Pierre Alain Clavien

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi Protection of the liver during hepatic surgery
    Pierre Alain Clavien
    Department of Visceral and Transplantation Surgery, University Hospital Zurich, 100 Raemistrasse, 8091 Zurich, Switzerland
    J Gastrointest Surg 8:313-27. 2004
  2. ncbi Strategies for safer liver surgery and partial liver transplantation
    Pierre Alain Clavien
    Swiss Hepato Pancreatico Biliary HPB Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland
    N Engl J Med 356:1545-59. 2007
  3. pmc Hepatic steatosis is a risk factor for postoperative complications after major hepatectomy: a matched case-control study
    Lucas McCormack
    Swiss Hepato Pancreato Biliary HPB Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Ramistrasse 100, Zurich, Switzerland
    Ann Surg 245:923-30. 2007
  4. doi Effects of pentoxifylline on liver regeneration: a double-blinded, randomized, controlled trial in 101 patients undergoing major liver resection
    Henrik Petrowsky
    Swiss HPB Hepato Pancreato Biliary Center, Departments of Surgery, University Hospital Zurich, Zurich, Switzerland
    Ann Surg 252:813-22. 2010
  5. pmc Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice
    F Dahm
    Swiss Hepato Pancreato Biliary Centre, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Ramistrasse 100, Zurich CH 8091, Switzerland
    Br J Cancer 98:98-105. 2008
  6. ncbi Surgical techniques for liver resection
    Pierre Alain Clavien
    Department of Visceral and Transplantation Surgery, University of Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    J Gastrointest Surg 10:166-7. 2006
  7. doi Liver regeneration: a spotlight on the novel role of platelets and serotonin
    Pierre Alain Clavien
    Swiss HPB Hepato Pancreatico Biliary Cente, Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    Swiss Med Wkly 138:361-70. 2008
  8. ncbi Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis
    Antonio Nocito
    Swiss Hepato Pancreato Biliary Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland
    Gastroenterology 133:608-18. 2007
  9. pmc Are two-stage hepatectomies associated with more complications than one-stage procedures?
    Erik Schadde
    Swiss HPB Center, Department of Surgery, University of Zurich Hospital, Switzerland
    HPB (Oxford) 15:411-7. 2013
  10. ncbi Mouse livers with macrosteatosis are more susceptible to normothermic ischemic injury than those with microsteatosis
    Nazia Selzner
    Laboratory of Hepatobiliary Surgery and Transplantation, Department of Visceral Surgery and Transplantation, University Hospital of Zurich, Zurich, Switzerland
    J Hepatol 44:694-701. 2006

Detail Information

Publications158 found, 100 shown here

  1. ncbi Protection of the liver during hepatic surgery
    Pierre Alain Clavien
    Department of Visceral and Transplantation Surgery, University Hospital Zurich, 100 Raemistrasse, 8091 Zurich, Switzerland
    J Gastrointest Surg 8:313-27. 2004
    ....
  2. ncbi Strategies for safer liver surgery and partial liver transplantation
    Pierre Alain Clavien
    Swiss Hepato Pancreatico Biliary HPB Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland
    N Engl J Med 356:1545-59. 2007
  3. pmc Hepatic steatosis is a risk factor for postoperative complications after major hepatectomy: a matched case-control study
    Lucas McCormack
    Swiss Hepato Pancreato Biliary HPB Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Ramistrasse 100, Zurich, Switzerland
    Ann Surg 245:923-30. 2007
    ..To assess the impact of microsteatosis (MiS) and macrosteatosis (MaS) on major hepatectomy...
  4. doi Effects of pentoxifylline on liver regeneration: a double-blinded, randomized, controlled trial in 101 patients undergoing major liver resection
    Henrik Petrowsky
    Swiss HPB Hepato Pancreato Biliary Center, Departments of Surgery, University Hospital Zurich, Zurich, Switzerland
    Ann Surg 252:813-22. 2010
    ..To evaluate the effects of pentoxifylline (PTX) on liver regeneration in patients undergoing major liver resection...
  5. pmc Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice
    F Dahm
    Swiss Hepato Pancreato Biliary Centre, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Ramistrasse 100, Zurich CH 8091, Switzerland
    Br J Cancer 98:98-105. 2008
    ..LCL-30 was an efficacious and safe agent. Future studies should identify an improved application route and effective partners for combination treatment...
  6. ncbi Surgical techniques for liver resection
    Pierre Alain Clavien
    Department of Visceral and Transplantation Surgery, University of Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    J Gastrointest Surg 10:166-7. 2006
  7. doi Liver regeneration: a spotlight on the novel role of platelets and serotonin
    Pierre Alain Clavien
    Swiss HPB Hepato Pancreatico Biliary Cente, Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    Swiss Med Wkly 138:361-70. 2008
    ..The role of platelets and serotonin is highlighted as novel contributors in this process...
  8. ncbi Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis
    Antonio Nocito
    Swiss Hepato Pancreato Biliary Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland
    Gastroenterology 133:608-18. 2007
    ..Serotonin degradation by monoamine oxidase A (MAO-A) was recently implicated as an important source of reactive oxygen species. We therefore tested the pathogenetic role of serotonin in a murine model of diet-induced steatohepatitis...
  9. pmc Are two-stage hepatectomies associated with more complications than one-stage procedures?
