David Conen

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi Noninvasive 24-h ambulatory blood pressure and cardiovascular disease: a systematic review and meta-analysis
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Hypertens 26:1290-9. 2008
  2. pmc Risk factors for incident atrial fibrillation with and without left atrial enlargement in women
    David Conen
    Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, United States Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, United States Department of Medicine, University Hospital, Basel, Switzerland, United States Electronic address
    Int J Cardiol 168:1894-9. 2013
  3. doi Genetic and phenotypic determinants of blood pressure and other cardiovascular risk factors (GAPP)
    David Conen
    Department of Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 143:w13728. 2013
  4. doi Premature atrial contractions in the general population: frequency and risk factors
    David Conen
    Department of Medicine, University Hospital, Petersgraben 4, 4031 Basel, Switzerland
    Circulation 126:2302-8. 2012
  5. pmc Socioeconomic status, blood pressure progression, and incident hypertension in a prospective cohort of female health professionals
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Eur Heart J 30:1378-84. 2009
  6. pmc Alcohol consumption and risk of incident atrial fibrillation in women
    David Conen
    Center for Arrhythmia Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JAMA 300:2489-96. 2008
  7. doi Twenty-four hour ambulatory blood pressure for the management of antihypertensive treatment: a randomized controlled trial
    D Conen
    Department of Cardiology, University Hospital, Basel, Switzerland
    J Hum Hypertens 23:122-9. 2009
  8. pmc Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    J Hypertens 26:1780-6. 2008
  9. ncbi Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study
    D Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Intern Med 263:376-85. 2008
  10. ncbi Clinical significance of high-sensitivity C-reactive protein in cardiovascular disease
    David Conen
    Harvard Medical School, Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston MA 02215, USA
    Biomark Med 1:229-41. 2007

Detail Information

Publications53

  1. ncbi Noninvasive 24-h ambulatory blood pressure and cardiovascular disease: a systematic review and meta-analysis
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Hypertens 26:1290-9. 2008
    ..We systematically assessed the evidence regarding the association between noninvasive 24-h systolic blood pressure and incident cardiovascular events...
  2. pmc Risk factors for incident atrial fibrillation with and without left atrial enlargement in women
    David Conen
    Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, United States Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, United States Department of Medicine, University Hospital, Basel, Switzerland, United States Electronic address
    Int J Cardiol 168:1894-9. 2013
    ..Left atrial (LA) enlargement facilitates induction and/or maintenance of atrial fibrillation (AF). However, little is known about risk factors for AF with normal LA size...
  3. doi Genetic and phenotypic determinants of blood pressure and other cardiovascular risk factors (GAPP)
    David Conen
    Department of Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 143:w13728. 2013
    ..The pathogenesis of elevated blood pressure and other cardiovascular risk factors in the population and their progression over time is still incompletely understood, especially in young and healthy adults...
  4. doi Premature atrial contractions in the general population: frequency and risk factors
    David Conen
    Department of Medicine, University Hospital, Petersgraben 4, 4031 Basel, Switzerland
    Circulation 126:2302-8. 2012
    ..Premature atrial contractions (PACs) are independent predictors of atrial fibrillation, stroke, and death. However, little is known about PAC frequency in the general population and its association with other cardiovascular risk factors...
  5. pmc Socioeconomic status, blood pressure progression, and incident hypertension in a prospective cohort of female health professionals
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Eur Heart J 30:1378-84. 2009
    ..The aim of this study was to examine the association between socioeconomic status, blood pressure (BP) progression, and incident hypertension...
  6. pmc Alcohol consumption and risk of incident atrial fibrillation in women
    David Conen
    Center for Arrhythmia Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JAMA 300:2489-96. 2008
    ..However, these studies were not powered to investigate the association of alcohol consumption and atrial fibrillation among women...
  7. doi Twenty-four hour ambulatory blood pressure for the management of antihypertensive treatment: a randomized controlled trial
    D Conen
    Department of Cardiology, University Hospital, Basel, Switzerland
    J Hum Hypertens 23:122-9. 2009
    ....
  8. pmc Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    J Hypertens 26:1780-6. 2008
    ..The aim of the present study was to assess the relationship of six previously characterized gene variants in the renin-angiotensin system and the NOS3 gene with blood pressure progression and incident hypertension...
  9. ncbi Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study
    D Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Intern Med 263:376-85. 2008
    ..The aim of this study was to assess the relationship between a set of well-characterized genetic variants of the renin-angiotensin system and the endothelial nitric oxide synthase (NOS3) gene and the incidence of type 2 diabetes...
