
J Am Coll Cardiol 60:1421-8. 2012..The purpose of this study was to assess whether changes of major atrial fibrillation (AF) risk factors and/or intercurrent cardiovascular events could explain the relationship between type 2 diabetes mellitus (T2D) and incident AF... - High prevalence of newly detected hypertension in hospitalized patients: the value of inhospital 24-h blood pressure measurementDavid Conen
Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
J Hypertens 24:301-6. 2006..CONCLUSIONS: By performing inhospital 24-h blood pressure measurement, a considerable number of patients with previously unknown hypertension can be detected... - Usefulness of B-type natriuretic peptide and C-reactive protein in predicting the presence or absence of left ventricular hypertrophy in patients with systemic hypertensionDavid Conen
Department of Cardiology, University Hospital Basel, Basel, Switzerland
Am J Cardiol 97:249-52. 2006..In conclusion, in hypertensive patients, echocardiographic LV hypertrophy can be excluded on the basis of a single blood sample for the determination of BNP and CRP... - Relation of renal function to risk for incident atrial fibrillation in womenRoopinder K Sandhu
Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
Am J Cardiol 109:538-42. 2012..However, a significant elevation in AF risk was observed at a threshold eGFR of <60 ml/min/1.73 m(2)... - Routine blood pressure measurements do not predict adverse events in hospitalized patientsDavid Conen
Department of Internal Medicine, University Hospital Basel, Switzerland
Am J Med 119:70.e17-22. 2006..CONCLUSION: Routine blood pressure measurements in a general hospital patient population do not predict clinical adverse events... - Drug-eluting versus bare-metal stents in large coronary arteriesChristoph Kaiser
Department of Cardiology, University Hospital, CH 4031 Basel, Switzerland
N Engl J Med 363:2310-9. 2010..We sought to confirm this observation and to assess whether this increase in risk was also seen with second-generation drug-eluting stents... - Guidance of antibiotic therapy with procalcitonin in lower respiratory tract infections: insights into the ProHOSP studyPhilipp Schuetz
Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
Virulence 1:88-92. 2010..In lower respiratory tract infections, PCT guidance had a differential effect on antibiotic exposure depending on the underlying type and severity of respiratory tract infection... - Meta-analysis identifies six new susceptibility loci for atrial fibrillationPatrick T Ellinor
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Nat Genet 44:670-5. 2012..The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules... - Amiodarone-induced thyrotoxicosis: clinical course and predictors of outcomeDavid Conen
Department of Cardiology, University Hospital, Basel, Switzerland
J Am Coll Cardiol 49:2350-5. 2007..This study sought to determine the clinical course and predictors of long-term outcome in patients with documented amiodarone-induced thyrotoxicosis (AIT)... - Differential citation rates of major cardiovascular clinical trials according to source of funding: a survey from 2000 to 2005David Conen
Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Circulation 118:1321-7. 2008..To address this issue, we used the number of citations per publication per year to assess differences in trial dissemination according to funding source... - Value of repeated cardiac magnetic resonance imaging in patients with suspected arrhythmogenic right ventricular cardiomyopathyDavid Conen
Department of Cardiology, University Hospital, Basel, Switzerland
J Cardiovasc Magn Reson 8:361-6. 2006..Thus, CMR diagnosis of early stage ARVC is difficult and should be made with caution... - Hypertension is an independent risk factor for contrast nephropathy after percutaneous coronary interventionDavid Conen
Department of Cardiology, University Hospital Basel, Switzerland
Int J Cardiol 110:237-41. 2006..0-20.5, p = 0.046). CONCLUSION: Hypertension is an independent risk factor for the development of contrast nephropathy. Further preventive strategies to lower the incidence of contrast nephropathy in hypertensive patients are warranted... - Use of a Mendelian randomization approach to assess the causal relation of gamma-Glutamyltransferase with blood pressure and serum insulin levelsDavid Conen
Department of Medicine, University Hospital Basel, Basel, Switzerland
Am J Epidemiol 172:1431-41. 2010..Using MR, the authors also observed a positive association of GGT with insulin (β = 0.19, 95% CI: 0.01, 0.37; P = 0.04). In conclusion, the authors found evidence for a direct causal relation of GGT with fasting insulin but not with BP... - Treating prehypertensionDavid Conen
N Engl J Med 355:417; author reply 417-8. 2006 - The use of B-type natriuretic peptides in the detection of myocardial ischemia in settings with rapid access to coronary angiographyDavid Conen
Int J Cardiol 119:416-8. 2007..In conclusion, BNP and NT-proBNP are not helpful in the evaluation of male patients with suspected myocardial ischemia in a tertiary care cardiology center with rapid access to coronary angiography...