    Erik Schadde
    Swiss HPB Center, Department of Surgery, University of Zurich Hospital, Switzerland
    HPB (Oxford) 15:411-7. 2013
    ..Whether they are associated with more complications is unclear. The aim of this study was to compare complications of one- and two-stage resections in a retrospective study...
  10. ncbi Mouse livers with macrosteatosis are more susceptible to normothermic ischemic injury than those with microsteatosis
    Nazia Selzner
    Laboratory of Hepatobiliary Surgery and Transplantation, Department of Visceral Surgery and Transplantation, University Hospital of Zurich, Zurich, Switzerland
    J Hepatol 44:694-701. 2006
    ..While steatosis is an established risk factor for post-operative complications, the impact of macro- vs. microvesicular steatosis on ischemic injury is unclear...
  11. ncbi Platelet-derived serotonin mediates liver regeneration
    Mickael Lesurtel
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    Science 312:104-7. 2006
    ..This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration...
  12. pmc Does pharmacological conditioning with the volatile anaesthetic sevoflurane offer protection in liver surgery?
    Ksenija Slankamenac
    Swiss HPB Hepato Pancreato Biliary Center, University Hospital of Zurich, Zurich, Switzerland
    HPB (Oxford) 14:854-62. 2012
    ..Whether the continuous application of volatile anaesthetics (pharmacological conditioning) also protects against I/R injury is unknown...
  13. doi Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation
    Jae Hwi Jang
    Swiss HPB Hepato Pancreato Biliary Center, Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    Hepatology 56:209-18. 2012
    ..Serotonin reloading of Tph1(-/-) mice reversed this phenotype, resulting in a reduction of circulating bile salts and liver injury...
  14. doi The impact of complications on costs of major surgical procedures: a cost analysis of 1200 patients
    René Vonlanthen
    Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    Ann Surg 254:907-13. 2011
    ..To assess the impact of postoperative complications on full in-hospital costs per case...
  15. doi Prospective phase II trial of neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head
    Stefan Heinrich
    Department of Visceral and Transplantation Surgery, Institute of Surgical Pathology, Swiss Hepato Pancreato Biliary Center, Zurich, Switzerland
    J Clin Oncol 26:2526-31. 2008
    ..To test the safety of neoadjuvant chemotherapy for resectable pancreatic cancer...
  16. ncbi Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomas
    Marc Oliver Riener
    Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    Histopathology 56:600-6. 2010
    ..To study the relevance of periostin, known to be involved in epithelial-mesenchymal transition (EMT), in hepatocellular and bile duct cancer...
  17. pmc Kupffer cell-dependent TNF-alpha signaling mediates injury in the arterialized small-for-size liver transplantation in the mouse
    Yinghua Tian
    Swiss Hepato Pancreatico Biliary Center, Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:4598-603. 2006
    ..In conclusion, interruption of TNF-alpha signaling or depletion of Kupffer cells improves survival after 30% liver transplantation, reduces liver injury, and enhances regeneration. The superior effects of PTX are mediated by IL-6...
  18. ncbi Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice
    Antonio Nocito
    Department of Visceral and Transplantation Surgery, Swiss Hepato Pancreato Biliary Center, University Hospital Zurich, Zurich, Switzerland
    Hepatology 45:369-76. 2007
    ..However, they mediate tissue repair and liver regeneration. Furthermore, platelet-derived serotonin is a mediator of hepatocyte proliferation in the postischemic liver, but has no impact on tissue remodeling...
  19. doi One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts donated after cardiac death
    Olivier de Rougemont
    Department of Surgery, Swiss Hepato Pancreatico Biliary Center, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Ann Surg 250:674-83. 2009
    ..To test, in a large animal model, the efficacy of machine perfusion to rescue livers after prolonged ischemic injury...
  20. doi The use of fatty liver grafts in modern allocation systems: risk assessment by the balance of risk (BAR) score
    Philipp Dutkowski
    Swiss HPB and Transplant Center, Department of Surgery, University Hospital Zurich, Switzerland
    Ann Surg 256:861-8; discussion 868-9. 2012
    ..To integrate the amount of hepatic steatosis in modern liver allocation models...
  21. pmc Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway
    Katarzyna Furrer
    Department of Surgery, Laboratory of the Swiss Hepato Pancreato Biliary and Transplantation Center, University of Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:2945-50. 2011
    ..DOI breaks this restraint through an endothelium-dependent mechanism driven by VEGF. This pathway highlights a target for reversing the age-associated decline in the capacity of the liver to regenerate...
  22. ncbi Assessment of a novel screening score for nutritional risk in predicting complications in gastro-intestinal surgery
    Marc Schiesser
    Division of Visceral and Transplant Surgery, University Hospital, Raemistrasse 100, 8091 Zurich, Switzerland
    Clin Nutr 27:565-70. 2008
    ..The aim of this study was to assess the value of the Nutrition Risk Screening 2002 score in predicting the incidence and severity of postoperative complications in gastrointestinal surgery...