  10. ncbi Clinical significance of high-sensitivity C-reactive protein in cardiovascular disease
    David Conen
    Harvard Medical School, Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston MA 02215, USA
    Biomark Med 1:229-41. 2007
    ..However, this controversy does not diminish the clinical utility of hsCRP as a biomarker of risk that, if appropriately used in clinical practice, can substantially improve clinical care...
  11. pmc Influence of systolic and diastolic blood pressure on the risk of incident atrial fibrillation in women
    David Conen
    Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 119:2146-52. 2009
    ..The influence of systolic and diastolic blood pressure (BP) on incident atrial fibrillation (AF) is not well studied among initially healthy, middle-aged women...
  12. doi Epidemiology of atrial fibrillation
    D Conen
    Department of Medicine, Cardiology Division, University Hospital, Basel, Switzerland
    Swiss Med Wkly 139:346-52. 2009
    ..Knowledge of these interrelationships may eventually help to develop new treatment strategies and decrease the burden of atrial fibrillation in the general population...
  13. pmc Influence of blood pressure and blood pressure change on the risk of congestive heart failure in the elderly
    David Conen
    Department of Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 140:202-8. 2010
    ..We therefore assessed the association of BP change over time with subsequent risk of CHF...
  14. pmc A multimarker approach to assess the influence of inflammation on the incidence of atrial fibrillation in women
    David Conen
    Center for Arrhythmia Prevention Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Eur Heart J 31:1730-6. 2010
    ..To assess the joint influence of inflammatory biomarkers on the risk of incident atrial fibrillation (AF) in women...
  15. pmc Caffeine consumption and incident atrial fibrillation in women
    David Conen
    Center for Arrhythmia Prevention, Department of Medicine, Brigham and Womenrsquos Hospital, Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 92:509-14. 2010
    ..It is somewhat controversial whether caffeine consumption is associated with an increased risk of developing atrial fibrillation (AF)...
  16. pmc Birth weight is a significant risk factor for incident atrial fibrillation
    David Conen
    Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 122:764-70. 2010
    ..Few if any studies have assessed the relationship between birth weight and incident atrial fibrillation (AF)...
  17. pmc Risk of death and cardiovascular events in initially healthy women with new-onset atrial fibrillation
    David Conen
    Department of Medicine, University Hospital, Petersgraben 4, 4031 Basel, Switzerland
    JAMA 305:2080-7. 2011
    ..The risks associated with new-onset atrial fibrillation (AF) among middle-aged women and populations with a low comorbidity burden are poorly defined...
  18. ncbi Natriuretic peptide precursor a gene polymorphisms and risk of blood pressure progression and incident hypertension
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Hypertension 50:1114-9. 2007
    ..031), respectively. If corroborated by other large-scale, prospective studies, our findings indicate that the natriuretic peptide precursor A gene plays a significant role in blood pressure regulation and development of hypertension...
  19. ncbi Montelukast and Churg-Strauss syndrome
    David Conen
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Swiss Med Wkly 134:377-80. 2004
    ..This case is noteworthy because the time course of events strongly suggests a direct aetiological role for montelukast in the development of CSS. The pathophysiological mechanism of the association remains unknown...
  20. ncbi C-reactive protein and B-type natriuretic peptides in never-treated white coat hypertensives
    David Conen
    Medical Outpatient Clinic, University Hospital Basel, Basel, Switzerland
    Hypertens Res 29:411-5. 2006
    ..36). The plasma concentrations of CRP and BNP did not differ between patients with white coat hypertension and those with sustained hypertension...
  21. ncbi Substantial intraindividual variability of BNP concentrations in patients with hypertension
    D Conen
    Department of Cardiology, University Hospital, Basel, Switzerland
    J Hum Hypertens 20:387-91. 2006
    ..Care should be taken in the interpretation of single BNP values below the currently accepted thresholds for heart failure...
  22. ncbi C-reactive protein and echocardiography have little impact on risk stratification in never-treated hypertensive patients
    D Conen
    Department of Cardiology, University Hospital Basel, Basel, Switzerland
    J Hum Hypertens 20:587-92. 2006
    ..An hsCRP cutoff level of 3 mg/l may be more suitable for risk stratification. Finally, our data suggest that depending on the population studied, there is minimal impact of echocardiography on risk stratification...
  23. pmc Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country
    D Conen
    Division of Hypertension and Vascular Medicine, CHUV, Lausanne, Switzerland
    BMC Public Health 4:9. 2004
    ....
  24. ncbi [Sudden onset of left-sided epigastric pain]
    D Conen
    Departement Innere Medizin, Kantonsspital Basel
    Praxis (Bern 1994) 92:294-6. 2003
  25. ncbi Effect of valsartan compared with valsartan/hydrochlorothiazide on plasma levels of cellular adhesion molecules: the Val-MARC trial
    D Conen
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Heart 94:e13. 2008
    ....
