Sophie Clement

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Expression and function of alpha-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation
    Sophie Clement
    Department of Geriatrics, Laboratory of Ageing, Geneva Hospital, Chene Bourg, Geneva, Switzerland
    J Cell Sci 120:229-38. 2007
  2. doi request reprint Role of seipin in lipid droplet morphology and hepatitis C virus life cycle
    Sophie Clement
    Division of Clinical Pathology, University Hospital, University of Geneva School of Medicine, Geneva, Switzerland
    J Gen Virol 94:2208-14. 2013
  3. doi request reprint PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism
    Marion Peyrou
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Hepatol 59:420-6. 2013
  4. doi request reprint Intrahepatic mRNA levels of SOCS1 and SOCS3 are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis C
    Stéphanie Pascarella
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Liver Int 33:94-103. 2013
  5. doi request reprint The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8
    Sophie Clement
    Division of Clinical Pathology, Geneva University Hospital, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Hepatol 52:635-43. 2010
  6. ncbi request reprint The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms
    Valerio Pazienza
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Hepatology 45:1164-71. 2007
  7. ncbi request reprint The N-terminal Ac-EEED sequence plays a role in alpha-smooth-muscle actin incorporation into stress fibers
    Sophie Clement
    Department of Pathology and Immunology, CMU, Geneva, Switzerland
    J Cell Sci 118:1395-404. 2005
  8. doi request reprint Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets
    Sophie Clement
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Hepatology 54:38-49. 2011
  9. pmc Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver
    Reto M Baertschiger
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland
    PLoS ONE 4:e6657. 2009
  10. doi request reprint Gene expression profile of Huh-7 cells expressing hepatitis C virus genotype 1b or 3a core proteins
    Valerio Pazienza
    Division of Clinical Pathology, University Hospitals and University of Geneva, Geneva, Switzerland
    Liver Int 29:661-9. 2009

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Expression and function of alpha-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation
    Sophie Clement
    Department of Geriatrics, Laboratory of Ageing, Geneva Hospital, Chene Bourg, Geneva, Switzerland
    J Cell Sci 120:229-38. 2007
    ..The application of both fusion peptides on beating embryoid bodies impairs frequency. These results suggest specific functional activities for actin isoforms in cardiogenesis and cardiomyocyte contractility...
  2. doi request reprint Role of seipin in lipid droplet morphology and hepatitis C virus life cycle
    Sophie Clement
    Division of Clinical Pathology, University Hospital, University of Geneva School of Medicine, Geneva, Switzerland
    J Gen Virol 94:2208-14. 2013
    ..These results suggest that the available outer surface of lipid droplets is a critical factor for HCV release, independent of the neutral lipid content of the cell. ..
  3. doi request reprint PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism
    Marion Peyrou
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Hepatol 59:420-6. 2013
    ..We showed that HCV induces steatosis via the downregulation of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN). We here investigated how PTEN may affect HCV production...
  4. doi request reprint Intrahepatic mRNA levels of SOCS1 and SOCS3 are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis C
    Stéphanie Pascarella
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Liver Int 33:94-103. 2013
    ..The suppressor of cytokine signalling (SOCS) family members have been suggested to affect the rate of virological response to therapy, but the published evidence is conflicting...
  5. doi request reprint The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8
    Sophie Clement
    Division of Clinical Pathology, Geneva University Hospital, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Hepatol 52:635-43. 2010
    ..e., to be mediated by virally-driven inflammation, a direct role of HCV in inducing fibrosis deposition has never been entirely excluded...
  6. ncbi request reprint The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms
    Valerio Pazienza
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Hepatology 45:1164-71. 2007
    ..We confirmed these findings by using agonists for PPARgamma (rosiglitazone) or short interfering RNAs for SOCS-7...
  7. ncbi request reprint The N-terminal Ac-EEED sequence plays a role in alpha-smooth-muscle actin incorporation into stress fibers
    Sophie Clement
    Department of Pathology and Immunology, CMU, Geneva, Switzerland
    J Cell Sci 118:1395-404. 2005
    ..Here, we propose a new mechanism of how alpha-smooth-muscle actin is incorporated in stress fibers involving the sequence Ac-EEED...
  8. doi request reprint Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets
    Sophie Clement
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Hepatology 54:38-49. 2011
    ..However, IRS1 knockdown per se did not alter the morphology of lipid droplets, and this suggests that other PTEN-dependent mechanisms are involved in this process...
  9. pmc Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver
    Reto M Baertschiger
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland
    PLoS ONE 4:e6657. 2009
    ..These results indicate that MSC in certain circumstances might be harmful due to their fibrogenic potential and this should be considered before potential use of MSC for cell therapy...
  10. doi request reprint Gene expression profile of Huh-7 cells expressing hepatitis C virus genotype 1b or 3a core proteins
    Valerio Pazienza
    Division of Clinical Pathology, University Hospitals and University of Geneva, Geneva, Switzerland
    Liver Int 29:661-9. 2009
    ..The liver disease expression in chronic hepatitis C patients is variable and may partially depend on the sequence of the infecting viral genotype...
  11. doi request reprint Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes
    Sophie Clement
    Division of Clinical Pathology, Geneva University Hospital, University of Geneva, Geneva, Switzerland
    Hepatology 48:799-807. 2008
    ..Investigation of the mechanism leading to the triglyceride accumulation showed that both a diminution of apolipoprotein B secretion and an increase in phosphoenolpyruvate carboxykinase messenger RNA may be involved...