  23. ncbi Small animal magnetic resonance imaging: an efficient tool to assess liver volume and intrahepatic vascular anatomy
    Emmanuel Melloul
    Department of Surgery, Laboratory of the Swiss Hepato Pancreato Biliary HPB and Transplantation Center, University Hospital Zurich, Zurich, Switzerland
    J Surg Res 187:458-65. 2014
    ..To develop a noninvasive technique to assess liver volumetry and intrahepatic portal vein anatomy in a mouse model of liver regeneration...
  24. ncbi Impact of integrated positron emission tomography and computed tomography on staging and management of gallbladder cancer and cholangiocarcinoma
    Henrik Petrowsky
    Swiss HPB Hepato Pancreato Biliary Center, Department of Visceral and Transplant Surgery, University Hospital Zurich, Switzerland
    J Hepatol 45:43-50. 2006
    ....
  25. pmc Positron emission tomography/computed tomography influences on the management of resectable pancreatic cancer and its cost-effectiveness
    Stefan Heinrich
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    Ann Surg 242:235-43. 2005
    ..We sought to determine the impact of positron emission tomography/computed tomography (PET/CT) on the management of presumed resectable pancreatic cancer and to assess the cost of this new staging procedure...
  26. pmc Laparoscopic gastric bypass is superior to laparoscopic gastric banding for treatment of morbid obesity
    Markus Weber
    Division of Visceral and Transplantation Surgery, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Ann Surg 240:975-82; discussion 982-3. 2004
    ..To define whether laparoscopic gastric banding or laparoscopic Roux-en-Y gastric bypass represents the better approach to treat patients with morbid obesity...
  27. doi Liver failure after extended hepatectomy in mice is mediated by a p21-dependent barrier to liver regeneration
    Kuno Lehmann
    Swiss Hepato Pancreatico Biliary Center, Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    Gastroenterology 143:1609-1619.e4. 2012
    ..We developed a mouse model to assess the regenerative capacity of a critically small liver remnant...
  28. ncbi Prevention of reperfusion injury and microcirculatory failure in macrosteatotic mouse liver by omega-3 fatty acids
    Ashraf Mohammad El-Badry
    Swiss HPB Hepato Pancreatico Biliary Centre, Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland
    Hepatology 45:855-63. 2007
    ..Preoperative dietary omega-3 PUFAs protect macrosteatotic livers against reperfusion injury and might represent a valuable method to expand the live liver donor pool...
  29. doi Chemical composition of hepatic lipids mediates reperfusion injury of the macrosteatotic mouse liver through thromboxane A(2)
    Ashraf Mohammad El-Badry
    Swiss HPB Hepato Pancreatico Biliary and Transplant Center, Department of Surgery, University Hospital of Zurich, Switzerland
    J Hepatol 55:1291-9. 2011
    ..Reduced tolerance of the macrosteatotic liver to I/R may be related to increased TXA(2) synthesis due to the predominance of Ω-6 FAs...
  30. doi Arguments against toxic effects of chemotherapy on liver injury and regeneration in an experimental model of partial hepatectomy
    Andreas Rickenbacher
    Department of Surgery, Swiss Hepato Pancreatico Biliary HPB Center, University Hospital Zurich, Zurich, Switzerland
    Liver Int 31:313-21. 2011
    ..New chemotherapy regimens are increasingly used in metastatic colorectal cancer to the liver before surgery. Some clinical observations have suggested that chemotherapy may affect liver regeneration...
  31. ncbi Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells
    Daniel Dindo
    Swiss HPB Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Mol Cancer Ther 5:1520-9. 2006
    ..Cationic long-chain pyridinium ceramides might be promising new drugs for cancer therapy through their mitochondrial preference...
  32. ncbi Cold ischemia decreases liver regeneration after partial liver transplantation in the rat: A TNF-alpha/IL-6-dependent mechanism
    Nazia Selzner
    Department of Visceral Surgery and Transplantation, University of Zurich, Switzerland
    Hepatology 36:812-8. 2002
    ..rIL-6 reversed impaired regeneration in the 10-hour cold ischemia group and suggests a primary role of nonparenchymal cells in modulating hepatocyte proliferation in the ischemic liver...
  33. pmc Does the novel PET/CT imaging modality impact on the treatment of patients with metastatic colorectal cancer of the liver?
    Markus Selzner
    Department of Visceral and Transplantation Surgery, University Hospital Zurich, Rämistrasse 10, 8091 Zurich, Switzerland
    Ann Surg 240:1027-34; discussion 1035-6. 2004
    ..To compare the diagnostic value of contrast-enhanced CT (ceCT) and 2-[18-F]-fluoro-2-deoxyglucose-PET/CT in patients with metastatic colorectal cancer to the liver...
  34. doi Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts
    Andrea Schlegel
    Swiss HPB and Transplant Center, Department of Surgery, University Hospital Zurich, Switzerland
    J Hepatol 58:278-86. 2013
    ..The aim of this study was to identify protective mechanisms of cold machine perfusion in liver grafts donated after cardiac death...
  35. doi New insight into hyperthermic intraperitoneal chemotherapy: induction of oxidative stress dramatically enhanced tumor killing in in vitro and in vivo models
    Kuno Lehmann
    Laboratory of the Swiss Hepato Pancreatico Biliary HPB and Transplantation Center, Department of Surgery, University Hospital Zurich, Ramistrasse 100, Zurich, Switzerland
    Ann Surg 256:730-7; discussion 737-8. 2012
    ..The induction of reactive oxygen species (ROS) by inhibiting the critical detoxification enzyme superoxide dismutase (SOD) during hyperthermia is an appealing approach to induce death of residual cancer cells...