  26. ncbi Interstitial lung disease in an intravenous drug user
    D Conen
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Respiration 70:101-3. 2003
  27. pmc Risk of cardiovascular events among women with high normal blood pressure or blood pressure progression: prospective cohort study
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, USA
    BMJ 335:432. 2007
    ..To compare cardiovascular risk among women with high normal blood pressure (130-9/85-9 mm Hg) against those with normal blood pressure (120-9/75-84 mm Hg) and those with baseline hypertension...
  28. pmc The long- and short-term impact of elevated body mass index on the risk of new atrial fibrillation the WHS (women's health study)
    Usha B Tedrow
    Center for Arrhythmia Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 55:2319-27. 2010
    ..The purpose of this study was to characterize the relationship between changes in body mass index (BMI) and incident atrial fibrillation (AF) in a large cohort of women...
  29. pmc Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study
    David Conen
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Hypertens 27:476-83. 2009
    ..The aim of the present study was to assess the association of 77 previously characterized gene variants in 52 candidate genes from various biological pathways with blood pressure (BP) progression and incident hypertension...
  30. pmc Socioeconomic status and incident type 2 diabetes mellitus: data from the Women's Health Study
    Timothy C Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e27670. 2011
    ..We prospectively examined whether socioeconomic status (SES) predicts incident type II diabetes (diabetes), a cardiovascular risk equivalent and burgeoning public health epidemic among women...
  31. pmc Novel genetic markers improve measures of atrial fibrillation risk prediction
    Brendan M Everett
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur Heart J 34:2243-51. 2013
    ..Atrial fibrillation (AF) is associated with adverse outcome. Whether recently discovered genetic risk markers improve AF risk prediction is unknown...
  32. pmc Physical activity and the risk of incident atrial fibrillation in women
    Brendan M Everett
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 4:321-7. 2011
    ..We hypothesized that regular PA, possibly acting through reductions in blood pressure and body mass index (BMI), would reduce the risk of incident atrial fibrillation (AF) in women...
  33. doi Factors associated with 24-hour urinary volume: the Swiss salt survey
    Tobias Schoen
    Department of Medicine, University Hospital, Basel, Switzerland
    BMC Nephrol 14:246. 2013
    ..Low 24-hour urine volume (24 UV) may be a significant risk factor for decline in kidney function. We therefore aimed to study associated markers and possible determinants of 24 UV in a sample of the Swiss population...
  34. pmc Smoking, smoking cessation, [corrected] and risk for symptomatic peripheral artery disease in women: a cohort study
    David Conen
    University Hospital, Basel, Switzerland
    Ann Intern Med 154:719-26. 2011
    ..Smoking has a well-documented detrimental effect on risk for myocardial infarction and stroke, but less information is available regarding peripheral artery disease (PAD), particularly among women...
  35. ncbi Blood pressure and risk of developing type 2 diabetes mellitus: the Women's Health Study
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Eur Heart J 28:2937-43. 2007
    ..To examine the relationship of blood pressure (BP) and BP progression with the subsequent development of type 2 diabetes...
  36. doi Risk for incident atrial fibrillation in patients who receive antihypertensive drugs: a nested case-control study
    Beat A Schaer
    University Hospital, Basel, Switzerland
    Ann Intern Med 152:78-84. 2010
    ..Different antihypertensive drug classes may alter risk for atrial fibrillation. Some studies suggest that drugs that interfere with the renin-angiotensin system may be favorable because of their effect on atrial remodeling...
  37. pmc Metabolic syndrome, inflammation, and risk of symptomatic peripheral artery disease in women: a prospective study
    David Conen
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Circulation 120:1041-7. 2009
    ..We therefore evaluated the relationship between MetS, inflammation, and incident PAD...
  38. ncbi High prevalence of newly detected hypertension in hospitalized patients: the value of inhospital 24-h blood pressure measurement
    David Conen
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    J Hypertens 24:301-6. 2006
    ..We hypothesized that 24-h blood pressure monitoring is an adequate tool to detect unrecognized hypertension among inpatients...
  39. pmc Lipoprotein subclass abnormalities and incident hypertension in initially healthy women
    Nina P Paynter
    Divisions of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin Chem 57:1178-87. 2011
    ..Whether lipoprotein particle size or subclass concentrations play a role in the development of hypertension is unknown...
