Sophie Clement

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi Expression and function of alpha-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation
    Sophie Clement
    Department of Geriatrics, Laboratory of Ageing, Geneva Hospital, Chene Bourg, Geneva, Switzerland
    J Cell Sci 120:229-38. 2007
  2. ncbi The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8
    Sophie Clement
    Division of Clinical Pathology, Geneva University Hospital, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Hepatol 52:635-43. 2010
  3. ncbi The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms
    Valerio Pazienza
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Hepatology 45:1164-71. 2007
  4. ncbi The N-terminal Ac-EEED sequence plays a role in alpha-smooth-muscle actin incorporation into stress fibers
    Sophie Clement
    Department of Pathology and Immunology, CMU, Geneva, Switzerland
    J Cell Sci 118:1395-404. 2005
  5. ncbi Intrahepatic mRNA levels of SOCS1 and SOCS3 are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis C
    Stéphanie Pascarella
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Liver Int 33:94-103. 2013
  6. ncbi Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets
    Sophie Clement
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Hepatology 54:38-49. 2011
  7. ncbi Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver
    Reto M Baertschiger
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland
    PLoS ONE 4:e6657. 2009
  8. ncbi Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes
    Sophie Clement
    Division of Clinical Pathology, Geneva University Hospital, University of Geneva, Geneva, Switzerland
    Hepatology 48:799-807. 2008
  9. ncbi Gene expression profile of Huh-7 cells expressing hepatitis C virus genotype 1b or 3a core proteins
    Valerio Pazienza
    Division of Clinical Pathology, University Hospitals and University of Geneva, Geneva, Switzerland
    Liver Int 29:661-9. 2009

Collaborators

Detail Information

Publications9

  1. ncbi Expression and function of alpha-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation
    Sophie Clement
    Department of Geriatrics, Laboratory of Ageing, Geneva Hospital, Chene Bourg, Geneva, Switzerland
    J Cell Sci 120:229-38. 2007
    ..The application of both fusion peptides on beating embryoid bodies impairs frequency. These results suggest specific functional activities for actin isoforms in cardiogenesis and cardiomyocyte contractility...
  2. ncbi The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8
    Sophie Clement
    Division of Clinical Pathology, Geneva University Hospital, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Hepatol 52:635-43. 2010
    ..e., to be mediated by virally-driven inflammation, a direct role of HCV in inducing fibrosis deposition has never been entirely excluded...
  3. ncbi The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms
    Valerio Pazienza
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Hepatology 45:1164-71. 2007
    ..CONCLUSION: Despite the small sequence divergence of the HCV core proteins of genotypes 3a and 1b, the 2 proteins appear to interfere with the insulin signaling pathway using genotype-specific mechanisms...
  4. ncbi The N-terminal Ac-EEED sequence plays a role in alpha-smooth-muscle actin incorporation into stress fibers
    Sophie Clement
    Department of Pathology and Immunology, CMU, Geneva, Switzerland
    J Cell Sci 118:1395-404. 2005
    ..Here, we propose a new mechanism of how alpha-smooth-muscle actin is incorporated in stress fibers involving the sequence Ac-EEED...
  5. ncbi Intrahepatic mRNA levels of SOCS1 and SOCS3 are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis C
    Stéphanie Pascarella
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Liver Int 33:94-103. 2013
    ..The suppressor of cytokine signalling (SOCS) family members have been suggested to affect the rate of virological response to therapy, but the published evidence is conflicting...
  6. ncbi Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets
    Sophie Clement
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Hepatology 54:38-49. 2011
    ..CONCLUSION: The down-regulation of PTEN and IRS1 is a critical event leading to the HCV genotype 3a-induced formation of large lipid droplets in hepatocytes...
  7. ncbi Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver
    Reto M Baertschiger
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland
    PLoS ONE 4:e6657. 2009
    ..These results indicate that MSC in certain circumstances might be harmful due to their fibrogenic potential and this should be considered before potential use of MSC for cell therapy...
  8. ncbi Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes
    Sophie Clement
    Division of Clinical Pathology, Geneva University Hospital, University of Geneva, Geneva, Switzerland
    Hepatology 48:799-807. 2008
    ..CONCLUSION: The monocyte chemoattractant protein-1 secreted by adipose tissue may induce steatosis not only recruiting macrophages but also acting directly on hepatocytes...
  9. ncbi Gene expression profile of Huh-7 cells expressing hepatitis C virus genotype 1b or 3a core proteins
    Valerio Pazienza
    Division of Clinical Pathology, University Hospitals and University of Geneva, Geneva, Switzerland
    Liver Int 29:661-9. 2009
    ..The liver disease expression in chronic hepatitis C patients is variable and may partially depend on the sequence of the infecting viral genotype...