  36. doi Same quality - higher price? The paradox of allocation: the first national single center analysis after the implementation of the new Swiss transplantation law: the ICU view
    Christian E Oberkofler
    Surgical Intensive Care Medicine, University Hospital of Zurich, Zurich, Switzerland
    Clin Transplant 25:921-8. 2011
    ..Liver graft allocation according to the MELD system may save lives at the price of increased intensive care efforts...
  37. doi The model for end-stage liver disease allocation system for liver transplantation saves lives, but increases morbidity and cost: a prospective outcome analysis
    Philipp Dutkowski
    Swiss Hepato Pancreatico Biliary and Transplant Center, Department of Surgery, Zurich, Switzerland
    Liver Transpl 17:674-84. 2011
    ..However, the postoperative course appears more difficult in the MELD era with increased financial burden, but reasonable patient and graft survival. This is the inevitable price to balance justice and utility in liver graft allocation...
  38. doi Sewed revascularization for arterialized liver transplantation in mice
    Bostjan Humar
    Laboratory of Hepatobiliary and Liver Transplantation, Department of Surgery, University Hospital of Zurich, Zurich, Switzerland
    J Surg Res 184:e1-7. 2013
    ..However, the use of cuffs may induce a tissue reaction, causing chronic obstruction of anastomosed vessels, leading to portal hypertension. Here, we applied the suture technique for arterialized liver transplantation in mice...
  39. ncbi Increased ischemic injury in old mouse liver: an ATP-dependent mechanism
    Markus Selzner
    Department of Visceral Surgery and Transplantation, Swiss HPB Center Hepato Pancreato Biliary Center, University Hospital Zurich, Switzerland
    Liver Transpl 13:382-90. 2007
    ..Improving intrahepatic ATP levels in old livers by glucose injection protects the old liver against ischemic injury and restores the protective effects of ischemic preconditioning...
  40. doi Expression of serotonin receptors in human hepatocellular cancer
    Christopher Soll
    Departments of Surgery and Pathology, Swiss Hepato Pancreato Biliary Center, University Hospital Zurich, Zurich, Switzerland
    Clin Cancer Res 18:5902-10. 2012
    ..The aim of this study is to investigate the expression of serotonin receptors in hepatocellular cancer and analyze their potential as a cytotoxic target...
  41. ncbi Right living donor hepatectomy in the presence of celiac artery stenosis
    Zakiyah Kadry
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Zurich, Switzerland
    Transplantation 75:769-72. 2003
    ..Incidental celiac artery stenosis has been cited as an exclusion criterion for adult donor right hepatectomy...
  42. ncbi Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications
    Felix Dahm
    Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland
    Am J Transplant 5:2605-10. 2005
    ..This definition should ease comparability of future clinical trials, and thus improve understanding of the pathogenesis of SFSS...
  43. doi Protection of pharmacological postconditioning in liver surgery: results of a prospective randomized controlled trial
    Beatrice Beck-Schimmer
    Swiss HPB Hepato Pancreato Biliary Center, University Hospital Zurich, Zurich, Switzerland
    Ann Surg 256:837-44; discission 844-5. 2012
    ..To elucidate the possible organ-protective effect of pharmacological postconditioning in patients undergoing liver resection with inflow occlusion...
  44. doi MRI: the new reference standard in quantifying hepatic steatosis?
    Dimitri Aristotle Raptis
    Department of Surgery, Swiss Hepato Pancreatico Biliary Center, University Hospital Zurich, Zurich, Switzerland
    Gut 61:117-27. 2012
    ..The purpose of this study was to assess non-invasive imaging modalities including MRI and CT and compare the quantitative amount of fat with data provided by the pathologist and a chemical lipid assay in leptin-deficient mouse livers...
  45. doi Activation of serotonin receptor-2B rescues small-for-size liver graft failure in mice
    Yinghua Tian
    Laboratory of Hepato Biliary Surgery and Liver Transplantation, Swiss Hepato Pancreato Biliary Center, Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    Hepatology 53:253-62. 2011
    ..Blockage of 5-HT2B blunted the protective effects of DOI. Whereas IL-6 levels were higher in DOI-treated animals, IL-6(-/-) mice were still protected by DOI, suggesting a protective pathway independent of IL-6...
  46. doi Novel and simple preoperative score predicting complications after liver resection in noncirrhotic patients
    Stefan Breitenstein
    Swiss HPB Hepato Pancreato Biliary Center, Department of Surgery, University Hospital of Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Ann Surg 252:726-34. 2010
    ..To develop and validate a simple score to predict postoperative complications by severity after liver resection, using readily available preoperative risk factors...
  47. ncbi Serotonin promotes tumor growth in human hepatocellular cancer
    Christopher Soll
    Department of Surgery, Swiss Hepato Pancreato Biliary Center, University Hospital Zurich, Switzerland
    Hepatology 51:1244-54. 2010
    ..Human biopsies revealed expression of the serotonin receptor HTR2B, correlating with downstream signals, e.g., phosphorylated p70S6K and proliferation...