  40. doi Type 2 diabetes mellitus and risk of incident atrial fibrillation in women
    Tobias Schoen
    Department of Medicine, University Hospital, Basel, Switzerland
    J Am Coll Cardiol 60:1421-8. 2012
    ..The purpose of this study was to assess whether changes of major atrial fibrillation (AF) risk factors and/or intercurrent cardiovascular events could explain the relationship between type 2 diabetes mellitus (T2D) and incident AF...
  41. ncbi Usefulness of B-type natriuretic peptide and C-reactive protein in predicting the presence or absence of left ventricular hypertrophy in patients with systemic hypertension
    David Conen
    Department of Cardiology, University Hospital Basel, Basel, Switzerland
    Am J Cardiol 97:249-52. 2006
    ..In conclusion, in hypertensive patients, echocardiographic LV hypertrophy can be excluded on the basis of a single blood sample for the determination of BNP and CRP...
  42. pmc Relation of renal function to risk for incident atrial fibrillation in women
    Roopinder K Sandhu
    Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
    Am J Cardiol 109:538-42. 2012
    ..However, a significant elevation in AF risk was observed at a threshold eGFR of <60 ml/min/1.73 m(2)...
  43. ncbi Routine blood pressure measurements do not predict adverse events in hospitalized patients
    David Conen
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Am J Med 119:70.e17-22. 2006
    ..Countless blood pressure measurements are performed every day for almost every hospitalized patient. We analyzed the value of routine blood pressure measurements on patient care in an unselected group of hospitalized patients...
  44. doi Drug-eluting versus bare-metal stents in large coronary arteries
    Christoph Kaiser
    Department of Cardiology, University Hospital, CH 4031 Basel, Switzerland
    N Engl J Med 363:2310-9. 2010
    ..We sought to confirm this observation and to assess whether this increase in risk was also seen with second-generation drug-eluting stents...
  45. doi Guidance of antibiotic therapy with procalcitonin in lower respiratory tract infections: insights into the ProHOSP study
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Virulence 1:88-92. 2010
    ..In lower respiratory tract infections, PCT guidance had a differential effect on antibiotic exposure depending on the underlying type and severity of respiratory tract infection...
  46. ncbi Value of repeated cardiac magnetic resonance imaging in patients with suspected arrhythmogenic right ventricular cardiomyopathy
    David Conen
    Department of Cardiology, University Hospital, Basel, Switzerland
    J Cardiovasc Magn Reson 8:361-6. 2006
    ..The purpose of this study was to assess the value of repeated cardiac magnetic resonance imaging (CMR) in patients referred for right ventricular arrhythmias and clinical suspicion of ARVC...
  47. pmc Meta-analysis identifies six new susceptibility loci for atrial fibrillation
    Patrick T Ellinor
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Nat Genet 44:670-5. 2012
    ..The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules...
  48. doi Differential citation rates of major cardiovascular clinical trials according to source of funding: a survey from 2000 to 2005
    David Conen
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Circulation 118:1321-7. 2008
    ..To address this issue, we used the number of citations per publication per year to assess differences in trial dissemination according to funding source...
  49. ncbi Amiodarone-induced thyrotoxicosis: clinical course and predictors of outcome
    David Conen
    Department of Cardiology, University Hospital, Basel, Switzerland
    J Am Coll Cardiol 49:2350-5. 2007
    ..This study sought to determine the clinical course and predictors of long-term outcome in patients with documented amiodarone-induced thyrotoxicosis (AIT)...
  50. ncbi Hypertension is an independent risk factor for contrast nephropathy after percutaneous coronary intervention
    David Conen
    Department of Cardiology, University Hospital Basel, Switzerland
    Int J Cardiol 110:237-41. 2006
    ..We hypothesised that hypertension is an independent risk factor for the development of contrast nephropathy in patients undergoing percutaneous coronary intervention...
  51. doi Use of a Mendelian randomization approach to assess the causal relation of gamma-Glutamyltransferase with blood pressure and serum insulin levels
    David Conen
    Department of Medicine, University Hospital Basel, Basel, Switzerland
    Am J Epidemiol 172:1431-41. 2010
    ..Using MR, the authors also observed a positive association of GGT with insulin (β = 0.19, 95% CI: 0.01, 0.37; P = 0.04). In conclusion, the authors found evidence for a direct causal relation of GGT with fasting insulin but not with BP...
  52. ncbi Treating prehypertension
    David Conen
    N Engl J Med 355:417; author reply 417-8. 2006
  53. ncbi The use of B-type natriuretic peptides in the detection of myocardial ischemia in settings with rapid access to coronary angiography
    David Conen
    Int J Cardiol 119:416-8. 2007
    ..In conclusion, BNP and NT-proBNP are not helpful in the evaluation of male patients with suspected myocardial ischemia in a tertiary care cardiology center with rapid access to coronary angiography...