  48. ncbi Stapled vs excision hemorrhoidectomy: long-term results of a prospective randomized trial
    Franc H Hetzer
    Department for Visceral and Transplantation Surgery, University Hospital of Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Arch Surg 137:337-40. 2002
    ..Furthermore, stapled hemorrhoidectomy is associated with lower hemorrhoidal recurrence on long-term follow-up...
  49. ncbi The wealth of nations and the dissemination of cardiovascular research
    Stephan Winnik
    University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland Department of Medicine, GZO Spital Wetzikon, Switzerland Electronic address
    Int J Cardiol 169:190-5. 2013
    ..This study aimed at understanding whether investigators from less wealthy countries were at a disadvantage in disseminating their research, after accounting for potential differences in research quality and infrastructure...
  50. ncbi Pancreatic cancer in cystic fibrosis after bilateral lung transplantation
    Henrik Petrowsky
    Swiss Hepato Pancreato Biliary Center, Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    Pancreas 33:430-2. 2006
    ..This case should sensitize physicians to be aware of the increased risk for pancreatic cancer in CF patients especially in those after lung transplantation with immunosuppression and prolonged survival...
  51. pmc A prospective, randomized, controlled trial comparing intermittent portal triad clamping versus ischemic preconditioning with continuous clamping for major liver resection
    Henrik Petrowsky
    Swiss Hepato Pancreato Biliary HPB Center, Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland
    Ann Surg 244:921-8; discussion 928-30. 2006
    ..To evaluate whether ischemic preconditioning (IP) with continuous clamping or intermittent clamping (IC) of the portal triad confers better protection during liver surgery...
  52. doi A lymphotoxin-driven pathway to hepatocellular carcinoma
    Johannes Haybaeck
    Department of Pathology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Cancer Cell 16:295-308. 2009
    ..Thus, sustained LT signaling represents a pathway involved in hepatitis-induced HCC...
  53. pmc Assessment of complications after pancreatic surgery: A novel grading system applied to 633 patients undergoing pancreaticoduodenectomy
    Michelle L DeOliveira
    Swiss HPB Hepato Pancreato Biliary Center, Department of Visceral and Transplantation Surgery, Zurich University Hospital, Zurich, Switzerland
    Ann Surg 244:931-7; discussion 937-9. 2006
    ..To define a simple and reproducible classification of complications following pancreaticoduodenectomy (PD) based on a therapy-oriented severity grading system...
  54. ncbi Should we deny surgery for malignant hepato-pancreatico-biliary tumors to elderly patients?
    Henrik Petrowsky
    Department of Visceral and Transplant Surgery, University Hospital Zurich, Raemistrasse 10, 8091 Zurich, Switzerland
    World J Surg 29:1093-100. 2005
    ..Therefore, surgical options should not be denied to elderly patients with a malignant HPB tumor, and the evaluation should include surgeons expert in HPB surgery...
  55. ncbi Retroperitoneal perforation of the colon caused by colonic tuberculosis: report of a case
    Stefan Heinrich
    Department of Visceral and Transplantation Surgery, Zurich, Switzerland
    Dis Colon Rectum 47:2211-4. 2004
    ..We report this extremely rare presentation of gastrointestinal tuberculosis to sensitize physicians to tuberculosis again, because incidence rates are increasing and this disease will certainly play a more important role in the future...
  56. ncbi Ischemic preconditioning protects the steatotic mouse liver against reperfusion injury: an ATP dependent mechanism
    Nazia Selzner
    Laboratory of Liver Transplantation and Hepatobiliary Surgery, Department of Visceral Surgery and Transplantation, University of Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    J Hepatol 39:55-61. 2003
    ..We evaluated whether ischemic preconditioning also confers protection in the fatty liver and whether it protects against the ATP loss...
  57. ncbi Open and laparoscopic living donor nephrectomy in Switzerland: a retrospective assessment of clinical outcomes and the motivation to donate
    Felix Dahm
    Department of Visceral and Transplantation Surgery, University Hospital Zurich, Ramistr 100, CH 8091 Zurich, Switzerland
    Nephrol Dial Transplant 21:2563-8. 2006
    ..The purpose of this study was to explore the impact of these techniques on donors' clinical outcomes, satisfaction and motivation to donate...
  58. pmc How should transection of the liver be performed?: a prospective randomized study in 100 consecutive patients: comparing four different transection strategies
    Mickael Lesurtel
    Department of Visceral and Transplant Surgery, University Hospital of Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Ann Surg 242:814-22, discussion 822-3. 2005
    ..To identify the most efficient parenchyma transection technique for liver resection using a prospective randomized protocol...
  59. ncbi Ischemic preconditioning and intermittent clamping improve murine hepatic microcirculation and Kupffer cell function after ischemic injury
    Katarína Vajdová
    Laboratory of Hepatobiliary and Transplantation Surgery, Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    Liver Transpl 10:520-8. 2004
    ....
  60. pmc Poor level of agreement on the management of postoperative pancreatic fistula: results of an international survey
    Emmanuel Melloul
    Department of Surgery, Swiss Hepato Pancreato Biliary and Transplantation Centre, University Hospital Zurich, Zurich, Switzerland
    HPB (Oxford) 15:307-14. 2013
    ..This study was conduced to evaluate current practice in the management of POPF after Whipple surgery and distal pancreatectomy (DP)...
  61. ncbi Sub-lethal oxidative stress triggers the protective effects of ischemic preconditioning in the mouse liver
    Hannes A Rudiger
    Laboratory for Hepatobiliary Surgery and Liver Transplantation, Department of Visceral Surgery and Transplantation, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    J Hepatol 39:972-7. 2003
    ..We hypothesize that a sub-lethal oxidative stress during ischemic preconditioning induces defense mechanisms preventing subsequent lethal injury...
  62. doi Chemotherapy before liver resection of colorectal metastases: friend or foe?
    Kuno Lehmann
    Swiss Hepato Pancreato Biliary HPB Center, Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    Ann Surg 255:237-47. 2012
    ..We conducted a systematic review of the published literature to critically assess benefits and risks of the use of preoperative chemotherapy in patients presenting with colorectal liver metastases...
  63. ncbi New device for the introduction of a circular stapler in laparoscopic gastric bypass surgery
    Markus K Muller
    Department of Visceral and Transplant Surgery, University Hospital Zurich, Switzerland
    Obes Surg 16:1559-62. 2006
    ..The introduction of the circular stapler through the thick abdominal wall in morbidly obese patients can be challenging. To overcome the difficulties of this task, a new device was developed and its use is presented...
  64. doi Treatment of ureteral complications after kidney transplantation with native ureteropyelostomy reduces the risk of pyelonephritis
    Kuno Lehmann
    Department of Visceral and Transplantation Surgery, University Hospital Zürich Clinic for Nephrology, University Hospital, Zurich, Switzerland
    Clin Transplant 25:201-6. 2011
    ..019). In conclusion, reflux and recurrent graft pyelonephritis can be treated effectively by secondary surgery. The use of native ureteropyelostomy may offer protection from graft pyelonephritis after secondary surgery...
  65. doi Robotic-assisted versus laparoscopic cholecystectomy: outcome and cost analyses of a case-matched control study
    Stefan Breitenstein
    Swiss HPB Hepato Pancreato Biliary Center, University Hospital of Zurich, Zurich, Switzerland
    Ann Surg 247:987-93. 2008
    ..To compare safety and costs of robotic-assisted and laparoscopic cholecystectomy in patients with symptomatic cholecystolithiasis...
  66. ncbi Use of severely steatotic grafts in liver transplantation: a matched case-control study
    Lucas McCormack
    Swiss HPB Hepato Pancreato Biliary Center, Department of Surgery, University Hospital Zurich, Switzerland
    Ann Surg 246:940-6; discussion 946-8. 2007
    ..Although there is a worldwide need to expand the pool of available liver grafts, cadaveric livers with severe steatosis (>60%) are discarded for orthotopic liver transplantation (OLT) by most centers...
  67. doi Frequent expression of the novel cancer testis antigen MAGE-C2/CT-10 in hepatocellular carcinoma
    Marc Oliver Riener
    Department of Pathology, University of Zurich, Zurich, Switzerland
    Int J Cancer 124:352-7. 2009
    ..CT antigens were not expressed in intra- and extrahepatic cholangiocarcinomas. Our results suggest that MAGE-C2/CT-10 may be a good candidate for peptide vaccination in patients with hepatocellular carcinoma...
  68. ncbi Postoperative bezoar ileus after early enteral feeding
    Konstantin J Dedes
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    J Gastrointest Surg 10:123-7. 2006
    ..Acute onset of abdominal pain and the development of small bowel obstruction are the main clinical symptoms of this severe complication. The pathogenesis of bezoar formation remains unclear...
  69. ncbi Liver fat quantification by dual-echo MR imaging outperforms traditional histopathological analysis
    Michael A Fischer
    Institute of Diagnostic Radiology, University Hospital Zurich, Raemistraße 100, 8091 Zurich, Switzerland
    Acad Radiol 19:1208-14. 2012
    ....
  70. doi Donor information for living donor liver transplantation: where can comprehensive information be found?
    Emmanuel Melloul
    Department of Surgery, University Hospital of Zurich, Zurich, Switzerland
    Liver Transpl 18:892-900. 2012
    ..We conclude that there is an urgent need to produce a Web site compliant with international standards for the quality of donor information...
  71. ncbi Laparoscopic pouch resizing and redo of gastro-jejunal anastomosis for pouch dilatation following gastric bypass
    Markus K Muller
    Department for Visceral and Transplant Surgery, University Hospital, Zurich, Switzerland
    Obes Surg 15:1089-95. 2005
    ..In the present paper, we report our experience with laparoscopic re-operation of enlarged gastric pouches after laparoscopic gastric bypass, with emphasis on technique and outcome...
  72. pmc Evidence-based pancreatic head resection for pancreatic cancer and chronic pancreatitis
    Markus Schafer
    Department of Surgery and Division of Gastroenterology, University of Zurich, Zurich, Switzerland
    Ann Surg 236:137-48. 2002
    ..To review the current status of pancreatoduodenectomy for pancreatic cancer and chronic pancreatitis using evidence-based methodology...
  73. doi Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver
    Olivier de Rougemont
    Swiss Hepato Pancreatico Biliary Center, Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    Liver Transpl 15:1172-82. 2009
    ..In the second section, static organ preservation and machine perfusion are addressed. Finally, the possibility of treating the recipient or postconditioning is discussed...
  74. doi Partial bile duct ligation in mice: a novel model of acute cholestasis
    Stefan Heinrich
    Department of Surgery, Laboratory for Hepatobiliary Research, Swiss Hepato Pancreato Biliary Center, University Hospital of Zurich, Zurich, Switzerland
    Surgery 149:445-51. 2011
    ..Because this model causes severe hepatic injury in mice, we developed a novel model of cholestasis using a partial bile duct ligation (pBDL) and evaluate different mechanisms of injury...
  75. ncbi Quality of life and morbidity after permanent sacral nerve stimulation for fecal incontinence
    Franc H Hetzer
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Zurich, Switzerland
    Arch Surg 142:8-13. 2007
    ..Permanent sacral nerve stimulation (SNS) is a promising emerging treatment for fecal incontinence. However, there is little data on morbidity and quality of life (QOL) during long-term stimulation...
  76. ncbi Contrast-enhanced 18F-FDG PET/CT: 1-stop-shop imaging for assessing the resectability of pancreatic cancer
    Klaus Strobel
    Division of Nuclear Medicine, Department of Medical Radiology, University Hospital Zurich, Zurich, Switzerland
    J Nucl Med 49:1408-13. 2008
    ..Our objective was to evaluate the value of combined contrast-enhanced (18)F-FDG PET/CT in assessing the resectability of pancreatic cancer and to compare enhanced PET/CT with the performance of PET alone and unenhanced PET/CT...
  77. doi Sinusectomy for primary pilonidal sinus: less is more
    Christopher Soll
    Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland
    Surgery 150:996-1001. 2011
    ..Sinusectomy of the track is an alternative operation. We here describe the long-term outcome of 257 patients operated between 2001 and 2010...
  78. doi A multicenter randomized clinical trial of primary anastomosis or Hartmann's procedure for perforated left colonic diverticulitis with purulent or fecal peritonitis
    Christian Eugen Oberkofler
    Department of Surgery, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland
    Ann Surg 256:819-26; discussion 826-7. 2012
    ..To evaluate the outcome after Hartmann's procedure (HP) versus primary anastomosis (PA) with diverting ileostomy for perforated left-sided diverticulitis...
  79. ncbi Comparison of arterialized and nonarterialized orthotopic liver transplantation in mice: prowess or relevant model?
    Yinghua Tian
    Division of Visceral Surgery and Transplantation, University Hospital of Zurich, Zurich, Switzerland
    Transplantation 74:1242-6. 2002
    ..Therefore, we developed a new model of OLT in mice, and we compared liver injury and animal survival in the presence and the absence of arterial blood supply...
  80. pmc Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report
    Pierre Alain Clavien
    Department of Surgery, Swiss HPB and Transplant Centers, University Hospital Zurich, Zurich, Switzerland
    Lancet Oncol 13:e11-22. 2012
    ....
  81. ncbi Selective portal vein embolization and ligation trigger different regenerative responses in the rat liver
    Katarzyna Furrer
    Department of Visceral and Transplantation Surgery, Swiss Hepato Pancreato Biliary HPB Center, University Hospital Zurich, Zurich, Switzerland
    Hepatology 47:1615-23. 2008
    ..The embolized part of the liver after PVE showed prominent foreign body reaction in the portal triad with accumulation of macrophages...
  82. ncbi A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anesthetic
    Beatrice Beck-Schimmer
    Swiss HPB Hepato Pancreatico Biliary Center, University of Zurich, Zurich, Switzerland
    Ann Surg 248:909-18. 2008
    ..To evaluate the effects of pharmacological preconditioning with a volatile anesthetic in patients undergoing liver resection with inflow occlusion...
  83. ncbi Emergency left colon resection for acute perforation: primary anastomosis or Hartmann's procedure? A case-matched control study
    Stefan Breitenstein
    Department of Visceral and Transplantation Surgery, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    World J Surg 31:2117-24. 2007
    ..The optimal treatment remains controversial for acute left-sided colon perforation. Therefore, the effectiveness and safety of primary anastomosis versus Hartmann's operation (HP) was compared in a case-matched control study...
  84. doi Assessment of hepatic steatosis by expert pathologists: the end of a gold standard
    Ashraf Mohammad El-Badry
    Department of Surgery, Swiss Hepato Pancreatico Biliary Center, University Hospital of Zurich, Zurich 8091, Switzerland
    Ann Surg 250:691-7. 2009
    ..Computerized image analysis is an alternative method for objective assessment of the degree of hepatic steatosis...
  85. doi Development and validation of a prediction score for postoperative acute renal failure following liver resection
    Ksenija Slankamenac
    Swiss Hepato Pancreato Biliary Center, Department of Surgery, University Hospital of Zurich, Zurich CH 8091, Switzerland
    Ann Surg 250:720-8. 2009
    ..To develop and validate a score to predict postoperative acute renal failure (ARF) after liver resection...
  86. ncbi Biological modulation of liver ischemia-reperfusion injury
    Olivier de Rougemont
    Department of Visceral and Transplantation Surgery, Swiss HPB and Transplant Center, University Hospital Zurich, Switzerland
    Curr Opin Organ Transplant 15:183-9. 2010
    ..This review gives a broad overview of the key factors of ischemic injury to the liver and presents the current modifications of preservation solutions and the few strategies of biological modulation in clinical use today...
  87. doi Cell adhesion molecules P-cadherin and CD24 are markers for carcinoma and dysplasia in the biliary tract
    Marc Oliver Riener
    Department of Pathology, University Hospital Zurich, 8091 Zurich, Switzerland
    Hum Pathol 41:1558-65. 2010
    ..Therefore, they may be useful markers for early detection and as targets for therapy of cholangiocarcinoma...
  88. ncbi Physician competency? Teaching old dogs new tricks
    Pierre Alain Clavien
    Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    J Gastrointest Surg 9:625-32. 2005
  89. ncbi When is steatosis too much for transplantation?
    Antonio Nocito
    Swiss Hepato Pancreatico Biliary Center, Department of Visceral and Transplant Surgery, University Hospital Zurich, Ramistr 100, CH 8091 Zurich, Switzerland
    J Hepatol 45:494-9. 2006
  90. doi Quantification of liver iron content with CT-added value of dual-energy
    Michael A Fischer
    Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistr 100, 8091 Zurich, Switzerland
    Eur Radiol 21:1727-32. 2011
    ..To evaluate the value of dual-energy CT (DECT) with use of an iron-specific, three-material decomposition algorithm for the quantification of liver iron content (LIC)...
  91. ncbi Improving outcome in patients undergoing liver surgery
    Katarzyna Furrer
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland
    Liver Int 27:26-39. 2007
    ..Currently, no drug or gene therapy approaches has reached the clinic. The future relies on new insight into mechanisms of ischemia-reperfusion injury...
  92. ncbi Three-year follow-up study of retrocolic versus antecolic laparoscopic Roux-en-Y gastric bypass
    Markus K Muller
    Department of Visceral and Transplantation Surgery, University Hospital Zurich, Switzerland
    Obes Surg 17:889-93. 2007
    ..In this study, we compared the retrocolic vs the antecolic technique with 3 years of follow-up. We hypothesized that the antecolic technique is superior to the retrocolic in terms of operation time and morbidity...
  93. pmc Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    J Clin Invest 116:2456-63. 2006
    ..Thus, nonspecific activation of innate immunity can drastically enhance susceptibility to immune destruction of a solid organ...
  94. ncbi Should living donor liver transplantation be part of every liver transplant program?
    Zakiyah Kadry
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Raemistrasse 100, Ehoer 39 8901, Zurich, Switzerland
    J Hepatol 43:32-7. 2005
  95. doi Prospective randomized controlled trial of simulator-based versus traditional in-surgery laparoscopic camera navigation training
    Florian M Franzeck
    Department of Visceral and Transplantation Surgery, University Hospital Zurich, 8091, Zurich, Switzerland
    Surg Endosc 26:235-41. 2012
    ..Computer-based simulator training is increasingly used in residency programs. However, no randomized controlled study has compared the effect of simulator-based versus the traditional OR-based training of camera navigation skills...
  96. doi A quarter century experience in liver trauma: a plea for early computed tomography and conservative management for all hemodynamically stable patients
    Henrik Petrowsky
    Department of Surgery, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland
    World J Surg 36:247-54. 2012
    ..The objective of the present study was to investigate the impact of change in liver trauma management on outcome...
  97. pmc Laparoscopic gastric pouch and remnant resection: a novel approach to refractory anastomotic ulcers after Roux-en-Y gastric bypass: case report
    Daniel C Steinemann
    Department of Visceral and Transplantation Surgery, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    BMC Surg 11:33. 2011
    ..However, marginal ulcers still recur in up to 10% of cases after revisional surgery, thus constituting a serious challenge for bariatric surgeons...
  98. pmc Model of end stage liver disease (MELD) score greater than 23 predicts length of stay in the ICU but not mortality in liver transplant recipients
    Christian E Oberkofler
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Raemistrasse 100, Zurich 8091, Switzerland
    Crit Care 14:R117. 2010
    ..There are reports of poorer patient outcome in transplant candidates with high MELD score, others though report no influence of MELD score on outcome and survival...
  99. pmc Management of delayed major visceral arterial bleeding after pancreatic surgery
    Markus Schafer
    Department of Surgery, Swiss Hepato Pancreato Biliary HPB Centre and Institute of Radiology, University Hospital of Zurich, Zurich, Switzerland
    HPB (Oxford) 13:132-8. 2011
    ..This study aimed to assess the management of major haemorrhagic complications after pancreatic surgery at a tertiary referral centre...
  100. ncbi Restoration of hepatic mast cells and expression of a different mast cell protease phenotype in regenerating rat liver after 70%-hepatectomy
    Martin Zweifel
    Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland
    Immunol Cell Biol 83:587-95. 2005
    ....
  101. ncbi Omega 3 - Omega 6: What is right for the liver?
    Ashraf Mohammad El-Badry
    Swiss HPB Hepato Pancreatico Biliary Centre, Department of Visceral and Transplant Surgery, University Hospital Zurich, Ramistrasse 100, CH 8091, Zurich, Switzerland
    J Hepatol 47:718-25. 2007
    ..This concise review article will focus on the role of PUFAs and eicosanoids in hepatic steatosis, microcirculation and ischemia/reperfusion injury...